{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:24:02Z","timestamp":1761204242894,"version":"build-2065373602"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960093"],"award-info":[{"award-number":["81960093"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.biocel.2020.105902","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T17:13:08Z","timestamp":1607533988000},"page":"105902","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Knockdown of dual oxidase 1 suppresses activin A-induced fibrosis in cardiomyocytes via the reactive oxygen species-dependent pyroptotic pathway"],"prefix":"10.1016","volume":"131","author":[{"given":"Shengwei","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungang","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongnan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Ying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0005","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1189\/jlb.72.2.347","article-title":"Potent induction of activin A secretion from monocytes and bone marrow stromal fibroblasts by cognate interaction with activated T cells","volume":"72","author":"Abe","year":"2002","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1055\/s-0037-1601350","article-title":"Inflammasomes in liver fibrosis","volume":"37","author":"Alegre","year":"2017","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.biocel.2020.105902_bib0015","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fncel.2014.00216","article-title":"Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells","volume":"8","author":"Alfonso-Loeches","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"16","key":"10.1016\/j.biocel.2020.105902_bib0020","doi-asserted-by":"crossref","first-page":"5051","DOI":"10.1073\/pnas.1420707112","article-title":"NADPH oxidase DUOX1 promotes long-term persistence of oxidative stress after an exposure to irradiation","volume":"112","author":"Ameziane-El-Hassani","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.biocel.2020.105902_bib0025","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ni.3798","article-title":"A current view on inflammation","volume":"18","year":"2017","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.biocel.2020.105902_bib0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00403-013-1416-8","article-title":"NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents","volume":"306","author":"Babalola","year":"2014","journal-title":"Arch. Dermatol. Res."},{"issue":"25","key":"10.1016\/j.biocel.2020.105902_bib0035","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1182\/blood-2016-07-730556","article-title":"The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype","volume":"128","author":"Basiorka","year":"2016","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.biocel.2020.105902_bib0040","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2018","article-title":"Activin A in mammalian physiology","volume":"99","author":"Bloise","year":"2019","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.biocel.2020.105902_bib0045","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri.2016.112","article-title":"Immunoregulation by members of the TGF\u03b2 superfamily","volume":"16","author":"Chen","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.biocel.2020.105902_bib0050","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1074\/jbc.M608083200","article-title":"ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages","volume":"282","author":"Cruz","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.biocel.2020.105902_bib0055","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/hep.24465","article-title":"NOX1\/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation","volume":"54","author":"Cui","year":"2011","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0060","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.abb.2007.04.016","article-title":"NOX in liver fibrosis","volume":"462","author":"De Minicis","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"issue":"6","key":"10.1016\/j.biocel.2020.105902_bib0065","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0092-8674(00)81696-7","article-title":"Smads: transcriptional activators of TGF-beta responses","volume":"95","author":"Derynck","year":"1998","journal-title":"Cell"},{"volume":"2018","year":"2018","author":"Fortunato","key":"10.1016\/j.biocel.2020.105902_bib0070"},{"issue":"3","key":"10.1016\/j.biocel.2020.105902_bib0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.diff.2016.06.004","article-title":"The cardiac fibroblast: origin, identity and role in homeostasis and disease","volume":"92","author":"Furtado","year":"2016","journal-title":"Differentiation: Res. Biol. Divers."},{"issue":"6","key":"10.1016\/j.biocel.2020.105902_bib0080","doi-asserted-by":"crossref","first-page":"G1324","DOI":"10.1152\/ajpgi.90564.2008","article-title":"Interleukin-1 participates in the progression from liver injury to fibrosis","volume":"296","author":"Gieling","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"9","key":"10.1016\/j.biocel.2020.105902_bib0085","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2005","article-title":"NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury","volume":"15","author":"Hecker","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2020.105902_bib0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2019.05.011","article-title":"Cardiac fibrosis - a short review of causes and therapeutic strategies","volume":"146","author":"Hinderer","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.biocel.2020.105902_bib0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1164\/rccm.200603-316OC","article-title":"Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13","volume":"176","author":"Hoshino","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"6","key":"10.1016\/j.biocel.2020.105902_bib0100","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1165\/rcmb.2008-0182OC","article-title":"Role of proinflammatory cytokines IL-18 and IL-1beta in bleomycin-induced lung injury in humans and mice","volume":"41","author":"Hoshino","year":"2009","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0105","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacc.2010.02.047","article-title":"Assessment of nonischemic myocardial fibrosis","volume":"56","author":"Jellis","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"issue":"8","key":"10.1016\/j.biocel.2020.105902_bib0110","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1093\/humrep\/dez109","article-title":"Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis","volume":"34","author":"Kauerhof","year":"2019","journal-title":"Hum. Reprod. (Oxford, England)"},{"issue":"10","key":"10.1016\/j.biocel.2020.105902_bib0115","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1172\/JCI94753","article-title":"Fibroblast-specific TGF-\u03b2-Smad2\/3 signaling underlies cardiac fibrosis","volume":"127","author":"Khalil","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.biocel.2020.105902_bib0120","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1165\/rcmb.2003-0306OC","article-title":"Enhanced expression of interleukin-18 and its receptor in idiopathic pulmonary fibrosis","volume":"31","author":"Kitasato","year":"2004","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"8","key":"10.1016\/j.biocel.2020.105902_bib0125","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s12272-016-0809-6","article-title":"Myofibroblasts and inflammatory cells as players of cardiac fibrosis","volume":"39","author":"Kurose","year":"2016","journal-title":"Arch. Pharm. Res."},{"issue":"7","key":"10.1016\/j.biocel.2020.105902_bib0130","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/CIRCRESAHA.116.302317","article-title":"Innate immunity and the failing heart: the cytokine hypothesis revisited","volume":"116","author":"Mann","year":"2015","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.biocel.2020.105902_bib0135","doi-asserted-by":"crossref","first-page":"G99","DOI":"10.1152\/ajpgi.00272.2007","article-title":"NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells","volume":"294","author":"Masamune","year":"2008","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.biocel.2020.105902_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107511","article-title":"Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis","volume":"209","author":"Pinar","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.biocel.2020.105902_bib0145","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1055\/s-0037-1607265","article-title":"Activin A in inflammation, tissue repair, and fibrosis: possible role as inflammatory and fibrotic mediator of uterine fibroid development and growth","volume":"35","author":"Protic","year":"2017","journal-title":"Semin. Reprod. Med."},{"issue":"5","key":"10.1016\/j.biocel.2020.105902_bib0150","doi-asserted-by":"crossref","first-page":"7144","DOI":"10.1096\/fj.201903073R","article-title":"TRAF3 promotes ROS production and pyroptosis by targeting ULK1 ubiquitination in macrophages","volume":"34","author":"Shen","year":"2020","journal-title":"FASEB J."},{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0155","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jacc.2004.03.069","article-title":"Potential anti-inflammatory role of activin A in acute coronary syndromes","volume":"44","author":"Smith","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.biocel.2020.105902_bib0160","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1111\/jcmm.12898","article-title":"Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1\u03b2\/IL-1R1\/MyD88\/NF-\u03baB pathway","volume":"20","author":"Song","year":"2016","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0165","doi-asserted-by":"crossref","first-page":"428","DOI":"10.4049\/jimmunol.1601395","article-title":"Duox1 regulates primary B cell function under the influence of IL-4 through BCR-mediated generation of hydrogen peroxide","volume":"202","author":"Sugamata","year":"2019","journal-title":"J. Immunol. (Baltimore, Md: 1950)"},{"issue":"1 Suppl","key":"10.1016\/j.biocel.2020.105902_bib0170","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1046\/j.1523-1755.2002.0610s1094.x","article-title":"Gene transfer of Smad7 using electroporation of adenovirus prevents renal fibrosis in post-obstructed kidney","volume":"61","author":"Terada","year":"2002","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.biocel.2020.105902_bib0175","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/cmi.2009.50","article-title":"A critical role of activin A in maturation of mouse peritoneal macrophages in vitro and in vivo","volume":"6","author":"Wang","year":"2009","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.biocel.2020.105902_bib0180","doi-asserted-by":"crossref","first-page":"e2937","DOI":"10.1038\/cddis.2017.292","article-title":"Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.biocel.2020.105902_bib0185","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41419-018-0573-2","article-title":"Cardiac fibrosis can be attenuated by blocking the activity of transglutaminase 2 using a selective small-molecule inhibitor","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biocel.2020.105902_bib0190","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/wdev.86","article-title":"The TGFbeta superfamily signaling pathway","volume":"2","author":"Weiss","year":"2013","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"issue":"3","key":"10.1016\/j.biocel.2020.105902_bib0195","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cytogfr.2006.01.001","article-title":"Roles of activin in tissue repair, fibrosis, and inflammatory disease","volume":"17","author":"Werner","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3","key":"10.1016\/j.biocel.2020.105902_bib0200","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20092121","article-title":"Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent","volume":"207","author":"Wilson","year":"2010","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.biocel.2020.105902_bib0205","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41419-019-1413-8","article-title":"Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors","volume":"10","author":"Yang","year":"2019","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.biocel.2020.105902_bib0210","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1002\/ejhf.942","article-title":"Immune mechanisms in heart failure","volume":"19","author":"Zhang","year":"2017","journal-title":"Eur. J. Heart Fail."}],"container-title":["The International Journal of Biochemistry &amp; Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520302193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272520302193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:19:39Z","timestamp":1761203979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272520302193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":42,"alternative-id":["S1357272520302193"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105902","relation":{},"ISSN":["1357-2725"],"issn-type":[{"type":"print","value":"1357-2725"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knockdown of dual oxidase 1 suppresses activin A-induced fibrosis in cardiomyocytes via the reactive oxygen species-dependent pyroptotic pathway","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2020.105902","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105902"}}