{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:35:28Z","timestamp":1790742928068,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ministry of University"},{"name":"Progetti di Ricerca di Interesse Nazionale"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.biocel.2019.105659","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T02:39:02Z","timestamp":1574390342000},"page":"105659","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Metabolic aspects of cardiovascular diseases: Is FoxO1 a player or a target?"],"prefix":"10.1016","volume":"118","author":[{"given":"Rossella","family":"Menghini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Casagrande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Iuliani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rizza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mavilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Cardellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Federici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.biocel.2019.105659_bib0005","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.3390\/ijms20102467","article-title":"Metabolomics of type 1 and type 2 diabetes","volume":"20","author":"Arneth","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biocel.2019.105659_bib0010","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1172\/JCI60329","article-title":"Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice","volume":"122","author":"Battiprolu","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"16","key":"10.1016\/j.biocel.2019.105659_bib0015","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1038\/onc.2008.21","article-title":"The FoxO code","volume":"27","author":"Calnan","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2019.105659_bib0020","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijcard.2017.07.096","article-title":"The impact of FOXO-1 to cardiac pathology in diabetes mellitus and diabetes-related metabolic abnormalities","volume":"245","author":"Chistiakov","year":"2017","journal-title":"Int. J. Cardiol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105659_bib0025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/CIRCRESAHA.115.303227","article-title":"FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis","volume":"115","author":"Dharaneeswaran","year":"2014","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biocel.2019.105659_bib0030","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.CIR.0000109498.77895.6F","article-title":"G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells","volume":"109","author":"Federici","year":"2004","journal-title":"Circulation"},{"issue":"33","key":"10.1016\/j.biocel.2019.105659_bib0035","doi-asserted-by":"crossref","first-page":"34741","DOI":"10.1074\/jbc.M314214200","article-title":"Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice","volume":"279","author":"Furuyama","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biocel.2019.105659_bib0040","doi-asserted-by":"crossref","first-page":"H479","DOI":"10.1152\/ajpheart.00191.2017","article-title":"FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression","volume":"313","author":"Gopal","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.biocel.2019.105659_bib0045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.18565\/cardio.2016.3.67-72","article-title":"Assessment of efficacy and safety of metabolic therapy with trimetazidine MB in patients with ischemic heart disease and chronic heart failure","volume":"56","author":"Gorbunova","year":"2016","journal-title":"Kardiologiia"},{"issue":"12","key":"10.1016\/j.biocel.2019.105659_bib0050","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.110.227371","article-title":"Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes","volume":"107","author":"Hariharan","year":"2010","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.biocel.2019.105659_bib0055","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.atherosclerosis.2012.09.040","article-title":"Asymmetric dimethylarginine predicts clinical outcomes in ischemic chronic heart failure","volume":"225","author":"Hsu","year":"2012","journal-title":"Atherosclerosis"},{"issue":"7","key":"10.1016\/j.biocel.2019.105659_bib0060","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1161\/ATVBAHA.110.222638","article-title":"Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine","volume":"31","author":"Hu","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"16","key":"10.1016\/j.biocel.2019.105659_bib0065","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.15252\/embj.201695518","article-title":"Role of glutamine and interlinked asparagine metabolism in vessel formation","volume":"36","author":"Huang","year":"2017","journal-title":"EMBO J."},{"issue":"7","key":"10.1016\/j.biocel.2019.105659_bib0070","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.bbamcr.2011.01.015","article-title":"Targeting fatty acid and carbohydrate oxidation--a novel therapeutic intervention in the ischemic and failing heart","volume":"1813","author":"Jaswal","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biocel.2019.105659_bib0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12933-016-0361-1","article-title":"Forkhead box transcription factor 1: role in the pathogenesis of diabetic cardiomyopathy","volume":"15","author":"Kandula","year":"2016","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.biocel.2019.105659_bib0080","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.atherosclerosis.2016.04.001","article-title":"Posttranslational modulation of FoxO1 contributes to cardiac remodeling in post-ischemic heart failure","volume":"249","author":"Kappel","year":"2016","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.biocel.2019.105659_bib0085","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1161\/ATVBAHA.114.305139","article-title":"Forkhead box O-1 modulation improves endothelial insulin resistance in human obesity","volume":"35","author":"Karki","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biocel.2019.105659_bib0090","first-page":"33","article-title":"Asymmetric dimethylarginine as a mediator of endothelial dysfunction and its association with insulin resistance syndromes","volume":"18","author":"Koleva","year":"2013","journal-title":"Endokrinologya"},{"issue":"4","key":"10.1016\/j.biocel.2019.105659_bib0095","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.cell.2017.09.045","article-title":"Selective inhibition of FOXO1 Activator\/Repressor balance modulates hepatic glucose handling","volume":"171","author":"Langlet","year":"2017","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biocel.2019.105659_bib0100","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/jcb.20963","article-title":"Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism","volume":"99","author":"Lin","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"8","key":"10.1016\/j.biocel.2019.105659_bib0105","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.2337\/db06-0369","article-title":"Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt\/FoxO signaling","volume":"55","author":"Marchetti","year":"2006","journal-title":"Diabetes"},{"issue":"15","key":"10.1016\/j.biocel.2019.105659_bib0110","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.109.864629","article-title":"MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1","volume":"120","author":"Menghini","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.biocel.2019.105659_bib0115","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.atherosclerosis.2015.07.026","article-title":"FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis","volume":"242","author":"Menghini","year":"2015","journal-title":"Atherosclerosis"},{"issue":"2","key":"10.1016\/j.biocel.2019.105659_bib0120","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cell.2006.12.029","article-title":"FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis","volume":"128","author":"Paik","year":"2007","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.biocel.2019.105659_bib0125","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1172\/JCI23126","article-title":"Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization","volume":"115","author":"Potente","year":"2005","journal-title":"J. Clin. Invest."},{"issue":"20","key":"10.1016\/j.biocel.2019.105659_bib0130","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1101\/gad.435107","article-title":"SIRT1 controls endothelial angiogenic functions during vascular growth","volume":"21","author":"Potente","year":"2007","journal-title":"Genes Dev."},{"issue":"2","key":"10.1016\/j.biocel.2019.105659_bib0135","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.freeradbiomed.2011.04.009","article-title":"Cardiac triglyceride accumulation following acute lipid excess occurs through activation of a FoxO1-iNOS-CD36 pathway","volume":"51","author":"Puthanveetil","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.biocel.2019.105659_bib0140","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cvr\/cvs426","article-title":"FoxO1 is crucial for sustaining cardiomyocyte metabolism and cell survival","volume":"97","author":"Puthanveetil","year":"2013","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.biocel.2019.105659_bib0145","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.2337\/db13-0095","article-title":"Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38\u03b1 MAPK during insulin resistance","volume":"62","author":"Qi","year":"2013","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.biocel.2019.105659_bib0150","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/CIRCHEARTFAILURE.114.001457","article-title":"Activation of Foxo1 by insulin resistance promotes cardiac dysfunction and \u03b2-myosin heavy chain gene expression","volume":"8","author":"Qi","year":"2015","journal-title":"Circ. Heart Fail."},{"issue":"35","key":"10.1016\/j.biocel.2019.105659_bib0155","doi-asserted-by":"crossref","first-page":"27396","DOI":"10.1074\/jbc.M110.140228","article-title":"Uncoupling of acetylation from phosphorylation regulates FoxO1 function independent of its subcellular localization","volume":"285","author":"Qiang","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"10","key":"10.1016\/j.biocel.2019.105659_bib0160","first-page":"1227","article-title":"Lysophosphatidic acid as a regulator of endothelial\/leukocyte interaction","volume":"79","author":"Rizza","year":"1999","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biocel.2019.105659_bib0165","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39780","article-title":"Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth","volume":"7","author":"Rudnicki","year":"2018","journal-title":"Elife"},{"issue":"9","key":"10.1016\/j.biocel.2019.105659_bib0170","doi-asserted-by":"crossref","first-page":"7468","DOI":"10.1074\/jbc.M110.179242","article-title":"FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress","volume":"286","author":"Sengupta","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"17","key":"10.1016\/j.biocel.2019.105659_bib0175","doi-asserted-by":"crossref","first-page":"12536","DOI":"10.1074\/jbc.M109.099630","article-title":"Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-kappaB p65","volume":"285","author":"Shimada","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.biocel.2019.105659_bib0180","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1073\/pnas.96.12.6931","article-title":"Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions","volume":"96","author":"Siess","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"24","key":"10.1016\/j.biocel.2019.105659_bib0185","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/eurheartj\/ehy124","article-title":"Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques","volume":"39","author":"Tomas","year":"2018","journal-title":"Eur. Heart J."},{"issue":"12","key":"10.1016\/j.biocel.2019.105659_bib0190","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1161\/ATVBAHA.110.219477","article-title":"Homozygosity for an allele encoding deacetylated FoxO1 protects macrophages from cholesterol-induced inflammation without increasing apoptosis","volume":"31","author":"Tsuchiya","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.biocel.2019.105659_bib0195","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/cvr\/cvs129","article-title":"Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury","volume":"94","author":"Ussher","year":"2012","journal-title":"Cardiovasc. Res."},{"issue":"25","key":"10.1016\/j.biocel.2019.105659_bib0200","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.jacc.2016.09.972","article-title":"The emerging role of metabolomics in the diagnosis and prognosis of cardiovascular disease","volume":"68","author":"Ussher","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/j.biocel.2019.105659_bib0205","first-page":"E127","article-title":"Role of RhoA and Rho kinase in lysophosphatidic acid-induced endothelial barrier dysfunction","volume":"20","author":"van Nieuw Amerongen","year":"2000","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"4","key":"10.1016\/j.biocel.2019.105659_bib0210","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/FJC.0000000000000054","article-title":"Heart failure and loss of metabolic control","volume":"63","author":"Wang","year":"2014","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"7585","key":"10.1016\/j.biocel.2019.105659_bib0215","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature16498","article-title":"FOXO1 couples metabolic activity and growth state in the vascular endothelium","volume":"529","author":"Wilhelm","year":"2016","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.biocel.2019.105659_bib0220","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/j.bbalip.2016.02.011","article-title":"Lipotoxicity in obesity and diabetes-related cardiac dysfunction","volume":"1861","author":"Zlobine","year":"2016","journal-title":"Biochim. Biophys. Acta"}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272519302365?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272519302365?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:14:47Z","timestamp":1761203687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272519302365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":44,"alternative-id":["S1357272519302365"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2019.105659","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolic aspects of cardiovascular diseases: Is FoxO1 a player or a target?","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2019.105659","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105659"}}