{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:42:20Z","timestamp":1783489340804,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biocel.2019.105579","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T12:50:25Z","timestamp":1565268625000},"page":"105579","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Molecular mechanisms of Cisplatin- induced placental toxicity and teratogenicity in rats and the ameliorating role of N-acetyl-cysteine"],"prefix":"10.1016","volume":"115","author":[{"given":"Mohamed S.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohey M.","family":"Mekawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Zeineb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1477-7827-3-28","article-title":"Role of oxidative stress in female reproduction","volume":"14","author":"Agarwal","year":"2005","journal-title":"Reprod Biol Endocrinol."},{"key":"10.1016\/j.biocel.2019.105579_bib0010","series-title":"Quantitative data analysis with SPSS Relase 10 for windows (chapter 2): Analysing Data with Computers First steps with SPSS 10 for windows","author":"Alan","year":"2001"},{"issue":"12","key":"10.1016\/j.biocel.2019.105579_bib0015","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1177\/106002809302701219","article-title":"Newer insights into Cisplatin nephrotoxicity","volume":"27","author":"Anand","year":"1993","journal-title":"Ann Pharmacother."},{"issue":"14","key":"10.1016\/j.biocel.2019.105579_bib0020","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1096\/fasebj.4.14.2227215","article-title":"Protection against Cisplatin toxicity by administration of glutathione ester","volume":"4","author":"Anderson","year":"1990","journal-title":"FASEB J."},{"issue":"5","key":"10.1016\/j.biocel.2019.105579_bib0025","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0270-9295(03)00089-5","article-title":"Cisplatin nephrotoxicity","volume":"23","author":"Arany","year":"2003","journal-title":"Semin Nephrol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0030","doi-asserted-by":"crossref","first-page":"F543","DOI":"10.1152\/ajprenal.00112.2004","article-title":"Cisplatin-induced cell death is EGFR\/src\/ERK signaling dependent in mouse proximal tubule cells","volume":"287","author":"Arany","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0035","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0041-008X(85)90104-8","article-title":"An analysis of factors responsible for resorption of embryos in Cisplatin-treated rats","volume":"80","author":"Bajt","year":"1985","journal-title":"Toxicol Appl Pharmacol."},{"key":"10.1016\/j.biocel.2019.105579_bib0040","series-title":"Theory and Practice of Histopathological Technique","author":"Bancroft","year":"1996"},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0045","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1681\/ASN.2004060494","article-title":"Cisplatin nephrotoxicity is mediated by deoxyribonuclease I","volume":"16","author":"Basnakian","year":"2005","journal-title":"Am Soc Nephrol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-4347(95)00098-4","article-title":"Characterization of cisplatin-glutathione adducts by liquid chromatographymass spectrometry. Evidence for their formation in vitro but not in vivo after concomitant administration of cisplatin and glutathione to rats and cancer patients","volume":"669","author":"Bernareggi","year":"1995","journal-title":"Chromatogr B Biomed Appl"},{"issue":"11","key":"10.1016\/j.biocel.2019.105579_bib0055","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1097\/00005537-200211000-00016","article-title":"Strategies for prevention of toxicity caused by platinum-based chemotherapy: review and summary of the annual meeting of the Blood-Brain Barrier Disruption Program, Gleneden Beach, Oregon, March 10, 2001","volume":"112","author":"Blakley","year":"2002","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.biocel.2019.105579_bib0060","first-page":"1663","article-title":"Cisplatin and platinum drugs at the molecular level","volume":"10","author":"Boulikas","year":"2003","journal-title":"Review). Oncol Rep."},{"issue":"1\u20132","key":"10.1016\/j.biocel.2019.105579_bib0065","first-page":"56","article-title":"Cisplatin ototoxicity in the guinea pig: vestibular and cochlear damage","volume":"182","author":"Bruno","year":"2003","journal-title":"Hearing Research"},{"key":"10.1016\/j.biocel.2019.105579_bib0070","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1126\/science.288.5475.2351","article-title":"A domain in TNF receptors that mediates ligandindependent receptor assembly and signaling","volume":"288","author":"Chan","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0075","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11745-999-0347-y","article-title":"Brain development and assessing the supply of polyunsaturated fatty acid","volume":"34","author":"Clandinin","year":"1999","journal-title":"Lipids"},{"key":"10.1016\/j.biocel.2019.105579_bib0080","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-4615-2554-7_25","article-title":"Iron regulation in the brain at the cell and molecular level","volume":"356","author":"Connor","year":"1994","journal-title":"Adv Exp Med Biol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0085","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00002820-199406000-00001","article-title":"Cisplatin: a clinical review. Part I--Current uses of Cisplatin and administration guidelines","volume":"17","author":"Cooley","year":"1994","journal-title":"Cancer Nurs."},{"issue":"4 Suppl 6","key":"10.1016\/j.biocel.2019.105579_bib0090","first-page":"31","article-title":"): Biologic and clinical developments of Cisplatin combined with radiation: concepts, utility, projections for new trials, and the emergence of carboplatin","volume":"16","author":"Coughlin","year":"1989","journal-title":"Semin Oncol."},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0095","first-page":"1","article-title":"Cisplatin nephrotoxicity: experimental and clinical studies","volume":"37","author":"Daugaard","year":"1990","journal-title":"Dan Med Bull."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000282888","article-title":"Effects of S-CMC on the Cisplatin toxicity in rats","volume":"57","author":"De\u011firmenci","year":"1996","journal-title":"Urol Int."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0105","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00280-007-0597-2","article-title":"Effect of N-acetylcysteine route of administration on chemoprotection against Cisplatin-induced toxicity in rat models","volume":"62","author":"Dickey","year":"2008","journal-title":"Cancer Chemother Pharmacol"},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0110","first-page":"87","article-title":"Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on Cisplatin-induced toxicity in rats","volume":"53","author":"El-Daly","year":"1998","journal-title":"Pharm Belg."},{"key":"10.1016\/j.biocel.2019.105579_bib0115","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.cbi.2006.10.001","article-title":"Study of feasibility of the treatment with procainamide hydrochloride and Cisplatin in pregnant mice","volume":"164","author":"Emanuela","year":"2006","journal-title":"Chemico-Biological Interactions"},{"issue":"7","key":"10.1016\/j.biocel.2019.105579_bib0125","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/00005537-200107000-00005","article-title":"L-n-acetyl-cysteine protection against Cisplatin-induced auditory neuronal and hair cell toxicity","volume":"111","author":"Feghali","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.biocel.2019.105579_bib0130","first-page":"257","article-title":"Cisplatin biochemical mechanism of action: from cytotoxicity to induction of cell death through interconnections between apoptotic and necrotic pathways","volume":"10","author":"Fuertesa","year":"2003","journal-title":"Curr. Med."},{"issue":"1\u20132","key":"10.1016\/j.biocel.2019.105579_bib0135","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.etp.2011.08.008","article-title":"Effect of cisplatin on rat placenta development","volume":"65","author":"Furukawa","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"issue":"5","key":"10.1016\/j.biocel.2019.105579_bib0140","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0890-6238(01)00156-3","article-title":"Cisplatin exposure induces mitochondrial toxicity in pregnant rats and their fetuses","volume":"15","author":"Gerschenson","year":"2001","journal-title":"Reprod Toxicol."},{"issue":"5","key":"10.1016\/j.biocel.2019.105579_bib0145","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/tcm.1770100507","article-title":"Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: cyclophosphamide, cis-platinum, adriamycin","volume":"10","author":"Giavini","year":"1990","journal-title":"Teratog Carcinog Mutagen."},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/carcin\/18.1.93","article-title":"Elevated mitochondrial Cisplatin-DNA adduct levels in rat tissues after transplacental Cisplatin exposure","volume":"18","author":"Giurgiovich","year":"1997","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.biocel.2019.105579_bib0155","first-page":"457","article-title":"Vinblastine, Cisplatin and bleomycin (VPB) adjuvant therapy does not induce dose-dependent damage in human chromosomes","volume":"36","author":"Gundy","year":"1989","journal-title":"Neoplasma"},{"issue":"22","key":"10.1016\/j.biocel.2019.105579_bib0160","first-page":"5925","article-title":"Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity","volume":"54","author":"Hanigan","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.biocel.2019.105579_bib0165","first-page":"3077","article-title":"Cisplatin-induced Apoptosis Proceeds by Caspase-3-dependent and- independent Pathways in Cisplatin-resistant and -sensitive Human Ovarian Cancer Cell Lines","volume":"59","author":"Henkels","year":"2009","journal-title":"Cancer Research."},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0170","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3835(99)00415-2","article-title":"Cisplatin-DNA adduct formation in rat spermatozoa and its effect on fetal development","volume":"151","author":"Hooser","year":"2000","journal-title":"Cancer Lett."},{"issue":"10","key":"10.1016\/j.biocel.2019.105579_bib0175","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s00204-006-0093-1","article-title":"Cadmium and Cisplatin damage erythropoietin-producing proximal renal tubular cells","volume":"80","author":"Horiguchi","year":"2006","journal-title":"Arch Toxicol."},{"issue":"8-9","key":"10.1016\/j.biocel.2019.105579_bib0180","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/PL00000762","article-title":"Molecular mechanisms involved in cisplatin cytotoxicity","volume":"57","author":"Jordan","year":"2000","journal-title":"Cell Mol Life Sci."},{"issue":"4","key":"10.1016\/j.biocel.2019.105579_bib0185","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1159\/000012191","article-title":"Cellular efflux pump and interaction between cisplatin and paclitaxel in ovarian cancer cells","volume":"59","author":"Kamazawa","year":"2000","journal-title":"Oncology"},{"issue":"8","key":"10.1016\/j.biocel.2019.105579_bib0190","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1248\/bpb.28.1385","article-title":"Relationship between cisplatin or nedaplatin-induced nephrotoxicity and renal accumulation","volume":"28","author":"Kawai","year":"2005","journal-title":"Biol Pharm Bull."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0195","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0041-008X(83)90305-8","article-title":"Embryotoxicity of Cisplatin in rats and mice","volume":"69","author":"Keller","year":"1983","journal-title":"Toxicol Appl Pharmacol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0200","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajog.2015.02.022","article-title":"How much platinum passes the placental barrier? Analysis of platinum applications in 21 patients with cervical cancer during pregnancy","volume":"213","author":"K\u00f6hler","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.biocel.2019.105579_bib0205","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0300-483X(85)90143-X","article-title":"Lack of severe malformation versus occurrence of marked embryotoxic effects affects after treatment of pregnant mice with cis-platinum","volume":"34","author":"Kopf-Maien","year":"1985","journal-title":"Toxicol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0210","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/tera.1420280207","article-title":"Effects of the cytostatic drug cis-platinum on the developing neocortex of the mouse","volume":"28","author":"K\u00f6pf-Maier","year":"1983","journal-title":"Teratology"},{"issue":"4","key":"10.1016\/j.biocel.2019.105579_bib0215","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1046\/j.1523-1755.1999.00687.x","article-title":"Apoptosis induced by cisplatin nephrotoxic injury","volume":"56","author":"Lau","year":"1999","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1600-079X.2001.280202.x","article-title":")Ototoxicity caused by Cisplatin is ameliorated by melatonin and other antioxidants","volume":"28","author":"Lopez-Gonzalez","year":"2000","journal-title":"J Pineal Res."},{"key":"10.1016\/j.biocel.2019.105579_bib0225","series-title":"Principles and methods of toxicology","article-title":"Test methods for assessing female reproductive and developmental toxicology","author":"Manson","year":"1994"},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0230","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/jat.1284","article-title":"Cisplatin induces mitochondrial oxidative stress with resultant energetic metabolism impairment, membrane rigidification and apoptosis in rat liver","volume":"28","author":"Martins","year":"2008","journal-title":"Appl Toxicol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0235","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s002800000145","article-title":"The role of caspase family protease, caspase-3 on cisplatin-induced apoptosis in cisplatin-resistant A431 cell line","volume":"46","author":"Mese","year":"2000","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biocel.2019.105579_bib0240","doi-asserted-by":"crossref","first-page":"7989","DOI":"10.1074\/jbc.274.12.7987","article-title":"FAS ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs","volume":"274","author":"Micheau","year":"1999","journal-title":"J Biol Chem."},{"key":"10.1016\/j.biocel.2019.105579_bib0245","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.biopha.2017.10.028","article-title":"The potential protective role of Akropower against Atrazine- induced humoral immunotoxicity in rabbits","volume":"96","author":"Morgan","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.biocel.2019.105579_bib0250","first-page":"7","article-title":"Teratogenic characteristics by single dosing of antineoplastic platinum complexes in rats","volume":"44","author":"Muranaka","year":"1991","journal-title":"Teratology"},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0255","doi-asserted-by":"crossref","first-page":"78","DOI":"10.14712\/fb2003049020078","article-title":"Assessment of nephrotoxicity in the chick embryo: effects of Cisplatin and 1,2-dibromoethane","volume":"49","author":"N\u00e1prstkov\u00e1","year":"2003","journal-title":"Folia Biol (Praha)"},{"issue":"Suppl 1","key":"10.1016\/j.biocel.2019.105579_bib0260","doi-asserted-by":"crossref","first-page":"SP73","DOI":"10.2131\/jts.34.S73","article-title":"Collaborative work on evaluation of ovarian toxicity. Two- or four-week repeated-dose studies and fertility study of Cisplatin in female rats","volume":"34","author":"Nozaki","year":"2009","journal-title":"Toxicol Sci."},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0265","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.cbi.2006.10.001","article-title":"Study of feasibility of the treatment with procainamide hydrochloride and Cisplatin in pregnant mice","volume":"164","author":"Ognio","year":"2006","journal-title":"Chem Biol Interact."},{"issue":"10","key":"10.1016\/j.biocel.2019.105579_bib0270","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s00204-003-0494-3","article-title":"Embryo-lethal and teratogenic effect of the new platinum compound DPR in pregnant mice","volume":"77","author":"Ognio","year":"2003","journal-title":"Arch Toxicol."},{"issue":"6","key":"10.1016\/j.biocel.2019.105579_bib0275","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/sj.bjc.6600786","article-title":"Role of cystine transport in intracellular glutathione level and cisplatin resistance in human ovarian cancer cell lines","volume":"88","author":"Okuno","year":"2003","journal-title":"Br J Cancer."},{"issue":"1-2","key":"10.1016\/j.biocel.2019.105579_bib0280","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.heares.2004.04.009","article-title":"RNA expression induced by Cisplatin in an organ of Corti-derived immortalized cell line","volume":"196","author":"Previati","year":"2004","journal-title":"Hear Res."},{"issue":"July\u2013August (5)","key":"10.1016\/j.biocel.2019.105579_bib0285","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/08880010590964381","article-title":"Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine","volume":"22","author":"Sastry","year":"2005","journal-title":"Pediatr Hematol Oncol."},{"issue":"11","key":"10.1016\/j.biocel.2019.105579_bib0290","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/S0006-2952(00)00478-0","article-title":"Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice","volume":"60","author":"Satoh","year":"2000","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"10.1016\/j.biocel.2019.105579_bib0295","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1080\/1071576021000005267","article-title":"Management of oxidative stress by heme oxygenase-1 in Cisplatin-induced toxicity in renal tubular cells","volume":"36","author":"Schaaf","year":"2002","journal-title":"Free Radic Res."},{"key":"10.1016\/j.biocel.2019.105579_bib0300","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s002800050030","article-title":"Cisplatin (CDDP) specifically induces apoptosis via sequential activation of caspase-8, -3 and -6 in osteosarcoma","volume":"45","author":"Seki","year":"2000","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.biocel.2019.105579_bib0305","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/03655230410017111","article-title":"The role of antioxidants in protection from ototoxic drugs","volume":"552","author":"Sergi","year":"2004","journal-title":"Acta Otolaryngol Suppl."},{"issue":"27","key":"10.1016\/j.biocel.2019.105579_bib0310","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1200\/JCO.2012.44.2806","article-title":"Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations","volume":"31","author":"Sequist","year":"2013","journal-title":"J Clin Oncol."},{"issue":"7","key":"10.1016\/j.biocel.2019.105579_bib0315","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3109\/15376516.2011.568985","article-title":"Possible mechanisms for N-acetyl cysteine and taurine in ameliorating acute renal failure induced by Cisplatin in rats","volume":"21","author":"Shalby","year":"2011","journal-title":"Toxicol Mech Methods."},{"issue":"47","key":"10.1016\/j.biocel.2019.105579_bib0320","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1038\/sj.onc.1206933","article-title":"Cisplatin: mode of cytotoxic action and molecular basis of resistance","volume":"22","author":"Siddik","year":"2003","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0325","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.onc.1210632","article-title":"Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin","volume":"27","author":"Siddiqui","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2019.105579_bib0330","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1126\/science.288.5475.2354","article-title":"FAS preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations","volume":"288","author":"Siegel","year":"2000","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0335","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0165-1110(85)90024-7","article-title":"Occupational exposure to anticancer drug-potential and real hazards","volume":"154","author":"Sorsa","year":"1985","journal-title":"Mutat Res."},{"key":"10.1016\/j.biocel.2019.105579_bib0340","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/sj.cdd.4401248","article-title":"Loss of drug-induced activation of the CD95 apoptotic pathway in a cisplatin-resistant testicular germ cell tumor cell line","volume":"10","author":"Spierings","year":"2003","journal-title":"Cell Death. Differ."},{"key":"10.1016\/j.biocel.2019.105579_bib0345","series-title":"Hazardous Materials Toxicology-Clinical Principles of Environmental Health","first-page":"876","year":"1992"},{"issue":"8","key":"10.1016\/j.biocel.2019.105579_bib0350","doi-asserted-by":"crossref","first-page":"487","DOI":"10.2165\/00003088-200443080-00001","article-title":"Drug transfer and metabolism by the human placenta","volume":"43","author":"Syme","year":"2004","journal-title":"Clin Pharmacokinet."},{"issue":"6","key":"10.1016\/j.biocel.2019.105579_bib0355","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.neuro.2006.04.010","article-title":"Neurotoxicity of oxaliplatin and Cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding","volume":"27","author":"Ta","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.biocel.2019.105579_bib0360","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000086055","article-title":"Cisplatin-associated nephrotoxicity and pathological events","volume":"148","author":"Taguchi","year":"2005","journal-title":"Contrib Nephrol."},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0365","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1124\/jpet.300.1.142","article-title":"Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice","volume":"300","author":"Townsend","year":"2002","journal-title":"Pharmacol Exp Ther."},{"issue":"1","key":"10.1016\/j.biocel.2019.105579_bib0370","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000042803.28024.92","article-title":"Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells","volume":"14","author":"Townsend","year":"2003","journal-title":"Am Soc Nephrol."},{"issue":"6","key":"10.1016\/j.biocel.2019.105579_bib0375","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1124\/dmd.31.6.705","article-title":"High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin","volume":"31","author":"Townsend","year":"2003","journal-title":"Drug Metab Dispos."},{"issue":"12 Suppl Pt 1","key":"10.1016\/j.biocel.2019.105579_bib0380","first-page":"S11","article-title":"Free radical oxidative damage and Alzheimer\u2019s disease","volume":"101","author":"Tuppo","year":"2001","journal-title":"Am Osteopath Assoc."},{"issue":"14","key":"10.1016\/j.biocel.2019.105579_bib0385","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1056\/NEJMoa0908721","article-title":"Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer","volume":"362","author":"Valle","year":"2010","journal-title":"N Engl J Med."},{"issue":"31","key":"10.1016\/j.biocel.2019.105579_bib0390","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1200\/JCO.2006.06.8429","article-title":"Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group","volume":"24","author":"Van Cutsem","year":"2006","journal-title":"J Clin Oncol."},{"key":"10.1016\/j.biocel.2019.105579_bib0395","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1756-9966-29-49","article-title":"Up-regulation of fas reverses cisplatin resistance of human small cell lung cancer cells","volume":"29","author":"Wei","year":"2010","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biocel.2019.105579_bib0400","series-title":"Environ Health Criteria 125: Platinum","first-page":"76","author":"WHO","year":"1991"},{"key":"10.1016\/j.biocel.2019.105579_bib0405","series-title":"International nonproprietary names (INN) for pharmaceutical substances","first-page":"125","author":"WHO","year":"1992"},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0410","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S1470-2045(13)70604-1","article-title":"A fatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial","volume":"15","author":"Wu","year":"2014","journal-title":"Lancet Oncol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105579_bib0415","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MAJ.0b013e31812dfe1e","article-title":"Cisplatin nephrotoxicity: a review","volume":"334","author":"Yao","year":"2007","journal-title":"Am J Med Sci."},{"issue":"3","key":"10.1016\/j.biocel.2019.105579_bib0420","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1124\/jpet.103.052225","article-title":"Role of cysteine S-conjugate beta-lyase in the metabolism of cisplatin","volume":"306","author":"Zhang","year":"2003","journal-title":"Pharmacol Exp Ther."},{"issue":"14","key":"10.1016\/j.biocel.2019.105579_bib0425","doi-asserted-by":"crossref","first-page":"4451","DOI":"10.1158\/0008-5472.CAN-13-0198","article-title":"Visualizing inhibition of nucleosome mobility and transcription by cisplatin-DNA interstrand crosslinks in live mammalian cells","volume":"73","author":"Zhu","year":"2013","journal-title":"Cancer Res."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272519301566?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272519301566?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:15:53Z","timestamp":1761203753000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272519301566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":85,"alternative-id":["S1357272519301566"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2019.105579","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular mechanisms of Cisplatin- induced placental toxicity and teratogenicity in rats and the ameliorating role of N-acetyl-cysteine","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2019.105579","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105579"}}