{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:18:03Z","timestamp":1792736283000,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP210103740"],"award-info":[{"award-number":["DP210103740"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1042528"],"award-info":[{"award-number":["APP1042528"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1121376"],"award-info":[{"award-number":["APP1121376"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.biocel.2021.105981","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T19:20:49Z","timestamp":1619119249000},"page":"105981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough"],"prefix":"10.1016","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9629-7923","authenticated-orcid":false,"given":"Aung Aung Kywe","family":"Moe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice E.","family":"McGovern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5270-1333","authenticated-orcid":false,"given":"Stuart B.","family":"Mazzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"50","key":"10.1016\/j.biocel.2021.105981_bib0005","doi-asserted-by":"crossref","first-page":"20018","DOI":"10.1073\/pnas.1110416108","article-title":"Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways","volume":"108","author":"Autr\u00e9aux","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.biocel.2021.105981_bib0010","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1113\/jphysiol.2003.057885","article-title":"Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs","volume":"557","author":"Canning","year":"2004","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.biocel.2021.105981_bib0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00408-015-9701-2","article-title":"The impact of chronic cough: a cross-sectional European survey","volume":"193","author":"Chamberlain","year":"2015","journal-title":"Lung"},{"issue":"3","key":"10.1016\/j.biocel.2021.105981_bib0020","doi-asserted-by":"crossref","first-page":"R489","DOI":"10.1152\/ajpregu.00313.2017","article-title":"Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs","volume":"314","author":"Chou","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.biocel.2021.105981_bib0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pupt.2018.11.003","article-title":"Prevalence of Arnold nerve reflex in subjects with and without chronic cough: relevance to Cough Hypersensitivity Syndromea","volume":"54","author":"Dicpinigaitis","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"1110","key":"10.1016\/j.biocel.2021.105981_bib0030","article-title":"Vagal afferent processing by the paratrigeminal nucleus","volume":"10","author":"Driessen","year":"2019","journal-title":"Front. Physiol."},{"issue":"378","key":"10.1016\/j.biocel.2021.105981_bib0035","article-title":"The role of the paratrigeminal nucleus in vagal afferent evoked respiratory reflexes: a neuroanatomical and functional study in Guinea pigs","volume":"6","author":"Driessen","year":"2015","journal-title":"Front. Physiol."},{"issue":"11","key":"10.1016\/j.biocel.2021.105981_bib0040","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1113\/JP279644","article-title":"A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs","volume":"598","author":"Driessen","year":"2020","journal-title":"J. Physiol."},{"issue":"24","key":"10.1016\/j.biocel.2021.105981_bib0045","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1113\/JP280220","article-title":"Evidence for multiple bulbar and higher brain circuits processing sensory inputs from the respiratory system in humans","volume":"598","author":"Farrell","year":"2020","journal-title":"J. Physiol."},{"issue":"4","key":"10.1016\/j.biocel.2021.105981_bib0050","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF02425070","article-title":"Anatomic basis of Arnold\u2019s ear-cough reflex","volume":"8","author":"Gupta","year":"1986","journal-title":"Surg. Radiol. Anat."},{"issue":"3","key":"10.1016\/j.biocel.2021.105981_bib0055","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41593-018-0074-8","article-title":"Mrgprs on vagal sensory neurons contribute to bronchoconstriction and airway hyper-responsiveness","volume":"21","author":"Han","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"3","key":"10.1016\/j.biocel.2021.105981_bib0060","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1124\/jpet.115.230383","article-title":"Pharmacology of bradykinin-evoked coughing in Guinea pigs","volume":"357","author":"Hewitt","year":"2016","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"4","key":"10.1016\/j.biocel.2021.105981_bib0065","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0203-20.2020","article-title":"Development of a mouse reporter strain for the purinergic P2X2 receptor","volume":"7","author":"Kim","year":"2020","journal-title":"eNeuro"},{"issue":"8","key":"10.1016\/j.biocel.2021.105981_bib0070","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1113\/JP275698","article-title":"Different role of TTX-sensitive voltage-gated sodium channel (Na(V) 1) subtypes in action potential initiation and conduction in vagal airway nociceptors","volume":"596","author":"Kollarik","year":"2018","journal-title":"J. Physiol."},{"issue":"8","key":"10.1016\/j.biocel.2021.105981_bib0075","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/WNR.0000000000001231","article-title":"Phenotypic distinctions between the nodose and jugular TRPV1-positive vagal sensory neurons in the cynomolgus monkey","volume":"30","author":"Kollarik","year":"2019","journal-title":"Neuroreport"},{"issue":"8","key":"10.1016\/j.biocel.2021.105981_bib0080","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.biocel.2021.105981_bib0085","doi-asserted-by":"crossref","first-page":"L858","DOI":"10.1152\/ajplung.90360.2008","article-title":"P2X2 receptors differentiate placodal vs. neural crest C-fiber phenotypes innervating guinea pig lungs and esophagus","volume":"295","author":"Kwong","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"4","key":"10.1016\/j.biocel.2021.105981_bib0090","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pupt.2006.10.007","article-title":"Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors","volume":"20","author":"Lee","year":"2007","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"Mar. (3)","key":"10.1016\/j.biocel.2021.105981_bib0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/cpt.2003","article-title":"Mechanisms and rationale for targeted therapies in refractory and unexplained chronic cough","volume":"109","author":"Mazzone","year":"2021","journal-title":"Clin. Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.biocel.2021.105981_bib0100","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"issue":"2","key":"10.1016\/j.biocel.2021.105981_bib0105","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1113\/jphysiol.2005.093153","article-title":"Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea\u2010pigs","volume":"569","author":"Mazzone","year":"2005","journal-title":"J. Physiol."},{"issue":"49","key":"10.1016\/j.biocel.2021.105981_bib0110","doi-asserted-by":"crossref","first-page":"9426","DOI":"10.1523\/JNEUROSCI.2430-20.2020","article-title":"Descending modulation of laryngeal vagal sensory processing in the brainstem orchestrated by the submedius thalamic nucleus","volume":"40","author":"Mazzone","year":"2020","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.biocel.2021.105981_bib0115","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s12035-019-01782-8","article-title":"Transcriptional profiling of individual airway projecting vagal sensory neurons","volume":"57","author":"Mazzone","year":"2020","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.biocel.2021.105981_bib0120","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1007\/s00429-014-0883-9","article-title":"Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents","volume":"220","author":"McGovern","year":"2015","journal-title":"Brain Struct. Funct."},{"issue":"18","key":"10.1016\/j.biocel.2021.105981_bib0125","doi-asserted-by":"crossref","first-page":"7041","DOI":"10.1523\/JNEUROSCI.5128-14.2015","article-title":"Distinct brainstem and forebrain circuits receiving tracheal sensory neuron inputs revealed using a novel conditional anterograde transsynaptic viral tracing system","volume":"35","author":"McGovern","year":"2015","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.biocel.2021.105981_bib0130","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1183\/09031936.00218613","article-title":"Expert opinion on the cough hypersensitivity syndrome in respiratory medicine","volume":"44","author":"Morice","year":"2014","journal-title":"Eur. Respir. J."},{"issue":"3","key":"10.1016\/j.biocel.2021.105981_bib0135","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cell.2020.03.004","article-title":"An airway protection program revealed by sweeping genetic control of vagal afferents","volume":"181","author":"Prescott","year":"2020","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.biocel.2021.105981_bib0140","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/lary.27201","article-title":"Treatment of chronic neurogenic cough with in-office superior laryngeal nerve block","volume":"128","author":"Simpson","year":"2018","journal-title":"Laryngoscope"},{"issue":"8","key":"10.1016\/j.biocel.2021.105981_bib0145","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S2213-2600(19)30471-0","article-title":"Gefapixant, a P2X3 receptor antagonist, for the treatment of refractory or unexplained chronic cough: a randomised, double-blind, controlled, parallel-group, phase 2b trial","volume":"8","author":"Smith","year":"2020","journal-title":"Lancet Respir. Med."},{"issue":"1","key":"10.1016\/j.biocel.2021.105981_bib0150","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.chest.2019.08.001","article-title":"The neurokinin-1 receptor antagonist orvepitant is a novel antitussive therapy for chronic refractory cough: results from a phase 2 pilot study (VOLCANO-1)","volume":"157","author":"Smith","year":"2020","journal-title":"CHEST"},{"issue":"5","key":"10.1016\/j.biocel.2021.105981_bib0155","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1183\/09031936.00218714","article-title":"The global epidemiology of chronic cough in adults: a systematic review and meta-analysis","volume":"45","author":"Song","year":"2015","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.biocel.2021.105981_bib0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2019.101810","article-title":"Nicotinic receptor dependent regulation of cough and other airway defensive reflexes","volume":"58","author":"Tao","year":"2019","journal-title":"Pulm. Pharmacol. Ther."},{"issue":"10","key":"10.1016\/j.biocel.2021.105981_bib0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185985","article-title":"Distinct and common expression of receptors for inflammatory mediators in vagal nodose versus jugular capsaicin-sensitive\/TRPV1-positive neurons detected by low input RNA sequencing","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272521000662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272521000662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:29:15Z","timestamp":1778801355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272521000662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":33,"alternative-id":["S1357272521000662"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2021.105981","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jugular vagal ganglia neurons and airway nociception: A target for treating chronic cough","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2021.105981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105981"}}