{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:57:00Z","timestamp":1790542620243,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200706"],"award-info":[{"award-number":["82200706"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2023QH484"],"award-info":[{"award-number":["ZR2023QH484"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.biocel.2026.107028","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:02:12Z","timestamp":1789398132000},"page":"107028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Hrd1 alleviates fatty liver ischemia-reperfusion injury by regulating the phenotypic polarization of Kupffer cells"],"prefix":"10.1016","volume":"201","author":[{"given":"Ang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shizhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheyu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faji","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.biocel.2026.107028_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.cell.2016.05.048","article-title":"Autoubiquitination of the hrd1 ligase triggers protein retrotranslocation in erad","volume":"166","author":"Baldridge","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2026.107028_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2020.02.025","article-title":"Role of oxidative stress in the pathogenesis of nonalcoholic fatty liver disease","volume":"152","author":"Chen","year":"2020","journal-title":"Free. Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.biocel.2026.107028_bib3","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.7150\/thno.82607","article-title":"Hepatocyte hspa12a inhibits macrophage chemotaxis and activation to attenuate liver ischemia\/reperfusion injury via suppressing glycolysis-mediated hmgb1 lactylation and secretion of hepatocytes","volume":"13","author":"Du","year":"2023","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-03357-1","article-title":"Arsenic trioxide induces macrophage autophagy and atheroprotection by regulating ros-dependent tfeb nuclear translocation and akt\/mtor pathway","volume":"12","author":"Fang","year":"2021","journal-title":"Cell. Death Dis."},{"issue":"12","key":"10.1016\/j.biocel.2026.107028_bib5","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41419-023-06379-7","article-title":"Rnf115\/bca2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response","volume":"14","author":"Feng","year":"2023","journal-title":"Cell. Death Dis."},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/15548627.2021.1895658","article-title":"The m\u00e9nage \u00e0 trois of autophagy, lipid droplets and liver disease","volume":"18","author":"Filali-Mouncef","year":"2022","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.biocel.2026.107028_bib7","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1111\/cas.15818","article-title":"Ppar\u03b3 inhibited tumor immune escape by inducing pd-l1 autophagic degradation","volume":"114","author":"Gou","year":"2023","journal-title":"Cancer Sci."},{"issue":"5","key":"10.1016\/j.biocel.2026.107028_bib8","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jhep.2021.12.012","article-title":"Macrophage scavenger receptor 1 mediates lipid-induced inflammation in non-alcoholic fatty liver disease","volume":"76","author":"Govaere","year":"2022","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.biocel.2026.107028_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib10","article-title":"Dexmedetomidine postconditioning attenuates myocardial ischemia\/reperfusion injury by activating the nrf2\/sirt3\/sod2 signaling pathway in the rats","volume":"28","author":"Hu","year":"2023","journal-title":"Redox Rep. Commun. Free. Radic. Res."},{"key":"10.1016\/j.biocel.2026.107028_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.molimm.2022.01.015","article-title":"Fam49b, restrained by mir-22, relieved hepatic ischemia\/reperfusion injury by inhibiting traf6\/ikk signaling pathway in a rac1-dependent manner","volume":"143","author":"Huang","year":"2022","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.biocel.2026.107028_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.add8579","article-title":"The erad system is restricted by elevated ceramides","volume":"9","author":"Hwang","year":"2023","journal-title":"Sci. Adv."},{"issue":"22","key":"10.1016\/j.biocel.2026.107028_bib13","article-title":"Zaluzanin c alleviates inflammation and lipid accumulation in kupffer cells and hepatocytes by regulating mitochondrial ros","volume":"28","author":"Jung","year":"2023","journal-title":"Mol. (Basel Switz.)"},{"key":"10.1016\/j.biocel.2026.107028_bib14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.freeradbiomed.2019.03.021","article-title":"Endoplasmic reticulum-associated degradation potentiates the infectivity of influenza a virus by regulating the host redox state","volume":"135","author":"Jung","year":"2019","journal-title":"Free. Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.biocel.2026.107028_bib15","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/TP.0000000000001999","article-title":"Ischemia-reperfusion injury in aged livers-the energy metabolism, inflammatory response, and autophagy","volume":"102","author":"Kan","year":"2018","journal-title":"Transplantation"},{"issue":"25","key":"10.1016\/j.biocel.2026.107028_bib16","doi-asserted-by":"crossref","first-page":"40817","DOI":"10.18632\/oncotarget.17256","article-title":"Rapamycin regulates macrophage activation by inhibiting nlrp3 inflammasome-p38 mapk-nf\u03bab pathways in autophagy- and p62-dependent manners","volume":"8","author":"Ko","year":"2017","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.biocel.2026.107028_bib17","first-page":"1220","article-title":"Acetyl-3-aminoethyl salicylate ameliorates hepatic ischemia\/reperfusion injury and liver graft survival through a high-mobility group box 1\/toll-like receptor 4-dependent mechanism","volume":"25","author":"Lai","year":"2019","journal-title":"Liver Transplant. Off. Publ. Am. Assoc. Study Liver Dis. Int. Liver Transplant. Soc."},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s11658-025-00721-x","article-title":"Maff alleviates hepatic ischemia-reperfusion injury by regulating the clcf1\/stat3 signaling pathway","volume":"30","author":"Lei","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1-2","key":"10.1016\/j.biocel.2026.107028_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: A disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2026.107028_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107928","article-title":"Fbxw5 aggravates hepatic ischemia\/reperfusion injury via promoting phosphorylation of ask1 in a traf6-dependent manner","volume":"99","author":"Li","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib21","doi-asserted-by":"crossref","first-page":"8123","DOI":"10.1038\/s41467-025-63531-x","article-title":"Evidence that mitochondria in macrophages are destroyed by microautophagy","volume":"16","author":"Lu","year":"2025","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.biocel.2026.107028_bib22","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1053\/j.gastro.2023.05.053","article-title":"Prevalence of liver steatosis and fibrosis in the general population and various high-risk populations: a nationwide study with 5.7 million adults in china","volume":"165","author":"Man","year":"2023","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biocel.2026.107028_bib23","unstructured":"National Research Council Committee for the Update of the Guide for the, C. and A. Use of Laboratory, 2011. The national academies collection: Reports funded by national institutes of health. In: Guide for the care and use of laboratory animals. National Academies Press (US) Copyright \u00a9 2011, National Academy of Sciences., Washington (DC)."},{"key":"10.1016\/j.biocel.2026.107028_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/srep17192","article-title":"Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin e","volume":"5","author":"Ni","year":"2015","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.biocel.2026.107028_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104779","article-title":"Pharmacological inhibition of dnmt1 restores macrophage autophagy and m2 polarization in western diet-induced nonalcoholic fatty liver disease","volume":"299","author":"Pant","year":"2023","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.biocel.2026.107028_bib26","first-page":"508","article-title":"Viability assessment and transplantation of fatty liver grafts using end-ischemic normothermic machine perfusion","volume":"29","author":"Patrono","year":"2023","journal-title":"Liver Transplant. Off. Publ. Am. Assoc. Study Liver Dis. Int. Liver Transplant. Soc."},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-026-72455-z","article-title":"Btg2 inhibits fmo1 ufmylation thus exacerbating ferroptosis and apoptosis in hepatic ischemia-reperfusion injury","volume":"17","author":"Peng","year":"2026","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.biocel.2026.107028_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/MOL.0000000000000535","article-title":"Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis","volume":"29","author":"Peters","year":"2018","journal-title":"Curr. Opin. Lipidol."},{"issue":"11","key":"10.1016\/j.biocel.2026.107028_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25115640","article-title":"Metabolic dysfunction-associated steatotic liver disease: From pathogenesis to current therapeutic options","volume":"25","author":"Portincasa","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"18","key":"10.1016\/j.biocel.2026.107028_bib30","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1111\/febs.16336","article-title":"Nrf2 and oxidative stress in liver ischemia\/reperfusion injury","volume":"289","author":"R","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.biocel.2026.107028_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112778","article-title":"Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating sp1\/bach1-pacs2 signaling","volume":"141","author":"Shen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biocel.2026.107028_bib32","article-title":"Roles of endoplasmic reticulum stress in immune responses","author":"So","year":"2018","journal-title":"Mol. Cells"},{"key":"10.1016\/j.biocel.2026.107028_bib33","article-title":"Reactive oxygen species induce fatty liver and ischemia-reperfusion injury by promoting inflammation and cell death","volume":"13","author":"Tang","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.biocel.2026.107028_bib34","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.7150\/ijms.52691","article-title":"Macrophage polarization and liver ischemia-reperfusion injury","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.biocel.2026.107028_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41420-019-0198-y","article-title":"Hyperglycemia exacerbates acetaminophen-induced acute liver injury by promoting liver-resident macrophage proinflammatory response via ampk\/pi3k\/akt-mediated oxidative stress","volume":"5","author":"Wang","year":"2019","journal-title":"Cell. Death Discov."},{"issue":"6","key":"10.1016\/j.biocel.2026.107028_bib36","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1083\/jcb.201708007","article-title":"Superoxide dismutases: Dual roles in controlling ros damage and regulating ros signaling","volume":"217","author":"Wang","year":"2018","journal-title":"J. Cell. Biol."},{"issue":"8","key":"10.1016\/j.biocel.2026.107028_bib37","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.molcel.2022.03.025","article-title":"Reshaping endoplasmic reticulum quality control through the unfolded protein response","volume":"82","author":"Wiseman","year":"2022","journal-title":"Mol. Cell."},{"issue":"6489","key":"10.1016\/j.biocel.2026.107028_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaz2449","article-title":"Structural basis of er-associated protein degradation mediated by the hrd1 ubiquitin ligase complex","volume":"368","author":"Wu","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.biocel.2026.107028_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2018.06.043","article-title":"Ire1alpha aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells","author":"Yang","year":"2018","journal-title":"Free. Radic. Biol. & Med."},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s13046-019-1480-9","article-title":"Ischemia reperfusion injury promotes recurrence of hepatocellular carcinoma in fatty liver via alox12-12hete-gpr31 signaling axis","volume":"38","author":"Yang","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s10020-023-00653-2","article-title":"Trim37 exacerbates hepatic ischemia\/reperfusion injury by facilitating ikkgamma translocation","volume":"29","author":"Yang","year":"2023","journal-title":"Mol. Med."},{"issue":"4","key":"10.1016\/j.biocel.2026.107028_bib42","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.7150\/thno.50905","article-title":"Mitochondrial ros promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting tfam-mediated mtdna maintenance","volume":"11","author":"Zhao","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.biocel.2026.107028_bib43","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1186\/s12967-023-04367-1","article-title":"Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: New insights from pathogenic mechanisms to clinically targeted therapy","volume":"21","author":"Zheng","year":"2023","journal-title":"J. Transl. Med."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135727252600138X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S135727252600138X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T20:06:56Z","timestamp":1790539616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S135727252600138X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":43,"alternative-id":["S135727252600138X"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2026.107028","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hrd1 alleviates fatty liver ischemia-reperfusion injury by regulating the phenotypic polarization of Kupffer cells","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2026.107028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107028"}}