{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:00:55Z","timestamp":1790600455802,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004366","name":"Tabriz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The International Journal of Biochemistry & Cell Biology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.biocel.2026.107036","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:35:55Z","timestamp":1790404555000},"page":"107036","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Small interfering RNA approaches for targeting nicotinic acetylcholine receptors: Current evidence and therapeutic perspectives"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-4036","authenticated-orcid":false,"given":"Narges","family":"Dastmalchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Rahbarghazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4593-4803","authenticated-orcid":false,"given":"Khalil","family":"Hajiasgharzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biocel.2026.107036_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119557","article-title":"Nicotinic acetylcholine receptors in chemotherapeutic drugs resistance: an emerging targeting candidate","volume":"278","author":"Afrashteh Nour","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1152\/physrev.00015.2008","article-title":"Mammalian nicotinic acetylcholine receptors: from structure to function","volume":"89","author":"Albuquerque","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biocel.2026.107036_bib3","article-title":"Nicotinic acetylcholine receptor pathways in cancer: from psychiatric clues to therapeutic opportunities","volume":"8","author":"Azadi","year":"2025","journal-title":"Cancer Rep."},{"key":"10.1016\/j.biocel.2026.107036_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114167","article-title":"Factors affecting drug delivery system translation: a focus on advanced technologies, biological barriers, and regulatory challenges","volume":"387","author":"Balash","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biocel.2026.107036_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166875","article-title":"Nicotinic acetylcholine receptors in cancer: limitations and prospects","volume":"1870","author":"Bele","year":"2024","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.biocel.2026.107036_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/md16100367","article-title":"APS8 delays tumor growth in mice by inducing apoptosis of lung adenocarcinoma cells expressing high number of \u03b17 nicotinic receptors","volume":"16","author":"Berne","year":"2018","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biocel.2026.107036_bib7","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1186\/s12885-019-6225-9","article-title":"Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL-RVG) via regulating \u03b17-nicotinic acetylcholine receptors\/ERK- EMT","volume":"19","author":"Bu","year":"2019","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib8","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.3390\/cells10082080","article-title":"YAP-dependent BiP induction is involved in nicotine-mediated oral cancer malignancy","volume":"10","author":"Chien","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biocel.2026.107036_bib9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3892\/br.2016.625","article-title":"Nicotinic acetylcholine receptors and cancer","volume":"4","author":"Dang","year":"2016","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.biocel.2026.107036_bib10","doi-asserted-by":"crossref","unstructured":"Dani, J.A., 2015. Neuronal nicotinic acetylcholine receptor structure and function and response to nicotine. pp. 3\u201319. https:\/\/doi.org\/10.1016\/bs.irn.2015.07.001.","DOI":"10.1016\/bs.irn.2015.07.001"},{"key":"10.1016\/j.biocel.2026.107036_bib11","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1172\/JCI28164","article-title":"Nicotine induces cell proliferation by \u03b2-arrestin \u2013 mediated activation of Src and Rb \u2013 Raf-1 pathways","volume":"116","author":"Dasgupta","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.biocel.2026.107036_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ijc.23894","article-title":"Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines","volume":"124","author":"Dasgupta","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2026.153906","article-title":"The potential roles of nicotinic acetylcholine receptors in the pathogenesis of multiple sclerosis: a comprehensive review","volume":"821","author":"Dastmalchi","year":"2026","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biocel.2026.107036_bib14","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.3390\/ijms26083456","article-title":"Recent update on siRNA therapeutics","volume":"26","author":"Ebenezer","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tips.2007.12.006","article-title":"Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis","volume":"29","author":"Egleton","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib16","first-page":"1","article-title":"Structure of neuronal nicotinic receptors","author":"Fasoli","year":"2015","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"10.1016\/j.biocel.2026.107036_bib17","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3892\/or.2017.5935","article-title":"\u03b17 nicotinic acetylcholine receptor in tumor-associated macrophages inhibits colorectal cancer metastasis through the JAK2\/STAT3 signaling pathway","volume":"38","author":"Fei","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biocel.2026.107036_bib18","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrc3725","article-title":"Connections of nicotine to cancer","volume":"14","author":"Grando","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib19","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1134\/S1062359022150109","article-title":"The effects of siRNA-mediated gene silencing of Alpha-7 nicotinic acetylcholine receptors on drug resistance to oxaliplatin in colorectal cancer cells","volume":"49","author":"Hajiasgharzadeh","year":"2022","journal-title":"Biol. Bull."},{"key":"10.1016\/j.biocel.2026.107036_bib20","first-page":"433","article-title":"The role of microRNAs in nicotine signaling","volume":"22","author":"Hajiasgharzadeh","year":"2023","journal-title":"EXCLI J."},{"key":"10.1016\/j.biocel.2026.107036_bib21","doi-asserted-by":"crossref","first-page":"14666","DOI":"10.1002\/jcp.28220","article-title":"Alpha7 nicotinic acetylcholine receptors in lung inflammation and carcinogenesis: friends or foes?","volume":"234","author":"Hajiasgharzadeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biocel.2026.107036_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.15171\/apb.2020.008","article-title":"Alpha7 nicotinic acetylcholine receptor mediates nicotine-induced apoptosis and cell cycle arrest of hepatocellular carcinoma HepG2 cells","volume":"10","author":"Hajiasgharzadeh","year":"2020","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.biocel.2026.107036_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117332","article-title":"Small interfering RNA targeting Alpha7 nicotinic acetylcholine receptor sensitizes hepatocellular carcinoma cells to sorafenib","volume":"244","author":"Hajiasgharzadeh","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03611","article-title":"The dual role of alpha7 nicotinic acetylcholine receptor in inflammation-associated gastrointestinal cancers","volume":"6","author":"Hajiasgharzadeh","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.biocel.2026.107036_bib25","doi-asserted-by":"crossref","first-page":"3263","DOI":"10.1002\/jcp.27015","article-title":"Small interfering RNA\u2013mediated gene suppression as a therapeutic intervention in hepatocellular carcinoma","volume":"234","author":"Hajiasgharzadeh","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.biocel.2026.107036_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1016730","article-title":"Hypersensitivity reactions to small molecule drugs","volume":"13","author":"Han","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biocel.2026.107036_bib27","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/89961","article-title":"Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis","volume":"7","author":"Heeschen","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.biocel.2026.107036_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41392-020-0207-x","article-title":"Therapeutic siRNA: state of the art","volume":"5","author":"Hu","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.biocel.2026.107036_bib29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pharmthera.2012.08.012","article-title":"Nicotinic acetylcholine receptors: from basic science to therapeutics","volume":"137","author":"Hurst","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biocel.2026.107036_bib30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nrd3010","article-title":"Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application","volume":"9","author":"Jackson","year":"2010","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.biocel.2026.107036_bib31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s004320100289","article-title":"Nicotinic receptor-mediated activation by the tobacco-specific nitrosamine NNK of a Raf-1\/MAP kinase pathway, resulting in phosphorylation of c-myc in human small cell lung carcinoma cells and pulmonary neuroendocrine cells","volume":"127","author":"Jull","year":"2001","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biocel.2026.107036_bib32","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/mt.2011.294","article-title":"Action and reaction: the biological response to siRNA and its delivery vehicles","volume":"20","author":"Kanasty","year":"2012","journal-title":"Mol. Ther."},{"key":"10.1016\/j.biocel.2026.107036_bib33","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1021\/acs.accounts.9b00368","article-title":"Lipid nanoparticle technology for clinical translation of siRNA therapeutics","volume":"52","author":"Kulkarni","year":"2019","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.biocel.2026.107036_bib34","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1093\/jnci\/djq300","article-title":"Overexpression and activation of the \u03b19-nicotinic receptor during tumorigenesis in human breast epithelial cells","volume":"102","author":"Lee","year":"2010","journal-title":"JNCI J. Natl. Cancer Inst."},{"key":"10.1016\/j.biocel.2026.107036_bib35","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1245\/s10434-011-1598-2","article-title":"Nicotine promotes cell migration through alpha7 nicotinic acetylcholine receptor in gastric cancer cells","volume":"18","author":"Lien","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.biocel.2026.107036_bib36","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/BF02740634","article-title":"Nicotinic acetylcholine receptors in health and disease","volume":"15","author":"Lindstrom","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biocel.2026.107036_bib37","doi-asserted-by":"crossref","first-page":"350","DOI":"10.2174\/1570159X15666170801103009","article-title":"Insights into nicotinic receptor signaling in nicotine addiction: implications for prevention and treatment","volume":"16","author":"Liu","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.biocel.2026.107036_bib38","first-page":"313","article-title":"RNA interference and its role in cancer therapy","volume":"4","author":"Mansoori","year":"2014","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.biocel.2026.107036_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106813","article-title":"Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors","volume":"194","author":"Matera","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biocel.2026.107036_bib40","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3390\/biom16020315","article-title":"Exploring the potential of receptor silencing in the tumor microenvironment by RNA interference","volume":"16","author":"Melo","year":"2026","journal-title":"Biomolecules"},{"key":"10.1016\/j.biocel.2026.107036_bib41","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2021.06.005","article-title":"Downregulation of DNMT3a expression by RNAi and its effect on NF-\u03baBs expression of thymic epithelial cells","volume":"237","author":"Meng","year":"2021","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.biocel.2026.107036_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00331","article-title":"RNA interference-induced innate immunity, off-target effect, or immune adjuvant?","volume":"8","author":"Meng","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biocel.2026.107036_bib43","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/onc.2012.163","article-title":"Nicotine\/cigarette smoke promotes metastasis of pancreatic cancer through \u03b17nAChR-mediated MUC4 upregulation","volume":"32","author":"Momi","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.biocel.2026.107036_bib44","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1124\/mol.106.023044","article-title":"\u03b14\u03b22 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine","volume":"70","author":"Moroni","year":"2006","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biocel.2026.107036_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2020.526455","article-title":"siRNA specificity: RNAi mechanisms and strategies to reduce off-target effects","volume":"11","author":"Neumeier","year":"2021","journal-title":"Front. Plant. Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s12032-022-01745-5","article-title":"Alpha7 nicotinic acetylcholine receptor expression in Sorafenib-resistant Hepatocellular carcinoma cells","volume":"39","author":"Nour","year":"2022","journal-title":"Med. Oncol."},{"key":"10.1016\/j.biocel.2026.107036_bib47","doi-asserted-by":"crossref","first-page":"19953","DOI":"10.1021\/jacs.9b09055","article-title":"A general mechanism for signal propagation in the nicotinic acetylcholine receptor family","volume":"141","author":"Oliveira","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.biocel.2026.107036_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0289098","article-title":"\u03b17 nicotinic acetylcholine receptor interaction with G proteins in breast cancer cell proliferation, motility, and calcium signaling","volume":"18","author":"Oz","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.biocel.2026.107036_bib49","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.addr.2015.01.007","article-title":"Preclinical and clinical development of siRNA-based therapeutics","volume":"87","author":"Ozcan","year":"2015","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.biocel.2026.107036_bib50","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/ijc.24299","article-title":"Inhibition of non-neuronal \u03b17-nicotinic receptor reduces tumorigenicity in A549 NSCLC xenografts","volume":"125","author":"Paleari","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib51","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.3390\/cells12152000","article-title":"Contribution of the \u03b15 nAChR subunit and \u03b15SNP to nicotine-induced proliferation and migration of human cancer cells","volume":"12","author":"Papapostolou","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.biocel.2026.107036_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108021","article-title":"Nicotinic acetylcholine receptors: conventional and unconventional ligands and signaling","volume":"168","author":"Papke","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.biocel.2026.107036_bib53","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrc2966","article-title":"RNA interference in the clinic: challenges and future directions","volume":"11","author":"Pecot","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105336","article-title":"Choline and nicotine increase glioblastoma cell proliferation by binding and activating \u03b17- and \u03b19- containing nicotinic receptors","volume":"163","author":"Pucci","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biocel.2026.107036_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.805123","article-title":"\u03b19-containing nicotinic receptors in cancer","volume":"15","author":"Pucci","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.biocel.2026.107036_bib56","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nbt936","article-title":"Rational siRNA design for RNA interference","volume":"22","author":"Reynolds","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biocel.2026.107036_bib57","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/138945012800398874","article-title":"\u03b17-nicotinic acetylcholine receptors: an old actor for new different roles","volume":"13","author":"Russo","year":"2013","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.biocel.2026.107036_bib58","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/ph13100294","article-title":"Overcoming barriers for siRNA therapeutics: from bench to bedside","volume":"13","author":"Sajid","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.biocel.2026.107036_bib59","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3390\/ijms27021091","article-title":"Chimeric approach to identify molecular determinants of nicotinic acetylcholine receptors","volume":"27","author":"Sapkota","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib60","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jconrel.2015.09.066","article-title":"Technologies for controlled, local delivery of siRNA","volume":"218","author":"Sarett","year":"2015","journal-title":"J. Control. Release"},{"key":"10.1016\/j.biocel.2026.107036_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2020.607959","article-title":"The \u03b15 nicotinic acetylcholine receptor subunit differentially modulates \u03b14\u03b22* and \u03b13\u03b24* receptors","volume":"12","author":"Scholze","year":"2020","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.biocel.2026.107036_bib62","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrc2590","article-title":"Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?","volume":"9","author":"Schuller","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib63","doi-asserted-by":"crossref","first-page":"680","DOI":"10.2174\/138945012800398883","article-title":"Regulatory role of the \u03b17nAChR in cancer","volume":"13","author":"Schuller","year":"2012","journal-title":"Curr. Drug. Targets"},{"key":"10.1016\/j.biocel.2026.107036_bib64","doi-asserted-by":"crossref","first-page":"71","DOI":"10.20517\/2394-4722.2017.18","article-title":"A new twist to neurotransmitter receptors and cancer","volume":"3","author":"Schuller","year":"2017","journal-title":"J. Cancer Metastas-.-. Treat."},{"key":"10.1016\/j.biocel.2026.107036_bib65","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s13402-020-00581-x","article-title":"CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer","volume":"44","author":"Shehwana","year":"2021","journal-title":"Cell. Oncol."},{"key":"10.1016\/j.biocel.2026.107036_bib66","series-title":"Nicotinic Acetylcholine Receptor Signaling in Neuroprotection","first-page":"137","article-title":"Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer\u2019s and Parkinson\u2019s diseases","author":"Shimohama","year":"2018"},{"key":"10.1016\/j.biocel.2026.107036_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/456743","article-title":"Nicotinic acetylcholine receptor signaling in tumor growth and metastasis","volume":"2011","author":"Singh","year":"2011","journal-title":"J. Oncol."},{"key":"10.1016\/j.biocel.2026.107036_bib68","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.etp.2015.07.001","article-title":"\u03b15-nAChR modulates nicotine-induced cell migration and invasion in A549 lung cancer cells","volume":"67","author":"Sun","year":"2015","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.biocel.2026.107036_bib69","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/toxsci\/kfac080","article-title":"Downregulation of stem-loop binding protein by nicotine via \u03b17-nicotinic acetylcholine receptor and its role in nicotine-induced cell transformation","volume":"189","author":"Sun","year":"2022","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.biocel.2026.107036_bib70","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3390\/md20030200","article-title":"Inflammation regulation via an agonist and antagonists of \u03b17 nicotinic acetylcholine receptors in RAW264.7 macrophages","volume":"20","author":"Tan","year":"2022","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.biocel.2026.107036_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106764","article-title":"Nicotinic acetylcholine receptors in neurological and psychiatric diseases","volume":"191","author":"Terry","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biocel.2026.107036_bib72","doi-asserted-by":"crossref","first-page":"9493","DOI":"10.1007\/s13277-015-4751-x","article-title":"Silencing A7-nAChR levels increases the sensitivity of gastric cancer cells to ixabepilone treatment","volume":"37","author":"Tu","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.biocel.2026.107036_bib73","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1007\/s13277-015-4260-y","article-title":"The \u03b17-nicotinic acetylcholine receptor mediates the sensitivity of gastric cancer cells to taxanes","volume":"37","author":"Tu","year":"2016","journal-title":"Tumor Biol."},{"key":"10.1016\/j.biocel.2026.107036_bib74","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/j.bcp.2013.08.001","article-title":"Neuronal nicotinic receptors as analgesic targets: It\u2019s a winding road","volume":"86","author":"Umana","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biocel.2026.107036_bib75","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1021\/acs.molpharmaceut.4c00334","article-title":"Tumor microenvironment responsive RNA drug delivery systems: intelligent platforms for sophisticated release","volume":"21","author":"Wang","year":"2024","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.biocel.2026.107036_bib76","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1245\/s10434-010-1504-3","article-title":"Nicotine enhances colon cancer cell migration by induction of fibronectin","volume":"18","author":"Wei","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.biocel.2026.107036_bib77","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/bjp.2008.185","article-title":"Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans","volume":"154","author":"Wessler","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biocel.2026.107036_bib78","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2742","article-title":"Knocking down barriers: advances in siRNA delivery","volume":"8","author":"Whitehead","year":"2009","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.biocel.2026.107036_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115073","article-title":"RNAi therapies: Expanding applications for extrahepatic diseases and overcoming delivery challenges","volume":"201","author":"Won Lee","year":"2023","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.biocel.2026.107036_bib80","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.bcp.2011.07.067","article-title":"Naturally-expressed nicotinic acetylcholine receptor subtypes","volume":"82","author":"Wu","year":"2011","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biocel.2026.107036_bib81","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/jcb.22270","article-title":"Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor","volume":"108","author":"Wu","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.biocel.2026.107036_bib82","doi-asserted-by":"crossref","first-page":"373","DOI":"10.5114\/ceji.2015.54602","article-title":"Role of \u03b17 nicotinic receptor in the immune system and intracellular signaling pathways","volume":"40","author":"Zdanowski","year":"2015","journal-title":"Cent. Eur. J. Immunol."},{"key":"10.1016\/j.biocel.2026.107036_bib83","doi-asserted-by":"crossref","first-page":"59199","DOI":"10.18632\/oncotarget.10498","article-title":"Role of a7-nicotinic acetylcholine receptor in nicotine-induced invasion and epithelial-to-mesenchymal transition in human non-small cell lung cancer cells","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biocel.2026.107036_bib84","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12943-025-02441-4","article-title":"The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets","volume":"24","author":"Zhang","year":"2025","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.biocel.2026.107036_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2026.118679","article-title":"Nicotinic acetylcholine receptors-targeting drug discovery","volume":"308","author":"Zhang","year":"2026","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biocel.2026.107036_bib86","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1158\/1078-0432.CCR-06-2898","article-title":"Nicotine induces hypoxia-inducible factor-1\u03b1 expression in human lung cancer cells via nicotinic acetylcholine receptor\u2013mediated signaling pathways","volume":"13","author":"Zhang","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biocel.2026.107036_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.970040","article-title":"Targeting \u03b17 nicotinic acetylcholine receptors for chronic pain","volume":"15","author":"Zhou","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.biocel.2026.107036_bib88","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1570159X15666170912110450","article-title":"Neuronal and extraneuronal nicotinic acetylcholine receptors","volume":"16","author":"Zoli","year":"2018","journal-title":"Curr. Neuropharmacol."}],"container-title":["The International Journal of Biochemistry & Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272526001469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1357272526001469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:38:51Z","timestamp":1790599131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1357272526001469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":88,"alternative-id":["S1357272526001469"],"URL":"https:\/\/doi.org\/10.1016\/j.biocel.2026.107036","relation":{},"ISSN":["1357-2725"],"issn-type":[{"value":"1357-2725","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Small interfering RNA approaches for targeting nicotinic acetylcholine receptors: Current evidence and therapeutic perspectives","name":"articletitle","label":"Article Title"},{"value":"The International Journal of Biochemistry & Cell Biology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biocel.2026.107036","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107036"}}