{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T07:04:57Z","timestamp":1768892697415,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270058"],"award-info":[{"award-number":["81270058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30770950"],"award-info":[{"award-number":["30770950"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["2009BB6072"],"award-info":[{"award-number":["2009BB6072"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science and Technology Research Project of Chongqing Education Committee","award":["KJ1500229"],"award-info":[{"award-number":["KJ1500229"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biocel.2017.08.004","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:01:00Z","timestamp":1502323260000},"page":"173-182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia"],"prefix":"10.1016","volume":"92","author":[{"given":"Wenli","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunbao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2017.08.004_bib0005","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jama.2016.10708","article-title":"Association of noninvasive ventilation strategies with mortality and bronchopulmonary dysplasia among 2Preterm infants: a systematic review and meta-analysis","volume":"316","author":"Isayama","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.biocel.2017.08.004_bib0010","doi-asserted-by":"crossref","first-page":"e20152163","DOI":"10.1542\/peds.2015-2163","article-title":"Placental complications and bronchopulmonary dysplasia EPIPAGE-2 cohort study","volume":"137","author":"Torchin","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.biocel.2017.08.004_bib0015","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.ajpath.2011.05.051","article-title":"Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions","volume":"179","author":"Kim","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0020","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1164\/rccm.200402-215OC","article-title":"Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat","volume":"170","author":"Yi","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biocel.2017.08.004_bib0025","doi-asserted-by":"crossref","first-page":"L246","DOI":"10.1152\/ajplung.00109.2013","article-title":"Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia","volume":"306","author":"Witsch","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0030","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00441-014-2035-1","article-title":"Aberrant elastin remodeling in the lungs of O2-exposed newborn mice; primarily results from perturbed interaction between integrins and elastin","volume":"359","author":"Han","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.biocel.2017.08.004_bib0035","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1164\/rccm.201012-2010OC","article-title":"Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice","volume":"184","author":"Hilgendorff","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biocel.2017.08.004_bib0040","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/30522","article-title":"Elastin is an essential determinant of arterial morphogenesis","volume":"393","author":"Li","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2017.08.004_bib0045","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1165\/ajrcmb.23.3.3906","article-title":"Impaired distal airway development in mice lacking elastin","volume":"23","author":"Wendel","year":"2000","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1089\/jir.2015.0080","article-title":"High-mobility group box-1 protein disrupts alveolar elastogenesis of hyperoxia-injured newborn lungs","volume":"36","author":"Yu","year":"2016","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.biocel.2017.08.004_bib0055","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1159\/000430185","article-title":"Interleukin-1\u03b2 promotes epithelial-derived alveolar elastogenesis via \u03b1v\u03b26 integrin-dependent TGF-\u03b2 activation","volume":"36","author":"Wang","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biocel.2017.08.004_bib0060","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1164\/rccm.201412-2291OC","article-title":"Elafin reverses pulmonary hypertension via caveolin-1-dependent bone morphogenetic protein signaling","volume":"191","author":"Nickel","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biocel.2017.08.004_bib0065","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1172\/JCI5099","article-title":"Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis","volume":"103","author":"Zaidi","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biocel.2017.08.004_bib0070","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1172\/JCI118692","article-title":"Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation","volume":"97","author":"Cowan","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biocel.2017.08.004_bib0075","doi-asserted-by":"crossref","first-page":"L341","DOI":"10.1152\/ajplung.00329.2013","article-title":"Alterations of mouse lung tissue dimensions during processing for morphometry: a comparison of methods","volume":"306","author":"Schneider","year":"2014","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0080","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1164\/rccm.200809-1522ST","article-title":"An official research policy statement of the American Thoracic Society\/European Respiratory Society: standards for quantitative assessment of lung structure","volume":"181","author":"Hsia","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biocel.2017.08.004_bib0085","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000196458","article-title":"Measurement of urinary desmosine as an indicator of acute pulmonary disease","volume":"62","author":"Starcher","year":"1995","journal-title":"Respiration"},{"key":"10.1016\/j.biocel.2017.08.004_bib0090","doi-asserted-by":"crossref","first-page":"36338","DOI":"10.18632\/oncotarget.5537","article-title":"Mitochondrial ATF2 translocation contributes to apoptosis induction and BRAF inhibitor resistance in melanoma through the interaction of Bim with VDAC1","volume":"6","author":"Gao","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biocel.2017.08.004_bib0095","doi-asserted-by":"crossref","first-page":"L3","DOI":"10.1152\/ajplung.00362.2007","article-title":"Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development?","volume":"294","author":"Bland","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0100","doi-asserted-by":"crossref","first-page":"L882","DOI":"10.1152\/ajplung.00211.2002","article-title":"Serine protease inhibitors modulate chemotactic cytokine production by human lung fibroblasts in vitro","volume":"284","author":"Numanami","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0105","doi-asserted-by":"crossref","first-page":"L1370","DOI":"10.1152\/ajplung.00367.2006","article-title":"Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease","volume":"292","author":"Bland","year":"2007","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1165\/rcmb.2003-0253OC","article-title":"Deficiency in neutrophil elastase does not impair neutrophil recruitment to inflamed sites","volume":"30","author":"Hirche","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0115","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1165\/rcmb.2007-0315OC","article-title":"Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury","volume":"39","author":"Kaynar","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0120","doi-asserted-by":"crossref","first-page":"15610","DOI":"10.1021\/bi051418i","article-title":"Elafin and its precursor trappin-2 still inhibit neutrophil serine proteinases when they are covalently bound to extracellular matrix proteins by tissue transglutaminase","volume":"44","author":"Guyot","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.biocel.2017.08.004_bib0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/mt.2014.162","article-title":"A functional variant of elafin with improved anti-inflammatory activity for pulmonary inflammation","volume":"23","author":"Small","year":"2015","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biocel.2017.08.004_bib0130","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1165\/rcmb.2002-0090OC","article-title":"Alveolar wall apoptosis causes lung destruction and emphysematous changes","volume":"28","author":"Aoshiba","year":"2003","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0135","doi-asserted-by":"crossref","first-page":"L301","DOI":"10.1152\/ajplung.00082.2013","article-title":"Curcumin protects the developing lung against long-term hyperoxic injury","volume":"305","author":"Aakurai","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0140","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.ajpath.2015.11.024","article-title":"Initial suppression of transforming growth factor-\u03b2 signaling and loss of TGFBI causes early alveolar structural defects resulting in bronchopulmonary dysplasia","volume":"186","author":"Ahlfeld","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0145","doi-asserted-by":"crossref","first-page":"L232","DOI":"10.1152\/ajplung.00530.2005","article-title":"Neutrophil elastase-initiated EGFR\/MEK\/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts","volume":"291","author":"DiCamillo","year":"2006","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0150","doi-asserted-by":"crossref","first-page":"17260","DOI":"10.1073\/pnas.0605556103","article-title":"VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis","volume":"103","author":"Ferrari","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biocel.2017.08.004_bib0155","doi-asserted-by":"crossref","first-page":"L23","DOI":"10.1152\/ajplung.00251.2009","article-title":"Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice","volume":"298","author":"Mokres","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0160","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1165\/rcmb.2003-0420OC","article-title":"Elastase mediates the release of growth factors from lung in vivo","volume":"31","author":"Buczek-Thomas","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0165","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/S0002-9440(10)63612-7","article-title":"Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia","volume":"163","author":"Gauldie","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0170","doi-asserted-by":"crossref","first-page":"L53","DOI":"10.1152\/ajplung.00298.2014","article-title":"Neutrophil elastase-induced elastin degradation mediates macrophage influx and lung injury in 60% O2-exposed neonatal rats","volume":"309","author":"Masood","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biocel.2017.08.004_bib0175","doi-asserted-by":"crossref","first-page":"L215","DOI":"10.1152\/ajplung.00405.2011","article-title":"Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth","volume":"303","author":"Hilgendorff","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272517301917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272517301917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:10:26Z","timestamp":1761203426000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272517301917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":35,"alternative-id":["S1357272517301917"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2017.08.004","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant human elafin promotes alveologenesis in newborn mice exposed to chronic hyperoxia","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2017.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}