{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:51:54Z","timestamp":1788871914942,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Hamdard National Foundation (HNF), Jamia Hamdard, New Delhi"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.biochi.2014.08.006","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T04:04:06Z","timestamp":1408507446000},"page":"101-110","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats"],"prefix":"10.1016","volume":"106","author":[{"given":"Amjid","family":"Ahad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd","family":"Mujeeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haseeb","family":"Ahsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waseem Ahmad","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2014.08.006_bib1","doi-asserted-by":"crossref","first-page":"202S","DOI":"10.1016\/S0895-7061(97)00154-4","article-title":"Pathogenesis and course of renal disease in IDDM\/NIDDM: differences and similarities","volume":"10","author":"Ritz","year":"1997","journal-title":"Am. J. Hypertens."},{"key":"10.1016\/j.biochi.2014.08.006_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biochi.2014.08.006_bib3","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11892-006-0080-1","article-title":"Inflammation and diabetic nephropathy","volume":"6","author":"Mora","year":"2006","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.biochi.2014.08.006_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1440-1797.2006.00576.x","article-title":"Macrophage accumulation in human progressive diabetic nephropathy","volume":"11","author":"Nguyen","year":"2006","journal-title":"Nephrol. Carlt."},{"key":"10.1016\/j.biochi.2014.08.006_bib5","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1093\/ndt\/gfh441","article-title":"Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis","volume":"19","author":"Chow","year":"2004","journal-title":"Nephrol. Dial. Transpl."},{"key":"10.1016\/j.biochi.2014.08.006_bib6","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1681\/ASN.V134894","article-title":"Role of high glucose-induced nuclear factor-kappaB activation in monocyte chemoattractant protein-1 expression by mesangial cells","volume":"13","author":"Ha","year":"2002","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2014.08.006_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1517\/14728222.8.5.401","article-title":"Role of oxidative stress and inflammation in the origin of Type 2 diabetes \u2013 a paradigm shift","volume":"8","author":"Pillarisetti","year":"2004","journal-title":"Exp. Opin. Ther. Target"},{"key":"10.1016\/j.biochi.2014.08.006_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.bbadis.2008.01.009","article-title":"High glucose induction of DNA-binding activity of the transcription factor NF\u03baB in patients with diabetic nephropathy","volume":"1782","author":"Yang","year":"2008","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.biochi.2014.08.006_bib9","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s001250051567","article-title":"High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent","volume":"43","author":"Park","year":"2000","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2014.08.006_bib10","first-page":"45","article-title":"Alternative therapies for type 2 diabetes","volume":"7","author":"Dey","year":"2002","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.biochi.2014.08.006_bib11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1038\/sj.ijo.0803563","article-title":"Adiponectin gene expression and adipocyte NF-kappaB transcriptional activity in elderly overweight and obese women: inter-relationships with fat distribution, hs-CRP, leptin and insulin resistance","volume":"31","author":"Zamboni","year":"2007","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biochi.2014.08.006_bib12","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0891-5849(00)00304-X","article-title":"Potential health impacts of excessive flavonoid intake","volume":"29","author":"Skibola","year":"2000","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2014.08.006_bib13","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0304-4165(99)00152-X","article-title":"Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi","volume":"1472","author":"Gao","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2014.08.006_bib14","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-2999(03)01378-5","article-title":"Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes","volume":"465","author":"Shen","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biochi.2014.08.006_bib15","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1142\/S0192415X96000050","article-title":"The anti-inflammatory activity of Scutellaria rivularis extracts and its active components, baicalin, baicalein and wogonin","volume":"24","author":"Lin","year":"1996","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.biochi.2014.08.006_bib16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mce.2012.06.002","article-title":"Baicalein, a natural product, selectively activating AMPKalpha(2) and ameliorates metabolic disorder in diet-induced mice","volume":"362","author":"Pu","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biochi.2014.08.006_bib17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.pbb.2010.07.007","article-title":"Baicalein is neuroprotective in rat MCAO model: role of 12\/15-lipoxygenase, mitogen-activated protein kinase and cytosolic phospholipase A2","volume":"96","author":"Cui","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.biochi.2014.08.006_bib18","series-title":"A\u00a0Text Book of Practical Physiology","first-page":"119","author":"Ghai","year":"1990"},{"key":"10.1016\/j.biochi.2014.08.006_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A\u00a0rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biochi.2014.08.006_bib20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.biochi.2014.08.006_bib21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.biochi.2014.08.006_bib22","series-title":"CRC Handbook of Methods in Oxygen Radical Research","first-page":"283","article-title":"Catalase activity","author":"Claiborne","year":"1985"},{"key":"10.1016\/j.biochi.2014.08.006_bib23","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1111\/j.1523-1755.2005.00727.x","article-title":"Kidney involvement in a nongenetic rat model of type 2 diabetes","volume":"68","author":"Danda","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib24","first-page":"237","article-title":"Alpha-tocopherol protects against the renal damage caused by potassium dichromate","volume":"218","author":"Arreola-Mendoza","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.biochi.2014.08.006_bib25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.biochi.2014.08.006_bib26","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/0006-2952(84)90353-8","article-title":"Differential distribution of glutathione and glutathione-related enzymes in rabbit kidney. Possible implications in analgesic nephropathy","volume":"33","author":"Mohandas","year":"1984","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2014.08.006_bib27","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1016\/S0021-9258(19)41206-4","article-title":"Purification and characterization of the flavoenzyme glutathione reductase from rat liver","volume":"250","author":"Carlberg","year":"1975","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.08.006_bib28","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.taap.2013.09.004","article-title":"Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-\u03b2 expression","volume":"273","author":"Siddiqui","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.biochi.2014.08.006_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cbi.2014.05.011","article-title":"Ellagic acid, an NF-\u03baB inhibitor, ameliorates renal function in experimental diabetic nephropathy","volume":"219","author":"Ahad","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biochi.2014.08.006_bib30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.1523-1755.2000.00836.x","article-title":"Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes","volume":"57","author":"Coimbra","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib31","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.lfs.2008.12.014","article-title":"Attenuation of diabetic nephropathy by tocotrienol: involvement of NFkB signaling pathway","volume":"84","author":"Kuhad","year":"2009","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2014.08.006_bib32","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1021\/np980163p","article-title":"Baicalein, an alpha-glucosidase inhibitor from Scutellaria baicalensis","volume":"61","author":"Nishioka","year":"1998","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.biochi.2014.08.006_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.expneurol.2011.04.002","article-title":"Baicalein alleviates diabetic peripheral neuropathy through inhibition of oxidative-nitrosative stress and p38 MAPK activation","volume":"230","author":"Stavniichuk","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biochi.2014.08.006_bib34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/ki.1995.262","article-title":"Glomerular actions of nitric oxide","volume":"48","author":"Raij","year":"1995","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib35","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1046\/j.1523-1755.2000.00220.x","article-title":"Renal nitric oxide production during the early phase of experimental diabetes mellitus","volume":"58","author":"Keynan","year":"2000","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/cs0900379","article-title":"Nitric oxide in streptozotocin-induced diabetes mellitus in rats","volume":"90","author":"Maree","year":"1996","journal-title":"Clin. Sci. Lond."},{"key":"10.1016\/j.biochi.2014.08.006_bib37","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ki.1992.370","article-title":"Thromboxane in the pathogenesis of glomerular injury in diabetes","volume":"42","author":"Craven","year":"1992","journal-title":"Kidney Int."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.biochi.2014.08.006_bib38","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2337\/diab.32.2.S34","article-title":"Polyantigenic expansion of basement membrane constituents in diabetic nephropathy","volume":"32","author":"Falk","year":"1983","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2014.08.006_bib39","first-page":"889","article-title":"Immunohistochemical localization of extracellular matrix components in human diabetic glomerular lesions","volume":"139","author":"Nerlich","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2014.08.006_bib40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1523-1755.1999.00590.x","article-title":"Molecular mechanisms of diabetic renal hypertrophy","volume":"56","author":"Wolf","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib41","doi-asserted-by":"crossref","first-page":"e62068","DOI":"10.1371\/journal.pone.0062068","article-title":"Celastrol, an NF-kappaB inhibitor, improves insulin resistance and attenuates renal injury in db\/db mice","volume":"8","author":"Kim","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.biochi.2014.08.006_bib42","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.2353\/ajpath.2006.050701","article-title":"Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective intervention","volume":"168","author":"Macconi","year":"2006","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.biochi.2014.08.006_bib43","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.2337\/db12-1562","article-title":"Antidiabetic actions of an estrogen receptor \u03b2 selective agonist","volume":"62","author":"Alonso-Magdalena","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2014.08.006_bib44","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1681\/ASN.V93433","article-title":"TNF-alpha increases albumin permeability of isolated rat glomeruli through the generation of superoxide","volume":"9","author":"McCarthy","year":"1998","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2014.08.006_bib45","first-page":"336","article-title":"Tumor necrosis factor in renal injury","volume":"21","author":"Baud","year":"1995","journal-title":"Miner. Electrol. Metabol."},{"key":"10.1016\/j.biochi.2014.08.006_bib46","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s004670200004","article-title":"Chronic diabetic nephropathy: role of inducible nitric oxide synthase","volume":"17","author":"Trachtman","year":"2002","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.biochi.2014.08.006_bib47","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1046\/j.1523-1755.1998.00119.x","article-title":"Transcriptional activation of transforming growth factor-beta1 in mesangial cell culture by high glucose concentration","volume":"54","author":"Hoffman","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib48","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0027-5107(01)00183-X","article-title":"Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation","volume":"480\u2013481","author":"Surh","year":"2001","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biochi.2014.08.006_bib49","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1042\/CS20120198","article-title":"Inflammation and the pathogenesis of diabetic nephropathy","volume":"124","author":"Wada","year":"2013","journal-title":"Clin. Sci. Lond."},{"key":"10.1016\/j.biochi.2014.08.006_bib50","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1046\/j.1523-1755.2002.00384.x","article-title":"Microangiopathic injury and augmented PAI-1 in human diabetic nephropathy","volume":"61","author":"Paueksakon","year":"2002","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.08.006_bib51","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1055\/s-2007-948213","article-title":"Association of low-grade inflammation with nephropathy in type 2 diabetic patients: role of elevated CRP-levels and 2 different gene-polymorphisms of proinflammatory cytokines","volume":"115","author":"Abrahamian","year":"2007","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.biochi.2014.08.006_bib52","first-page":"1","article-title":"Role of TNF and IL-1 in the development of diabetic nephropathy","volume":"5","author":"Hasegawa","year":"1995","journal-title":"Nefrologia"},{"key":"10.1016\/j.biochi.2014.08.006_bib53","doi-asserted-by":"crossref","first-page":"450","DOI":"10.2337\/diab.42.3.450","article-title":"mRNA expression of growth factors in glomeruli from diabetic rats","volume":"42","author":"Nakamura","year":"1993","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2014.08.006_bib54","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.2174\/092986710793348581","article-title":"Oxidative stress in diabetic nephropathy","volume":"17","author":"Kashihara","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biochi.2014.08.006_bib55","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/phrs.2000.0761","article-title":"Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells","volume":"43","author":"Gao","year":"2001","journal-title":"Pharmacol. Res."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908414002247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908414002247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T22:48:11Z","timestamp":1649976491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908414002247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":55,"alternative-id":["S0300908414002247"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2014.08.006","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2014.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. and Soci\u00e9t\u00e9 fran\u00e7aise de biochimie et biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}