{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:57:15Z","timestamp":1791266235197,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Italian Association for Cancer Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Verona Research Founding"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.biocel.2017.12.008","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T13:53:50Z","timestamp":1513000430000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLC\u03b31\/Src-mediated paxillin hyperphosphorylation"],"prefix":"10.1016","volume":"95","author":[{"given":"R.","family":"Montone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.G.","family":"Romanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Baruzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Ferrarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Liboi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.-J.","family":"Lievens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2017.12.008_bib0005","doi-asserted-by":"crossref","first-page":"17437","DOI":"10.1074\/jbc.270.29.17437","article-title":"Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase","volume":"270","author":"Bellis","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1096-8628(19990702)85:1<53::AID-AJMG10>3.0.CO;2-F","article-title":"Severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN): phenotypic analysis of a new skeletal dysplasia caused by a Lys650Met mutation in fibroblast growth factor receptor 3","volume":"85","author":"Bellus","year":"1999","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0015","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1111\/j.1742-4658.2007.05835.x","article-title":"The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor","volume":"274","author":"Bonaventure","year":"2007","journal-title":"FEBS J."},{"key":"10.1016\/j.biocel.2017.12.008_bib0020","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1091\/mbc.9.7.1803","article-title":"Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin","volume":"9","author":"Brown","year":"1998","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.biocel.2017.12.008_bib0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev.cellbio.12.1.463","article-title":"Focal adhesions, contractility, and signaling","volume":"12","author":"Burridge","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0030","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.119.4.893","article-title":"Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly","volume":"119","author":"Burridge","year":"1992","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0035","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1016\/j.cellsig.2007.04.002","article-title":"Phospholipase C-gamma1 potentiates integrin-dependent cell spreading and migration through Pyk2\/paxillin activation","volume":"19","author":"Choi","year":"2007","journal-title":"Cell Signal."},{"key":"10.1016\/j.biocel.2017.12.008_bib0040","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ng0496-390","article-title":"Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3","volume":"12","author":"Colvin","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","article-title":"Mechanisms underlying differential responses to FGF signaling","volume":"16","author":"Dailey","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.biocel.2017.12.008_bib0050","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/jcs.018044","article-title":"Paxillin comes of age","volume":"121","author":"Deakin","year":"2008","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0055","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0092-8674(00)81069-7","article-title":"Fibroblast growth factor receptor 3 is a negative regulator of bone growth","volume":"84","author":"Deng","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2017.12.008_bib0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/humu.21636","article-title":"Sixteen years and counting: the current understanding of fibroblast growth factor receptor 3 (FGFR3) signaling in skeletal dysplasias","volume":"33","author":"Foldynova-Trantirkova","year":"2012","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.biocel.2017.12.008_bib0065","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0955-0674(00)00255-6","article-title":"Assembly and mechanosensory function of focal contacts","volume":"13","author":"Geiger","year":"2001","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm2593","article-title":"Environmental sensing through focal adhesions","volume":"10","author":"Geiger","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0075","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.bone.2006.11.030","article-title":"Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1","volume":"41","author":"Harada","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.biocel.2017.12.008_bib0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1023\/A:1020914026829","article-title":"Fibroblast growth factor receptor 3 mutations in achondroplasia and related forms of dwarfism","volume":"3","author":"Horton","year":"2002","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.biocel.2017.12.008_bib0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.str.2013.07.017","article-title":"Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation","volume":"21","author":"Huang","year":"2013","journal-title":"Structure"},{"key":"10.1016\/j.biocel.2017.12.008_bib0090","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1242\/jcs.00845","article-title":"FAK promotes organization of fibronectin matrix and fibrillar adhesions","volume":"117","author":"Ili\u0107","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0095","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/hmg\/10.12.1255","article-title":"Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice","volume":"10","author":"Iwata","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1146\/annurev.cb.11.110195.002115","article-title":"The molecular architecture of focal adhesions","volume":"11","author":"Jockusch","year":"1995","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0105","doi-asserted-by":"crossref","first-page":"31586","DOI":"10.18632\/oncotarget.8040","article-title":"FAK and paxillin, two potential targets in pancreatic cancer","volume":"7","author":"Kanteti","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biocel.2017.12.008_bib0110","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1093\/emboj\/18.9.2459","article-title":"Src family kinases are required for integrin but not PDGFR signal transduction","volume":"18","author":"Klinghoffer","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.biocel.2017.12.008_bib0115","doi-asserted-by":"crossref","first-page":"D165","DOI":"10.2741\/Klint","article-title":"Signal transduction by fibroblast growth factor receptors","volume":"4","author":"Klint","year":"1999","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0120","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2217\/14796694.4.1.71","article-title":"Novel therapeutic targets in bladder cancer: mutation and expression of FGF receptors","volume":"4","author":"Knowles","year":"2008","journal-title":"Future Oncol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0125","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1242\/dev.105536","article-title":"A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation","volume":"142","author":"Kozhemyakina","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.biocel.2017.12.008_bib0130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mrrev.2013.11.001","article-title":"The paradox of FGFR3 signaling in skeletal dysplasia: why chondrocytes growth arrest while other cells over proliferate","volume":"759","author":"Krejci","year":"2014","journal-title":"Mutat. Res. Rev. Mutat. Res."},{"key":"10.1016\/j.biocel.2017.12.008_bib0135","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature01657","article-title":"Developmental regulation of the growth plate","volume":"423","author":"Kronenberg","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2017.12.008_bib0140","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1017\/erm.2012.4","article-title":"FGFR3 targeting strategies for achondroplasia","volume":"14","author":"Laederich","year":"2012","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.biocel.2017.12.008_bib0145","first-page":"A890","article-title":"Expression of fibroblast growth factor receptor 3 in glial cells from a TD I fetus carrying a K650 M mutation","volume":"73","author":"Legeai-Mallet","year":"2003","journal-title":"Am. J. Hum. Genet. Suppl."},{"key":"10.1016\/j.biocel.2017.12.008_bib0150","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bone.2003.09.002","article-title":"Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias","volume":"34","author":"Legeai-Mallet","year":"2004","journal-title":"Bone"},{"key":"10.1016\/j.biocel.2017.12.008_bib0155","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.cell.2010.06.011","article-title":"Cell signaling by receptor tyrosine kinases","volume":"141","author":"Lemmon","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2017.12.008_bib0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/hmg\/8.1.35","article-title":"A Lys644Glu substitution in Fibroblast Growth Factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors","volume":"8","author":"Li","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0165","doi-asserted-by":"crossref","first-page":"6007","DOI":"10.1242\/jcs.01519","article-title":"FRS2- dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity","volume":"117","author":"Li","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0170","doi-asserted-by":"crossref","first-page":"17344","DOI":"10.1074\/jbc.M212710200","article-title":"The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum","volume":"278","author":"Lievens","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0175","doi-asserted-by":"crossref","first-page":"43254","DOI":"10.1074\/jbc.M405247200","article-title":"The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affect receptor trafficking and signaling","volume":"279","author":"Lievens","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0180","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.jmb.2006.01.058","article-title":"K644E\/M FGFR3 mutants activate Erk1\/2 from the endoplasmic Reticulum through FRS2a and PLCg-independent pathways","volume":"357","author":"Lievens","year":"2006","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0185","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1016\/j.biocel.2008.05.017","article-title":"Transient dimerization and interaction with ERGIC-53 occur in the fibroblast growth factor receptor 3 early secretory pathway","volume":"40","author":"Lievens","year":"2008","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0190","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0195","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-5793(02)03255-6","article-title":"FGF receptor ubiquitylation: dependence on tyrosine kinase ctivity and role in downregulation","volume":"528","author":"Monsonego-Ornan","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biocel.2017.12.008_bib0200","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1101\/gad.1179104","article-title":"Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype","volume":"18","author":"Murakami","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.biocel.2017.12.008_bib0205","doi-asserted-by":"crossref","first-page":"27155","DOI":"10.1016\/S0021-9258(19)61492-4","article-title":"Tyrosine phosphorylation of paxillin alpha is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells","volume":"275","author":"Nakamura","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0210","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/03008207.2015.1051224","article-title":"FGFR3 biology and skeletal disease","volume":"56","author":"Narayana","year":"2015","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.biocel.2017.12.008_bib0215","doi-asserted-by":"crossref","first-page":"d781","DOI":"10.2741\/A321","article-title":"FGF signaling in skeletal development","volume":"3","author":"Naski","year":"1998","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0220","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/ng0696-233","article-title":"Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia","volume":"13","author":"Naski","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0225","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ydbio.2006.09.052","article-title":"Regulation of chondrocyte differentiation by actin-severing protein adseverin","volume":"302","author":"Nurminsky","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0230","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1101\/gad.266551.115","article-title":"Fibroblast growth factor signaling in skeletal development and disease","volume":"29","author":"Ornitz","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.biocel.2017.12.008_bib0235","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","article-title":"Actin, a central player in cell shape and movement","volume":"326","author":"Pollard","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.biocel.2017.12.008_bib0240","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cm.21209","article-title":"Phosphorylation and turnover of paxillin in focal contacts is controlled by force and defines the dynamic state of the adhesion site","volume":"72","author":"Qin","year":"2015","journal-title":"Cytoskeleton"},{"issue":"52","key":"10.1016\/j.biocel.2017.12.008_bib0245","doi-asserted-by":"crossref","first-page":"35250","DOI":"10.1074\/jbc.273.52.35250","article-title":"Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation","volume":"273","author":"Raffioni","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0250","doi-asserted-by":"crossref","first-page":"6906","DOI":"10.1128\/MCB.17.12.6906","article-title":"Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation","volume":"17","author":"Richardson","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0255","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1242\/jcs.115.3.553","article-title":"Induction of chondrocyte growth arrest by FGF: transcriptional and cytoskeletal alterations","volume":"115","author":"Rozenblatt-Rosen","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0260","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1615\/CritRevOncog.v11.i1.30","article-title":"Role of the cytoskeletal protein paxillin in oncogenesis","volume":"11","author":"Sattler","year":"2000","journal-title":"Crit. Rev. Oncog."},{"key":"10.1016\/j.biocel.2017.12.008_bib0265","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1242\/jcs.045112","article-title":"Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions","volume":"123","author":"Schaller","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biocel.2017.12.008_bib0270","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbamcr.2004.04.008","article-title":"Control of motile and invasive cell phenotypes by focal adhesion kinase","volume":"1692","author":"Schlaepfer","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2017.12.008_bib0275","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1086\/302275","article-title":"A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene","volume":"64","author":"Tavormina","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0280","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.gendis.2014.09.005","article-title":"Fibroblast growth factor (FGF) signaling in development and skeletal diseases","volume":"1","author":"Teven","year":"2014","journal-title":"Genes Dis."},{"key":"10.1016\/j.biocel.2017.12.008_bib0285","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/376267a0","article-title":"Specific and redundant roles of Src and Fyn in organizing the cytoskeleton","volume":"376","author":"Thomas","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2017.12.008_bib0290","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1038\/ncb0402-e97","article-title":"Adhesion assembly, disassembly and turnover in migrating cells \u2013 over and over and over again","volume":"4","author":"Webb","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0295","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ncb1094","article-title":"FAK\u2013Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly","volume":"6","author":"Webb","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0300","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0168-9525(97)01131-1","article-title":"FGFR activation in skeletal disorders: too much of a good thing","volume":"13","author":"Webster","year":"1997","journal-title":"Trends Genet."},{"key":"10.1016\/j.biocel.2017.12.008_bib0305","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1128\/MCB.16.8.4081","article-title":"Profound ligand-indipendent kinase activation of FGFR3 by the activation loop mutation responsible for a lethal skeletal dysplasia, thanatophoric dysplasia type II","volume":"16","author":"Webster","year":"1996","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0310","doi-asserted-by":"crossref","first-page":"11626","DOI":"10.1074\/jbc.M409158200","article-title":"RhoA\/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis","volume":"280","author":"Woods","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jcp.21110","article-title":"Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions","volume":"213","author":"Woods","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biocel.2017.12.008_bib0320","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.joca.2008.07.002","article-title":"Rac1 signaling regulates CTGF\/CCN2 gene expression via TGFbeta\/Smad signaling in chondrocytes","volume":"17","author":"Woods","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.biocel.2017.12.008_bib0325","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/jcb.24467","article-title":"ATDC5: an excellent in vitro model cell line for skeletal development","volume":"114","author":"Yao","year":"2013","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biocel.2017.12.008_bib0330","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrc1366","article-title":"A renaissance for SRC","volume":"4","author":"Yeatman","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2017.12.008_bib0335","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.03314","article-title":"A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions","volume":"120","author":"Zaidel-Bar","year":"2007","journal-title":"J. Cell Sci."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135727251730314X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135727251730314X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:08:50Z","timestamp":1761203330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135727251730314X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":67,"alternative-id":["S135727251730314X"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2017.12.008","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mutant FGFR3 associated with SADDAN disease causes cytoskeleton disorganization through PLC\u03b31\/Src-mediated paxillin hyperphosphorylation","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2017.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}