{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:13:28Z","timestamp":1783685608509,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.biocel.2024.106699","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T22:29:56Z","timestamp":1732055396000},"page":"106699","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Use of Myriocin as co-adjuvant in glaucoma surgery: An in vitro study"],"prefix":"10.1016","volume":"177","author":[{"given":"Linda","family":"Montavoci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Zulueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele Dei","family":"Cas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delfina","family":"Tosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Bernardelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Autelitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Trinchera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6140-6969","authenticated-orcid":false,"given":"Anna","family":"Caretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biocel.2024.106699_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00019606-200603000-00009","article-title":"Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts","volume":"15","author":"Arocho","year":"2006","journal-title":"Diagn. Mol. Pathol."},{"issue":"5","key":"10.1016\/j.biocel.2024.106699_bib2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen."},{"issue":"JUL","key":"10.1016\/j.biocel.2024.106699_bib3","article-title":"Sphingolipid synthesis inhibition by myriocin administration enhances lipid consumption and ameliorates lipid response to myocardial ischemia reperfusion injury","volume":"10","author":"Bonezzi","year":"2019","journal-title":"Front Physiol."},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s00417-009-1221-4","article-title":"Paclitaxel inhibits growth, migration and collagen production of human Tenon\u2019s fibroblasts-potential use in drug-eluting glaucoma drainage devices","volume":"248","author":"Choritz","year":"2010","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib5","first-page":"449","article-title":"Antimetabolite-induced apoptosis in Tenon\u2019s capsule fibroblasts","volume":"39","author":"Crowston","year":"1998","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s10561-012-9325-1","article-title":"A standardized laboratory and surgical method for in vitro culture isolation and expansion of primary human Tenon\u2019s fibroblasts","volume":"14","author":"Falco","year":"2013","journal-title":"Cell Tissue Bank"},{"issue":"7","key":"10.1016\/j.biocel.2024.106699_bib7","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1167\/iovs.18-24258","article-title":"YAP\/TAZ are essential for TGF-\u03b22-mediated conjunctival fibrosis","volume":"59","author":"Futakuchi","year":"2018","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"12","key":"10.1016\/j.biocel.2024.106699_bib8","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.ophtha.2022.07.003","article-title":"Treatment outcomes in the primary tube versus trabeculectomy study after 5 years of follow-up","volume":"129","author":"Gedde","year":"2022","journal-title":"Ophthalmology"},{"key":"10.1016\/j.biocel.2024.106699_bib9","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1194\/jlr.M026039","article-title":"Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]","volume":"53","author":"Gorshkova","year":"2012","journal-title":"J. Lipid Res."},{"issue":"4","key":"10.1016\/j.biocel.2024.106699_bib10","first-page":"486","article-title":"The inhibitory effect of connective tissue growth factor antibody on postoperative fibrosis in a rabbit model of trabeculectomy","volume":"17","author":"Hassanpour","year":"2022","journal-title":"J. Ophthalmic Vis. Res"},{"issue":"11","key":"10.1016\/j.biocel.2024.106699_bib11","doi-asserted-by":"crossref","first-page":"10284","DOI":"10.1074\/jbc.M412348200","article-title":"Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice","volume":"280","author":"Hojjati","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"SEP","key":"10.1016\/j.biocel.2024.106699_bib12","article-title":"Inhibiting ceramide synthesis attenuates hepatic steatosis and fibrosis in rats with non-alcoholic fatty liver disease","volume":"10","author":"Jiang","year":"2019","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"SEP","key":"10.1016\/j.biocel.2024.106699_bib13","article-title":"Inhibiting ceramide synthesis attenuates hepatic steatosis and fibrosis in rats with non-alcoholic fatty liver disease","volume":"10","author":"Jiang","year":"2019","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.biocel.2024.106699_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2014.00123","article-title":"Fibroblasts in fibrosis: novel roles and mediators","volume":"5","author":"Kendall","year":"2014","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.biocel.2024.106699_bib15","article-title":"Beta radiation for glaucoma surgery","author":"Kirwan","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.biocel.2024.106699_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.108119","article-title":"Epigallocatechin-3-gallate (EGCG) inhibits myofibroblast transformation of human Tenon\u2019s fibroblasts","volume":"197","author":"Lin","year":"2020","journal-title":"Exp. Eye Res."},{"issue":"6","key":"10.1016\/j.biocel.2024.106699_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234706","article-title":"Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models","volume":"15","author":"Lin","year":"2020","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.biocel.2024.106699_bib18","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1167\/iovs.07-1610","article-title":"Lovastatin Inhibits TGF-\u03b2\u2013induced myofibroblast transdifferentiation in human tenon fibroblasts","volume":"49","author":"Meyer-ter-Vehn","year":"2008","journal-title":"Invest Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/bbrc.1995.1827","article-title":"Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1\/myriocin","volume":"211","author":"Miyake","year":"1995","journal-title":"Biochem Biophys. Res Commun."},{"issue":"13","key":"10.1016\/j.biocel.2024.106699_bib20","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1167\/iovs.16-19706","article-title":"Details of the collagen and elastin architecture in the human limbal conjunctiva, tenon\u2019s capsule and sclera revealed by two-photon excited fluorescence microscopy","volume":"57","author":"Park","year":"2016","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biocel.2024.106699_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.00372","article-title":"Myriocin effect on tvrm4 retina, an autosomal dominant pattern of retinitis pigmentosa","volume":"14","author":"Piano","year":"2020","journal-title":"Front Neurosci."},{"issue":"11","key":"10.1016\/j.biocel.2024.106699_bib22","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/ejn.12196","article-title":"Cone survival and preservation of visual acuity in an animal model of retinal degeneration","volume":"37","author":"Piano","year":"2013","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.biocel.2024.106699_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10717544.2019.1574936","article-title":"Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa","volume":"26","author":"Platania","year":"2019","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.biocel.2024.106699_bib24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10717544.2019.1574936","article-title":"Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa","volume":"26","author":"Platania","year":"2019","journal-title":"Drug Deliv."},{"issue":"5","key":"10.1016\/j.biocel.2024.106699_bib25","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"10.1016\/j.biocel.2024.106699_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.2003.tb03205.x","article-title":"Smad3: a key player in pathogenetic mechanisms dependent on TGF-\u03b2","volume":"995","author":"Roberts","year":"2003","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.preteyeres.2007.12.002","article-title":"Fibrotic disorders in the eye: targets of gene therapy","volume":"27","author":"Saika","year":"2008","journal-title":"Prog. Retin Eye Res."},{"key":"10.1016\/j.biocel.2024.106699_bib28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.exer.2015.03.021","article-title":"Conjunctival fibrosis following filtering glaucoma surgery","volume":"142","author":"Schlunck","year":"2016","journal-title":"Exp. Eye Res."},{"issue":"5","key":"10.1016\/j.biocel.2024.106699_bib29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1089\/jop.2010.0064","article-title":"Effect of doxycycline on postoperative scarring after trabeculectomy in an experimental rabbit model","volume":"26","author":"Sen","year":"2010","journal-title":"J. Ocul. Pharm. Ther."},{"issue":"3","key":"10.1016\/j.biocel.2024.106699_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11030657","article-title":"Novel therapies for the prevention of fibrosis in glaucoma filtration surgery","volume":"11","author":"Shao","year":"2023","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.biocel.2024.106699_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e15368","article-title":"Scar formation in the presence of mitomycin C and the anti-fibrotic antibody in a rabbit model of glaucoma microsurgery: a pilot study","volume":"9","author":"Shukla","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.biocel.2024.106699_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.109928","article-title":"Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis","volume":"81","author":"Signorelli","year":"2021","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.biocel.2024.106699_bib33","first-page":"1645269","article-title":"Use of Anti-VEGF agents in glaucoma surgery","volume":"2017","author":"Slabaugh","year":"2017","journal-title":"J. Ophthalmol."},{"issue":"9","key":"10.1016\/j.biocel.2024.106699_bib34","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.200441","article-title":"Suppression of the TGF-\u03b2 pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro","volume":"7","author":"Stahnke","year":"2020","journal-title":"R. Soc. Open Sci."},{"issue":"43","key":"10.1016\/j.biocel.2024.106699_bib35","doi-asserted-by":"crossref","first-page":"18706","DOI":"10.1073\/pnas.1007644107","article-title":"Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa","volume":"107","author":"Strettoi","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.biocel.2024.106699_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232565","article-title":"An image J plugin for the high throughput image analysis of in vitro scratch wound healing assays","volume":"15","author":"Suarez-Arnedo","year":"2020","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.biocel.2024.106699_bib37","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.2337\/db09-1293","article-title":"Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption","volume":"59","author":"Ussher","year":"2010","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.biocel.2024.106699_bib38","article-title":"Intra-operative mitomycin C for glaucoma surgery","volume":"2005","author":"Wilkins","year":"2005","journal-title":"Cochrane Database Syst. Rev."},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/ICU.0000000000000729","article-title":"History, presence, and future of mitomycin C in glaucoma filtration surgery","volume":"32","author":"Wolters","year":"2021","journal-title":"Curr. Opin. Ophthalmol."},{"issue":"1\u20132","key":"10.1016\/j.biocel.2024.106699_bib40","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11010-020-03760-4","article-title":"Trehalose attenuates TGF-\u03b21-induced fibrosis of hSCFs by activating autophagy","volume":"470","author":"Wu","year":"2020","journal-title":"Mol. Cell Biochem"},{"issue":"2","key":"10.1016\/j.biocel.2024.106699_bib41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.biocel.2024.106699_bib42","first-page":"841","article-title":"Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice","volume":"12","author":"Yamanaka","year":"2006","journal-title":"Mol. Vis."},{"issue":"8","key":"10.1016\/j.biocel.2024.106699_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/cells11081301","article-title":"Emerging evidence of noncoding RNAs in bleb scarring after glaucoma filtration surgery","volume":"11","author":"Yu","year":"2022","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.biocel.2024.106699_bib44","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1167\/iovs.18-26526","article-title":"Rosiglitazone treatment prevents postoperative fibrosis in a rabbit model of glaucoma filtration surgery","volume":"60","author":"Zhang","year":"2019","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biocel.2024.106699_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109628","article-title":"Niclosamide inhibits TGF-\u03b21-induced fibrosis of human Tenon\u2019s fibroblasts by regulating the MAPK-ERK1\/2 pathway","volume":"235","author":"Zhang","year":"2023","journal-title":"Exp. Eye Res"},{"key":"10.1016\/j.biocel.2024.106699_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2019.105622","article-title":"Inflammatory role of extracellular sphingolipids in Cystic Fibrosis","volume":"116","author":"Zulueta","year":"2019","journal-title":"Int J. Biochem Cell Biol."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524001924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524001924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T15:17:45Z","timestamp":1733066265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272524001924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":46,"alternative-id":["S1357272524001924"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106699","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Use of Myriocin as co-adjuvant in glaucoma surgery: An in vitro study","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106699","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106699"}}