{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T20:02:29Z","timestamp":1772827349138,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001797","name":"Curtin University of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001202","name":"Gastroenterological Society of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001799","name":"Murdoch University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.biocel.2021.105933","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:20:59Z","timestamp":1612268459000},"page":"105933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury"],"prefix":"10.1016","volume":"134","author":[{"given":"Francis D.","family":"Gratte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Pasic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Dianah B.","family":"Abu Bakar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7648-5858","authenticated-orcid":false,"given":"Jully","family":"Gogoi-Tiwari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Carlessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Kisseleva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant A.","family":"Ramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0417-3411","authenticated-orcid":false,"given":"John K.","family":"Olynyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina E.E.","family":"Tirnitz-Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.biocel.2021.105933_bib0005","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1136\/gutjnl-2019-320203","article-title":"Harnessing liver progenitors in the treatment of liver fibrosis: a step in the right direction?","volume":"69","author":"Breitkopf-Heinlein","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2021.105933_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104720","article-title":"Intercellular crosstalk of hepatic stellate cells in liver fibrosis: new insights into therapy","volume":"155","author":"Cai","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.biocel.2021.105933_bib0015","article-title":"Hepatic progenitor cells contribute to the progression of 2-acetylaminofluorene\/carbon tetrachloride-induced cirrhosis via the non-canonical Wnt pathway","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.biocel.2021.105933_bib0020","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/hep4.1290","article-title":"Combatting fibrosis: exosome-based therapies in the regression of liver fibrosis","volume":"3","author":"Chen","year":"2019","journal-title":"Hepatol. Commun."},{"issue":"6","key":"10.1016\/j.biocel.2021.105933_bib0025","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1136\/gutjnl-2019-318812","article-title":"Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells","volume":"69","author":"Dai","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2021.105933_bib0030","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fimmu.2014.00039","article-title":"TWEAK and LT\u03b2 signaling during chronic liver disease","volume":"5","author":"Dwyer","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biocel.2021.105933_bib0035","article-title":"TWEAK\/Fn14 signalling promotes cholangiocarcinoma niche formation and progression","author":"Dwyer","year":"2020","journal-title":"J. Hepatol."},{"issue":"6","key":"10.1016\/j.biocel.2021.105933_bib0040","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1053\/j.gastro.2012.08.024","article-title":"Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice","volume":"143","author":"Espa\u00f1ol-Su\u00f1er","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.biocel.2021.105933_bib0045","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jhep.2013.08.012","article-title":"The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury","volume":"60","author":"Grzelak","year":"2014","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.biocel.2021.105933_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171480","article-title":"Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease","volume":"12","author":"Grzelak","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.biocel.2021.105933_bib0055","doi-asserted-by":"crossref","DOI":"10.1038\/srep42563","article-title":"Transcriptome-based repurposing of apigenin as a potential anti-fibrotic agent targeting hepatic stellate cells","volume":"7","author":"Hicks","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.biocel.2021.105933_bib0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/gut.2010.224436","article-title":"Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response","volume":"60","author":"Kallis","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2021.105933_bib0065","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","author":"Kisseleva","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"24","key":"10.1016\/j.biocel.2021.105933_bib0070","doi-asserted-by":"crossref","first-page":"9448","DOI":"10.1073\/pnas.1201840109","article-title":"Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis","volume":"109","author":"Kisseleva","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"10.1016\/j.biocel.2021.105933_bib0075","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1016\/j.ajpath.2016.03.005","article-title":"Divergent inflammatory, fibrogenic, and liver progenitor cell dynamics in two common mouse models of chronic liver injury","volume":"186","author":"K\u00f6hn-Gaone","year":"2016","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.biocel.2021.105933_bib0080","doi-asserted-by":"crossref","first-page":"G143","DOI":"10.1152\/ajpgi.00215.2015","article-title":"The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis","volume":"310","author":"K\u00f6hn-Gaone","year":"2016","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"5","key":"10.1016\/j.biocel.2021.105933_bib0085","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1159\/000445269","article-title":"New developments on the treatment of liver fibrosis","volume":"34","author":"Koyama","year":"2016","journal-title":"Dig. Dis."},{"issue":"5","key":"10.1016\/j.biocel.2021.105933_bib0090","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/gutjnl-2014-306842","article-title":"Pathobiology of liver fibrosis: a translational success story","volume":"64","author":"Lee","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.biocel.2021.105933_bib0095","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.coph.2019.09.006","article-title":"New and emerging anti-fibrotic therapeutics entering or already in clinical trials in chronic liver diseases","volume":"49","author":"Lemoinne","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.biocel.2021.105933_bib0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1755-1536-6-19","article-title":"Experimental liver fibrosis research: update on animal models, legal issues and translational aspects","volume":"6","author":"Liedtke","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"2","key":"10.1016\/j.biocel.2021.105933_bib0105","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0002-9440(10)65299-6","article-title":"Oval cell numbers in human chronic liver diseases are directly related to disease severity","volume":"154","author":"Lowes","year":"1999","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.biocel.2021.105933_bib0110","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2015.017","article-title":"High-yield and high-purity isolation of hepatic stellate cells from normal and fibrotic mouse livers","volume":"10","author":"Mederacke","year":"2015","journal-title":"Nat. Protoc."},{"issue":"14","key":"10.1016\/j.biocel.2021.105933_bib0115","doi-asserted-by":"crossref","first-page":"17431","DOI":"10.18632\/oncotarget.7836","article-title":"A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis","volume":"7","author":"M\u00fcller","year":"2016","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.biocel.2021.105933_bib0120","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/lt.24007","article-title":"Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation","volume":"20","author":"Prakoso","year":"2014","journal-title":"Liver Transplant."},{"issue":"7663","key":"10.1016\/j.biocel.2021.105933_bib0125","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature23015","article-title":"Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration","volume":"547","author":"Raven","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biocel.2021.105933_bib0130","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/hep.22597","article-title":"Lymphotoxin-beta receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury","volume":"49","author":"Ruddell","year":"2009","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biocel.2021.105933_bib0135","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1053\/jhep.2003.50097","article-title":"Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype","volume":"37","author":"Schnabl","year":"2003","journal-title":"Hepatology"},{"issue":"9615","key":"10.1016\/j.biocel.2021.105933_bib0140","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan","year":"2008","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.biocel.2021.105933_bib0145","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1016\/j.biocel.2007.06.008","article-title":"Isolation, culture and immortalisation of hepatic oval cells from adult mice fed a choline-deficient, ethionine-supplemented diet","volume":"39","author":"Tirnitz-Parker","year":"2007","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.biocel.2021.105933_bib0150","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/hep.23663","article-title":"Tumor necrosis factor-like weak inducer of apoptosis is a mitogen for liver progenitor cells","volume":"52","author":"Tirnitz-Parker","year":"2010","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biocel.2021.105933_bib0155","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/hep.26701","article-title":"Role of TWEAK in coregulating liver progenitor cell and fibrogenic responses","volume":"59","author":"Tirnitz-Parker","year":"2014","journal-title":"Hepatology"},{"issue":"5","key":"10.1016\/j.biocel.2021.105933_bib0160","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1002\/hep.30340","article-title":"Cellular plasticity in liver regeneration: spotlight on cholangiocytes","volume":"69","author":"Tirnitz-Parker","year":"2019","journal-title":"Hepatology"},{"issue":"1 Suppl","key":"10.1016\/j.biocel.2021.105933_bib0165","doi-asserted-by":"crossref","first-page":"S15","DOI":"10.1016\/j.jhep.2015.02.039","article-title":"Hepatic fibrosis: concept to treatment","volume":"62","author":"Trautwein","year":"2015","journal-title":"J. Hepatol."},{"issue":"4","key":"10.1016\/j.biocel.2021.105933_bib0170","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1053\/j.gastro.2012.06.036","article-title":"Deactivation of hepatic stellate cells during liver fibrosis resolution in mice","volume":"143","author":"Troeger","year":"2012","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.biocel.2021.105933_bib0175","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.biocel.2021.105933_bib0180","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1002\/hep.22820","article-title":"Relation between liver progenitor cell expansion and extracellular matrix deposition in a CDE-induced murine model of chronic liver injury","volume":"49","author":"Van Hul","year":"2009","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.biocel.2021.105933_bib0185","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/hep.26706","article-title":"Ductular reaction in hereditary hemochromatosis: the link between hepatocyte senescence and fibrosis progression","volume":"59","author":"Wood","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.biocel.2021.105933_bib0190","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41467-019-14138-6","article-title":"SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis","volume":"11","author":"Zhou","year":"2020","journal-title":"Nat. Commun."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272521000170?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272521000170?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T07:19:21Z","timestamp":1761203961000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272521000170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":38,"alternative-id":["S1357272521000170"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2021.105933","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2021.105933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105933"}}