{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:32:29Z","timestamp":1769913149961,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.biocel.2018.10.011","type":"journal-article","created":{"date-parts":[[2018,10,28]],"date-time":"2018-10-28T17:51:51Z","timestamp":1540749111000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Experimental diabetes mellitus exacerbates ischemia\/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt\/Drp1 interaction"],"prefix":"10.1016","volume":"105","author":[{"given":"Aibin","family":"Tao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kvietys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Rui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2018.10.011_bib0005","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/path.4113","article-title":"Oxidative stress and myocardial injury in the diabetic heart","volume":"229","author":"Ansley","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0010","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s12576-015-0365-8","article-title":"Contribution of apoptosis in myocardial reperfusion injury and loss of cardioprotection in diabetes mellitus","volume":"65","author":"Badalzadeh","year":"2015","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.biocel.2018.10.011_bib0015","article-title":"Mitochondrial NAD(+)\/NADH redox state and diabetic cardiomyopathy","author":"Berthiaume","year":"2017","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.biocel.2018.10.011_bib0020","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.devcel.2017.02.020","article-title":"The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species","volume":"40","author":"Bordt","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biocel.2018.10.011_bib0025","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fphys.2011.00013","article-title":"Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury","volume":"2","author":"Camara","year":"2011","journal-title":"Front. Physiol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1001\/jama.2015.7008","article-title":"Association of cardiometabolic multimorbidity with mortality","volume":"314","author":"Di","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.biocel.2018.10.011_bib0035","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cardiores.2006.01.016","article-title":"Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole","volume":"70","author":"Di","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2018.10.011_bib0040","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12491","article-title":"Melatonin prevents Drp1-mediated mitochondrial fission in diabetic hearts through SIRT1-PGC1alpha pathway","author":"Ding","year":"2018","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.biocel.2018.10.011_bib0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12933-015-0299-8","article-title":"SIRT1 protects against myocardial ischemia-reperfusion injury via activating eNOS in diabetic rats","volume":"14","author":"Ding","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0050","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.bbamcr.2011.01.014","article-title":"Mitochondrial dysfunction in diabetic cardiomyopathy","volume":"1813","author":"Duncan","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2018.10.011_bib0055","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cardiores.2003.12.023","article-title":"Role of apoptosis in reperfusion injury","volume":"61","author":"Eefting","year":"2004","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2018.10.011_bib0060","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: the evolution of a concept","volume":"6","author":"Granger","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0065","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pathophys.2017.09.003","article-title":"Reperfusion therapy-What\u2019s with the obstructed, leaky and broken capillaries?","volume":"24","author":"Granger","year":"2017","journal-title":"Pathophysiology"},{"key":"10.1016\/j.biocel.2018.10.011_bib0070","first-page":"935","article-title":"Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations","volume":"38","author":"Hausenloy","year":"2017","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biocel.2018.10.011_bib0075","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1161\/CIRCULATIONAHA.110.958033","article-title":"Silent information regulator 1 protects the heart from ischemia\/reperfusion","volume":"122","author":"Hsu","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2018.10.011_bib0080","article-title":"Reactive oxygen species and mitochondrial dynamics: the yin and Yang of mitochondrial dysfunction and Cancer progression","volume":"7","author":"Jezek","year":"2018","journal-title":"Antioxidants Basel (Basel)"},{"key":"10.1016\/j.biocel.2018.10.011_bib0085","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.yjmcc.2011.09.013","article-title":"Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice","volume":"51","author":"Kawashima","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0090","doi-asserted-by":"crossref","first-page":"37114","DOI":"10.1038\/srep37114","article-title":"Cardioprotection by combination of three compounds from ShengMai preparations in mice with myocardial ischemia\/reperfusion injury through AMPK activation-mediated mitochondrial fission","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biocel.2018.10.011_bib0095","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCHEARTFAILURE.113.000672","article-title":"Angiotensin 1-7 ameliorates diabetic cardiomyopathy and diastolic dysfunction in db\/db mice by reducing lipotoxicity and inflammation","volume":"7","author":"Mori","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"10.1016\/j.biocel.2018.10.011_bib0100","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bbamcr.2017.03.006","article-title":"Molecular regulation of mitochondrial dynamics in cardiac disease","volume":"1864","author":"Nan","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2018.10.011_bib0105","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/1087057106294710","article-title":"SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents","volume":"11","author":"Nayagam","year":"2006","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.biocel.2018.10.011_bib0110","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1038\/s41598-017-01659-7","article-title":"Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKalpha1\/2-LKB1","volume":"7","author":"Pal","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biocel.2018.10.011_bib0115","doi-asserted-by":"crossref","first-page":"e95","DOI":"10.1016\/j.ddmec.2010.07.002","article-title":"Regulation of mitochondrial processes: a target for heart failure","volume":"7","author":"Palaniyandi","year":"2010","journal-title":"Drug Discov. Today Dis. Mech."},{"key":"10.1016\/j.biocel.2018.10.011_bib0120","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCRESAHA.113.300536","article-title":"Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging","volume":"114","author":"Pillai","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2018.10.011_bib0125","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.yjmcc.2012.07.019","article-title":"Dilated cardiomyopathy and mitochondrial dysfunction in Sirt1-deficient mice: a role for Sirt1-Mef2 in adult heart","volume":"53","author":"Planavila","year":"2012","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0130","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fphar.2018.00176","article-title":"Mitochondrial fission is required for angiotensin II-Induced cardiomyocyte apoptosis mediated by a Sirt1-p53 signaling pathway","volume":"9","author":"Qi","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0135","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1093\/cvr\/cvs015","article-title":"Reduction in IL-33 expression exaggerates ischaemia\/reperfusion-induced myocardial injury in mice with diabetes mellitus","volume":"94","author":"Rui","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2018.10.011_bib0140","doi-asserted-by":"crossref","first-page":"11389","DOI":"10.1073\/pnas.1513047112","article-title":"Mitochondrial calcium overload is a key determinant in heart failure","volume":"112","author":"Santulli","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.biocel.2018.10.011_bib0145","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1096\/fj.12-226225","article-title":"Dynamin-related protein 1 (Drp1)-mediated diastolic dysfunction in myocardial ischemia-reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission","volume":"28","author":"Sharp","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.biocel.2018.10.011_bib0150","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/dneu.22519","article-title":"To mdivi-1 or not to mdivi-1: Is that the question?","volume":"77","author":"Smith","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0155","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.bcp.2018.01.038","article-title":"Activation of mitochondrial fusion provides a new treatment for mitochondria-related diseases","volume":"150","author":"Szabo","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0160","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.biocel.2017.05.006","article-title":"Doxorubicin-induced cardiomyocyte apoptosis: role of mitofusin 2","volume":"88","author":"Tang","year":"2017","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biocel.2018.10.011_bib0165","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.bbadis.2015.07.015","article-title":"Cardiomyocyte-fibroblast interaction contributes to diabetic cardiomyopathy in mice: role of HMGB1\/TLR4\/IL-33 axis","volume":"1852","author":"Tao","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2018.10.011_bib0170","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3892\/ijmm.2017.3014","article-title":"(-)-Epigallocatechin-3-gallate attenuates myocardial injury induced by ischemia\/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions","volume":"40","author":"Wu","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biocel.2018.10.011_bib0175","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jocn.2016.10.038","article-title":"Protective effect of nicotinamide adenine dinucleotide (NAD(+)) against spinal cord ischemia-reperfusion injury via reducing oxidative stress-induced neuronal apoptosis","volume":"36","author":"Xie","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.biocel.2018.10.011_bib0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098972","article-title":"Nicotinamide mononucleotide, an intermediate of NAD+ synthesis, protects the heart from ischemia and reperfusion","volume":"9","author":"Yamamoto","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biocel.2018.10.011_bib0185","doi-asserted-by":"crossref","first-page":"e2625","DOI":"10.1038\/cddis.2017.43","article-title":"Ginsenoside Rg5 increases cardiomyocyte resistance to ischemic injury through regulation of mitochondrial hexokinase-II and dynamin-related protein 1","volume":"8","author":"Yang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biocel.2018.10.011_bib0190","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/jpi.12269","article-title":"Reduced silent information regulator 1 signaling exacerbates myocardial ischemia-reperfusion injury in type 2 diabetic rats and the protective effect of melatonin","volume":"59","author":"Yu","year":"2015","journal-title":"J. Pineal Res."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272518302358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272518302358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:14:17Z","timestamp":1761203657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272518302358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":38,"alternative-id":["S1357272518302358"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2018.10.011","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Experimental diabetes mellitus exacerbates ischemia\/reperfusion-induced myocardial injury by promoting mitochondrial fission: Role of down-regulation of myocardial Sirt1 and subsequent Akt\/Drp1 interaction","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2018.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}