{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:44:42Z","timestamp":1791254682602,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1016\/j.biochi.2007.08.012","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T11:24:06Z","timestamp":1188991446000},"page":"1447-1453","source":"Crossref","is-referenced-by-count":54,"title":["Hedgehog and adipogenesis: Fat and fiction"],"prefix":"10.1016","volume":"89","author":[{"given":"Wendy","family":"Cousin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Fontaine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Peraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2007.08.012_bib1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.beem.2005.07.006","article-title":"Transgenic animal models for the study of adipose tissue biology","volume":"19","author":"Bluher","year":"2005","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab"},{"key":"10.1016\/j.biochi.2007.08.012_bib2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nrm2066","article-title":"Adipocyte differentiation from the inside out","volume":"7","author":"Rosen","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib3","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/nrn1990","article-title":"Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development","volume":"7","author":"Fuccillo","year":"2006","journal-title":"Nat. Rev. Neurosci"},{"key":"10.1016\/j.biochi.2007.08.012_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nn983","article-title":"Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo","volume":"6","author":"Lai","year":"2003","journal-title":"Nat. Neurosci"},{"key":"10.1016\/j.biochi.2007.08.012_bib5","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1002\/jcb.20635","article-title":"Indian hedgehog: its roles and regulation in endochondral bone development","volume":"96","author":"Lai","year":"2005","journal-title":"J. Cell. Biochem"},{"key":"10.1016\/j.biochi.2007.08.012_bib6","doi-asserted-by":"crossref","first-page":"6382","DOI":"10.1073\/pnas.0608449104","article-title":"Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone","volume":"104","author":"Maeda","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biochi.2007.08.012_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nature03100","article-title":"Tissue repair and stem cell renewal in carcinogenesis","volume":"432","author":"Beachy","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2007.08.012_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.devcel.2005.01.008","article-title":"Hedgehog signaling: from the Drosophila cuticle to anti-cancer drugs","volume":"8","author":"Briscoe","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biochi.2007.08.012_bib9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/nrc1229","article-title":"Hedgehog signalling in cancer formation and maintenance","volume":"3","author":"Pasca di Magliano","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biochi.2007.08.012_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nrc796","article-title":"Gli and hedgehog in cancer: tumours, embryos and stem cells","volume":"2","author":"Ruiz i Altaba","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biochi.2007.08.012_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nrm1622","article-title":"Communicating with Hedgehogs","volume":"6","author":"Hooper","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/dev.02169","article-title":"Signaling from Smo to Ci\/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates","volume":"133","author":"Huangfu","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.biochi.2007.08.012_bib13","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.tcb.2006.02.004","article-title":"Hedgehog signalling: how to get from Smo to Ci and Gli","volume":"16","author":"Osterlund","year":"2006","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1042\/BJ20061723","article-title":"Pathways of signal transduction employed by vertebrate Hedgehogs","volume":"403","author":"Riobo","year":"2007","journal-title":"Biochem. J."},{"key":"10.1016\/j.biochi.2007.08.012_bib15","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1242\/jcs.03309","article-title":"Hedgehog signaling","volume":"120","author":"Varjosalo","year":"2007","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biochi.2007.08.012_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02061","article-title":"Hedgehog signalling in the mouse requires intraflagellar transport proteins","volume":"426","author":"Huangfu","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2007.08.012_bib17","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1242\/dev.01894","article-title":"Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors","volume":"132","author":"Liu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.biochi.2007.08.012_bib18","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.4161\/cc.5.13.2928","article-title":"Control of murine kidney development by sonic hedgehog and its GLI effectors","volume":"5","author":"Gill","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biochi.2007.08.012_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jpurol.2006.03.002","article-title":"Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1beta in persistent cloaca and associated kidney malformations","volume":"3","author":"Jenkins","year":"2007","journal-title":"J. Pediatr. Urol"},{"key":"10.1016\/j.biochi.2007.08.012_bib20","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1242\/jcs.114.11.2085","article-title":"Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation","volume":"114","author":"Spinella-Jaegle","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.biochi.2007.08.012_bib21","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.bone.2003.07.004","article-title":"Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells","volume":"33","author":"van der Horst","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.biochi.2007.08.012_bib22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/10445490050021186","article-title":"BMP-2 and sonic hedgehog have contrary effects on adipocyte-like differentiation of C3H10T1\/2 cells","volume":"19","author":"Zehentner","year":"2000","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cmet.2005.11.012","article-title":"Hedgehog signaling plays a conserved role in inhibiting fat formation","volume":"3","author":"Suh","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.biochi.2007.08.012_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nchembio753","article-title":"Purmorphamine activates the Hedgehog pathway by targeting Smoothened","volume":"2","author":"Sinha","year":"2006","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib25","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.chembiol.2004.06.010","article-title":"Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway","volume":"11","author":"Wu","year":"2004","journal-title":"Chem. Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bbrc.2004.01.053","article-title":"Adipocyte differentiation of multipotent cells established from human adipose tissue","volume":"315","author":"Rodriguez","year":"2004","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.biochi.2007.08.012_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1126\/science.290.5489.134","article-title":"Function of GATA transcription factors in preadipocyte-adipocyte transition","volume":"290","author":"Tong","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.biochi.2007.08.012_bib28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1074\/jbc.270.4.1515","article-title":"GATA-3 dominant negative mutant. Functional redundancy of the T cell receptor alpha and beta enhancers","volume":"270","author":"Smith","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.biochi.2007.08.012_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1358\/dnp.2003.16.9.829340","article-title":"GATA transcription factors and fat cell formation","volume":"16","author":"Tong","year":"2003","journal-title":"Drug News Perspect"},{"key":"10.1016\/j.biochi.2007.08.012_bib30","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1110955","article-title":"TAZ, a transcriptional modulator of mesenchymal stem cell differentiation","volume":"309","author":"Hong","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biochi.2007.08.012_bib31","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1534-5807(02)00360-X","article-title":"The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation","volume":"3","author":"Fajas","year":"2002","journal-title":"Dev. Cell"},{"issue":"23","key":"10.1016\/j.biochi.2007.08.012_bib32","doi-asserted-by":"crossref","first-page":"16860","DOI":"10.1074\/jbc.M610943200","article-title":"The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity","volume":"282","author":"Luan","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 1","key":"10.1016\/j.biochi.2007.08.012_bib33","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/sj.ijo.0802906","article-title":"Atypical transcriptional regulators and cofactors of PPARgamma","volume":"29","author":"Miard","year":"2005","journal-title":"Int. J. Obes. (Lond.)"},{"key":"10.1016\/j.biochi.2007.08.012_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1097-2765(01)00327-6","article-title":"The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation","volume":"8","author":"Thomas","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biochi.2007.08.012_bib35","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signaling","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.biochi.2007.08.012_bib36","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1242\/dev.01564","article-title":"Sequential roles of Hedgehog and Wnt signaling in osteoblast development","volume":"132","author":"Hu","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.biochi.2007.08.012_bib37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.cub.2007.01.062","article-title":"Inhibitory Gli3 activity negatively regulates Wnt\/beta-catenin signaling","volume":"17","author":"Ulloa","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib38","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s002580050265","article-title":"Adipocyte differentiation is modulated by secreted delta-like (dlk) variants and requires the expression of membrane-associated dlk","volume":"64","author":"Garces","year":"1999","journal-title":"Differentiation"},{"key":"10.1016\/j.biochi.2007.08.012_bib39","doi-asserted-by":"crossref","first-page":"E103","DOI":"10.1152\/ajpendo.00605.2004","article-title":"Plasminogen activator inhibitor-1 modulates adipocyte differentiation","volume":"290","author":"Liang","year":"2006","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"10.1016\/j.biochi.2007.08.012_bib40","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.bbrc.2006.08.112","article-title":"Inhibition of the anti-adipogenic Hedgehog signaling pathway by cyclopamine does not trigger adipocyte differentiation","volume":"349","author":"Cousin","year":"2006","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1016\/j.biochi.2007.08.012_bib41","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0960-9822(01)00229-9","article-title":"Wnt signals are targets and mediators of Gli function","volume":"11","author":"Mullor","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib42","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1101\/gad.1025302","article-title":"Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened","volume":"16","author":"Chen","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.biochi.2007.08.012_bib43","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1126\/science.280.5369.1603","article-title":"Teratogen-mediated inhibition of target tissue response to Shh signaling","volume":"280","author":"Cooper","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.biochi.2007.08.012_bib44","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/labinvest.3700253","article-title":"Cilium-generated signaling and cilia-related disorders","volume":"85","author":"Pan","year":"2005","journal-title":"Lab. Invest"},{"issue":"7","key":"10.1016\/j.biochi.2007.08.012_bib45","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1007\/s00467-007-0435-0","article-title":"Bardet-Biedl syndrome: beyond the cilium","volume":"22","author":"Tobin","year":"2007","journal-title":"Pediatr. Nephrol"},{"key":"10.1016\/j.biochi.2007.08.012_bib46","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1126\/science.277.5329.1109","article-title":"Altered neural cell fates and medulloblastoma in mouse patched mutants","volume":"277","author":"Goodrich","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.biochi.2007.08.012_bib47","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00005792-198703000-00002","article-title":"Nevoid basal-cell carcinoma syndrome","volume":"66","author":"Gorlin","year":"1987","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.biochi.2007.08.012_bib48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/dbio.2001.0419","article-title":"A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)","volume":"239","author":"Makino","year":"2001","journal-title":"Dev. Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ddr.10115","article-title":"Increases in adipose and total body weight, but not in lean body mass, associated with subcutaneous administration of Sonic hedgehog-Ig fusion protein to mice","volume":"57","author":"Martin","year":"2002","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.biochi.2007.08.012_bib50","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1093\/jn\/134.11.2979","article-title":"Inhibition of Hedgehog signaling protects adult mice from diet-induced weight gain","volume":"134","author":"Buhman","year":"2004","journal-title":"J. Nutr"},{"key":"10.1016\/j.biochi.2007.08.012_bib51","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0896-6273(03)00561-0","article-title":"Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches","volume":"39","author":"Machold","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.biochi.2007.08.012_bib52","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.0604568103","article-title":"Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration","volume":"103","author":"Trowbridge","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biochi.2007.08.012_bib53","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nrd2086","article-title":"Targeting the Hedgehog pathway in cancer","volume":"5","author":"Rubin","year":"2006","journal-title":"Nat. Rev. Drug Discov"},{"key":"10.1016\/j.biochi.2007.08.012_bib54","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.crvi.2005.12.012","article-title":"Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome","volume":"329","author":"Ailhaud","year":"2006","journal-title":"C.R. Biol."},{"key":"10.1016\/j.biochi.2007.08.012_bib55","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.numecd.2006.10.005","article-title":"Metabolic syndrome pathophysiology: the role of adipose tissue","volume":"17","author":"Laclaustra","year":"2007","journal-title":"Nutr. Metab. Cardiovasc. Dis"},{"key":"10.1016\/j.biochi.2007.08.012_bib56","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/187152006778226495","article-title":"Targeting the hedgehog signaling pathway with small molecules","volume":"6","author":"Kiselyov","year":"2006","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.biochi.2007.08.012_bib57","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.yexcr.2003.10.020","article-title":"Transdifferentiation of preadipose cells into smooth muscle-like cells: role of aortic carboxypeptidase-like protein","volume":"293","author":"Abderrahim-Ferkoune","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biochi.2007.08.012_bib58","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1194\/jlr.M200346-JLR200","article-title":"Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?","volume":"44","author":"Massiera","year":"2003","journal-title":"J. Lipid Res."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090840700226X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090840700226X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:04:37Z","timestamp":1629666277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030090840700226X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["S030090840700226X"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2007.08.012","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}