{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:09:27Z","timestamp":1790374167558,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK08193-1A1"],"award-info":[{"award-number":["DK08193-1A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["EY018100"],"award-info":[{"award-number":["EY018100"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.biochi.2012.09.022","type":"journal-article","created":{"date-parts":[[2012,9,23]],"date-time":"2012-09-23T10:46:18Z","timestamp":1348397178000},"page":"258-263","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Differential regulation of GLUT1 activity in human corneal limbal epithelial cells and fibroblasts"],"prefix":"10.1016","volume":"95","author":[{"given":"David P.","family":"Kuipers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared P.","family":"Scripture","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Gunnink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Salie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Schotanus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L.","family":"Ubels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry L.","family":"Louters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2012.09.022_bib1","first-page":"1442","article-title":"The X Y, Z hypothesis of corneal epithelial maintenance","volume":"24","author":"Thoft","year":"1983","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1177\/153537020122601007","article-title":"Differential expression of Na:K:2Cl cotransporter, glucose transporter 1, and aquaporin 1 in freshly isolated and cultured bovine corneal tissues","volume":"226","author":"Bildin","year":"2001","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.biochi.2012.09.022_bib3","first-page":"2887","article-title":"GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye","volume":"35","author":"Kumagai","year":"1994","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib4","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1006\/exer.1996.0159","article-title":"Glucose transporter 1 expression is enhanced during corneal epithelial wound repair","volume":"63","author":"Takahashi","year":"1996","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2012.09.022_bib5","first-page":"1659","article-title":"Ultracytochemical localization of the erythrocyte\/HepG2-type glucose transporter (GLUT1) in the ciliary body and iris of the rat eye","volume":"32","author":"Takata","year":"1991","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib6","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S0021-5155(00)00222-7","article-title":"Glucose transporter 1 expression in corneal wound repair under high serum glucose level","volume":"44","author":"Takahashi","year":"2000","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2012.09.022_bib7","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.biochi.2006.08.004","article-title":"Acute activation of glucose uptake by glucose deprivation in L929 fibroblast cells","volume":"88","author":"Roelofs","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2012.09.022_bib8","doi-asserted-by":"crossref","first-page":"E568","DOI":"10.1152\/ajpendo.00372.2003","article-title":"Glucose deprivation enhances targeting of GLUT1 to lipid rafts in 3T3-L1 adipocytes","volume":"286","author":"Kumar","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biochi.2012.09.022_bib9","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1242\/jcs.115.11.2433","article-title":"Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK)","volume":"115","author":"Barnes","year":"2002","journal-title":"J.\u00a0Cell. Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib10","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s004240100577","article-title":"Hyperosmotic shock induces both activation and translocation of glucose transporters in mammalian cells","volume":"442","author":"Barros","year":"2001","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.biochi.2012.09.022_bib11","doi-asserted-by":"crossref","first-page":"17225","DOI":"10.1016\/S0021-9258(19)85326-7","article-title":"Rapid activation of GLUT-1 glucose transporter following inhibition of oxidative phosphorylation in clone 9 cells","volume":"268","author":"Shetty","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2012.09.022_bib12","doi-asserted-by":"crossref","first-page":"C377","DOI":"10.1152\/ajpcell.00060.2003","article-title":"Distribution of Glut1 in detergent-resistant membranes (DRMs) and non-DRM domains: effect of treatment with azide","volume":"285","author":"Rubin","year":"2003","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"10.1016\/j.biochi.2012.09.022_bib13","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.lfs.2005.05.082","article-title":"Methylene blue stimulates 2-deoxyglucose uptake in L929 fibroblast cells","volume":"78","author":"Louters","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00125-007-0853-3","article-title":"Metal-activated C-peptide facilitates glucose clearance and the release of a nitric\u00a0oxide stimulus via the GLUT1 transporter","volume":"51","author":"Meyer","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2012.09.022_bib15","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.biochi.2011.04.013","article-title":"Berberine acutely activates the glucose transport activity of GLUT1","volume":"93","author":"Cok","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2012.09.022_bib16","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.biochi.2010.10.006","article-title":"Effects of cinnamaldehyde on the glucose transport activity of GLUT1","volume":"93","author":"Plaisier","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2012.09.022_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.cbi.2009.08.008","article-title":"Dual action of phenylarsine oxide on the glucose transport activity of GLUT1","volume":"182","author":"Scott","year":"2009","journal-title":"Chemico-Biol. Interact."},{"key":"10.1016\/j.biochi.2012.09.022_bib18","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.biochi.2011.12.005","article-title":"Nitroxyl (HNO) acutely activates the glucose uptake activity of GLUT1","volume":"94","author":"Salie","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2012.09.022_bib19","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1167\/iovs.02-0851","article-title":"Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines","volume":"44","author":"Gipson","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib20","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.1128\/MCB.22.14.5157-5172.2002","article-title":"A\u00a0two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status","volume":"22","author":"Rheinwald","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.biochi.2012.09.022_bib21","doi-asserted-by":"crossref","first-page":"23037","DOI":"10.1074\/jbc.M109.033332","article-title":"Association of cell surface mucins with galectin-3 contributes to the ocular surface epithelial barrier","volume":"284","author":"Argueso","year":"2009","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2012.09.022_bib22","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.exer.2011.09.005","article-title":"Stratified corneal limbal epithelial cells are protected from UVB-induced apoptosis by elevated extracellular K(+)","volume":"93","author":"Schotanus","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2012.09.022_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.exer.2009.02.023","article-title":"Elevated extracellular K+ inhibits apoptosis of corneal epithelial cells exposed to UV-B radiation","volume":"89","author":"Singleton","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2012.09.022_bib24","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1097\/ICO.0b013e31812f6d8e","article-title":"Deviated mechanism of wound healing in diabetic corneas","volume":"26","author":"Chikama","year":"2007","journal-title":"Cornea"},{"key":"10.1016\/j.biochi.2012.09.022_bib25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.brainresbull.2009.08.008","article-title":"Diabetic keratopathy and treatment by modulation of the opioid growth factor (OGF)-OGF receptor (OGFr) axis with naltrexone: a review","volume":"81","author":"McLaughlin","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.biochi.2012.09.022_bib26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1590\/S0004-27492008000700018","article-title":"Tear film and ocular surface changes in diabetes mellitus","volume":"71","author":"Alves","year":"2008","journal-title":"Arq. Bras. Oftalmol."},{"key":"10.1016\/j.biochi.2012.09.022_bib27","doi-asserted-by":"crossref","first-page":"PL215","DOI":"10.1016\/S0024-3205(99)00408-7","article-title":"Inhibition of glucose uptake and suppression of glucose transporter 1 mRNA expression in L929 cells by tumour necrosis factor-alpha","volume":"65","author":"Liong","year":"1999","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib28","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/S0024-3205(03)00119-X","article-title":"Acute effects of troglitazone and nitric oxide on glucose uptake in L929 fibroblast cells","volume":"72","author":"Van Dyke","year":"2003","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2012.09.022_bib29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1021\/bi001660j","article-title":"Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors","volume":"40","author":"Vera","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2012.09.022_bib30","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1248\/bpb.30.2120","article-title":"Berberine activates GLUT1-mediated glucose uptake in 3T3-L1 adipocytes","volume":"30","author":"Kim","year":"2007","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biochi.2012.09.022_bib31","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1016\/j.bbagen.2006.09.007","article-title":"Berberine-stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK","volume":"1760","author":"Cheng","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2012.09.022_bib32","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.metabol.2006.10.025","article-title":"Berberine stimulates glucose transport through a mechanism distinct from insulin","volume":"56","author":"Zhou","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.biochi.2012.09.022_bib33","first-page":"47","article-title":"Intracellular protein glycation in cultured retinal capillary pericytes and endothelial cells exposed to high-glucose concentration","volume":"45","author":"Chibber","year":"1999","journal-title":"Cell. Mol. Biol. (Noisy-le-grand)"},{"key":"10.1016\/j.biochi.2012.09.022_bib34","doi-asserted-by":"crossref","first-page":"8096","DOI":"10.1021\/bi060398x","article-title":"Ultrastructure of human erythrocyte GLUT1","volume":"45","author":"Graybill","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2012.09.022_bib35","doi-asserted-by":"crossref","first-page":"E836","DOI":"10.1152\/ajpendo.00496.2009","article-title":"Will the original glucose transporter isoform please stand up!","volume":"297","author":"Carruthers","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.biochi.2012.09.022_bib36","doi-asserted-by":"crossref","first-page":"9734","DOI":"10.1021\/bi00030a011","article-title":"Glucose transporter function is controlled by transporter oligomeric structure. A single, intramolecular disulfide promotes GLUT1 tetramerization","volume":"34","author":"Zottola","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2012.09.022_bib37","first-page":"141","article-title":"Metabolic genes in cancer: their roles in tumor progression and clinical implications","volume":"1805","author":"Furuta","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2012.09.022_bib38","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1517\/14728220903307509","article-title":"GLUT1 as a therapeutic target in hepatocellular carcinoma","volume":"13","author":"Amann","year":"2009","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/j.biochi.2012.09.022_bib39","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2174\/138955709788922610","article-title":"HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms","volume":"9","author":"Marin-Hernandez","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biochi.2012.09.022_bib40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pharmthera.2008.09.005","article-title":"Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond","volume":"121","author":"Ganapathy","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biochi.2012.09.022_bib41","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1189\/jlb.0108024","article-title":"Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival","volume":"84","author":"Maciver","year":"2008","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.biochi.2012.09.022_bib42","doi-asserted-by":"crossref","first-page":"e23205","DOI":"10.1371\/journal.pone.0023205","article-title":"Modulation of glucose transporter 1 (GLUT1) expression levels alters mouse mammary tumor cell growth in\u00a0vitro and in\u00a0vivo","volume":"6","author":"Young","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2012.09.022_bib43","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/jcp.20166","article-title":"Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer","volume":"202","author":"Macheda","year":"2005","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.biochi.2012.09.022_bib44","doi-asserted-by":"crossref","first-page":"C530","DOI":"10.1152\/ajpcell.00145.2012","article-title":"Non-competitive blocking of human Glut1 hexose transporter by Methylxanthines reveals an exofacial regulatory binding site","author":"Ojeda","year":"2012","journal-title":"Am. J. Physiol. Cell. Physiol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090841200380X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090841200380X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:06:40Z","timestamp":1759540000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030090841200380X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S030090841200380X"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2012.09.022","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential regulation of GLUT1 activity in human corneal limbal epithelial cells and fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2012.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}