{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:57:24Z","timestamp":1781643444178,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.biocel.2017.01.007","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T07:23:35Z","timestamp":1484810615000},"page":"96-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["The selective cytotoxicity of DSF-Cu attributes to the biomechanical properties and cytoskeleton rearrangements in the normal and cancerous nasopharyngeal epithelial cells"],"prefix":"10.1016","volume":"84","author":[{"given":"Yaping","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congran","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biocel.2017.01.007_bib0005","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2174\/187152710790966678","article-title":"Disulfiram: an old therapeutic with new applications","volume":"9","author":"Barth","year":"2010","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"11","key":"10.1016\/j.biocel.2017.01.007_bib0010","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1021\/jp910682q","article-title":"Atomic force microscope-related study membrane-associated cytotoxicity in human pterygium fibroblasts induced by mitomycin C","volume":"114","author":"Cai","year":"2010","journal-title":"J. Phys. Chem. B"},{"issue":"27","key":"10.1016\/j.biocel.2017.01.007_bib0015","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1021\/jm049568z","article-title":"Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells","volume":"47","author":"Cen","year":"2004","journal-title":"J. Med. Chem."},{"issue":"21","key":"10.1016\/j.biocel.2017.01.007_bib0020","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1158\/0008-5472.CAN-06-2126","article-title":"Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity","volume":"66","author":"Chen","year":"2006","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.biocel.2017.01.007_bib0025","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10585-012-9531-z","article-title":"Cytoskeletal stiffness, friction, and fluidity of cancer cell lines with different metastatic potential","volume":"30","author":"Coughlin","year":"2013","journal-title":"Clin. Exp. Metastasis"},{"issue":"12","key":"10.1016\/j.biocel.2017.01.007_bib0030","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nnano.2007.388","article-title":"Nanomechanical analysis of cells from cancer patients","volume":"2","author":"Cross","year":"2007","journal-title":"Nat. Nanotechnol."},{"issue":"38","key":"10.1016\/j.biocel.2017.01.007_bib0035","doi-asserted-by":"crossref","first-page":"384003","DOI":"10.1088\/0957-4484\/19\/38\/384003","article-title":"AFM-based analysis of human metastatic cancer cells","volume":"19","author":"Cross","year":"2008","journal-title":"Nanotechnology"},{"issue":"3","key":"10.1016\/j.biocel.2017.01.007_bib0040","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2174\/156800911794519806","article-title":"Targeting malignancies with disulfiram (Antabuse): multidrug resistance, angiogenesis, and proteasome","volume":"11","author":"Cvek","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"issue":"22","key":"10.1016\/j.biocel.2017.01.007_bib0045","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa031317","article-title":"Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer","volume":"349","author":"Forastiere","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"20","key":"10.1016\/j.biocel.2017.01.007_bib0050","doi-asserted-by":"crossref","first-page":"7630","DOI":"10.1073\/pnas.1200107109","article-title":"Hydrodynamic stretching of single cells for large population mechanical phenotyping","volume":"109","author":"Gossett","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5350","key":"10.1016\/j.biocel.2017.01.007_bib0055","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.biocel.2017.01.007_bib0060","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biocel.2017.01.007_bib0065","doi-asserted-by":"crossref","first-page":"E101","DOI":"10.1038\/ncb0402-e101","article-title":"Intercellular adhesion, signalling and the cytoskeleton","volume":"4","author":"Jamora","year":"2002","journal-title":"Nat. Cell Biol."},{"issue":"3","key":"10.1016\/j.biocel.2017.01.007_bib0070","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s00253-010-2747-4","article-title":"Photoinactivation effects of hematoporphyrin monomethyl ether on Gram-positive and \u2212negative bacteria detected by atomic force microscopy","volume":"88","author":"Jin","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biocel.2017.01.007_bib0075","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/156800911794519798","article-title":"Disulfiram, and disulfiram derivatives as novel potential anticancer drugs targeting the ubiquitin-proteasome system in both preclinical and clinical studies","volume":"11","author":"Kona","year":"2011","journal-title":"Curr. Cancer Drug Targets"},{"issue":"10","key":"10.1016\/j.biocel.2017.01.007_bib0080","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.1529\/biophysj.105.071506","article-title":"Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics","volume":"90","author":"Kumar","year":"2006","journal-title":"Biophys. J ."},{"issue":"3","key":"10.1016\/j.biocel.2017.01.007_bib0085","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.tibtech.2007.01.005","article-title":"Biomechanics approaches to studying human diseases","volume":"25","author":"Lee","year":"2007","journal-title":"Trends Biotechnol."},{"issue":"4","key":"10.1016\/j.biocel.2017.01.007_bib0090","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s002490050213","article-title":"Elasticity of normal and cancerous human bladder cells studied by scanning force microscopy","volume":"28","author":"Lekka","year":"1999","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.biocel.2017.01.007_bib0095","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biochi.2016.09.019","article-title":"How cellular membrane properties are affected by the actin cytoskeleton","volume":"130","author":"Lemiere","year":"2016","journal-title":"Biochimie"},{"issue":"2","key":"10.1016\/j.biocel.2017.01.007_bib0100","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.febslet.2005.12.037","article-title":"Elasticity and adhesion of resting and lipopolysaccharide-stimulated macrophages","volume":"580","author":"Leporatti","year":"2006","journal-title":"FEBS Lett."},{"issue":"12","key":"10.1016\/j.biocel.2017.01.007_bib0105","doi-asserted-by":"crossref","first-page":"4825","DOI":"10.7314\/APJCP.2015.16.12.4825","article-title":"Progresses and challenges in chemotherapy for loco- regionally advanced nasopharyngeal carcinoma","volume":"16","author":"Liang","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.biocel.2017.01.007_bib0110","doi-asserted-by":"crossref","first-page":"20946","DOI":"10.18632\/oncotarget.4173","article-title":"Mechanical phenotype of cancer cells: cell softening and loss of stiffness sensing","volume":"6","author":"Lin","year":"2015","journal-title":"Oncotarget"},{"issue":"18","key":"10.1016\/j.biocel.2017.01.007_bib0115","doi-asserted-by":"crossref","first-page":"15966","DOI":"10.18632\/oncotarget.3862","article-title":"Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biocel.2017.01.007_bib0120","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1021\/mp049917l","article-title":"Disulfiram metabolites permanently inactivate the human multidrug resistance P-glycoprotein","volume":"1","author":"Loo","year":"2004","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.biocel.2017.01.007_bib0125","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ncb2024","article-title":"miR-9, a MYC\/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis","volume":"12","author":"Ma","year":"2010","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.biocel.2017.01.007_bib0130","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10911-006-9002-8","article-title":"Multifaceted role of Rho proteins in angiogenesis","volume":"10","author":"Merajver","year":"2005","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"issue":"31","key":"10.1016\/j.biocel.2017.01.007_bib0135","doi-asserted-by":"crossref","first-page":"7986","DOI":"10.1021\/bi800753x","article-title":"AFM: a nanotool in membrane biology","volume":"47","author":"Muller","year":"2008","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/j.biocel.2017.01.007_bib0140","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4161\/cam.5.2.14401","article-title":"The filamins: organizers of cell structure and function","volume":"5","author":"Nakamura","year":"2011","journal-title":"Cell Adhes. Migr."},{"issue":"11","key":"10.1016\/j.biocel.2017.01.007_bib0145","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/nnano.2012.167","article-title":"The nanomechanical signature of breast cancer","volume":"7","author":"Plodinec","year":"2012","journal-title":"Nat. Nanotechnol."},{"issue":"1","key":"10.1016\/j.biocel.2017.01.007_bib0150","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0006-3495(00)76614-8","article-title":"Drug-induced changes of cytoskeletal structure and mechanics in fibroblasts: an atomic force microscopy study","volume":"78","author":"Rotsch","year":"2000","journal-title":"Biophys. J ."},{"issue":"4","key":"10.1016\/j.biocel.2017.01.007_bib0155","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1158\/1535-7163.MCT-10-0028","article-title":"Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed","volume":"9","author":"Salerni","year":"2010","journal-title":"Mol. Cancer Ther."},{"issue":"5","key":"10.1016\/j.biocel.2017.01.007_bib0160","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.3892\/ol.2015.2982","article-title":"Artesunate altered cellular mechanical properties leading to deregulation of cell proliferation and migration in esophageal squamous cell carcinoma","volume":"9","author":"Shi","year":"2015","journal-title":"Oncol. Lett."},{"issue":"6","key":"10.1016\/j.biocel.2017.01.007_bib0165","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00249-008-0311-2","article-title":"Probing elasticity and adhesion of live cells by atomic force microscopy indentation","volume":"37","author":"Sirghi","year":"2008","journal-title":"Eur. Biophys. J."},{"issue":"12","key":"10.1016\/j.biocel.2017.01.007_bib0170","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1529\/biophysj.106.101386","article-title":"Fibroblast adaptation and stiffness matching to soft elastic substrates","volume":"93","author":"Solon","year":"2007","journal-title":"Biophys. J ."},{"issue":"3","key":"10.1016\/j.biocel.2017.01.007_bib0175","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/01.jcp.0000222512.25649.08","article-title":"The status of disulfiram: a half of a century later","volume":"26","author":"Suh","year":"2006","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.biocel.2017.01.007_bib0180","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.intimp.2016.09.026","article-title":"Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro","volume":"40","author":"Sun","year":"2016","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.biocel.2017.01.007_bib0185","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/sca.21013","article-title":"AFM feature definition for neural cells on nanofibrillar tissue scaffolds","volume":"34","author":"Tiryaki","year":"2012","journal-title":"Scanning"},{"issue":"123","key":"10.1016\/j.biocel.2017.01.007_bib0190","doi-asserted-by":"crossref","first-page":"123ra126","DOI":"10.1126\/scitranslmed.3002738","article-title":"A biophysical indicator of vaso-occlusive risk in sickle cell disease","volume":"4","author":"Wood","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/j.biocel.2017.01.007_bib0195","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/bjc.2011.126","article-title":"Disulfiram modulated ROS-MAPK and NFkappaB pathways and targeted breast cancer cells with cancer stem cell-like properties","volume":"104","author":"Yip","year":"2011","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.biocel.2017.01.007_bib0200","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cancergencyto.2003.09.007","article-title":"Sequential cytogenetic and molecular cytogenetic characterization of an SV40T-immortalized nasopharyngeal cell line transformed by Epstein-Barr virus latent membrane protein-1 gene","volume":"150","author":"Zhang","year":"2004","journal-title":"Cancer Genet. Cytogenet."},{"issue":"10","key":"10.1016\/j.biocel.2017.01.007_bib0205","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.1158\/0008-5472.CAN-09-3752","article-title":"Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo","volume":"70","author":"Zhang","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2017.01.007_bib0210","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1038\/srep02615","article-title":"The ClC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis","volume":"3","author":"Zhang","year":"2013","journal-title":"Sci. Rep."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272517300146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272517300146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:05:27Z","timestamp":1761203127000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272517300146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":42,"alternative-id":["S1357272517300146"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2017.01.007","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The selective cytotoxicity of DSF-Cu attributes to the biomechanical properties and cytoskeleton rearrangements in the normal and cancerous nasopharyngeal epithelial cells","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2017.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}