{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T12:31:58Z","timestamp":1771072318777,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100005815","name":"Firland Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005815","id-type":"DOI","asserted-by":"crossref"}]},{"name":"BSF","award":["2008017"],"award-info":[{"award-number":["2008017"]}]},{"name":"National Institute of Health (NIH)","award":["AI090048"],"award-info":[{"award-number":["AI090048"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.biochi.2013.02.011","type":"journal-article","created":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T14:11:37Z","timestamp":1361887897000},"page":"1319-1325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3\u2033)-Ii\/AAC(6\u2032)-IId from Serratia marcescens"],"prefix":"10.1016","volume":"95","author":[{"given":"Keith D.","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Garneau-Tsodikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2013.02.011_bib1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s00253-005-0279-0","article-title":"Molecular understanding of aminoglycoside action and resistance","volume":"70","author":"Jana","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.biochi.2013.02.011_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.drup.2010.08.003","article-title":"Aminoglycoside modifying enzymes","volume":"13","author":"Ramirez","year":"2010","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.biochi.2013.02.011_bib3","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/cbic.200900779","article-title":"The future of aminoglycosides: the end or renaissance?","volume":"11","author":"Houghton","year":"2010","journal-title":"Chembiochem"},{"key":"10.1016\/j.biochi.2013.02.011_bib4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2007.06.049","article-title":"A\u00a0common mechanism of cellular death induced by bactericidal antibiotics","volume":"130","author":"Kohanski","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2013.02.011_bib5","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1021\/bi060723g","article-title":"Characterization of the bifunctional aminoglycoside-modifying enzyme ANT(3\u2032)-Ii\/AAC(6\u2032)-IId from Serratia marcescens","volume":"45","author":"Kim","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2013.02.011_bib6","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/AAC.46.5.1402-1409.2002","article-title":"Presence of a group II intron in a multiresistant Serratia marcescens strain that harbors three integrons and a novel gene fusion","volume":"46","author":"Centron","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1074-5521(99)80006-4","article-title":"Prodigious substrate specificity of AAC(6\u2032)-APH(2\"), an aminoglycoside antibiotic resistance determinant in enterococci and staphylococci","volume":"6","author":"Daigle","year":"1999","journal-title":"Chem. Biol."},{"key":"10.1016\/j.biochi.2013.02.011_bib8","doi-asserted-by":"crossref","first-page":"D1","DOI":"10.2741\/culebras","article-title":"Aminoglycoside resistance mediated by the bifunctional enzyme 6\u2032-N-aminoglycoside acetyltransferase-2\"-O-aminoglycoside phosphotransferase","volume":"4","author":"Culebras","year":"1999","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biochi.2013.02.011_bib9","doi-asserted-by":"crossref","first-page":"43262","DOI":"10.1074\/jbc.M112.416453","article-title":"Revisiting the nucleotide and aminoglycoside substrate specificity of the bifunctional aminoglycoside Acetyltransferase(6\u2032)-ie\/aminoglycoside Phosphotransferase(2\")-ia enzyme","volume":"287","author":"Frase","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2013.02.011_bib10","doi-asserted-by":"crossref","first-page":"5270","DOI":"10.1021\/bi700111z","article-title":"Mechanistic characterization of the bifunctional aminoglycoside-modifying enzyme AAC(3)-Ib\/AAC(6\u2032)-Ib\u2032 from Pseudomonas aeruginosa","volume":"46","author":"Kim","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2013.02.011_bib11","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1128\/AAC.46.3.638-645.2002","article-title":"Molecular characterization of a novel class 1 integron containing bla(GES-1) and a fused product of aac3-Ib\/aac6\u2032-Ib\u2032 gene cassettes in Pseudomonas aeruginosa","volume":"46","author":"Dubois","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.mib.2009.06.013","article-title":"The bifunctional enzymes of antibiotic resistance","volume":"12","author":"Zhang","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.biochi.2013.02.011_bib13","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1128\/AAC.48.12.4693-4702.2004","article-title":"Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6\u2032)-30\/aac(6\u2032)-Ib\u2032: report from the SENTRY Antimicrobial Surveillance Program","volume":"48","author":"Mendes","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib14","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1128\/AAC.00312-11","article-title":"Effects of altering aminoglycoside structures on bacterial resistance enzyme activities","volume":"55","author":"Green","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib15","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1021\/ja964278w","article-title":"Properties of a bifunctional bacterial antibiotic resistance enzyme that catalyzes ATP-dependent 2\"-phosphorylation and acetyl-CoA-dependent 6\u2032-acetylation of aminoglycosides","volume":"119","author":"Azucena","year":"1997","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biochi.2013.02.011_bib16","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1039\/c0ob01133a","article-title":"Assessment of 6\u2033- and 6\u2033\u2033-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance","volume":"9","author":"Shaul","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.biochi.2013.02.011_bib17","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1111\/j.1742-4658.2008.06460.x","article-title":"Hexameric ring structure of the N-terminal domain of Mycobacterium tuberculosis DnaB helicase","volume":"275","author":"Biswas","year":"2008","journal-title":"Febs J."},{"key":"10.1016\/j.biochi.2013.02.011_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/cbic.200900584","article-title":"Exploring the substrate promiscuity of drug-modifying enzymes for the chemoenzymatic generation of N-acylated aminoglycosides","volume":"11","author":"Green","year":"2010","journal-title":"ChemBioChem"},{"key":"10.1016\/j.biochi.2013.02.011_bib19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.ab.2008.12.014","article-title":"A\u00a0nonradioactive high-throughput assay for screening and characterization of adenylation domains for nonribosomal peptide combinatorial biosynthesis","volume":"386","author":"McQuade","year":"2009","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biochi.2013.02.011_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2010.10.119","article-title":"Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4 \u2032)","volume":"403","author":"Porter","year":"2010","journal-title":"Biochem. Biophys Res. Commun."},{"key":"10.1016\/j.biochi.2013.02.011_bib21","doi-asserted-by":"crossref","first-page":"9846","DOI":"10.1021\/bi049135y","article-title":"Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6\u2032)-APH(2\u2032)","volume":"43","author":"Boehr","year":"2004","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2013.02.011_bib22","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1128\/AAC.06378-11","article-title":"Small-angle X-ray scattering analysis of the bifunctional antibiotic resistance enzyme aminoglycoside (6\u2032) acetyltransferase-ie\/aminoglycoside (2\u2032) phosphotransferase-ia reveals a rigid solution structure","volume":"56","author":"Caldwell","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib23","doi-asserted-by":"crossref","first-page":"5831","DOI":"10.1128\/AAC.00932-12","article-title":"Cosubstrate Tolerance of the aminoglycoside resistance enzyme Eis from Mycobacterium tuberculosis","volume":"56","author":"Chen","year":"2012","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib24","doi-asserted-by":"crossref","first-page":"13305","DOI":"10.1021\/bi00041a005","article-title":"Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase","volume":"34","author":"Pedersen","year":"1995","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2013.02.011_bib25","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1021\/ja076835s","article-title":"NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4\u2032): the pattern of OH\/NH3(+) substitution determines the preferred antibiotic binding mode and is critical for drug inactivation","volume":"130","author":"Revuelta","year":"2008","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biochi.2013.02.011_bib26","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1128\/AAC.34.12.2381","article-title":"Appearance of amikacin and tobramycin resistance due to 4\u2032-aminoglycoside nucleotidyltransferase [ANT(4\u2032)-II] in gram-negative pathogens","volume":"34","author":"Jacoby","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.biochi.2013.02.011_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/embor.2008.9","article-title":"Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance","volume":"9","author":"Maurice","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biochi.2013.02.011_bib28","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.chembiol.2004.03.017","article-title":"A\u00a0bacterial acetyltransferase capable of regioselective N-acetylation of antibiotics and histones","volume":"11","author":"Vetting","year":"2004","journal-title":"Chem. Biol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908413000680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908413000680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,18]],"date-time":"2018-10-18T12:01:50Z","timestamp":1539864110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908413000680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0300908413000680"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2013.02.011","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3\u2033)-Ii\/AAC(6\u2032)-IId from Serratia marcescens","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2013.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}