{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:01:42Z","timestamp":1768291302239,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.biocel.2024.106687","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T23:36:19Z","timestamp":1731108979000},"page":"106687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Integrative multi-omics and big data analysis of global nutrition and radiotherapy trends"],"prefix":"10.1016","volume":"177","author":[{"given":"Sibo","family":"Meng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dizhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enhao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linli","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-8962","authenticated-orcid":false,"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.biocel.2024.106687_bib1","article-title":"Effects of food-based interventions in the management of chemoradiotherapy-induced nausea and vomiting: a systematic review","volume":"31","author":"A","year":"2023","journal-title":"Support Care Cancer"},{"issue":"0","key":"10.1016\/j.biocel.2024.106687_bib2","author":"A","year":"2024","journal-title":"J. Endocrinol. Invest"},{"issue":"6","key":"10.1016\/j.biocel.2024.106687_bib3","article-title":"Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention","volume":"55","author":"Alexandra Iulia","year":"2019","journal-title":"Med. (Kaunas. )"},{"issue":"12","key":"10.1016\/j.biocel.2024.106687_bib4","article-title":"Impact of Preoperative Malnutrition on Patients with Pancreatic Neoplasms Post-Duodenopancreatectomy: A Retrospective Cohort Study","volume":"16","author":"Alvarez","year":"2024","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.biocel.2024.106687_bib5","article-title":"The Association of Change in Weight During Radiotherapy Treatment With Clinical Outcomes in Patients With Stage I-III Esophageal Cancer","volume":"76","author":"Andrew","year":"2024","journal-title":"Nutr. Cancer"},{"issue":"12","key":"10.1016\/j.biocel.2024.106687_bib6","article-title":"Effects of Weight Loss on Key Obesity-Related Biomarkers Linked to the Risk of Endometrial Cancer: A Systematic Review and Meta-Analysis","volume":"16","author":"Angela","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/j.biocel.2024.106687_bib7","article-title":"Radiotherapy-induced metabolic hallmarks in the tumor microenvironment","volume":"8","author":"Anjali","year":"2022","journal-title":"Trends Cancer"},{"key":"10.1016\/j.biocel.2024.106687_bib8","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"bibliometrix: An R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J. Informetr."},{"issue":"4","key":"10.1016\/j.biocel.2024.106687_bib9","article-title":"Radiotherapy-induced thyroid disorders","volume":"30","author":"Barbara","year":"2004","journal-title":"Cancer Treat. Rev."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib10","article-title":"Omega-3 nanoemulgel in prevention of radiation-induced oral mucositis and its associated effect on microbiome: a randomized clinical trial","volume":"23","author":"Basma","year":"2023","journal-title":"BMC Oral. Health"},{"issue":"7","key":"10.1016\/j.biocel.2024.106687_bib11","article-title":"Elevated pretreatment lactate dehydrogenase and albumin-to-alkaline phosphatase ratio predict poor prognosis and early treatment discontinuation in head and neck cancer patients with preexistent diabetes mellitus","volume":"125","author":"Camil Ciprian","year":"2024","journal-title":"Bratisl. Lek. Listy"},{"issue":"3","key":"10.1016\/j.biocel.2024.106687_bib12","article-title":"Correlation between plasma lycopene levels in patients with laryngeal carcinoma and postoperative adverse complications of chemoradiotherapy and nutritional risks","volume":"281","author":"Ce","year":"2023","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib13","article-title":"Prospective study on health-related quality of life, oral mucositis and oral health on during treatment of head and neck cancer","volume":"24","author":"Charlott","year":"2024","journal-title":"BMC Oral. Health"},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib14","article-title":"Dietary fibre supplementation enhances radiotherapy tumour control and alleviates intestinal radiation toxicity","volume":"12","author":"Chee Kin","year":"2024","journal-title":"Microbiome"},{"issue":"3","key":"10.1016\/j.biocel.2024.106687_bib15","article-title":"Genetic variants and normal tissue toxicity after radiotherapy: a systematic review","volume":"92","author":"Christian Nicolaj","year":"2009","journal-title":"Radio. Oncol."},{"issue":"2","key":"10.1016\/j.biocel.2024.106687_bib16","article-title":"Nutritional Status and Incidence of Radiation-Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients Treated with Chemoradiotherapy","volume":"76","author":"Chunhong","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"20","key":"10.1016\/j.biocel.2024.106687_bib17","article-title":"Prognostic nutritional index and serum lactate dehydrogenase predict the prognosis of nasopharyngeal carcinoma patients who received intensity-modulated radiation therapy","volume":"149","author":"Chunxia","year":"2023","journal-title":"J. Cancer Res Clin. Oncol."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib18","article-title":"Nutrition outcomes and treatment toxicities in patients with head and neck cancer receiving helical intensity-modulated radiotherapy","volume":"37","author":"Claire","year":"2023","journal-title":"J. Hum. Nutr. Diet."},{"issue":"6","key":"10.1016\/j.biocel.2024.106687_bib19","article-title":"Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma","volume":"6","author":"Elena","year":"2023","journal-title":"Life Sci. Alliance"},{"issue":"3","key":"10.1016\/j.biocel.2024.106687_bib20","doi-asserted-by":"crossref","first-page":"667","DOI":"10.17576\/jsm-2024-5303-14","article-title":"SF1: A Standardised Fraction of Clinacanthus nutans that Inhibits the Stemness Properties of Cancer Stem-Like Cells Derived from Cervical Cancer","volume":"53","author":"Faridah","year":"2024","journal-title":"Sains Malays."},{"issue":"10","key":"10.1016\/j.biocel.2024.106687_bib21","article-title":"Assessing Nutritional Status in Gastric Cancer Patients after Total versus Subtotal Gastrectomy: Cross-Sectional Study","volume":"16","author":"Fawzy","year":"2024","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.biocel.2024.106687_bib22","article-title":"The role of the nutrition in malnourished cancer patients: Revisiting an old dilemma","volume":"43","author":"Federico","year":"2024","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.biocel.2024.106687_bib23","first-page":"1","article-title":"Effect of Nutritional Intervention on the Management of Radiotherapy and Chemotherapy for Nasopharyngeal Carcinoma","volume":"76","author":"Fengrong","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"4","key":"10.1016\/j.biocel.2024.106687_bib24","article-title":"May Nutritional Status Positively Affect Disease Progression and Prognosis in Patients with Esophageal and Pharyngeal Cancers? A Scoping Review of the Current Clinical Studies","volume":"11","author":"Georgios","year":"2023","journal-title":"Med Sci. (Basel)"},{"issue":"12","key":"10.1016\/j.biocel.2024.106687_bib25","article-title":"Proteome-wide mendelian randomization identifies causal plasma proteins in venous thromboembolism development","volume":"68","author":"Haobo","year":"2023","journal-title":"J. Hum. Genet"},{"issue":"7","key":"10.1016\/j.biocel.2024.106687_bib26","article-title":"Severe obesity is associated with worse outcomes than lean metabolic dysfunction-associated steatotic liver disease","volume":"8","author":"Jaideep","year":"2024","journal-title":"Hepatol. Commun."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib27","article-title":"ESPEN guidelines on nutrition in cancer patients","volume":"36","author":"Jann","year":"2016","journal-title":"Clin. Nutr."},{"issue":"6","key":"10.1016\/j.biocel.2024.106687_bib28","article-title":"Prognostic nutritional index and neutrophil-lymphocyte ratio predict toxicities and prognosis in patients with cervical cancer treated with curative radiochemotherapy","volume":"123","author":"Jenny Ling-Yu","year":"2023","journal-title":"J. Formos. Med Assoc."},{"issue":"7","key":"10.1016\/j.biocel.2024.106687_bib29","article-title":"Effects of early nutritional intervention on oral mucositis and basic conditions in patients receiving radiotherapy for head and neck cancer: Randomized controlled trial (ChiCTR2000031418)","volume":"43","author":"Jinlong","year":"2024","journal-title":"Clin. Nutr."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib30","article-title":"Clinical, Functional, and Nutritional Efficacy of a Glutamine-Enriched Oligomeric Diet in Patients with Rectal Cancer","volume":"76","author":"Johanna Del Carmen","year":"2023","journal-title":"Nutr. Cancer"},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib31","article-title":"Genomic-driven nutritional interventions for radiotherapy-resistant rectal cancer patient","volume":"13","author":"Joshua","year":"2023","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.biocel.2024.106687_bib32","article-title":"Nutritional Status as a Prognostic Factor for Survival in Palliative Care: A Retrospective Observational Analysis of Home Parenteral Nutrition in Cancer Patients with Inoperable Malignant Bowel Obstruction","volume":"16","author":"Karolina","year":"2024","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.biocel.2024.106687_bib33","article-title":"Definition and classification of cancer cachexia: an international consensus","volume":"12","author":"Kenneth","year":"2011","journal-title":"Lancet Oncol."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib34","article-title":"The influence of diet on anti-cancer immune responsiveness","volume":"16","author":"Laura","year":"2018","journal-title":"J. Transl. Med"},{"issue":"3","key":"10.1016\/j.biocel.2024.106687_bib35","article-title":"Integration of metabolomics and transcriptomics reveals convergent pathways driving radiation-induced salivary gland dysfunction","volume":"53","author":"Lauren","year":"2021","journal-title":"Physiol. Genom."},{"issue":"12","key":"10.1016\/j.biocel.2024.106687_bib36","article-title":"Nutritional Profile, Disease Severity, and Quality of Life of Patients with Inflammatory Bowel Disease: A Case-Control Study","volume":"16","author":"Lea","year":"2024","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.biocel.2024.106687_bib37","article-title":"The effect of early oral nutritional supplements on improving nutritional outcomes and radiation-induced oral mucositis for nasopharyngeal carcinoma patients undergoing concurrent chemoradiotherapy","volume":"45","author":"Li","year":"2023","journal-title":"Head. Neck"},{"issue":"0)","key":"10.1016\/j.biocel.2024.106687_bib38","article-title":"Predict nutrition-related adverse outcomes in head and neck cancer patients undergoing radiotherapy: A systematic review","volume":"197","author":"Lichuan","year":"2024","journal-title":"Radio. Oncol."},{"issue":"9","key":"10.1016\/j.biocel.2024.106687_bib39","article-title":"Nutritional Prognosis of Patients Submitted to Radiotherapy and Its Implications in Treatment","volume":"16","author":"Mariana Maroso Molina","year":"2024","journal-title":"Nutrients"},{"issue":"0","key":"10.1016\/j.biocel.2024.106687_bib40","article-title":"visualization and knowledge discovery in bibliographic databases","volume":"2005","author":"Marie","year":"2006","journal-title":"AMIA Annu Symp. Proc."},{"issue":"4","key":"10.1016\/j.biocel.2024.106687_bib41","article-title":"Inflammatory microenvironment remodelling by tumour cells after radiotherapy","volume":"20","author":"Martin","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"5","key":"10.1016\/j.biocel.2024.106687_bib42","article-title":"ESPEN practical guideline","volume":"40","author":"Maurizio","year":"2021","journal-title":"Clin. Nutr. Cancer Clin. Nutr."},{"issue":"0)","key":"10.1016\/j.biocel.2024.106687_bib43","article-title":"The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer: A systematic review","volume":"188","author":"Mette Overgaard","year":"2023","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.biocel.2024.106687_bib44","first-page":"8","article-title":"Initial psychometric assessment of a functional oral intake scale for dysphagia in stroke patients","volume":"86","author":"Michael","year":"2005","journal-title":"Arch. Phys. Med Rehabil."},{"issue":"0","key":"10.1016\/j.biocel.2024.106687_bib45","article-title":"Associations of different dietary patterns, bone mineral density, and fracture risk among elderly women: the China Osteoporosis Prevalence Study","volume":"15","author":"Nan","year":"2024","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"2","key":"10.1016\/j.biocel.2024.106687_bib46","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"Nees Jan","year":"2010","journal-title":"Scientometrics"},{"issue":"2","key":"10.1016\/j.biocel.2024.106687_bib47","article-title":"Effect of individualized nutritional intervention on head and neck cancer patients receiving radiotherapy","volume":"32","author":"Peng","year":"2024","journal-title":"Support Care Cancer"},{"issue":"4","key":"10.1016\/j.biocel.2024.106687_bib48","article-title":"Risk factors and the nomogram model for malnutrition in patients with nasopharyngeal carcinoma","volume":"32","author":"Pengpeng","year":"2024","journal-title":"Support Care Cancer"},{"issue":"0)","key":"10.1016\/j.biocel.2024.106687_bib49","article-title":"Carbon Ion Radiotherapy Evokes a Metabolic Reprogramming and Individualized Response in Prostate Cancer","volume":"9","author":"Renli","year":"2021","journal-title":"Front Public Health"},{"issue":"4","key":"10.1016\/j.biocel.2024.106687_bib50","doi-asserted-by":"crossref","first-page":"881","DOI":"10.17576\/jsm-2024-5304-12","article-title":"Evaluating the Cytotoxic Activity of Lactobacillus plantarum IIA-1A5 against MCF-7 Human Breast Cancer Cells and Identifying Its Surface Layer Protein Gene","volume":"53","author":"Reza","year":"2024","journal-title":"Sains Malays."},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib51","article-title":"Efficacy of Eicosapentaenoic Acid (EPA) Containing Protein Supplement in Preventing Weight Loss in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: Retrospective Observations with Historical Controls","volume":"76","author":"Sanath Kumar","year":"2024","journal-title":"Indian J. Otolaryngol. Head. Neck Surg."},{"issue":"19","key":"10.1016\/j.biocel.2024.106687_bib52","article-title":"Performance of a simplified nutrition screening tool for outpatient radiotherapy cancer patients","volume":"102","author":"Supisara","year":"2023","journal-title":"Med. (Baltim. )"},{"issue":"1","key":"10.1016\/j.biocel.2024.106687_bib53","article-title":"Predicting prognosis in colorectal cancer patients with curative resection using albumin, lymphocyte count and RAS mutations","volume":"14","author":"Toshiya","year":"2024","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.biocel.2024.106687_bib54","article-title":"AI-Assisted Body Composition Assessment Using CT Imaging in Colorectal Cancer Patients: Predictive Capacity for Sarcopenia and Malnutrition Diagnosis","volume":"16","author":"Virginia","year":"2024","journal-title":"Nutrients"},{"issue":"0)","key":"10.1016\/j.biocel.2024.106687_bib55","article-title":"Effect of nonpharmacological interventions on nutrition status, complications and quality of life in head and neck cancer patients undergoing radiotherapy: A systematic review and meta-analysis","author":"Xiaolei","year":"2024","journal-title":"Int J. Nurs. Pr."},{"issue":"6","key":"10.1016\/j.biocel.2024.106687_bib56","article-title":"Acute skin toxicity and self-management ability among Chinese breast cancer radiotherapy patients: a qualitative study","volume":"32","author":"Xiaomeng","year":"2024","journal-title":"Support Care Cancer"},{"issue":"0)","key":"10.1016\/j.biocel.2024.106687_bib57","article-title":"Radiation-induced chronic pain plagues head and neck cancer survivors: A cross-sectional analysis from the Cohort in Radiotherapy-related Nervous System Complications","author":"Xuzheng","year":"2024","journal-title":"J. Pain."},{"issue":"3","key":"10.1016\/j.biocel.2024.106687_bib58","article-title":"Novel insight into metabolic reprogrammming in cancer radioresistance: A promising therapeutic target in radiotherapy","volume":"19","author":"Yilin","year":"2023","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.biocel.2024.106687_bib59","first-page":"0","article-title":"Beyond success: unveiling the hidden potential of radiotherapy and immunotherapy in solid tumors","author":"Yuze","year":"2024","journal-title":"Cancer Commun. (Lond. )"},{"issue":"2","key":"10.1016\/j.biocel.2024.106687_bib60","article-title":"Effect of the hospital-community-family (HCF) nutritional management on patients with esophageal and head and neck cancers undergoing radiotherapy: a randomized control trial","volume":"12","author":"Zijian","year":"2023","journal-title":"Transl. Cancer Res"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524001808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524001808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T15:17:45Z","timestamp":1733066265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272524001808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":60,"alternative-id":["S1357272524001808"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106687","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative multi-omics and big data analysis of global nutrition and radiotherapy trends","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106687"}}