{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:48:11Z","timestamp":1793159291170,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.biocel.2026.107030","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:26:31Z","timestamp":1789831591000},"page":"107030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["PIWI-interacting RNAs: Biogenesis, molecular mechanisms, computational advances, and roles in human health and disease"],"prefix":"10.1016","volume":"201","author":[{"given":"Eman M.","family":"Ibrahim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam Hossam","family":"El Dine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatem","family":"Zayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"ElHefnawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2026.107030_bib1","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.csbj.2022.02.026","article-title":"Identification of piRNA disease associations using deep learning (piRDA)","volume":"20","author":"Ali","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"6","key":"10.1016\/j.biocel.2026.107030_bib2","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.molcel.2008.09.003","article-title":"A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice","volume":"31","author":"Aravin","year":"2008","journal-title":"Mol. Cell."},{"issue":"6","key":"10.1016\/j.biocel.2026.107030_bib3","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.cell.2007.01.043","article-title":"Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila","volume":"128","author":"Brennecke","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biocel.2026.107030_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.848105","article-title":"PIWI-interacting RNAs (piRNAs): promising applications as emerging biomarkers for digestive system cancer","volume":"9","author":"Cai","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.biocel.2026.107030_bib5","article-title":"PIWI-Interacting RNAs in brain health and disease: biogenesis, mechanisms, and therapeutic horizons","author":"Cai","year":"2025","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13045-021-01104-3","article-title":"The biogenesis and biological function of PIWI-interacting RNA in cancer","volume":"14","author":"Chen","year":"2021","journal-title":"J. Hematol. & Oncol."},{"issue":"3","key":"10.1016\/j.biocel.2026.107030_bib7","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nsmb.2230","article-title":"An alternative mode of microRNA target recognition","volume":"19","author":"Chi","year":"2012","journal-title":"Nat. Struct. & Mol. Biol."},{"key":"10.1016\/j.biocel.2026.107030_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2025.1540313","article-title":"PIWI proteins and piRNAs: key regulators of stem cell biology","volume":"13","author":"Claro-Linares","year":"2025","journal-title":"Front. Cell. Dev. Biol."},{"issue":"22","key":"10.1016\/j.biocel.2026.107030_bib9","doi-asserted-by":"crossref","first-page":"6397","DOI":"10.1038\/s44318-025-00579-x","article-title":"PIWI proteins tether the piRNA biogenesis machinery to mitochondria during mammalian spermatogenesis","volume":"44","author":"Gao","year":"2025","journal-title":"EMBO J."},{"key":"10.1016\/j.biocel.2026.107030_bib10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40364-024-00563-3","article-title":"Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells","volume":"12","author":"Garcia-Borja","year":"2024","journal-title":"Biomark. Res."},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1080\/15476286.2021.2010960","article-title":"piRNAQuest V.2: an updated resource for searching through the piRNAome of multiple species","volume":"19","author":"Ghosh","year":"2022","journal-title":"RNA Biol."},{"issue":"7099","key":"10.1016\/j.biocel.2026.107030_bib12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature04917","article-title":"A germline-specific class of small RNAs binds mammalian Piwi proteins","volume":"442","author":"Girard","year":"2006","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.biocel.2026.107030_bib13","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1101\/gad.1434406","article-title":"A novel class of small RNAs in mouse spermatogenic cells","volume":"20","author":"Grivna","year":"2006","journal-title":"Genes. & Dev."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib14","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s10555-020-09863-0","article-title":"piRNAs: biogenesis and their potential roles in cancer","volume":"39","author":"Guo","year":"2020","journal-title":"Cancer Metastas-.-. Rev."},{"key":"10.1016\/j.biocel.2026.107030_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.csbj.2024.01.011","article-title":"Databases and computational methods for the identification of piRNA-related molecules: a survey","volume":"23","author":"Guo","year":"2024","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/biom12020186","article-title":"piRNAs and PIWI Proteins as Diagnostic and Prognostic Markers of Genitourinary Cancers","volume":"12","author":"Hanusek","year":"2022","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.biocel.2026.107030_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010671","article-title":"iPiDA-GCN: Identification of piRNA-disease associations based on Graph Convolutional Network","volume":"18","author":"Hou","year":"2022","journal-title":"PLOS Comput. Biol."},{"key":"10.1016\/j.biocel.2026.107030_bib18","article-title":"A Review: PI3K\/AKT\/mTOR signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma","volume":"12","author":"Huang","year":"2022","journal-title":"Front. Oncol."},{"issue":"20","key":"10.1016\/j.biocel.2026.107030_bib19","doi-asserted-by":"crossref","first-page":"11166","DOI":"10.3390\/ijms222011166","article-title":"A Review of Discovery Profiling of PIWI-Interacting RNAs and Their Diverse Functions in Metazoans","volume":"22","author":"Huang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biocel.2026.107030_bib20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s12964-024-01724-5","article-title":"piRNA associates with immune diseases","volume":"22","author":"Jiang","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.biocel.2026.107030_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13856","article-title":"A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan","volume":"7","author":"Jones","year":"2016","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib22","first-page":"2713","article-title":"Deep-piRNA: Bi-Layered Prediction Model for PIWI-Interacting RNA Using Discriminative Features","volume":"70","author":"Khan","year":"2022","journal-title":"Comput. Mater. & Contin."},{"issue":"3","key":"10.1016\/j.biocel.2026.107030_bib23","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nmeth.2341","article-title":"A biophysical miRNA-mRNA interaction model infers canonical and noncanonical targets","volume":"10","author":"Khorshid","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biocel.2026.107030_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2025.112745","article-title":"miRNA and piRNA differential expression profiles in Alzheimer's disease: A potential source of pathology and tool for diagnosis","volume":"204","author":"Landon","year":"2025","journal-title":"Exp. Gerontol."},{"issue":"14","key":"10.1016\/j.biocel.2026.107030_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkt435","article-title":"CLIP-based prediction of mammalian microRNA binding sites","volume":"41","author":"Liu","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12943-019-1052-9","article-title":"The emerging function of the piRNA\/piwi complex in cancer","volume":"18","author":"Liu","year":"2019","journal-title":"Mol. Cancer"},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s12539-021-00428-5","article-title":"Computational Methods and Online Resources for Identification of piRNA-Related Molecules","volume":"13","author":"Liu","year":"2021","journal-title":"Interdiscip. Sci. Comput. Life Sci."},{"key":"10.1016\/j.biocel.2026.107030_bib28","series-title":"2023 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)","first-page":"251","article-title":"Prediction of piRNA-mRNA interactions based on an interactive inference network","author":"Liu","year":"2023"},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3390\/electronics13010092","article-title":"MLPPF: Multi-Label Prediction of piRNA Functions Based on Pretrained k-mer, Positional Embedding and an Improved TextRNN Model","volume":"13","author":"Liu","year":"2024","journal-title":"Electronics"},{"key":"10.1016\/j.biocel.2026.107030_bib30","article-title":"Prediction of Cancer-Related piRNAs Based on Network-Based Stratification Analysis","author":"Liu","year":"2022","journal-title":"Int. J. Softw. Eng. & Intell. Syst. 22(05) 903913"},{"issue":"8","key":"10.1016\/j.biocel.2026.107030_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nrg3495","article-title":"PIWI-associated RNAs (piRNAs): from generation to transgenerational epigenetic inheritance","volume":"14","author":"Luteijn","year":"2013","journal-title":"Nat. Rev. Genet."},{"issue":"6","key":"10.1016\/j.biocel.2026.107030_bib32","first-page":"3829","article-title":"Analysis of piRNA expression spectra in a non-alcoholic fatty liver disease mouse model induced by a methionine- and choline-deficient diet","volume":"19","author":"Ma","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biocel.2026.107030_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41390-026-04894-9","article-title":"MiR-182-5p, miR-122-5p and hsa-piR-28004 as indicators of disease and treatment in pediatric familial hypercholesterolemia","author":"Mair","year":"2026","journal-title":"Pediatr. Res."},{"issue":"10","key":"10.1016\/j.biocel.2026.107030_bib34","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1261\/rna.033282.112","article-title":"Analysis of the accessibility of CLIP bound sites reveals that nucleation of the miRNA:mRNA pairing occurs preferentially at the 3\u2032-end of the seed match","volume":"18","author":"Marin","year":"2012","journal-title":"RNA"},{"key":"10.1016\/j.biocel.2026.107030_bib35","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12864-023-09380-8","article-title":"ETGPDA: identification of piRNA-disease associations based on embedding transformation graph convolutional network","volume":"24","author":"Meng","year":"2023","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.biocel.2026.107030_bib36","first-page":"487","article-title":"Les piARN forgent un syst\u00e8me immunitaire pour le g\u00e9nome [The piRNAs forge an immune system for the genome]","volume":"29","author":"Muller","year":"2013","journal-title":"Mdecine Sci."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib37","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41576-018-0073-3","article-title":"PIWI-associated RNAs (piRNAs): small RNAs with big functions","volume":"20","author":"Ozata","year":"2019","journal-title":"Nat. Rev. Genet."},{"issue":"6","key":"10.1016\/j.biocel.2026.107030_bib38","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/genes15060653","article-title":"PIWI-Interacting RNAs: A Pivotal Regulator in Neurological Development and Disease","volume":"15","author":"Pan","year":"2024","journal-title":"Genes"},{"key":"10.1016\/j.biocel.2026.107030_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1495035","article-title":"Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease","volume":"12","author":"Patel","year":"2024","journal-title":"Front. Cell. Dev. Biol."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib40","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1007\/s13277-015-4056-0","article-title":"piR-55490 inhibits the growth of lung carcinoma by suppressing mTOR signaling","volume":"37","author":"Peng","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/j.biocel.2026.107030_bib41","article-title":"Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA","author":"Perera","year":"2019","journal-title":"Figshare"},{"key":"10.1016\/j.biocel.2026.107030_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2025.1611805","article-title":"Identification of oncofetal PIWI-interacting RNAs as potential prognostic biomarkers in non-small cell lung cancer","volume":"16","author":"Pewarchuk","year":"2025","journal-title":"Front. Genet."},{"issue":"17","key":"10.1016\/j.biocel.2026.107030_bib43","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.1016\/j.molcel.2025.08.007","article-title":"Target RNA recognition drives PIWI complex assembly for transposon silencing","volume":"85","author":"Portell-Montserrat","year":"2025","journal-title":"Mol. Cell."},{"key":"10.1016\/j.biocel.2026.107030_bib44","article-title":"Acute and inherited piRNA-mediated silencing in a rde-3 ribonucleotidyltransferase mutant","volume":"2022","author":"Priyadarshini","year":"2022","journal-title":"Micro Biol."},{"issue":"3","key":"10.1016\/j.biocel.2026.107030_bib45","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2012.02.057","article-title":"A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity","volume":"149","author":"Rajasethupathy","year":"2012","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.biocel.2026.107030_bib46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1039\/C6MB00699J","article-title":"Small RNA sequencing revealed dysregulated piRNAs in Alzheimer's disease and their probable role in pathogenesis","volume":"13","author":"Roy","year":"2017","journal-title":"Mol. Biosyst."},{"issue":"4","key":"10.1016\/j.biocel.2026.107030_bib47","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1101\/gad.209767.112","article-title":"Multiple roles for Piwi in silencing Drosophila transposons","volume":"27","author":"Rozhkov","year":"2013","journal-title":"Genes. & Dev."},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib48","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/s12935-021-02034-3","article-title":"Epigenetic roles of PIWI proteins and piRNAs in colorectal cancer","volume":"21","author":"Sadoughi","year":"2021","journal-title":"Cancer Cell. Int."},{"issue":"_1","key":"10.1016\/j.biocel.2026.107030_bib49","doi-asserted-by":"crossref","first-page":"D173","DOI":"10.1093\/nar\/gkm696","article-title":"piRNABank: a web resource on classified and clustered Piwi-interacting RNAs","volume":"36","author":"Sai Lakshmi","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biocel.2026.107030_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1157818","article-title":"Role of piRNA biogenesis and its neuronal function in the development of neurodegenerative diseases","volume":"15","author":"Sato","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.biocel.2026.107030_bib51","doi-asserted-by":"crossref","first-page":"375","DOI":"10.14348\/molcells.2016.0013","article-title":"MicroRNA Target Recognition: Insights from Transcriptome-Wide Non-Canonical Interactions","volume":"39","author":"Seok","year":"2016","journal-title":"Mol. Cells"},{"issue":"4","key":"10.1016\/j.biocel.2026.107030_bib52","doi-asserted-by":"crossref","DOI":"10.1002\/jmr.2949","article-title":"Predicting sequence and structural features of effective piRNA target binding sites","volume":"35","author":"Singh","year":"2022","journal-title":"J. Mol. Recognit."},{"key":"10.1016\/j.biocel.2026.107030_bib53","doi-asserted-by":"crossref","first-page":"30700","DOI":"10.1109\/ACCESS.2021.3070083","article-title":"Prediction of Piwi-Interacting RNAs and Their Functions via Convolutional Neural Network","volume":"9","author":"Tahir","year":"2021","journal-title":"IEEE Access."},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-017-0001-7","article-title":"Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues","volume":"1","author":"Tosar","year":"2018","journal-title":"Commun. Biol."},{"issue":"D1","key":"10.1016\/j.biocel.2026.107030_bib55","doi-asserted-by":"crossref","first-page":"D265","DOI":"10.1093\/nar\/gkab1012","article-title":"piRBase: integrating piRNA annotation in all aspects","volume":"50","author":"Wang","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.biocel.2026.107030_bib56","doi-asserted-by":"crossref","first-page":"D175","DOI":"10.1093\/nar\/gky1043","article-title":"piRBase: a comprehensive database of piRNA sequences","volume":"47","author":"Wang","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biocel.2026.107030_bib57","article-title":"piRNN: deep learning algorithm for piRNA prediction","volume":"6","author":"Wang","year":"2018","journal-title":"PeerJ"},{"key":"10.1016\/j.biocel.2026.107030_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.asoc.2024.111523","article-title":"A piRNA-disease association model incorporating sequence multi-source information with graph convolutional networks (iSGPDA)","volume":"157","author":"Wang","year":"2024","journal-title":"Appl. Soft Comput."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41580-022-00528-0","article-title":"Emerging roles and functional mechanisms of PIWI-interacting RNAs","volume":"24","author":"Wang","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"5","key":"10.1016\/j.biocel.2026.107030_bib60","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1158\/1055-9965.EPI-19-1148","article-title":"Serum PIWI-Interacting RNAs piR-020619 and piR-020450 Are Promising Novel Biomarkers for Early Detection of Colorectal Cancer","volume":"29","author":"Wang","year":"2020","journal-title":"Cancer Epidemiol. Biomark. & Prev."},{"issue":"13","key":"10.1016\/j.biocel.2026.107030_bib61","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1101\/gad.1425706","article-title":"Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes","volume":"20","author":"Watanabe","year":"2006","journal-title":"Genes. & Dev."},{"key":"10.1016\/j.biocel.2026.107030_bib62","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12915-025-02221-y","article-title":"iPiDA-LGE: a local and global graph ensemble learning framework for identifying piRNA-disease associations","volume":"23","author":"Wei","year":"2025","journal-title":"BMC Biol."},{"issue":"18","key":"10.1016\/j.biocel.2026.107030_bib63","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1242\/dev.094037","article-title":"piRNAs: From biogenesis to function","volume":"141","author":"Weick","year":"2014","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib64","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12943-018-0767-3","article-title":"Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer","volume":"17","author":"Weng","year":"2018","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib65","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/s12964-023-01368-x","article-title":"Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases","volume":"21","author":"Wu","year":"2023","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.biocel.2026.107030_bib66","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12859-021-04428-6","article-title":"Identifying piRNA targets on mRNAs in C. elegans using a deep multi-head attention network","volume":"22","author":"Yang","year":"2021","journal-title":"BMC Bioinforma."},{"issue":"9","key":"10.1016\/j.biocel.2026.107030_bib67","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1111\/cas.13300","article-title":"piR-823 contributes to colorectal tumorigenesis by enhancing the transcriptional activity of HSF1","volume":"108","author":"Yin","year":"2017","journal-title":"Cancer Sci."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1013936","article-title":"PAIRNet: Predicting PIWI cleavage specificity via position-aware RNA interaction modeling","volume":"22","author":"Zeng","year":"2026","journal-title":"PLOS Comput. Biol."},{"issue":"2","key":"10.1016\/j.biocel.2026.107030_bib69","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/cr.2015.4","article-title":"MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes","volume":"25","author":"Zhang","year":"2015","journal-title":"Cell. Res."},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib70","first-page":"940","article-title":"Role of piwi-interacting RNA-651 in the carcinogenesis of non-small cell lung cancer","volume":"15","author":"Zhang","year":"2018","journal-title":"Oncol. Lett."},{"issue":"4","key":"10.1016\/j.biocel.2026.107030_bib71","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac217","article-title":"PIWI-interacting RNAs in human diseases: databases and computational models","volume":"23","author":"Zhang","year":"2022","journal-title":"Brief. Bioinforma."},{"issue":"1","key":"10.1016\/j.biocel.2026.107030_bib72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12859-025-06068-6","article-title":"Mammalian piRNA target prediction using a hierarchical attention model","volume":"26","author":"Zhang","year":"2025","journal-title":"BMC Bioinforma."},{"issue":"5","key":"10.1016\/j.biocel.2026.107030_bib73","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.3390\/ijms23052469","article-title":"Dysregulation of Human Somatic piRNA Expression in Parkinson's Disease Subtypes and Stages","volume":"23","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.biocel.2026.107030_bib74","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac393","article-title":"Line graph attention networks for predicting disease-associated Piwi-interacting RNAs","volume":"23","author":"Zheng","year":"2022","journal-title":"Brief. Bioinforma."},{"issue":"12","key":"10.1016\/j.biocel.2026.107030_bib75","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s00109-021-02132-9","article-title":"piRNA pathway in the cardiovascular system: a novel regulator of cardiac differentiation, repair and regeneration","volume":"99","author":"Zhou","year":"2021","journal-title":"J. Mol. Med."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272526001408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272526001408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:25:57Z","timestamp":1790245557000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272526001408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":75,"alternative-id":["S1357272526001408"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2026.107030","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PIWI-interacting RNAs: Biogenesis, molecular mechanisms, computational advances, and roles in human health and disease","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2026.107030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107030"}}