{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:19:25Z","timestamp":1761203965982,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T00:00:00Z","timestamp":1604793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biocel.2020.105883","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T09:36:15Z","timestamp":1604828175000},"page":"105883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Macrophage mitochondrial superoxides as a target for atherosclerotic disease treatment"],"prefix":"10.1016","volume":"129","author":[{"given":"Laszlo A.","family":"Groh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels P.","family":"Riksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2020.105883_bib0005","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic Pathways in BCG-Induced Trained Immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.biocel.2020.105883_bib0010","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2020.105883_bib0015","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/01.CIR.0000023921.93743.89","article-title":"Mitochondrial integrity and function in atherogenesis","volume":"106","author":"Ballinger","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.biocel.2020.105883_bib0020","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1161\/ATVBAHA.114.303887","article-title":"Oxidized low-density lipoprotein induces long-term proinflammatory cytokine production and foam cell formation via epigenetic reprogramming of monocytes","volume":"34","author":"Bekkering","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biocel.2020.105883_bib0025","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.atherosclerosis.2016.10.019","article-title":"Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo","volume":"254","author":"Bekkering","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.biocel.2020.105883_bib0030","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exger.2010.01.003","article-title":"The sites and topology of mitochondrial superoxide production","volume":"45","author":"Brand","year":"2010","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.biocel.2020.105883_bib0035","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.2174\/1381612054065783","article-title":"Role of antioxidants in atherosclerosis: epidemiological and clinical update","volume":"11","author":"Cherubini","year":"2005","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.biocel.2020.105883_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western diet triggers NLRP3-dependent innate immune reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2020.105883_bib0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0921-8734(92)90021-G","article-title":"Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease","volume":"275","author":"Corral-Debrinski","year":"1992","journal-title":"Mutat. Res."},{"issue":"211\u2013220","key":"10.1016\/j.biocel.2020.105883_bib0050","first-page":"e215","article-title":"The itaconate pathway is a central regulatory node linking innate immune tolerance and trained immunity","volume":"29","author":"Dom\u00ednguez-Andr\u00e9s","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.biocel.2020.105883_bib0055","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2020.105883_bib0060","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13667","article-title":"The targeted anti-oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue","volume":"6","author":"Gottwald","year":"2018","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.biocel.2020.105883_bib0065","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nrm3801","article-title":"Cellular mechanisms and physiological consequences of redox-dependent signalling","volume":"15","author":"Holmstr\u00f6m","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biocel.2020.105883_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.14-42","article-title":"A mitochondrial superoxide theory for oxidative stress diseases and aging","volume":"56","author":"Indo","year":"2015","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.biocel.2020.105883_bib0075","doi-asserted-by":"crossref","first-page":"24108","DOI":"10.1038\/srep24108","article-title":"Mitochondria-targeted esculetin alleviates mitochondrial dysfunction by AMPK-mediated nitric oxide and SIRT3 regulation in endothelial cells: potential implications in atherosclerosis","volume":"6","author":"Karnewar","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biocel.2020.105883_bib0080","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00109-020-01915-w","article-title":"Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein","volume":"98","author":"Keating","year":"2020","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.biocel.2020.105883_bib0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107548","article-title":"The Set7 lysine methyltransferase regulates plasticity in oxidative phosphorylation necessary for trained immunity induced by \u03b2-Glucan","volume":"31","author":"Keating","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.biocel.2020.105883_bib0090","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.biocel.2020.105883_bib0095","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.freeradbiomed.2011.11.026","article-title":"The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+\/-\/ApoE-\/- mice","volume":"52","author":"Mercer","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biocel.2020.105883_bib0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1021\/acs.accounts.7b00339","article-title":"High-density lipoprotein nanobiologics for precision medicine","volume":"51","author":"Mulder","year":"2018","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.biocel.2020.105883_bib0105","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/01.ATV.16.7.831","article-title":"The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture","volume":"16","author":"Navab","year":"1996","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biocel.2020.105883_bib0110","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biocel.2020.105883_bib0115","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"O\u2019Neill","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biocel.2020.105883_bib0120","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2020.105883_bib0125","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.biocel.2020.105883_bib0130","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.redox.2016.12.035","article-title":"Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: oxidative eustress","volume":"11","author":"Sies","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.biocel.2020.105883_bib0135","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.3389\/fimmu.2018.03155","article-title":"mTOR-Dependent Oxidative Stress Regulates oxLDL-Induced Trained Innate Immunity in Human Monocytes","volume":"9","author":"Sohrabi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biocel.2020.105883_bib0140","first-page":"1","article-title":"Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation","author":"Tang","year":"2015","journal-title":"Sci. Adv."},{"key":"10.1016\/j.biocel.2020.105883_bib0145","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biocel.2020.105883_bib0150","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11883-018-0737-7","article-title":"Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End?","volume":"20","author":"Toledo-Ibelles","year":"2018","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.biocel.2020.105883_bib0155","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCRESAHA.119.315800","article-title":"Catecholamines Induce Trained Immunity in Monocytes In Vitro and In Vivo","volume":"127","author":"van der Heijden","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2020.105883_bib0160","first-page":"317","article-title":"Aldosterone induces trained immunity: the role of fatty acid synthesis","volume":"116","author":"van der Heijden","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biocel.2020.105883_bib0165","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/CIRCRESAHA.114.302153","article-title":"Macrophage mitochondrial oxidative stress promotes atherosclerosis and nuclear factor-kappaB-mediated inflammation in macrophages","volume":"114","author":"Wang","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.biocel.2020.105883_bib0170","first-page":"139","article-title":"Oxidation, lipoproteins, and atherosclerosis: which is wrong, the antioxidants or the theory?","volume":"8","author":"Williams","year":"2005","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520302004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520302004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:17:46Z","timestamp":1761203866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272520302004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":34,"alternative-id":["S1357272520302004"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105883","relation":{},"ISSN":["1357-2725"],"issn-type":[{"type":"print","value":"1357-2725"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage mitochondrial superoxides as a target for atherosclerotic disease treatment","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105883"}}