{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:50:02Z","timestamp":1789469402999,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Institute of Pharmaceutical Education and Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.biochi.2014.12.015","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T02:18:24Z","timestamp":1420424304000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":82,"special_numbering":"C","title":["Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-\u03baB\/iNOS signaling in diabetic rat"],"prefix":"10.1016","volume":"110","author":[{"given":"Sabbir","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopabandhu","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kulbhushan","family":"Tikoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2014.12.015_bib1","first-page":"S21","article-title":"The evaluation of diabetic nephropathy: preventing complications","volume":"1","author":"Tuttle","year":"2010","journal-title":"Adv. Stud. Med."},{"key":"10.1016\/j.biochi.2014.12.015_bib2","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1681\/ASN.2006040377","article-title":"How does proteinuria cause progressive renal damage?","volume":"17","author":"Abbate","year":"2006","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2014.12.015_bib3","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.ki.5000410","article-title":"The podocyte's response to injury: role in proteinuria and glomerulosclerosis","volume":"69","author":"Shankland","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.12.015_bib4","doi-asserted-by":"crossref","first-page":"e60546","DOI":"10.1371\/journal.pone.0060546","article-title":"Autophagy attenuates diabetic glomerular damage through protection of hyperglycemia-induced podocyte injury","volume":"8","author":"Fang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.biochi.2014.12.015_bib5","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1172\/JCI39492","article-title":"Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice","volume":"120","author":"Hartleben","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.biochi.2014.12.015_bib6","first-page":"193757","article-title":"The role of autophagy in the pathogenesis of diabetic nephropathy","volume":"2013","author":"Yamahara","year":"2013","journal-title":"J.\u00a0Diabetes Res."},{"key":"10.1016\/j.biochi.2014.12.015_bib7","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.semnephrol.2013.11.003","article-title":"Autophagy: emerging therapeutic target for diabetic nephropathy","volume":"34","author":"Kume","year":"2014","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.biochi.2014.12.015_bib8","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1126\/science.1099993","article-title":"Autophagy in health and disease: a double-edged sword","volume":"306","author":"Shintani","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biochi.2014.12.015_bib9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1038\/ki.2011.39","article-title":"Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor","volume":"79","author":"Gilbert","year":"2011","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.12.015_bib10","first-page":"227","article-title":"Environmental factors and primary prevention in type 1 diabetes","volume":"15","author":"Ilonen","year":"2009","journal-title":"Pediatr. Endocrinol. Diabetes Metab."},{"key":"10.1016\/j.biochi.2014.12.015_bib11","doi-asserted-by":"crossref","first-page":"F14","DOI":"10.1152\/ajprenal.00200.2010","article-title":"The role of epigenetics in the pathology of diabetic complications","volume":"299","author":"Villeneuve","year":"2010","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biochi.2014.12.015_bib12","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1038\/sj.ki.5002388","article-title":"Histone deacetylase inhibitors: a novel class of therapeutic agents in diabetic nephropathy","author":"Lee","year":"2007","journal-title":"Kidney Int. Suppl."},{"key":"10.1016\/j.biochi.2014.12.015_bib13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biochi.2014.12.015_bib14","doi-asserted-by":"crossref","first-page":"4705","DOI":"10.1016\/S0021-9258(17)37600-7","article-title":"Role of transcription factor NF-kappa B\/Rel in induction of nitric oxide synthase","volume":"269","author":"Xie","year":"1994","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2014.12.015_bib15","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1053\/gast.2001.23239","article-title":"NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis","volume":"120","author":"Hatano","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biochi.2014.12.015_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.14712\/fb2007053020037","article-title":"Valproic acid, a molecular lead to multiple regulatory pathways","volume":"53","author":"Kostrouchova","year":"2007","journal-title":"Folia Biol. (Praha)"},{"key":"10.1016\/j.biochi.2014.12.015_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","volume":"2010","author":"Chateauvieux","year":"2010","journal-title":"J.\u00a0Biomed. Biotechnol."},{"key":"10.1016\/j.biochi.2014.12.015_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.fct.2014.08.010","article-title":"Sodium butyrate, a HDAC inhibitor ameliorates eNOS, iNOS and TGF-beta1-induced fibrogenesis, apoptosis and DNA damage in the kidney of juvenile diabetic rats","volume":"73c","author":"Khan","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biochi.2014.12.015_bib19","doi-asserted-by":"crossref","first-page":"F729","DOI":"10.1152\/ajprenal.00086.2009","article-title":"Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury","volume":"297","author":"Noh","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biochi.2014.12.015_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1126\/science.1216990","article-title":"Function and molecular mechanism of acetylation in autophagy regulation","volume":"336","author":"Yi","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.biochi.2014.12.015_bib21","doi-asserted-by":"crossref","first-page":"6561","DOI":"10.1073\/pnas.1204429109","article-title":"Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death","volume":"109","author":"Gammoh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2014.12.015_bib22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ki.2014.111","article-title":"Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy","volume":"86","author":"Wang","year":"2014","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2014.12.015_bib23","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"Gottlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.biochi.2014.12.015_bib24","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1681\/ASN.2010111196","article-title":"Valproic acid attenuates proteinuria and kidney injury","volume":"22","author":"Van Beneden","year":"2011","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2014.12.015_bib25","first-page":"2682","article-title":"Valproic acid attenuates the multiple-organ dysfunction in a rat model of septic shock","volume":"123","author":"Shang","year":"2010","journal-title":"Chin. Med. J. (Engl.)"},{"key":"10.1016\/j.biochi.2014.12.015_bib26","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1007\/s00018-008-8521-4","article-title":"Valproic acid attenuates inflammation in experimental autoimmune neuritis","volume":"65","author":"Zhang","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biochi.2014.12.015_bib27","first-page":"1","article-title":"Sodium valproate, a histone deacetylase inhibitor ameliorates cyclophosphamide-induced genotoxicity and cytotoxicity in the colon of mice","author":"Khan","year":"2014","journal-title":"J.\u00a0Basic Clin. Physiol. Pharmacol."},{"key":"10.1016\/j.biochi.2014.12.015_bib28","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuroscience.2012.07.013","article-title":"Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats","volume":"221","author":"Zhang","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.biochi.2014.12.015_bib29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bcp.2014.02.004","article-title":"Valproic acid suppresses lipopolysaccharide-induced cyclooxygenase-2 expression via MKP-1 in murine brain microvascular endothelial cells","volume":"88","author":"Chuang","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2014.12.015_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.intimp.2013.06.027","article-title":"Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-kappaB nuclear translocation","volume":"17","author":"Zhong","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biochi.2014.12.015_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.reprotox.2011.09.007","article-title":"Investigation on sodium valproate induced germ cell damage, oxidative stress and genotoxicity in male Swiss mice","volume":"32","author":"Khan","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.biochi.2014.12.015_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.bjc.6603851","article-title":"Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial","volume":"97","author":"Atmaca","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.biochi.2014.12.015_bib33","first-page":"68","article-title":"Effect of sodium valproate on the toxicity of cyclophosphamide in the testes of mice: influence of pre- and post-treatment schedule","volume":"70","author":"Khan","year":"2013","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.biochi.2014.12.015_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.mrgentox.2014.04.020","article-title":"Influence of 3-aminobenzamide, an inhibitor of poly(ADP-ribose)polymerase, in the evaluation of the genotoxicity of doxorubicin, cyclophosphamide and zidovudine in female mice","volume":"770","author":"Yadav","year":"2014","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.biochi.2014.12.015_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1177\/0960327114531992","article-title":"Valproate ameliorates thioacetamide-induced fibrosis by hepatic stellate cell inactivation","volume":"34","author":"Aher","year":"2015","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biochi.2014.12.015_bib36","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.mrgentox.2012.10.009","article-title":"Pretreatment with valproic acid, a histone deacetylase inhibitor, enhances the sensitivity of the peripheral blood micronucleus assay in rodents","volume":"751","author":"Ahmad","year":"2013","journal-title":"Mutat. Res."},{"key":"10.1016\/j.biochi.2014.12.015_bib37","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.bbrc.2014.02.055","article-title":"Zinc protects cyclophosphamide-induced testicular damage in rat: involvement of metallothionein, tesmin and Nrf2","volume":"445","author":"Maremanda","year":"2014","journal-title":"Biochem.. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2014.12.015_bib38","first-page":"1","article-title":"Pre-pubertal exposure of cytarabine-induced testicular atrophy, impaired spermatogenesis and germ cell DNA damage in SD rats","author":"Namoju","year":"2014","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.biochi.2014.12.015_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2014.02.001","article-title":"Protective role of sodium butyrate, a HDAC inhibitor on beta-cell proliferation, function and glucose homeostasis through modulation of p38\/ERK MAPK and apoptotic pathways: study in juvenile diabetic rat","volume":"213","author":"Khan","year":"2014","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biochi.2014.12.015_bib40","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2174\/0929867053363207","article-title":"Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies","volume":"12","author":"Pacher","year":"2005","journal-title":"Curr. Med. Chem."},{"issue":"Pt 2","key":"10.1016\/j.biochi.2014.12.015_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/bj2980249","article-title":"Nitric oxide synthases in mammals","volume":"298","author":"Knowles","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/j.biochi.2014.12.015_bib42","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1900\/RDS.2005.2.19","article-title":"Proteomic identification and immunolocalization of increased renal calbindin-D28k expression in OVE26 diabetic mice","volume":"2","author":"Thongboonkerd","year":"2005","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.biochi.2014.12.015_bib43","doi-asserted-by":"crossref","first-page":"F1182","DOI":"10.1152\/ajprenal.00268.2006","article-title":"Profiling of human mesangial cell subproteomes reveals a role for calmodulin in glucose uptake","volume":"292","author":"Ramachandra Rao","year":"2007","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biochi.2014.12.015_bib44","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1681\/ASN.2005121355","article-title":"Wnt\/beta-catenin signaling modulates survival of high glucose-stressed mesangial cells","volume":"17","author":"Lin","year":"2006","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2014.12.015_bib45","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1681\/ASN.2006101084","article-title":"Podocin participates in the assembly of tight junctions between foot processes in nephrotic podocytes","volume":"18","author":"Shono","year":"2007","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2014.12.015_bib46","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/j.ajpath.2011.01.044","article-title":"Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism","volume":"178","author":"Advani","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2014.12.015_bib47","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00210-013-0928-2","article-title":"Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats","volume":"387","author":"Brar","year":"2014","journal-title":"Naunyn. Schmiedeb. Arch. Pharmacol."},{"key":"10.1016\/j.biochi.2014.12.015_bib48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","article-title":"Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation","volume":"30","author":"Viatour","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biochi.2014.12.015_bib49","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.4161\/auto.21151","article-title":"Curbing autophagy and histone deacetylases to kill cancer cells","volume":"8","author":"Gammoh","year":"2012","journal-title":"Autophagy"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090841400399X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090841400399X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:07:10Z","timestamp":1759540030000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030090841400399X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":49,"alternative-id":["S030090841400399X"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2014.12.015","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproate attenuates the proteinuria, podocyte and renal injury by facilitating autophagy and inactivation of NF-\u03baB\/iNOS signaling in diabetic rat","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2014.12.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}