{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:14:22Z","timestamp":1772687662054,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Project of Innovation in Science and Technology","award":["17411950402"],"award-info":[{"award-number":["17411950402"]}]},{"name":"Project of Shanghai Science and Technology Committee","award":["134119a7600"],"award-info":[{"award-number":["134119a7600"]}]},{"name":"Project of Shanghai Science and Technology Committee","award":["17441903200"],"award-info":[{"award-number":["17441903200"]}]},{"name":"Project of Shanghai Science and Technology Committee","award":["17411950402"],"award-info":[{"award-number":["17411950402"]}]},{"name":"Cross research fund for medicine and Engineering of Shanghai Jiao Tong University","award":["YG2011M27"],"award-info":[{"award-number":["YG2011M27"]}]},{"name":"Cross research fund for medicine and Engineering of Shanghai Jiao Tong University","award":["YG2015MS36"],"award-info":[{"award-number":["YG2015MS36"]}]},{"name":"Project of Shanghai health and family planning","award":["20174Y0228"],"award-info":[{"award-number":["20174Y0228"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.biocel.2020.105773","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T11:47:34Z","timestamp":1590148054000},"page":"105773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Metabolomics study of the metabolic changes in hepatoblastoma cells in response to NTCP\/SLC10A1 overexpression"],"prefix":"10.1016","volume":"125","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1048-7150","authenticated-orcid":false,"given":"Ruicheng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenjie","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yimei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2020.105773_bib0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.redox.2017.08.009","article-title":"Short overview on metabolomics approach to study pathophysiology of oxidative stress in cancer","volume":"14","author":"Andrisic","year":"2018","journal-title":"Redox Biol."},{"issue":"12","key":"10.1016\/j.biocel.2020.105773_bib0010","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/nrc3613","article-title":"Immunity, inflammation and cancer: a leading role for adenosine","volume":"13","author":"Antonioli","year":"2013","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.biocel.2020.105773_bib0015","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.it.2012.02.009","article-title":"CD73: a potent suppressor of antitumor immune responses","volume":"33","author":"Beavis","year":"2012","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.biocel.2020.105773_bib0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.devcel.2018.09.020","article-title":"Metabolic remodeling during liver regeneration","volume":"47","author":"Caldez","year":"2018","journal-title":"Dev. Cell"},{"issue":"6","key":"10.1016\/j.biocel.2020.105773_bib0025","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1203\/PDR.0b013e318170a6b5","article-title":"Expression of hepatocyte transporters and nuclear receptors in children with early and late-stage biliary atresia","volume":"63","author":"Chen","year":"2008","journal-title":"Pediatr. Res."},{"issue":"2\u20133","key":"10.1016\/j.biocel.2020.105773_bib0030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.mam.2012.07.004","article-title":"The solute carrier family 10 (SLC10): beyond bile acid transport","volume":"34","author":"Claro da Silva","year":"2013","journal-title":"Mol. Aspects Med."},{"issue":"10","key":"10.1016\/j.biocel.2020.105773_bib0035","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1172\/JCI84431","article-title":"HIF1alpha and metabolic reprogramming in inflammation","volume":"126","author":"Corcoran","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biocel.2020.105773_bib0040","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ejca.2015.09.023","article-title":"The Children\u2019s Hepatic tumors International Collaboration (CHIC): novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model","volume":"52","author":"Czauderna","year":"2016","journal-title":"Eur. J. Cancer (Oxford, England: 1990)"},{"key":"10.1016\/j.biocel.2020.105773_bib0045","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/B978-0-12-394316-3.00004-1","article-title":"The SLC10 carrier family: transport functions and molecular structure","volume":"70","author":"Doring","year":"2012","journal-title":"Curr. Top. Membr."},{"issue":"1","key":"10.1016\/j.biocel.2020.105773_bib0050","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/hep.29672","article-title":"New insights into diagnosis and therapeutic options for proliferative hepatoblastoma","volume":"68","author":"Hooks","year":"2018","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.biocel.2020.105773_bib0055","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1136\/gutjnl-2015-310686","article-title":"The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B","volume":"65","author":"Hu","year":"2016","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.biocel.2020.105773_bib0060","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nrm.2016.25","article-title":"Metabolomics: beyond biomarkers and towards mechanisms","volume":"17","author":"Johnson","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.biocel.2020.105773_bib0065","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/hep.510230518","article-title":"Molecular and functional characterization of bile acid transport in human hepatoblastoma HepG2 cells","volume":"23","author":"Kullak-Ublick","year":"1996","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.biocel.2020.105773_bib0070","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1053\/gast.1997.v113.pm9322525","article-title":"Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas","volume":"113","author":"Kullak-Ublick","year":"1997","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.biocel.2020.105773_bib0075","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1053\/j.gastro.2003.06.005","article-title":"Enterohepatic bile salt transporters in normal physiology and liver disease","volume":"126","author":"Kullak-Ublick","year":"2004","journal-title":"Gastroenterology"},{"issue":"41","key":"10.1016\/j.biocel.2020.105773_bib0080","doi-asserted-by":"crossref","first-page":"E9640","DOI":"10.1073\/pnas.1809695115","article-title":"Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment","volume":"115","author":"Lan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.biocel.2020.105773_bib0085","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1124\/jpet.106.106591","article-title":"Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver","volume":"319","author":"Libra","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"10","key":"10.1016\/j.biocel.2020.105773_bib0090","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.humpath.2009.07.003","article-title":"Hep G2 is a hepatoblastoma-derived cell line","volume":"40","author":"Lopez-Terrada","year":"2009","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.biocel.2020.105773_bib0095","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.mam.2017.01.006","article-title":"Bile acids and their receptors","volume":"56","author":"Martinot","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.biocel.2020.105773_bib0100","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1038\/ncomms3909","article-title":"Adenosine is required for sustained inflammasome activation via the A\u2082A receptor and the HIF-1\u03b1 pathway","volume":"4","author":"Ouyang","year":"2013","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.biocel.2020.105773_bib0105","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2015.11.043","article-title":"Circadian clock control of liver metabolic functions","volume":"150","author":"Reinke","year":"2016","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.biocel.2020.105773_bib0110","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1124\/dmd.117.078238","article-title":"Quantitative expression of hepatobiliary transporters and functional uptake of substrates in hepatic two-dimensional sandwich cultures: a comparative evaluation of upcyte and primary human hepatocytes","volume":"46","author":"Schaefer","year":"2018","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.biocel.2020.105773_bib0115","series-title":"The Role of the Sodium-taurocholate Cotransporting Polypeptide (NTCP) and of the Bile Salt Export Pump (BSEP) in Physiology and Pathophysiology of Bile Formation","first-page":"205","author":"Stieger","year":"2011"},{"issue":"13","key":"10.1016\/j.biocel.2020.105773_bib0120","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.ejca.2006.05.011","article-title":"Liver cancer in European children: incidence and survival, 1978-1997. Report from the automated childhood cancer information system project","volume":"42","author":"Stiller","year":"2006","journal-title":"Eur. J. Cancer (Oxford, England: 1990)"},{"issue":"1","key":"10.1016\/j.biocel.2020.105773_bib0125","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hep.28888","article-title":"Genomic analysis of hepatoblastoma identifies distinct molecular and prognostic subgroups","volume":"65","author":"Sumazin","year":"2017","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.biocel.2020.105773_bib0130","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.biocel.2020.105773_bib0135","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrc.2017.86","article-title":"Targeting immunosuppressive adenosine in cancer","volume":"17","author":"Vijayan","year":"2017","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.biocel.2020.105773_bib0140","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1124\/dmd.113.056309","article-title":"Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions","volume":"42","author":"Vildhede","year":"2014","journal-title":"Drug Metab. Dispos."},{"issue":"7","key":"10.1016\/j.biocel.2020.105773_bib0145","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrd.2016.32","article-title":"Emerging applications of metabolomics in drug discovery and precision medicine","volume":"15","author":"Wishart","year":"2016","journal-title":"Nat. Rev. Drug Discovery"},{"key":"10.1016\/j.biocel.2020.105773_bib0150","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.antiviral.2015.06.002","article-title":"NTCP opens the door for hepatitis B virus infection","volume":"121","author":"Yan","year":"2015","journal-title":"Antiviral Res."},{"issue":"8","key":"10.1016\/j.biocel.2020.105773_bib0155","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1158\/2159-8290.CD-14-0341","article-title":"Targeting cancer-derived adenosine: new therapeutic approaches","volume":"4","author":"Young","year":"2014","journal-title":"Cancer Discov."},{"issue":"1","key":"10.1016\/j.biocel.2020.105773_bib0160","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.canlet.2016.02.051","article-title":"Multidisciplinary effort in treating children with hepatoblastoma in China","volume":"375","author":"Yuan","year":"2016","journal-title":"Cancer Lett."},{"issue":"7484","key":"10.1016\/j.biocel.2020.105773_bib0165","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature12811","article-title":"Structural basis of the alternating-access mechanism in a bile acid transporter","volume":"505","author":"Zhou","year":"2014","journal-title":"Nature"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135727252030090X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135727252030090X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:18:33Z","timestamp":1761203913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135727252030090X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":33,"alternative-id":["S135727252030090X"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105773","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics study of the metabolic changes in hepatoblastoma cells in response to NTCP\/SLC10A1 overexpression","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105773"}}