{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:24:39Z","timestamp":1790061879988,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":813,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo (FAPESP)"},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.biochi.2011.01.009","type":"journal-article","created":{"date-parts":[[2011,2,7]],"date-time":"2011-02-07T09:11:17Z","timestamp":1297069877000},"page":"941-947","source":"Crossref","is-referenced-by-count":56,"title":["Cell cycle arrest evidence, parasiticidal and bactericidal properties induced by l-amino acid oxidase from Bothrops atrox snake venom"],"prefix":"10.1016","volume":"93","author":[{"given":"Raquel","family":"de Melo Alves Paiva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"de Freitas Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilmara Ausech","family":"Antonucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder Henrique","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de Lourdes Pires Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly C.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Lucarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Cesar","family":"Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemeire Cristina","family":"Linhari Rodrigues Pietro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Henrique","family":"Gomes Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suely Vilela","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2011.01.009_bib1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0021-9258(18)96172-7","article-title":"On the reaction mechanism of Crotalus adamanteus l-amino acid oxidase","volume":"242","author":"Massey","year":"1967","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2011.01.009_bib2","unstructured":"B. Curti, S. Ronchi, P.M. Simoneta, d- and l-amino acid oxidases. in: F. Mueller (Ed.), Chemistry and Biochemistry of Flavoenzyme, third ed. (1992), Boca Raton pp. 69\u201394."},{"key":"10.1016\/j.biochi.2011.01.009_bib3","series-title":"Enzynmes from Snake Venom","first-page":"579","article-title":"l-amino acid oxidases and lactate dehydrogenase","author":"Tan","year":"1998"},{"key":"10.1016\/j.biochi.2011.01.009_bib4","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0014-5793(02)03608-6","article-title":"Antimicrobial action of achacin is mediated by l-amino acid oxidase activity","volume":"531","author":"Ehara","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biochi.2011.01.009_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.toxicon.2005.06.005","article-title":"Cloning and biochemical characterization of APIT, a new l-amino acid oxidase from Aplysia punctata","volume":"46","author":"Butzke","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0041-0101(02)00102-2","article-title":"Snake venom l-amino acid oxidases","volume":"40","author":"Du","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib7","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbrc.2003.08.044","article-title":"Molecular characterization of Trimeresurus stejnegeri venom l-amino acid oxidase with potential anti-HIV activity","volume":"309","author":"Zhang","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2011.01.009_bib8","first-page":"4","article-title":"Ontogenetic variation in the venoms proteome of the Amazonian snake Bothrops atrox","volume":"11","author":"Gu\u00e9rcio","year":"2006","journal-title":"Proteome Sci."},{"key":"10.1016\/j.biochi.2011.01.009_bib9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1006\/bbrc.1996.0996","article-title":"Identification of the snake venom substance that induces apoptosis","volume":"224","author":"Suhr","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2011.01.009_bib10","doi-asserted-by":"crossref","first-page":"9539","DOI":"10.1074\/jbc.272.14.9539","article-title":"Apoxin I, a novel apoptosis-inducing factor with l-amino acid oxidase activity purified from Western diamondback rattlesnake venom","volume":"272","author":"Torii","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2011.01.009_bib11","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/bi992416z","article-title":"Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with l-amino acid oxidase activity","volume":"39","author":"Torii","year":"2000","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2011.01.009_bib12","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.cbpa.2008.07.007","article-title":"Evidence of caspase-mediated apoptosis induced by l-amino acid oxidase isolated from Bothrops atrox snake venom","volume":"151","author":"Alves*","year":"2008","journal-title":"Comp. Biochem. Physiol. A"},{"key":"10.1016\/j.biochi.2011.01.009_bib13","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/0041-0101(94)90407-3","article-title":"Purification and characterization of l-amino acid oxidase from King cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation","volume":"32","author":"Li","year":"1994","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib14","first-page":"345","article-title":"l-amino acid oxidase from Trimeresurus jerdonii snake venom: purification, characterization, platelet aggregation-inducing and antibacterial effects","volume":"11","author":"Lu","year":"2002","journal-title":"J.\u00a0Nat. Toxins"},{"key":"10.1016\/j.biochi.2011.01.009_bib15","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.1016\/j.bmc.2004.03.049","article-title":"Platelet aggregation and antibacterial effects of an l-amino acid oxidase purified from Bothrops alternatus snake venom","volume":"12","author":"St\u00e1beli","year":"2004","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biochi.2011.01.009_bib16","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1016\/j.bmc.2006.06.025","article-title":"Biochemical and functional characterization of an l-amino acid oxidase isolated from Bothrops pirajai snake venom","volume":"14","author":"Izidoro","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biochi.2011.01.009_bib17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1006\/abbi.1999.1287","article-title":"Isolation and structural characterization of a cytotoxic l-amino acid oxidase from Agkistrodon contortrix laticinctus snake venom: preliminary crystallographic data","volume":"368","author":"Souza","year":"1999","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biochi.2011.01.009_bib18","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.biochi.2010.01.013","article-title":"Biochemical, functional and structural characterization of Akbu-LAAO: a novel snake venom l-amino acid oxidase from Agkistrodon blomhoffii ussurensis","volume":"92","author":"Sun","year":"2010","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2011.01.009_bib19","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.biochi.2008.12.004","article-title":"Structural and functional properties of Bp-LAAO, a new l-amino acid oxidase isolated from Bothrops pauloensis snake venom","volume":"91","author":"Rodrigues","year":"2009","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2011.01.009_bib20","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.toxicon.2009.06.004","article-title":"Purification and characterization of a new l-amino acid oxidase from Daboia russellii siamensis venom","volume":"54","author":"Zhong","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1742-4658.2009.07497.x","article-title":"Novel l-amino acid oxidase with antibacterial activity against methicillin-resistant Staphylococcus aureus isolated from epidermal mucus of the flounder Platichthys stellatus","volume":"277","author":"Kasai","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.biochi.2011.01.009_bib22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.toxicon.2009.11.013","article-title":"Antibacterial and antiparasitic effects of Bothrops marajoensis venom and its fractions: phospholipase A2 and l-amino acid oxidase","volume":"55","author":"Costa Torres","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib23","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s10495-006-7959-9","article-title":"Mechanisms of cell death induction by l-amino acid oxidase, a major component of ophidian venom","volume":"11","author":"Ande","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.biochi.2011.01.009_bib24","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm2351","article-title":"Regulation of DNA repair throughout the cell cycle","volume":"9","author":"Branzei","year":"2008","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.biochi.2011.01.009_bib25","unstructured":"NCCLS (2001), In National Committee for Clinical Laboratory Standards. Development of in vitro susceptibility testing and quality control parameters. Approved Guideline, second ed. NCCLS document M23-A2, Wayne, Pa."},{"key":"10.1016\/j.biochi.2011.01.009_bib26","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1128\/AAC.46.8.2720-2722.2002","article-title":"Resazurin microtiter assay plate: simple and inexpensive method for detection of drug resistance in Mycobacterium tuberculosis","volume":"46","author":"Palomino","year":"2002","journal-title":"Antimicrobial Agents Chemother."},{"key":"10.1016\/j.biochi.2011.01.009_bib27","series-title":"Manual of Clinical Microbiology (5th)","author":"Balows","year":"1991"},{"key":"10.1016\/j.biochi.2011.01.009_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/abbi.2000.1790","article-title":"Structural and functional characterization of BnSP-7, a Lys49 myotoxic phospholipase A(2) homologue from Bothrops neuwiedi pauloensis venom","volume":"378","author":"Soares","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biochi.2011.01.009_bib29","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/PL00008532","article-title":"Setting of a colorimetric method to determine the viability of Trypanosoma cruzi epimastigotes","volume":"86","author":"Muelas-Serrano","year":"2000","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.biochi.2011.01.009_bib30","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1023\/A:1026497306006","article-title":"Apoptotic and necrotic cell death are both induced by electroporation in HL60 human promyeloid leukaemia cells","volume":"2","author":"Pi\u00f1ero","year":"1997","journal-title":"Apoptosis"},{"key":"10.1016\/j.biochi.2011.01.009_bib31","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbrc.2006.12.217","article-title":"Molecular approaches for structural characterization of Bothrops l-amino acid oxidases with antiprotozoal activity: cDNA cloning, comparative sequence analysis, and molecular modeling","volume":"355","author":"Fran\u00e7a","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2011.01.009_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pep.2006.09.016","article-title":"Molecular cloning, expression and purification of l-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma","volume":"52","author":"Kommuju","year":"2007","journal-title":"Protein Exp. Purif."},{"key":"10.1016\/j.biochi.2011.01.009_bib33","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0041-0101(91)90210-I","article-title":"Antibacterial effects of different snake venoms: purification and characterization of antibacterial proteins from Pseudechis australis (Australian king brown or mulga snake) venom","volume":"29","author":"Stiles","year":"1991","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib34","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/oxfordjournals.jbchem.a022287","article-title":"Comparison of the apoptotic pathways induced by l-amino acid oxidase and hydrogen peroxide","volume":"125","author":"Suhr","year":"1999","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.biochi.2011.01.009_bib35","article-title":"Anticancer effect of Lycium barbarum polysaccharides on colon cancer cells involves G0\/G1 phase arrest","author":"Mao","year":"2010","journal-title":"Med. Oncol."},{"key":"10.1016\/j.biochi.2011.01.009_bib36","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3109\/10408419609105484","article-title":"Antioxidant defense in parasitic protozoa","volume":"22","author":"Mehlotra","year":"1996","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.biochi.2011.01.009_bib37","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1006\/bbrc.2000.4175","article-title":"Bothrops moojeni venom kills Leishmania spp. with hydrogen peroxide generated by its l-amino acid oxidase","volume":"280","author":"Tempone","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2011.01.009_bib38","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.toxicon.2008.12.004","article-title":"Antigenic, microbicidal and antiparasitic properties of a l-amino acid oxidase isolated from Bothrops jararaca snake venom","volume":"53","author":"Ciscotto","year":"2008","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib39","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/14786410701592679","article-title":"Isolation and characterization of ACTX-6: a cytotoxic l-amino acid oxidase from Agkistrodon acutus snake venom","volume":"22","author":"Zhang","year":"2008","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.biochi.2011.01.009_bib40","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/abbi.2000.2130","article-title":"Isolation, structural and a functional characterization of an apoptosis inducing l-amino acid oxidase from Leaf-nosed viper (Eristocophis macmahoni) snake venom","volume":"384","author":"Ali","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biochi.2011.01.009_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0014-5793(96)00989-1","article-title":"Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell","volume":"397","author":"Skulachev","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biochi.2011.01.009_bib42","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-5793(02)03319-7","article-title":"Programmed death in yeast as adaptation?","volume":"528","author":"Skulachev","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biochi.2011.01.009_bib43","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.toxicon.2009.04.017","article-title":"Purification, characterization and biological activities of the l-amino acid oxidase from Bungarus fasciatus snake venom","volume":"54","author":"Wei","year":"2009","journal-title":"Toxicon"},{"key":"10.1016\/j.biochi.2011.01.009_bib44","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.bbapap.2006.01.021","article-title":"Isolation and characterization of an apoptotic and platelet aggregation inhibiting l-amino acid oxidase from Vipera berus berus (common viper) venom","volume":"1764","author":"Samel","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2011.01.009_bib45","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/jcp.20689","article-title":"The p53 tumor suppressor participates in multiple cell cycle checkpoints","volume":"209","author":"Giono","year":"2006","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.biochi.2011.01.009_bib46","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0092-8674(94)90540-1","article-title":"G1 phase progression: cycling on cue","volume":"79","author":"Sherr","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2011.01.009_bib47","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cbi.2009.11.006","article-title":"Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteins","volume":"183","author":"Gupta","year":"2010","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biochi.2011.01.009_bib48","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.etp.2008.09.006","article-title":"Apoptosis of human hepatocellular carcinoma cell (HepG2) induced by cardiotoxin III through S-phase arrest","volume":"61","author":"Chen","year":"2009","journal-title":"Exp. Toxicol. Pathol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908411000150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908411000150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T17:21:35Z","timestamp":1637256095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908411000150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0300908411000150"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2011.01.009","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}