{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:45:25Z","timestamp":1786985125587,"version":"build-2736575974"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biocel.2019.105592","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T17:39:15Z","timestamp":1566668355000},"page":"105592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development"],"prefix":"10.1016","volume":"115","author":[{"given":"Diego Assis","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Xisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica Domingues","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Baceti","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Pereira","family":"Moura Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Yudi","family":"Icimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Sant\u2019Anna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Gimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia","family":"de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Llesuy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise C.","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Laurindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Galvonas","family":"Jasiulionis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9199-3076","authenticated-orcid":false,"given":"Fabiana Henriques Machado de","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2019.105592_bib0005","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jphotobiol.2018.06.005","article-title":"Ultraviolet radiation-mediated development of cutaneous melanoma: an update","volume":"185","author":"Emri","year":"2018","journal-title":"J. Photochem. Photobiol. B"},{"issue":"5","key":"10.1016\/j.biocel.2019.105592_bib0010","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell. Signal."},{"issue":"12","key":"10.1016\/j.biocel.2019.105592_bib0015","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1593\/neo.07712","article-title":"Oxidative stress modulates DNA methylation during melanocyte anchorage blockade associated with malignant transformation","volume":"9","author":"Campos","year":"2007","journal-title":"Neoplasia"},{"issue":"June (1\u20132)","key":"10.1016\/j.biocel.2019.105592_bib0020","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.mrfmmm.2011.02.015","article-title":"Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis","volume":"711","author":"Ziech","year":"2011","journal-title":"Mutat. Res."},{"issue":"7\u20138","key":"10.1016\/j.biocel.2019.105592_bib0025","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.biocel.2007.04.007","article-title":"Superoxide anion: oncogenic reactive oxygen species?","volume":"39","author":"Pervaiz","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"10","key":"10.1016\/j.biocel.2019.105592_bib0030","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.freeradbiomed.2011.02.022","article-title":"Endothelial nitric oxide synthase uncoupling as a key mediator of melanocyte malignant transformation associated with sustained stress conditions","volume":"50","author":"Melo","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"12","key":"10.1016\/j.biocel.2019.105592_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081937","article-title":"Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation","volume":"8","author":"Molognoni","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0040","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1172\/JCI30102","article-title":"Overexpression of Akt converts radial growth melanoma to vertical growth melanoma","volume":"117","author":"Govindarajan","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.biocel.2019.105592_bib0045","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1158\/0008-5472.CAN-08-3745","article-title":"NADPH oxidase 4 contributes to transformation phenotype of melanoma cells by regulating G2-M cell cycle progression","volume":"69","author":"Yamaura","year":"2009","journal-title":"Cancer Res."},{"issue":"8","key":"10.1016\/j.biocel.2019.105592_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040690","article-title":"Mitochondrial respiration \u2013 an important therapeutic target in melanoma","volume":"7","author":"Barbi de Moura","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.biocel.2019.105592_bib0055","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1042\/BJ20150645","article-title":"Enhanced OXPHOS, glutaminolysis and \u03b2-oxidation constitute the metastatic phenotype of melanoma cells","volume":"473","author":"Rodrigues","year":"2016","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.biocel.2019.105592_bib0060","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1152\/ajpregu.00323.2002","article-title":"Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase","volume":"284","author":"Fleming","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"7","key":"10.1016\/j.biocel.2019.105592_bib0065","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/eurheartj\/ehr304","article-title":"Nitric oxide synthases: regulation and function","volume":"33","author":"F\u00f6rstermann","year":"2012","journal-title":"Eur. Heart J."},{"issue":"2","key":"10.1016\/j.biocel.2019.105592_bib0070","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.ATV.0000196554.85799.77","article-title":"Endothelial nitric oxide synthase: host defense enzyme of the endothelium?","volume":"26","author":"Rabelink","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"9","key":"10.1016\/j.biocel.2019.105592_bib0075","doi-asserted-by":"crossref","first-page":"7540","DOI":"10.1074\/jbc.M410241200","article-title":"Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin","volume":"280","author":"Cardounel","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.biocel.2019.105592_bib0080","doi-asserted-by":"crossref","first-page":"9573","DOI":"10.1074\/jbc.274.14.9573","article-title":"Mechanism of superoxide generation by neuronal nitric-oxide synthase","volume":"274","author":"Pou","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"Pt 3","key":"10.1016\/j.biocel.2019.105592_bib0085","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","article-title":"Nitric oxide synthases: structure, function and inhibition","volume":"357","author":"Alderton","year":"2001","journal-title":"Biochem. J."},{"issue":"18","key":"10.1016\/j.biocel.2019.105592_bib0090","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1021\/bi0361867","article-title":"Structures of the neuronal and endothelial nitric oxide synthase heme domain with D-nitroarginine-containing dipeptide inhibitors bound","volume":"43","author":"Flinspach","year":"2004","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0095","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1161\/01.ATV.0000110785.96039.f6","article-title":"Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease","volume":"24","author":"Alp","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0100","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/BJ20110293","article-title":"Tetrahydrobiopterin: biochemistry and pathophysiology","volume":"438","author":"Werner","year":"2011","journal-title":"Biochem. J."},{"issue":"5","key":"10.1016\/j.biocel.2019.105592_bib0105","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.2353\/ajpath.2010.100025","article-title":"Roles of tetrahydrobiopterin in promoting tumor angiogenesis","volume":"177","author":"Chen","year":"2010","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.biocel.2019.105592_bib0110","first-page":"861","article-title":"Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression","volume":"26","author":"Cho","year":"2011","journal-title":"Oncol. Rep."},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0115","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ijc.27706","article-title":"Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages","volume":"132","author":"Pickert","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.biocel.2019.105592_bib0120","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1124\/jpet.113.203828","article-title":"Sepiapterin ameliorates chemically induced murine colitis and azoxymethane-induced colon cancer","volume":"347","author":"Cardnell","year":"2013","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.biocel.2019.105592_bib0125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1186\/s12885-015-1447-y","article-title":"Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target","volume":"15","author":"Yco","year":"2015","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biocel.2019.105592_bib0130","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1476-4598-12-22","article-title":"Timp1 interacts with beta-1 integrin and CD63 along melanoma genesis and confers anoikis resistance by activating PI3-K signaling pathway independently of Akt phosphorylation","volume":"12","author":"Toricelli","year":"2013","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.biocel.2019.105592_bib0135","doi-asserted-by":"crossref","first-page":"C413","DOI":"10.1152\/ajpcell.00188.2006","article-title":"Analysis of DHE-derived oxidation products by HPLC in the assessment of superoxide production and NADPH oxidase activity in vascular systems","volume":"292","author":"Fernandes","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105592_bib0140","doi-asserted-by":"crossref","first-page":"H482","DOI":"10.1152\/ajpheart.2001.281.2.H482","article-title":"Tetrahydrobiopterin levels regulate endothelial cell proliferation","volume":"281","author":"Marinos","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0145","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1172\/JCI0215215","article-title":"Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice","volume":"110","author":"Ozaki","year":"2002","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.biocel.2019.105592_bib0150","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/01.RES.0000187447.03525.72","article-title":"Stoichiometric relationships between endothelial tetrahydrobiopterin, endothelial NO synthase (eNOS) activity, and eNOS coupling in vivo: insights from transgenic mice with endothelial-targeted GTP cyclohydrolase 1 and eNOS overexpression","volume":"97","author":"Bendall","year":"2005","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.biocel.2019.105592_bib0155","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1074\/jbc.M805403200","article-title":"Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression","volume":"284","author":"Crabtree","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.biocel.2019.105592_bib0160","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/CS20070108","article-title":"Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease","volume":"113","author":"Schmidt","year":"2007","journal-title":"Clin. Sci. (Lond.)"},{"issue":"8","key":"10.1016\/j.biocel.2019.105592_bib0165","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.freeradbiomed.2009.07.024","article-title":"Tetrahydrobiopterin, superoxide, and vascular dysfunction","volume":"47","author":"V\u00e1squez-Vivar","year":"2009","journal-title":"Free Radic. Biol. Med."},{"issue":"18","key":"10.1016\/j.biocel.2019.105592_bib0170","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1089\/ars.2013.5566","article-title":"Tetrahydrobiopterin in cardiovascular health and disease","volume":"20","author":"Bendall","year":"2014","journal-title":"Antioxid. Redox Signal."},{"issue":"December (15)","key":"10.1016\/j.biocel.2019.105592_bib0175","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1096\/fj.04-1702fje","article-title":"GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats","volume":"18","author":"Meininger","year":"2004","journal-title":"FASEB J."},{"issue":"February (8)","key":"10.1016\/j.biocel.2019.105592_bib0180","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1161\/CIRCULATIONAHA.107.748236","article-title":"Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression insalt-sensitive low-renin hypertension","volume":"117","author":"Du","year":"2008","journal-title":"Circulation"},{"issue":"September (3)","key":"10.1016\/j.biocel.2019.105592_bib0185","doi-asserted-by":"crossref","first-page":"H903","DOI":"10.1152\/ajpheart.00936.2010","article-title":"Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism","volume":"301","author":"Karuppiah","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105592_bib0190","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1254\/jjp.80.177","article-title":"Stimulation of in vitro angiogenesis by tetrahydrobiopterin in bovine aortic endothelial cells","volume":"80","author":"Shimizu","year":"1999","journal-title":"Jpn. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.biocel.2019.105592_bib0195","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.numecd.2006.01.007","article-title":"Primary role of superoxide anion generation in the cascade of events leading to endothelial dysfunction and damage in high glucose treated HUVEC","volume":"17","author":"Quagliaro","year":"2007","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"issue":"8","key":"10.1016\/j.biocel.2019.105592_bib0200","doi-asserted-by":"crossref","first-page":"9353","DOI":"10.18632\/oncotarget.6981","article-title":"Paracrine effect of GTP cyclohydrolase and angiopoietin-1 interaction in stromal fibroblasts on tumor Tie2 activation and breast cancer growth","volume":"7","author":"Chen","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.biocel.2019.105592_bib0205","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1158\/1541-7786.MCR-15-0057-T","article-title":"The role of nitric oxide synthase uncoupling in tumor progression","volume":"13","author":"Rabender","year":"2015","journal-title":"Mol. Cancer Res."},{"issue":"12","key":"10.1016\/j.biocel.2019.105592_bib0210","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0215","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0748233710386408","article-title":"Roles of reactive oxygen species and mitochondria in cadmium-induced injury of liver cells","volume":"27","author":"Liu","year":"2011","journal-title":"Toxicol. Ind. Health"},{"issue":"3","key":"10.1016\/j.biocel.2019.105592_bib0220","doi-asserted-by":"crossref","first-page":"511","DOI":"10.3892\/ijmm.2013.1235","article-title":"Redox regulation of tumor suppressor PTEN in cancer and aging (review)","volume":"31","author":"Kitagishi","year":"2013","journal-title":"Int. J. Mol. Med."},{"issue":"2","key":"10.1016\/j.biocel.2019.105592_bib0225","doi-asserted-by":"crossref","first-page":"103","DOI":"10.2174\/1568009053202072","article-title":"NO news is not necessarily good news in cancer","volume":"5","author":"Ekmekcioglu","year":"2005","journal-title":"Curr. Cancer Drug Targets"},{"issue":"4","key":"10.1016\/j.biocel.2019.105592_bib0230","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2013.01.041","article-title":"Applications for nitric oxide in halting proliferation of tumor cells","volume":"431","author":"Reynolds","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.biocel.2019.105592_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10715760701762407","article-title":"Nitric oxide activated by p38 and NF-kappaB facilitates apoptosis and cell cycle arrest under oxidative stress in evodiamine-treated human melanoma A375-S2 cells","volume":"42","author":"Yang","year":"2008","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.biocel.2019.105592_bib0240","first-page":"318","article-title":"Antiapoptotic role of endogenous nitric oxide in human melanoma cells","volume":"61","author":"Salvucci","year":"2001","journal-title":"Cancer Res."},{"issue":"11","key":"10.1016\/j.biocel.2019.105592_bib0245","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1074\/jbc.272.11.7253","article-title":"Superoxide formation and macrophage resistance to nitric oxide-mediated apoptosis","volume":"272","author":"Br\u00fcne","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"3\u20134","key":"10.1016\/j.biocel.2019.105592_bib0250","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/ars.2005.7.497","article-title":"The intimate relation between nitric oxide and superoxide in apoptosis and cell survival","volume":"7","author":"Br\u00fcne","year":"2005","journal-title":"Antioxid. Redox Signal."},{"issue":"October (3)","key":"10.1016\/j.biocel.2019.105592_bib0255","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1006\/bbrc.1995.2579","article-title":"Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity","volume":"215","author":"Chen","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"January (1)","key":"10.1016\/j.biocel.2019.105592_bib0260","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1172\/JCI119131","article-title":"Tetrahydrobiopterin restores endothelial function in hypercholesterolemia","volume":"99","author":"Stroes","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"November (11)","key":"10.1016\/j.biocel.2019.105592_bib0265","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/s001250051551","article-title":"Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus","volume":"43","author":"Heitzer","year":"2000","journal-title":"Diabetologia"},{"issue":"February (2)","key":"10.1016\/j.biocel.2019.105592_bib0270","first-page":"E36","article-title":"Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers\u202f: evidence for a dysfunctional nitric oxide synthase","volume":"86","author":"Meinertz","year":"2000","journal-title":"Circ. Res."},{"issue":"January (1)","key":"10.1016\/j.biocel.2019.105592_bib0275","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ymgme.2003.09.014","article-title":"Plasma tetrahydrobiopterin and its pharmacokinetic following oral administration","volume":"81","author":"Fiege","year":"2004","journal-title":"Mol. Genet. Metab."},{"issue":"May (1)","key":"10.1016\/j.biocel.2019.105592_bib0280","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymgme.2019.04.004","article-title":"International best practice for the evaluation of responsiveness to sapropterin dihydrochloride in patients with phenylketonuria","volume":"127","author":"Muntau","year":"2019","journal-title":"Mol. Genet. Metab."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272519301694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272519301694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:16:24Z","timestamp":1761203784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272519301694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":56,"alternative-id":["S1357272519301694"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2019.105592","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imbalance between nitric oxide and superoxide anion induced by uncoupled nitric oxide synthase contributes to human melanoma development","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2019.105592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105592"}}