{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:13:21Z","timestamp":1778602401793,"version":"3.51.4"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS 2018-1"],"award-info":[{"award-number":["FRGS 2018-1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FP011-2018A"],"award-info":[{"award-number":["FP011-2018A"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.biocel.2020.105800","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T01:45:45Z","timestamp":1594604745000},"page":"105800","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8973-7556","authenticated-orcid":false,"given":"Juliana","family":"Jamal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-5149","authenticated-orcid":false,"given":"Margaret M.","family":"Roebuck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siam-Yee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P.","family":"Frostick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azlina Amir","family":"Abbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azhar Mahmood","family":"Merican","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seow-Hui","family":"Teo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5757-0731","authenticated-orcid":false,"given":"Amanda","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sik-Loo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Bou-Gharios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-2521","authenticated-orcid":false,"given":"Pooi-Fong","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0005","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1053\/joca.2000.0368","article-title":"Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation","volume":"9","author":"Bakker","year":"2001","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.biocel.2020.105800_bib0010","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1559-0275-11-6","article-title":"Proteomic analysis of human osteoarthritis synovial fluid","volume":"11","author":"Balakrishnan","year":"2014","journal-title":"Clin. Proteomics"},{"issue":"1","key":"10.1016\/j.biocel.2020.105800_bib0015","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/ageing\/26.1.15","article-title":"Comfortable and maximum walking speed of adults aged 20-79 years: reference values and determinants","volume":"26","author":"Bohannon","year":"1997","journal-title":"Age Ageing"},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0020","first-page":"354","article-title":"Cellular senescence: a link between cancer and age-related degenerative disease?","volume":"21","author":"Campisi","year":"2011","journal-title":"Semin. Cancer Biol."},{"issue":"10","key":"10.1016\/j.biocel.2020.105800_bib0025","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"Cline","year":"2007","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.joca.2007.07.014","article-title":"In vitro expansion affects the response of chondrocytes to mechanical stimulation","volume":"16","author":"Das","year":"2008","journal-title":"Osteoarthr. Cartil."},{"issue":"12","key":"10.1016\/j.biocel.2020.105800_bib0035","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1038\/nprot.2009.191","article-title":"Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo","volume":"4","author":"Debacq-Chainiaux","year":"2009","journal-title":"Nat. Protoc."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0040","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data","volume":"18","author":"Doncheva","year":"2019","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0045","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/art.23495","article-title":"Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury","volume":"58","author":"Elsaid","year":"2008","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0050","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jnr.10835","article-title":"Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system","volume":"74","author":"Gardner","year":"2003","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0055","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5812\/ijem.3505","article-title":"Normality tests for statistical analysis: a guide for non-statisticians","volume":"10","author":"Ghasemi","year":"2012","journal-title":"Int. J. Endocrinol. Metab."},{"issue":"14","key":"10.1016\/j.biocel.2020.105800_bib0060","doi-asserted-by":"crossref","first-page":"11041","DOI":"10.1074\/jbc.M004709200","article-title":"Antagonistic regulation of type I collagen gene expression by Interferon-\u03b3 and transforming growth Factor-\u03b2: INTEGRATION AT THE LEVEL OF p300\/CBP TRANSCRIPTIONAL COACTIVATORS","volume":"276","author":"Ghosh","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0065","first-page":"815","article-title":"Biomechanical factors in osteoarthritis. Best practice & research","volume":"25","author":"Guilak","year":"2011","journal-title":"Clin. Rheumatol."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0070","first-page":"205","article-title":"Knee osteoarthritis prevalence, risk factors, pathogenesis and features: part I","volume":"2","author":"Heidari","year":"2011","journal-title":"Caspian J. Intern. Med."},{"key":"10.1016\/j.biocel.2020.105800_bib0075","series-title":"Handbook of Proteolytic Enzymes","first-page":"740","article-title":"217 - aggrecanases 1 and 2","author":"Hughes","year":"2004"},{"issue":"12","key":"10.1016\/j.biocel.2020.105800_bib0080","first-page":"802","article-title":"Mechanotransduction and extracellular matrix homeostasis. Nature reviews","volume":"15","author":"Humphrey","year":"2014","journal-title":"Molecular cell biology"},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0085","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1113\/jphysiol.2007.146753","article-title":"Cyclic movement stimulates hyaluronan secretion into the synovial cavity of rabbit joints","volume":"586","author":"Ingram","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.biocel.2020.105800_bib0090","doi-asserted-by":"crossref","DOI":"10.1038\/srep18910","article-title":"Lubricin\/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro","volume":"6","author":"Iqbal","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0095","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jep.2014.04.025","article-title":"Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway","volume":"154","author":"Jamal","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.biocel.2020.105800_bib0100","doi-asserted-by":"crossref","first-page":"40","DOI":"10.22203\/eCM.v013a04","article-title":"Bioregulation of lubricin expression by growth factors and cytokines","volume":"13","author":"Jones","year":"2007","journal-title":"Eur. Cell. Mater."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1247\/csf.27.139","article-title":"Gene expression of type I and type III collagen by mechanical stretch in anterior cruciate ligament cells","volume":"27","author":"Kim","year":"2002","journal-title":"Cell Struct. Funct."},{"issue":"4","key":"10.1016\/j.biocel.2020.105800_bib0110","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0115","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/jcp.10030","article-title":"Proteoglycans of the extracellular matrix and growth control","volume":"189","author":"Kresse","year":"2001","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.biocel.2020.105800_bib0120","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/art.37963","article-title":"Overexpression of sirtuin 6 suppresses inflammatory responses and bone destruction in mice with collagen-induced arthritis","volume":"65","author":"Lee","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0125","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cger.2010.03.002","article-title":"Age-related changes in the musculoskeletal system and the development of osteoarthritis","volume":"26","author":"Loeser","year":"2010","journal-title":"Clin. Geriatr. Med."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0130","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.biocel.2020.105800_bib0135","first-page":"37","article-title":"Osteoarthritis pathogenesis - a complex process that involves the entire joint","volume":"7","author":"Man","year":"2014","journal-title":"J. Med. Life"},{"issue":"8","key":"10.1016\/j.biocel.2020.105800_bib0140","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.matbio.2005.08.006","article-title":"Hyaluronan secretion by synoviocytes is mechanosensitive","volume":"24","author":"Momberger","year":"2005","journal-title":"Matrix Biology: J. Int. Soc. Matrix Biol."},{"key":"10.1016\/j.biocel.2020.105800_bib0145","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.freeradbiomed.2012.10.525","article-title":"Seven sirtuins for seven deadly diseases ofaging","volume":"56","author":"Morris","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0150","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000471","article-title":"Synovial fibroblasts in 2017","volume":"3","author":"Ospelt","year":"2017","journal-title":"RMD Open"},{"issue":"8","key":"10.1016\/j.biocel.2020.105800_bib0155","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s10529-011-0610-z","article-title":"Stretching skeletal muscle in vitro: does it replicate in vivo physiology?","volume":"33","author":"Passey","year":"2011","journal-title":"Biotechnol. Lett."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0160","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00264-015-2707-9","article-title":"The role of adipocytokines in the pathogenesis of knee joint osteoarthritis","volume":"39","author":"Richter","year":"2015","journal-title":"Int. Orthop."},{"key":"10.1016\/j.biocel.2020.105800_bib0165","series-title":"Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas","first-page":"537","article-title":"30 - role of immunohistochemistry in elucidating lung cancer metastatic to the ovary from primary ovarian carcinoma","author":"Robinson-Bennett","year":"2006"},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0170","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s10616-014-9692-5","article-title":"Dynamic assessment of cell viability, proliferation and migration using real time cell analyzer system (RTCA)","volume":"67","author":"Roshan Moniri","year":"2015","journal-title":"Cytotechnology"},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0175","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1053\/joms.2003.50141","article-title":"The effects of mechanical strain on synovial fibroblasts","volume":"61","author":"Sambajon","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0180","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0185","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/ar144","article-title":"The stressed synovium","volume":"3","author":"Schett","year":"2001","journal-title":"Arthritis Res."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20030585","article-title":"Impact of mechanical load on the expression profile of synovial fibroblasts from patients with and without osteoarthritis","volume":"20","author":"Schroder","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biocel.2020.105800_bib0195","doi-asserted-by":"crossref","first-page":"14002","DOI":"10.1038\/boneres.2014.2","article-title":"TGF-\u03b2 signaling and the development of osteoarthritis","volume":"2","author":"Shen","year":"2014","journal-title":"Bone Res."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0200","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0049-0172(91)90007-M","article-title":"Physiology of normal and abnormal synovium","volume":"21","author":"Simkin","year":"1991","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.biocel.2020.105800_bib0205","doi-asserted-by":"crossref","first-page":"100","DOI":"10.2174\/1874312901105010100","article-title":"The normal synovium","volume":"5","author":"Smith","year":"2011","journal-title":"Open Rheumatol. J."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0210","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.rehab.2016.03.005","article-title":"Altered joint tribology in osteoarthritis: Reduced lubricin synthesis due to the inflammatory process. New horizons for therapeutic approaches","volume":"59","author":"Szychlinska","year":"2016","journal-title":"Ann. Phys. Rehabil. Med."},{"issue":"9","key":"10.1016\/j.biocel.2020.105800_bib0215","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1002\/art.24864","article-title":"SIRT1 regulation of apoptosis of human chondrocytes","volume":"60","author":"Takayama","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.biocel.2020.105800_bib0220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.11005\/jbm.2018.25.2.65","article-title":"Differential role of transforming growth factor-beta in an osteoarthritic or a healthy joint","volume":"25","author":"van der Kraan","year":"2018","journal-title":"J. Bone Metab."},{"key":"10.1016\/j.biocel.2020.105800_bib0225","series-title":"Kelley and Firestein\u2019s Textbook of Rheumatology (Tenth Edition)","first-page":"20","article-title":"Chapter 2 - synovium","author":"Veale","year":"2017"},{"key":"10.1016\/j.biocel.2020.105800_bib0230","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.biocel.2020.105800_bib0235","doi-asserted-by":"crossref","DOI":"10.1038\/srep17602","article-title":"Overexpression of Sirtuin 6 suppresses cellular senescence and NF-\u03baB mediated inflammatory responses in osteoarthritis development","volume":"5","author":"Wu","year":"2015","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biocel.2020.105800_bib0240","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3109\/03008207.2011.632828","article-title":"Comparative study of normal and rheumatoid arthritis fibroblast-like synoviocytes proliferation under cyclic mechanical stretch: role of prostaglandin E2","volume":"53","author":"Yan","year":"2012","journal-title":"Connect. Tissue Res."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0245","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/eos.12082","article-title":"Synthesis of hyaluronan and superficial zone protein in synovial membrane cells modulated by fluid flow","volume":"121","author":"Yanagida-Suekawa","year":"2013","journal-title":"Eur. J. Oral Sci."},{"issue":"6","key":"10.1016\/j.biocel.2020.105800_bib0250","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/ard.2007.086884","article-title":"Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes","volume":"68","author":"Yatabe","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.biocel.2020.105800_bib0255","series-title":"A Summary of the Malaysian Clinical Practice Guidelines on Management of Obesity 2004","author":"Zainudin","year":"2014"},{"issue":"12","key":"10.1016\/j.biocel.2020.105800_bib0260","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/j.joca.2015.06.014","article-title":"SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritis","volume":"23","author":"Zhang","year":"2015","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.biocel.2020.105800_bib0265","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.joca.2015.04.002","article-title":"CCL3 serves as a potential plasma biomarker in knee degeneration (osteoarthritis)","volume":"23","author":"Zhao","year":"2015","journal-title":"Osteoarthr. Cartil."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520301175?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520301175?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:42:31Z","timestamp":1778600551000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272520301175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":53,"alternative-id":["S1357272520301175"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105800","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of the mechanical responses of synovial fibroblasts by osteoarthritis-associated inflammatory stressors","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105800","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2020 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105800"}}