{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:06:15Z","timestamp":1793639175643,"version":"4.5.1"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP2\/417\/45"],"award-info":[{"award-number":["RGP2\/417\/45"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.biocel.2024.106716","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T22:43:59Z","timestamp":1733438639000},"page":"106716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Prevention of fenitrothion induced hepatic toxicity by saponarin via modulating TLR4\/MYD88, JAK1\/STAT3 and NF-\u03baB signaling pathways"],"prefix":"10.1016","volume":"179","author":[{"given":"Hesham M.","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"El Safadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Faisal","family":"Hayat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Al-Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biocel.2024.106716_bib1","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s11033-020-05286-w","article-title":"Bitter apricot ethanolic extract induces apoptosis through increasing expression of Bax\/Bcl-2 ratio and caspase-3 in PANC-1 pancreatic cancer cells","volume":"47","author":"Aamazadeh","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib2","first-page":"5609734","article-title":"Impact of exposure to fenitrothion on vital organs in rats","volume":"2016","author":"Abdel-Ghany","year":"2016","journal-title":"J. Toxicol."},{"key":"10.1016\/j.biocel.2024.106716_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2021.104959","article-title":"The ameliorative effect of curcumin on hepatic CYP1A1 and CYP1A2 genes dysregulation and hepatorenal damage induced by fenitrothion oral intoxication in male rats","volume":"179","author":"Abd-Elhakim","year":"2021","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.biocel.2024.106716_bib4","series-title":"In Methods of enzymatic analysis","first-page":"673","article-title":"Catalase","author":"Aebi","year":"1974"},{"issue":"9","key":"10.1016\/j.biocel.2024.106716_bib5","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1177\/0748233708100090","article-title":"Histopathological changes in the liver and kidney tissues of wistar albino rat exposed to fenitrothion","volume":"24","author":"Afshar","year":"2008","journal-title":"Toxicol. Ind. Health"},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib6","article-title":"Effect of tea (Camellia sinensis) and olive (Olea europaea L.) leaves extracts on male mice exposed to diazinon","volume":"2013","author":"Al-Attar","year":"2013","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.biocel.2024.106716_bib7","doi-asserted-by":"crossref","unstructured":"Apayd\u0131n, F.G., Kalender, S., Ba\u015f, H., & Kalender, Y. (2023). Protective role of gallic acid against fenitrothion-induced hepatotoxicity and nephrotoxicity via oxidative stress, histopathological and biochemical alterations. https:\/\/doi.org\/10.21203\/rs.3.rs-2699186\/v1.","DOI":"10.21203\/rs.3.rs-2699186\/v1"},{"issue":"4","key":"10.1016\/j.biocel.2024.106716_bib8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1002\/pro.4043","article-title":"Structural and functional understanding of the toll-like receptors","volume":"30","author":"Asami","year":"2021","journal-title":"Protein Sci."},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41575-018-0079-5","article-title":"Control and dysregulation of redox signalling in the gastrointestinal tract","volume":"16","author":"Campbell","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"14","key":"10.1016\/j.biocel.2024.106716_bib10","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Purification and characterization of the flavoenzyme glutathione reductase from rat liver","volume":"250","author":"Carlberg","year":"1975","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biocel.2024.106716_bib11","first-page":"1","author":"Das","year":"2021","journal-title":"Mech. Interact. Autophagy Apoptosis Cancer Apoptosis"},{"issue":"7","key":"10.1016\/j.biocel.2024.106716_bib12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.chemosphere.2004.08.025","article-title":"Photocatalytic removal of fenitrothion in pure and natural waters by photo-Fenton reaction","volume":"57","author":"Derbalah","year":"2004","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pestbp.2008.01.006","article-title":"Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide","volume":"91","author":"Elhalwagy","year":"2008","journal-title":"Pestic. Biochem. Physiol."},{"issue":"3","key":"10.1016\/j.biocel.2024.106716_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3844\/ajptsp.2014.177.188","article-title":"Protective role of vitamin C and green tea extract on malathion-induced hepatotoxicity and nephrotoxicity in rats","volume":"9","author":"Elzoghby","year":"2014","journal-title":"Am. J. Pharmacol. Toxicol."},{"key":"10.1016\/j.biocel.2024.106716_bib15","doi-asserted-by":"crossref","unstructured":"Espinoza Navarro, O., Ponce La Rosa, C., & Bustos Obreg\u00f3n, E. (2017). Organophosphorous pesticides: Their effects on biosentinel species and humans. control and application in Chile. \u3008https:\/\/repositorio.uchile.cl\/handle\/2250\/148707\u3009.","DOI":"10.4067\/S0717-95022017000300041"},{"key":"10.1016\/j.biocel.2024.106716_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145671","article-title":"Androgenic activation, impairment of the monoaminergic system and altered behavior in zebrafish larvae exposed to environmental concentrations of fenitrothion","volume":"775","author":"Faria","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biocel.2024.106716_bib17","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.ecoenv.2019.01.004","article-title":"Protective effect of N-acetylcysteine on fenitrothion-induced toxicity: the antioxidant status and metabolizing enzymes expression in rats","volume":"171","author":"Galal","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.biocel.2024.106716_bib18","first-page":"100","article-title":"Chlorpyrifos-induced oxidative stress and tissue damage in the liver of Swiss albino mice: the protective antioxidative role of root extract of Withania somnifera","volume":"1","author":"Gopinath","year":"2014","journal-title":"IJIRST"},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutat. Res. \/Genet. Toxicol. Environ. Mutagen."},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/1354750X.2021.1875505","article-title":"Quercetin ameliorates the hepatic apoptosis of foetal rats induced by in utero exposure to fenitrothion via the transcriptional regulation of paraoxonase-1 and apoptosis-related genes","volume":"26","author":"Ibrahim","year":"2021","journal-title":"Biomarkers"},{"issue":"4","key":"10.1016\/j.biocel.2024.106716_bib21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/antiox8040108","article-title":"Flavonoid analysis and antioxidant activities of the Bryonia alba L. Aerial parts","volume":"8","author":"Ielciu","year":"2019","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5897\/JEBR2012.0042","article-title":"Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat","volume":"5","author":"Ismail","year":"2013","journal-title":"J. Evolut. Biol. Res."},{"issue":"10","key":"10.1016\/j.biocel.2024.106716_bib23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.biocel.2024.106716_bib24","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1038\/nprot.2014.138","article-title":"The cellular thermal shift assay for evaluating drug target interactions in cells","volume":"9","author":"Jafari","year":"2014","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.biocel.2024.106716_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3, 4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib26","first-page":"130","volume":"21","author":"Kakkar","year":"1984","journal-title":"A modified spectrophotometric assay of superoxide dismutase"},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib27","first-page":"CS1","article-title":"Curious fatal intentional poisoning case with organophosphate pesticide","volume":"13","author":"Kallel","year":"2006","journal-title":"Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res."},{"issue":"25","key":"10.1016\/j.biocel.2024.106716_bib28","doi-asserted-by":"crossref","first-page":"22285","DOI":"10.1021\/acsomega.3c00267","article-title":"Saponarin, a di-glycosyl flavone from barley (Hordeum vulgare L.): an effective compound for plant defense and therapeutic application","volume":"8","author":"Kantharaj","year":"2023","journal-title":"ACS Omega"},{"issue":"5","key":"10.1016\/j.biocel.2024.106716_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.biocel.2024.106716_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s00249-021-01537-1","article-title":"Standard operating procedure for fluorescent thermal shift assay (FTSA) for determination of protein\u2013ligand binding and protein stability","volume":"50","author":"Kazlauskas","year":"2021","journal-title":"Eur. Biophys. J."},{"key":"10.1016\/j.biocel.2024.106716_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106507","article-title":"Toll-like receptors and metabolic (dysfunction)-associated fatty liver disease","volume":"185","author":"Khanmohammadi","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.biocel.2024.106716_bib32","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3390\/antiox10091454","article-title":"Multiple antioxidative and bioactive molecules of oats (Avena sativa L.) in human health","volume":"10","author":"Kim","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.biocel.2024.106716_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112301","article-title":"Effect of Hibiscus syriacus Linnaeus extract and its active constituent, saponarin, in animal models of stress-induced sleep disturbances and pentobarbital-induced sleep","volume":"146","author":"Kim","year":"2022","journal-title":"Biomed. Pharmacother."},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/jmf.2021.K.0092","article-title":"Barley sprout water extract and saponarin mitigate triacylglycerol accumulation in 3T3-L1 adipocytes","volume":"25","author":"Kim","year":"2022","journal-title":"J. Med. Food"},{"issue":"23","key":"10.1016\/j.biocel.2024.106716_bib35","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.3390\/ijerph16234866","article-title":"Suicide overall and suicide by pesticide rates among South Korean workers: a 15-year population-based study","volume":"16","author":"Kim","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"7","key":"10.1016\/j.biocel.2024.106716_bib36","doi-asserted-by":"crossref","first-page":"440","DOI":"10.3390\/nu8070440","article-title":"Barley sprouts extract attenuates alcoholic fatty liver injury in mice by reducing inflammatory response","volume":"8","author":"Lee","year":"2016","journal-title":"Nutrients"},{"issue":"20","key":"10.1016\/j.biocel.2024.106716_bib37","doi-asserted-by":"crossref","first-page":"7103","DOI":"10.3390\/molecules27207103","article-title":"In silico methods for identification of potential active sites of therapeutic targets","volume":"27","author":"Liao","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3390\/biom13010119","article-title":"The role of JAK\/STAT pathway in fibrotic diseases: molecular and cellular mechanisms","volume":"13","author":"Liu","year":"2023","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.biocel.2024.106716_bib39","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"methods"},{"key":"10.1016\/j.biocel.2024.106716_bib40","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1681\/ASN.V1091997","article-title":"In vitro and in vivo immunomodulatory effects of RDP1258, a novel synthetic peptide","volume":"10","author":"Magee","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib41","article-title":"Residues and dissipation of fenitrothion in green bean (Phaseolus vulgaris) and soil","volume":"2012","author":"Malhat","year":"2012","journal-title":"Int.\u00a0Sch.\u00a0Res.\u00a0Not."},{"issue":"16","key":"10.1016\/j.biocel.2024.106716_bib42","doi-asserted-by":"crossref","first-page":"8431","DOI":"10.3390\/ijms22168431","article-title":"Anti-inflammatory and anti-allergic effects of saponarin and its impact on signaling pathways of RAW 264.7, RBL-2H3, and HaCaT Cells","volume":"22","author":"Min","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"Biochim. Et. Biophys. Acta (BBA) Gen. Subj."},{"issue":"16","key":"10.1016\/j.biocel.2024.106716_bib44","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.biocel.2024.106716_bib45","first-page":"276","article-title":"Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction.","volume":"44","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem"},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib46","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/toxsci\/kfl012","article-title":"Toll-like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants","volume":"92","author":"Pestka","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"4","key":"10.1016\/j.biocel.2024.106716_bib47","doi-asserted-by":"crossref","DOI":"10.1063\/5.0014475","article-title":"Scalable molecular dynamics on CPU and GPU architectures with NAMD","volume":"153","author":"Phillips","year":"2020","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.biocel.2024.106716_bib48","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.toxrep.2020.12.002","article-title":"Toxic effects of fenitrothion on freshwater microcosms in Bangladesh","volume":"7","author":"Rahman","year":"2020","journal-title":"Toxicol. Rep."},{"key":"10.1016\/j.biocel.2024.106716_bib49","series-title":"Methods and Protocols","first-page":"149","article-title":"HiBiT Cellular Thermal Shift Assay (HiBiT CETSA)","author":"Ramachandran","year":"2023"},{"issue":"4073","key":"10.1016\/j.biocel.2024.106716_bib50","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1126\/science.179.4073.588","article-title":"Selenium: biochemical role as a component of glutathione peroxidase","volume":"179","author":"Rotruck","year":"1973","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib51","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202201029","article-title":"The preventive and therapeutic potential of the flavonoids in liver cirrhosis: current and future perspectives","volume":"20","author":"Sahu","year":"2023","journal-title":"Chem. Biodivers."},{"issue":"3","key":"10.1016\/j.biocel.2024.106716_bib52","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/hep.20603","article-title":"Contribution of Toll-like receptor\/myeloid differentiation factor 88 signaling to murine liver regeneration","volume":"41","author":"Seki","year":"2005","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.biocel.2024.106716_bib53","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1039\/C4FO00612G","article-title":"Saponarin from barley sprouts inhibits NF-\u03baB and MAPK on LPS-induced RAW 264.7 cells","volume":"5","author":"Seo","year":"2014","journal-title":"Food Funct."},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00114-022-01788-8","article-title":"Side-effects of pesticides on non-target insects in agriculture: a mini-review","volume":"109","author":"Serr\u00e3o","year":"2022","journal-title":"Sci. Nat."},{"issue":"6","key":"10.1016\/j.biocel.2024.106716_bib55","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.str.2011.03.019","article-title":"A smoothed backbone-dependent rotamer library for proteins derived from adaptive kernel density estimates and regressions","volume":"19","author":"Shapovalov","year":"2011","journal-title":"Structure"},{"key":"10.1016\/j.biocel.2024.106716_bib56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jphotobiol.2016.09.025","article-title":"Binding interaction of ramipril with bovine serum albumin (BSA): insights from multi-spectroscopy and molecular docking methods","volume":"164","author":"Shi","year":"2016","journal-title":"J. Photochem. Photobiol. B: Biol."},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib57","article-title":"Hepatoprotective and antioxidant effects of saponarin, isolated from Gypsophila trichotoma Wend. on paracetamol-induced liver damage in rats","volume":"2013","author":"Simeonova","year":"2013","journal-title":"BioMed. Res. Int."},{"issue":"5","key":"10.1016\/j.biocel.2024.106716_bib58","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.phymed.2016.02.024","article-title":"Antidiabetic and antioxidant effects of saponarin from Gypsophila trichotoma on streptozotocin-induced diabetic normotensive and hypertensive rats","volume":"23","author":"Simeonova","year":"2016","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.biocel.2024.106716_bib59","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biocel.2024.106716_bib60","doi-asserted-by":"crossref","first-page":"93","DOI":"10.6061\/clinics\/2013(01)OA15","article-title":"Fenitrothion induced oxidative stress and morphological alterations of sperm and testes in male sprague-dawley rats","volume":"68","author":"Taib","year":"2013","journal-title":"Clinics"},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib61","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1515\/reveh-2020-0048","article-title":"Toxicity of carbon tetrachloride, free radicals and role of antioxidants","volume":"36","author":"Unsal","year":"2021","journal-title":"Rev. Environ. Health"},{"key":"10.1016\/j.biocel.2024.106716_bib62","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.fct.2013.01.056","article-title":"Chlorpyrifos induced hepatotoxic and hematologic changes in rats: the role of quercetin and catechin","volume":"55","author":"Uzun","year":"2013","journal-title":"Food Chem. Toxicol."},{"issue":"91","key":"10.1016\/j.biocel.2024.106716_bib63","first-page":"51809","article-title":"Determination of protein-ligand interactions using differential scanning fluorimetry","author":"Vivoli","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.biocel.2024.106716_bib64","first-page":"85","article-title":"The toxicity of fenitrothion and permethrin","author":"Wang","year":"2012","journal-title":"Insectic. Pest Eng."},{"issue":"2","key":"10.1016\/j.biocel.2024.106716_bib65","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jmgm.2005.12.005","article-title":"Automatic atom type and bond type perception in molecular mechanical calculations","volume":"25","author":"Wang","year":"2006","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.biocel.2024.106716_bib66","unstructured":"WHO, F.(2018). Pesticide residues in food 2018-Report 2018-Joint FAO. In. Geneva, Switzerland; FAO: Rome, Italy, 2018; Volume 234, ISBN 9789251311561.WHO Meeting on Pesticide Residues."},{"key":"10.1016\/j.biocel.2024.106716_bib67","unstructured":"WHO, F.(2019). O-Dimethyl O-4-Nitro-m-Tolyl Phosphorothioate; WHO: Geneva, Switzerland; FAO: Rome, Italy, 2019.Specifications and Evaluations for Public Health Pesticides Fenitrothion O,."},{"key":"10.1016\/j.biocel.2024.106716_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106210","article-title":"The role of JAK\/STAT signaling pathway and its inhibitors in diseases","volume":"80","author":"Xin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biocel.2024.106716_bib69","series-title":"Liver and kidney functional indices of pregnant rats following the administration of the crude alkaloids from Senna alata","article-title":"Roxb) leaves","author":"Yakubu","year":"2012"},{"issue":"7","key":"10.1016\/j.biocel.2024.106716_bib70","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200018RR","article-title":"A non-polar fraction of Saponaria officinalis L. acted as a TLR4\/MD2 complex antagonist and inhibited TLR4\/MyD88 signaling in vitro and in vivo","volume":"36","author":"Yu","year":"2022","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.biocel.2024.106716_bib71","first-page":"361","article-title":"Effects of acute fenitrothion insecticide exposure on DNA damage and oxidative stress biomarkers and health of Nile tilapia fingerlings, Oreochromis niloticus","volume":"6","author":"Zeid","year":"2014","journal-title":"L. World"},{"key":"10.1016\/j.biocel.2024.106716_bib72","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.tifs.2021.01.046","article-title":"Protective effects of dietary flavonoids against pesticide-induced toxicity: a review","volume":"109","author":"Zeng","year":"2021","journal-title":"Trends Food Sci. Technol."},{"issue":"4","key":"10.1016\/j.biocel.2024.106716_bib73","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/mco2.104","article-title":"NF-\u03baB signaling in inflammation and cancer","volume":"2","author":"Zhang","year":"2021","journal-title":"MedComm"}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524002097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272524002097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,2]],"date-time":"2025-02-02T13:48:17Z","timestamp":1738504097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272524002097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":73,"alternative-id":["S1357272524002097"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106716","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevention of fenitrothion induced hepatic toxicity by saponarin via modulating TLR4\/MYD88, JAK1\/STAT3 and NF-\u03baB signaling pathways","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2024.106716","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106716"}}