{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:57:01Z","timestamp":1777888621561,"version":"3.51.4"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2308085Y44"],"award-info":[{"award-number":["2308085Y44"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272450"],"award-info":[{"award-number":["82272450"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371575"],"award-info":[{"award-number":["82371575"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071591"],"award-info":[{"award-number":["82071591"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.biocel.2024.106618","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T12:31:09Z","timestamp":1721737869000},"page":"106618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["NS8593 inhibits chondrocyte ferroptosis and alleviates cartilage injury in rat adjuvant arthritis through TRPM7 \/ HO-1 pathway"],"prefix":"10.1016","volume":"174","author":[{"given":"Wenjuan","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rendi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renpeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"30","key":"10.1016\/j.biocel.2024.106618_bib1","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1707380114","article-title":"TRPM7 senses oxidative stress to release Zn(2+) from unique intracellular vesicles","volume":"114","author":"Abiria","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.biocel.2024.106618_bib2","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1172\/JCI69485","article-title":"Prolactin promotes cartilage survival and attenuates inflammation in inflammatory arthritis","volume":"123","author":"Ad\u00e1n","year":"2013","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.biocel.2024.106618_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ceca.2017.02.004","article-title":"Store-operated Ca(2+) entry is not required for fertilization-induced Ca(2+) signaling in mouse eggs","volume":"65","author":"Bernhardt","year":"2017","journal-title":"Cell Calcium"},{"issue":"4","key":"10.1016\/j.biocel.2024.106618_bib4","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1476-5381.2012.01855.x","article-title":"Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7","volume":"166","author":"Chubanov","year":"2012","journal-title":"Br. J. Pharm."},{"issue":"1","key":"10.1016\/j.biocel.2024.106618_bib5","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1038\/s41467-021-22454-z","article-title":"Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis","volume":"12","author":"Deng","year":"2021","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.biocel.2024.106618_bib6","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.devcel.2012.04.006","article-title":"Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis","volume":"22","author":"Desai","year":"2012","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.biocel.2024.106618_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1161\/CIRCEP.110.957407","article-title":"Inhibition of small-conductance Ca2+-activated K+ channels terminates and protects against atrial fibrillation","volume":"3","author":"Diness","year":"2010","journal-title":"Circ. Arrhythm. Electro"},{"key":"10.1016\/j.biocel.2024.106618_bib8","unstructured":"Dixon, S.J., et al., Ferroptosis: an iron-dependent form of nonapoptotic cell death. (1097-4172 (Electronic))."},{"issue":"5","key":"10.1016\/j.biocel.2024.106618_bib9","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.biocel.2024.106618_bib10","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1161\/CIRCRESAHA.109.206771","article-title":"TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation","volume":"106","author":"Du","year":"2010","journal-title":"Circ. Res"},{"issue":"7","key":"10.1016\/j.biocel.2024.106618_bib11","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1073\/pnas.1821022116","article-title":"Ferroptosis as a target for protection against cardiomyopathy","volume":"116","author":"Fang","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.biocel.2024.106618_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1161\/ATVBAHA.117.310391","article-title":"TRPM7 kinase controls calcium responses in arterial thrombosis and stroke in mice","volume":"38","author":"Gotru","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.biocel.2024.106618_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res"},{"key":"10.1016\/j.biocel.2024.106618_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2019.104715","article-title":"Gastrodin protects against glutamate-induced ferroptosis in HT-22 cells through Nrf2\/HO-1 signaling pathway","volume":"62","author":"Jiang","year":"2020","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.biocel.2024.106618_bib15","unstructured":"Jiang, X.A.-O., B.A.-O. Stockwell, and M.A.-O. Conrad, Ferroptosis: mechanisms, biology and role in disease. (1471-0080 (Electronic))."},{"issue":"19","key":"10.1016\/j.biocel.2024.106618_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194968","article-title":"Programmed cell-death by ferroptosis: antioxidants as mitigators","volume":"20","author":"Kajarabille","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biocel.2024.106618_bib17","doi-asserted-by":"crossref","unstructured":"Kwon, M.Y., , 2015. Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death. (1949-2553 (Electronic)).","DOI":"10.18632\/oncotarget.5162"},{"key":"10.1016\/j.biocel.2024.106618_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111933","article-title":"TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKC\u03b1-HuR axis in rheumatoid arthritis","volume":"132","author":"Lin","year":"2024","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.biocel.2024.106618_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108302","article-title":"A pan-cancer-bioinformatic-based literature review of TRPM7 in cancers","volume":"240","author":"Liu","year":"2022","journal-title":"Pharm. Ther."},{"issue":"5","key":"10.1016\/j.biocel.2024.106618_bib20","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.apsb.2021.12.007","article-title":"Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1","volume":"12","author":"Luo","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"6837","key":"10.1016\/j.biocel.2024.106618_bib21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/35079092","article-title":"LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability","volume":"411","author":"Nadler","year":"2001","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.biocel.2024.106618_bib22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/S0092-8674(03)01019-5","article-title":"The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death","volume":"115","author":"Nicotera","year":"2003","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.biocel.2024.106618_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells10112857","article-title":"Management of rheumatoid arthritis: an overview","volume":"10","author":"Radu","year":"2021","journal-title":"Cells"},{"issue":"5506","key":"10.1016\/j.biocel.2024.106618_bib24","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1126\/science.1058519","article-title":"TRP-PLIK, a bifunctional protein with kinase and ion channel activities","volume":"291","author":"Runnels","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.biocel.2024.106618_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ncomms1108","article-title":"TRPM7 is essential for Mg(2+) homeostasis in mammals","volume":"1","author":"Ryazanova","year":"2010","journal-title":"Nat. Commun."},{"issue":"Pt 21","key":"10.1016\/j.biocel.2024.106618_bib26","first-page":"4561","article-title":"TRPM7 regulates proliferation and polarisation of macrophages","volume":"127","author":"Schilling","year":"2014","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.biocel.2024.106618_bib27","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0092-8674(03)00556-7","article-title":"Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7","volume":"114","author":"Schmitz","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2024.106618_bib28","unstructured":"Seibt, T.M., B. Proneth, and M. Conrad, Role of GPX4 in ferroptosis and its pharmacological implication. (1873-4596 (Electronic))."},{"issue":"1","key":"10.1016\/j.biocel.2024.106618_bib29","doi-asserted-by":"crossref","DOI":"10.7326\/AITC201901010","article-title":"Rheumatoid arthritis","volume":"170","author":"Sparks","year":"2019","journal-title":"Ann. Intern Med."},{"issue":"5","key":"10.1016\/j.biocel.2024.106618_bib30","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1124\/mol.106.027110","article-title":"Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons","volume":"70","author":"Str\u00f8baek","year":"2006","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.biocel.2024.106618_bib31","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1038\/s41598-020-59355-y","article-title":"TRPM7 contributes to progressive nephropathy","volume":"10","author":"Suzuki","year":"2020","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biocel.2024.106618_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21031071","article-title":"Dual role of chondrocytes in rheumatoid arthritis: the chicken and the egg","volume":"21","author":"Tseng","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.biocel.2024.106618_bib33","doi-asserted-by":"crossref","unstructured":"Wang, Y.A.-O., , 2023. Pharmacological Inhibition of Ferroptosis as a Therapeutic Target for Neurodegenerative Diseases and Strokes. (2198-3844 (Electronic)).","DOI":"10.1002\/advs.202300325"},{"issue":"1","key":"10.1016\/j.biocel.2024.106618_bib34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/14397595.2019.1704976","article-title":"Comparative study of HO-1 expressing synovial lining cells between RA and OA","volume":"31","author":"Yang","year":"2021","journal-title":"Mod. Rheuma"},{"issue":"1","key":"10.1016\/j.biocel.2024.106618_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-022-00198-w","article-title":"Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis","volume":"10","author":"Yang","year":"2022","journal-title":"Bone Res"},{"key":"10.1016\/j.biocel.2024.106618_bib36","doi-asserted-by":"crossref","unstructured":"Yang, S., 2022. A Dual Role of Heme Oxygenase-1 in Tuberculosis. (1664-3224 (Electronic)).","DOI":"10.3389\/fimmu.2022.842858"},{"issue":"1","key":"10.1016\/j.biocel.2024.106618_bib37","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/s41467-023-36154-3","article-title":"Adipose-specific deletion of the cation channel TRPM7 inhibits TAK1 kinase-dependent inflammation and obesity in male mice","volume":"14","author":"Zhong","year":"2023","journal-title":"Nat. Commun."},{"issue":"26","key":"10.1016\/j.biocel.2024.106618_bib38","doi-asserted-by":"crossref","first-page":"11976","DOI":"10.7150\/thno.50663","article-title":"Novel insights into ferroptosis: implications for age-related diseases","volume":"10","author":"Zhou","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.biocel.2024.106618_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102411","article-title":"TRPM7 channel inhibition attenuates rheumatoid arthritis articular chondrocyte ferroptosis by suppression of the PKC\u03b1-NOX4 axis","volume":"55","author":"Zhou","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.biocel.2024.106618_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115707","article-title":"Targeting regulated chondrocyte death in osteoarthritis therapy","volume":"215","author":"Zhu","year":"2023","journal-title":"Biochem Pharm."},{"issue":"15","key":"10.1016\/j.biocel.2024.106618_bib41","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1042\/CS20200827","article-title":"Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function","volume":"134","author":"Zou","year":"2020","journal-title":"Clin. Sci. (Lond. )"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524001109?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524001109?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:51:25Z","timestamp":1777611085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272524001109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":41,"alternative-id":["S1357272524001109"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106618","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NS8593 inhibits chondrocyte ferroptosis and alleviates cartilage injury in rat adjuvant arthritis through TRPM7 \/ HO-1 pathway","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106618"}}