{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:13:37Z","timestamp":1772774017772,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"College of Pharmacy-specialized Research Fund (from the Institute for New Drug Development) of Keimyung University"},{"name":"Ministry of Science, ICT & Future Planning","award":["NRF-2013R1A1A1062064"],"award-info":[{"award-number":["NRF-2013R1A1A1062064"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.biochi.2014.07.003","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T23:31:22Z","timestamp":1405467082000},"page":"129-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells"],"prefix":"10.1016","volume":"105","author":[{"given":"Byoungduck","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2014.07.003_bib1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.biochi.2014.07.003_bib2","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2014.07.003_bib3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molmed.2005.11.007","article-title":"RANKL-RANK signaling in osteoclastogenesis and bone disease","volume":"12","author":"Wada","year":"2006","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biochi.2014.07.003_bib4","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/16852","article-title":"OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis","volume":"397","author":"Kong","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2014.07.003_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/bjc.1987.13","article-title":"The clinical course of bone metastases from breast cancer","volume":"55","author":"Coleman","year":"1987","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biochi.2014.07.003_bib6","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nrc867","article-title":"Metastasis to bone: causes, consequences and therapeutic opportunities","volume":"2","author":"Mundy","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biochi.2014.07.003_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease: clinical features, pathophysiology and treatment strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.biochi.2014.07.003_bib8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2014.07.003_bib9","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1074\/jbc.M009713200","article-title":"Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway","volume":"276","author":"Chang","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib10","first-page":"65","article-title":"Triptolide inhibits the growth and metastasis of solid tumors","volume":"2","author":"Yang","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.biochi.2014.07.003_bib11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0304-3835(96)04554-5","article-title":"Evaluation of the mutagenic, cytotoxic, and antitumor potential of triptolide, a highly oxygenated diterpene isolated from Tripterygium wilfordii","volume":"112","author":"Shamon","year":"1997","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biochi.2014.07.003_bib12","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1158\/1078-0432.CCR-07-0416","article-title":"Enhanced antitumor effect of combined triptolide and ionizing radiation","volume":"13","author":"Wang","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biochi.2014.07.003_bib13","doi-asserted-by":"crossref","first-page":"11395","DOI":"10.1074\/jbc.M411189200","article-title":"Prostaglandin E2 enhances osteoclastic differentiation of precursor cells through protein kinase A-dependent phosphorylation of TAK1","volume":"280","author":"Kobayashi","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib14","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1006\/bbrc.1999.2008","article-title":"Interactions between cancer and bone marrow cells induce osteoclast differentiation factor expression and osteoclast-like cell formation in\u00a0vitro","volume":"267","author":"Chikatsu","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2014.07.003_bib15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1365-2141.2004.05018.x","article-title":"Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblast pathway of osteoclast stimulation","volume":"126","author":"Lai","year":"2004","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.biochi.2014.07.003_bib16","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1172\/JCI11685","article-title":"Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone","volume":"107","author":"Zhang","year":"2001","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.biochi.2014.07.003_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nm1519","article-title":"NF-kappaB in breast cancer cells promotes osteolytic bone metastasis by inducing osteoclastogenesis via GM-CSF","volume":"13","author":"Park","year":"2007","journal-title":"Nat. Med."},{"issue":"Suppl.","key":"10.1016\/j.biochi.2014.07.003_bib18","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0092-8674(02)00703-1","article-title":"Missing pieces in the NF-kappaB puzzle","volume":"109","author":"Ghosh","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2014.07.003_bib19","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1210\/endo.142.3.8031","article-title":"Receptor activator of nuclear factor-kappa b ligand activates nuclear factor-kappa b in osteoclast precursors","volume":"142","author":"Wei","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2014.07.003_bib20","doi-asserted-by":"crossref","first-page":"21132","DOI":"10.1074\/jbc.273.33.21132","article-title":"NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation","volume":"273","author":"Uhlik","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib21","doi-asserted-by":"crossref","first-page":"37219","DOI":"10.1074\/jbc.C400258200","article-title":"The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis","volume":"279","author":"Dai","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ccr.2004.09.003","article-title":"Nuclear factor-kappaB: the enemy within","volume":"6","author":"Aggarwal","year":"2004","journal-title":"Cancer Cell."},{"key":"10.1016\/j.biochi.2014.07.003_bib23","doi-asserted-by":"crossref","first-page":"7724","DOI":"10.1074\/jbc.274.12.7724","article-title":"Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif","volume":"274","author":"Darnay","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib24","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1074\/jbc.M008198200","article-title":"Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways","volume":"276","author":"Zhang","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib25","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1073\/pnas.96.7.3540","article-title":"Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand","volume":"96","author":"Hsu","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biochi.2014.07.003_bib26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1359\/jbmr.2002.17.4.612","article-title":"Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand","volume":"17","author":"Yamamoto","year":"2002","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.biochi.2014.07.003_bib27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S8756-3282(99)00105-2","article-title":"Required and nonessential functions of nuclear factor-kappa B in bone cells","volume":"25","author":"Boyce","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.biochi.2014.07.003_bib28","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/nm1197-1285","article-title":"Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2","volume":"3","author":"Iotsova","year":"1997","journal-title":"Nat. Med."},{"key":"10.1016\/j.biochi.2014.07.003_bib29","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1101\/gad.11.24.3482","article-title":"Requirement for NF-kappaB in osteoclast and B-cell development","volume":"11","author":"Franzoso","year":"1997","journal-title":"Genes. Dev."},{"key":"10.1016\/j.biochi.2014.07.003_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","article-title":"Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation","volume":"93","author":"Lacey","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2014.07.003_bib31","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1084\/jem.186.12.2075","article-title":"TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor","volume":"186","author":"Wong","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.biochi.2014.07.003_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.4049\/jimmunol.163.1.434","article-title":"Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function","volume":"163","author":"Jimi","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.biochi.2014.07.003_bib33","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1359\/jbmr.2002.17.7.1200","article-title":"NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis","volume":"17","author":"Xing","year":"2002","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.biochi.2014.07.003_bib34","doi-asserted-by":"crossref","first-page":"30499","DOI":"10.1074\/jbc.M104725200","article-title":"TAT fusion proteins containing tyrosine 42-deleted IkappaBalpha arrest osteoclastogenesis","volume":"276","author":"Abu-Amer","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.07.003_bib35","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.4049\/jimmunol.171.10.5547","article-title":"Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis","volume":"171","author":"Clohisy","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.biochi.2014.07.003_bib36","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1158\/1078-0432.162.11.1","article-title":"Expression of receptor activator of nuclear factor-kappaB is inversely correlated with metastatic phenotype in breast carcinoma","volume":"11","author":"Bhatia","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biochi.2014.07.003_bib37","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1182\/blood-2003-06-2151","article-title":"Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis","volume":"103","author":"Bharti","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.biochi.2014.07.003_bib38","doi-asserted-by":"crossref","first-page":"10137","DOI":"10.1073\/pnas.0403621101","article-title":"NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis","volume":"101","author":"Biswas","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biochi.2014.07.003_bib39","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1093\/jnci\/91.22.1956","article-title":"Inhibition of NF-kappaB, clonogenicity, and radiosensitivity of human cancer cells","volume":"91","author":"Pajonk","year":"1999","journal-title":"J.\u00a0Natl. Cancer Inst."},{"key":"10.1016\/j.biochi.2014.07.003_bib40","first-page":"5438","article-title":"Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in\u00a0vitro and correlates with bone destruction in\u00a0vivo","volume":"63","author":"Farrugia","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.biochi.2014.07.003_bib41","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1182\/blood.V98.13.3527","article-title":"Myeloma cells induce imbalance in the osteoprotegerin\/osteoprotegerin ligand system in the human bone marrow environment","volume":"98","author":"Giuliani","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.biochi.2014.07.003_bib42","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/jsre.2001.6204","article-title":"Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells","volume":"100","author":"Mancino","year":"2001","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.biochi.2014.07.003_bib43","doi-asserted-by":"crossref","unstructured":"Zhao X., Sun X., Gao F., Luo J., Sun Z., Effects of ulinastatin and docataxel on breast tumor growth and expression of IL-6, IL-8, and TNF-alpha, J. Exp. Clin. Cancer Res. 30, 22.","DOI":"10.1186\/1756-9966-30-22"},{"key":"10.1016\/j.biochi.2014.07.003_bib44","doi-asserted-by":"crossref","first-page":"L958","DOI":"10.1152\/ajplung.2000.279.5.L958","article-title":"Anti-inflammatory effects of triptolide in human bronchial epithelial cells","volume":"279","author":"Zhao","year":"2000","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.biochi.2014.07.003_bib45","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1097\/00001756-200305230-00037","article-title":"Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures","volume":"14","author":"Zhou","year":"2003","journal-title":"Neuroreport"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908414001813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908414001813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T08:02:32Z","timestamp":1689408152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908414001813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":45,"alternative-id":["S0300908414001813"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2014.07.003","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triptolide, a diterpene, inhibits osteoclastogenesis, induced by RANKL signaling and human cancer cells","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2014.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}