{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T06:24:11Z","timestamp":1761805451092,"version":"build-2065373602"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100011479","name":"Baotou Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.biocel.2020.105736","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T11:33:25Z","timestamp":1583148805000},"page":"105736","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Acid\/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR"],"prefix":"10.1016","volume":"122","author":[{"given":"Xiemei","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Che","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinbao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6975-6867","authenticated-orcid":false,"given":"Jianyuan","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2020.105736_bib0005","series-title":"Esophageal Cancer and Beyond","first-page":"1","article-title":"Esophagus and esophageal cancer","author":"Chai","year":"2018"},{"key":"10.1016\/j.biocel.2020.105736_bib0010","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.3748\/wjg.v18.i45.6521","article-title":"Esophageal malignancy \u2013 a growing concern","volume":"18","author":"Chai","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biocel.2020.105736_bib0015","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/labinvest.2010.101","article-title":"CCN1 induces a reversible epithelial-mesenchymal transition in gastric epithelial cells","volume":"90","author":"Chai","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biocel.2020.105736_bib0020","first-page":"565","article-title":"TRPV6 mediates capsaicin-induced apoptosis in gastric cancer cells \u2013 mechanisms behind a possible new \u201chot\u201d cancer treatment","volume":"1773","author":"Chow","year":"2007","journal-title":"BBA Mol Cell Res."},{"key":"10.1016\/j.biocel.2020.105736_bib0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.yexcr.2017.10.015","article-title":"CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis","volume":"361","author":"Dang","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biocel.2020.105736_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cyto.2018.12.020","article-title":"Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NF\u03baB activation","volume":"116","author":"Dang","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.biocel.2020.105736_bib0035","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1002\/jcb.27515","article-title":"CCN1 induces apoptosis in esophageal adenocarcinoma through p53-dependent downregulation of survivin","volume":"120","author":"Dang","year":"2019","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biocel.2020.105736_bib0040","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.25343","article-title":"Transformation of benign Barrett\u2019s epithelium by repeated acid and bile exposure over 65 weeks: a novel in vitro model","volume":"128","author":"Das","year":"2011","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biocel.2020.105736_bib0045","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/gut.2006.103697","article-title":"Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett\u2019s oesophagus","volume":"56","author":"Dvorak","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2020.105736_bib0050","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1016\/j.biocel.2007.02.007","article-title":"TRAIL signaling: decisions between life and death","volume":"39","author":"Falschlehner","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.biocel.2020.105736_bib0055","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1136\/gut.2009.202325","article-title":"Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells","volume":"60","author":"Haag","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2020.105736_bib0060","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41419-017-0165-6","article-title":"c-FLIP is a target of the E3 ligase deltex1 in gastric cancer","volume":"9","author":"Hsu","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biocel.2020.105736_bib0065","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00000658-199609000-00012","article-title":"Gastric juice protects against the development of esophageal adenocarcinoma in the rat","volume":"224","author":"Ireland","year":"1996","journal-title":"Ann. Surg."},{"key":"10.1016\/j.biocel.2020.105736_bib0070","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbamcr.2011.01.026","article-title":"Caspase-8 and Bid: caught in the act between death receptors and mitochondria","volume":"1813","author":"Kantari","year":"2011","journal-title":"Biochim. Biophys. Acta Mol Cell Res."},{"key":"10.1016\/j.biocel.2020.105736_bib0075","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nrc.2017.28","article-title":"Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy","volume":"17","author":"Karstedt","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2020.105736_bib0080","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0039-6060(97)90327-5","article-title":"Composition and concentration of bile acid reflux into the esophagus of patients with gastroesophageal reflux disease","volume":"122","author":"Kauer","year":"1997","journal-title":"Surgery"},{"key":"10.1016\/j.biocel.2020.105736_bib0085","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/cdd.2009.35","article-title":"PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability","volume":"16","author":"Kaunisto","year":"2009","journal-title":"Cell Death Dif."},{"key":"10.1016\/j.biocel.2020.105736_bib0090","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1128\/MCB.21.24.8247-8254.2001","article-title":"FLICE-inhibitory protein: regulators of death receptor-mediated apoptosis","volume":"21","author":"Krueger","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biocel.2020.105736_bib0095","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1111\/febs.13520","article-title":"Death in the fast lane: what\u2019s next for necroptosis?","volume":"283","author":"Oberst","year":"2016","journal-title":"FEBS J."},{"key":"10.1016\/j.biocel.2020.105736_bib0100","doi-asserted-by":"crossref","first-page":"16632","DOI":"10.1074\/jbc.M109.095083","article-title":"Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation","volume":"285","author":"Oberst","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2020.105736_bib0105","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.yexcr.2012.01.019","article-title":"Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions","volume":"318","author":"Ozturk","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biocel.2020.105736_bib0110","first-page":"176","article-title":"c-FLIP, a master anti-apoptotic regulator","volume":"34","author":"Safa","year":"2012","journal-title":"Exp. Oncol."},{"key":"10.1016\/j.biocel.2020.105736_bib0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/B978-0-12-801430-1.00004-4","article-title":"Characterization of the ripoptosome and its components: implications for anti-inflammatory and cancer therapy","volume":"545","author":"Schilling","year":"2014","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biocel.2020.105736_bib0120","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1042\/BST0380348","article-title":"The role of acid and bile reflux in esophagitis and Barrett\u2019s metaplasia","volume":"38","author":"Souza","year":"2010","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.biocel.2020.105736_bib0125","doi-asserted-by":"crossref","first-page":"30321","DOI":"10.3390\/ijms161226232","article-title":"FLIP the switch: regulation of apoptosis and necroptosis by cFLIP","volume":"16","author":"Tsuchiya","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biocel.2020.105736_bib0130","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.drup.2004.11.002","article-title":"Lessons from TRAIL-resistance mechanisms in colorectal cancer cells: paving the road to patient-tailored therapy","volume":"7","author":"Van Geelen","year":"2004","journal-title":"Drug Resist. Update"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520300534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520300534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:17:13Z","timestamp":1761203833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272520300534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":26,"alternative-id":["S1357272520300534"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105736","relation":{},"ISSN":["1357-2725"],"issn-type":[{"type":"print","value":"1357-2725"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acid\/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105736","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105736"}}