{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:13:11Z","timestamp":1784916791737,"version":"3.55.0"},"update-to":[{"DOI":"10.1016\/j.biochi.2015.03.015","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000}}],"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002509","name":"Keimyung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.biochi.2015.03.015","type":"journal-article","created":{"date-parts":[[2015,4,4]],"date-time":"2015-04-04T20:32:49Z","timestamp":1428179569000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["RETRACTED: Effects of geniposide on hepatocytes undergoing epithelial\u2013mesenchymal transition in hepatic fibrosis by targeting TGF\u03b2\/Smad and ERK-MAPK signaling pathways"],"prefix":"10.1016","volume":"113","author":[{"given":"Ji-Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaewoo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoungduck","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2015.03.015_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.biochi.2015.03.015_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biochi.2014.10.013","article-title":"Hypoxia-inducible factor-1alpha in hepatic fibrosis: a promising therapeutic target","volume":"108C","author":"Zhan","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2015.03.015_bib3","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1074\/jbc.275.4.2247","article-title":"Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury","volume":"275","author":"Friedman","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2015.03.015_bib4","doi-asserted-by":"crossref","first-page":"22089","DOI":"10.1074\/jbc.M700998200","article-title":"Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in\u00a0vitro","volume":"282","author":"Kaimori","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2015.03.015_bib5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/hep.22397","article-title":"Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways","volume":"48","author":"Nitta","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2015.03.015_bib6","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrm1835","article-title":"Complex networks orchestrate epithelial-mesenchymal transitions","volume":"7","author":"Thiery","year":"2006","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.biochi.2015.03.015_bib7","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1038\/sj.onc.1207690","article-title":"c-Ski inhibits the TGF-beta signaling pathway through stabilization of inactive smad complexes on smad-binding elements","volume":"23","author":"Suzuki","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.biochi.2015.03.015_bib8","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hep.24254","article-title":"Sorafenib inhibits transforming growth factor beta1-mediated epithelial-mesenchymal transition and apoptosis in mouse hepatocytes","volume":"53","author":"Chen","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2015.03.015_bib9","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.bbrc.2010.02.050","article-title":"Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway","volume":"393","author":"Min","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2015.03.015_bib10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/cr.2009.5","article-title":"TGF-beta-induced epithelial to mesenchymal transition","volume":"19","author":"Xu","year":"2009","journal-title":"Cell. Res."},{"key":"10.1016\/j.biochi.2015.03.015_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbrc.2006.12.035","article-title":"Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase\/Akt signal pathway","volume":"353","author":"Cho","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2015.03.015_bib12","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1146\/annurev.cellbio.21.022404.142018","article-title":"Specificity and versatility in tgf-beta signaling through smads","volume":"21","author":"Feng","year":"2005","journal-title":"Annu Rev. Cell. Dev. Biol."},{"key":"10.1016\/j.biochi.2015.03.015_bib13","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/hep.23156","article-title":"Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes","volume":"50","author":"Pan","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2015.03.015_bib14","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1002\/hep.23196","article-title":"Epithelial-to-mesenchymal transitions in the liver","volume":"50","author":"Choi","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2015.03.015_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.2042-7158.2011.01256.x","article-title":"Hepatoprotective effects of geniposide in a rat model of nonalcoholic steatohepatitis","volume":"63","author":"Ma","year":"2011","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.biochi.2015.03.015_bib16","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/aps.2008.17","article-title":"Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin","volume":"30","author":"Wu","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.biochi.2015.03.015_bib17","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1248\/bpb.34.1613","article-title":"Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells","volume":"34","author":"Kojima","year":"2011","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biochi.2015.03.015_bib18","first-page":"567","article-title":"Genipin, a constituent of Gardenia jasminoides Ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells","volume":"27","author":"Kim","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biochi.2015.03.015_bib19","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1248\/bpb.33.1841","article-title":"Geniposide induces the expression of heme oxygenase-1 via PI3K\/Nrf2-signaling to enhance the antioxidant capacity in primary hippocampal neurons","volume":"33","author":"Yin","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.biochi.2015.03.015_bib20","first-page":"2886","article-title":"Geniposide inhibits CoCl2-induced PC12 cells death via the mitochondrial pathway","volume":"122","author":"Guo","year":"2009","journal-title":"Chin. Med. J. Engl."},{"key":"10.1016\/j.biochi.2015.03.015_bib21","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1021\/bm800724q","article-title":"pH-sensitive genipin-cross-linked chitosan microspheres for heparin removal","volume":"9","author":"Kaminski","year":"2008","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biochi.2015.03.015_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10495-011-0659-0","article-title":"Protective effect of melittin on inflammation and apoptosis in acute liver failure","volume":"17","author":"Park","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.biochi.2015.03.015_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.bbrc.2014.05.089","article-title":"Apamin inhibits hepatic fibrosis through suppression of transforming growth factor beta1-induced hepatocyte epithelial-mesenchymal transition","volume":"450","author":"Lee","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2015.03.015_bib24","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10495-011-0659-0","article-title":"Protective effect of melittin on inflammation and apoptosis in acute liver failure","volume":"17","author":"Park","year":"2012","journal-title":"Apoptosis"},{"key":"10.1016\/j.biochi.2015.03.015_bib25","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.bbrc.2012.08.087","article-title":"Suppression of thymus- and activation-regulated chemokine (TARC\/CCL17) production by 3-O-beta-D-glucopyanosylspinasterol via blocking NF-kappaB and STAT1 signaling pathways in TNF-alpha and IFN-gamma-induced HaCaT keratinocytes","volume":"427","author":"Jung","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2015.03.015_bib26","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1053\/j.gastro.2008.04.038","article-title":"Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage","volume":"135","author":"Dooley","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biochi.2015.03.015_bib27","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ceb.2009.01.021","article-title":"Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition","volume":"21","author":"Heldin","year":"2009","journal-title":"Curr. Opin. Cell. Biol."},{"key":"10.1016\/j.biochi.2015.03.015_bib28","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/jgm.1355","article-title":"Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis","volume":"11","author":"Park","year":"2009","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.biochi.2015.03.015_bib29","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/jcb.22085","article-title":"Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK\/JNK and AP-1","volume":"106","author":"Kook","year":"2009","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.biochi.2015.03.015_bib30","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1210\/en.2012-1626","article-title":"Sp1 and Sp3 transcription factors mediate leptin-induced collagen alpha1(I) gene expression in primary culture of male rat hepatic stellate cells","volume":"153","author":"Garcia-Ruiz","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2015.03.015_bib31","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1478-3231.2010.02205.x","article-title":"Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms","volume":"30","author":"Copple","year":"2010","journal-title":"Liver Int."},{"issue":"4","key":"10.1016\/j.biochi.2015.03.015_bib32","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1111\/liv.12638","article-title":"Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT\/mTOR\/p70S6K and TGFbeta\/Smad signalling pathways","volume":"35","author":"Li","year":"2015","journal-title":"Liver Int."},{"key":"10.1016\/j.biochi.2015.03.015_bib33","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/art.23379","article-title":"Fibroblast-specific perturbation of transforming growth factor beta signaling provides insight into potential pathogenic mechanisms of scleroderma-associated lung fibrosis: exaggerated response to alveolar epithelial injury in a novel mouse model","volume":"58","author":"Hoyles","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.biochi.2015.03.015_bib34","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.biochi.2015.03.015_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00018-010-0514-4","article-title":"Smad linker region phosphorylation in the regulation of extracellular matrix synthesis","volume":"68","author":"Burch","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biochi.2015.03.015_bib36","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00018-010-0315-9","article-title":"TGF-beta stimulates biglycan synthesis via p38 and ERK phosphorylation of the linker region of Smad2","volume":"67","author":"Burch","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.biochi.2015.03.015_bib37","doi-asserted-by":"crossref","first-page":"12546","DOI":"10.1021\/bi050560g","article-title":"Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3","volume":"44","author":"Matsuura","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2015.03.015_bib38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00109-003-0517-9","article-title":"The role of epithelial-to-mesenchymal transition in renal fibrosis","volume":"82","author":"Zeisberg","year":"2004","journal-title":"J.\u00a0Mol. Med. Berl."},{"key":"10.1016\/j.biochi.2015.03.015_bib39","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1053\/jhep.2001.28457","article-title":"Transforming growth factor beta and the liver","volume":"34","author":"Bissell","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2015.03.015_bib40","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-beta signaling and the fibrotic response","volume":"18","author":"Leask","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.biochi.2015.03.015_bib41","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1593\/neo.04241","article-title":"Activation of the Erk pathway is required for TGF-beta1-induced EMT in\u00a0vitro","volume":"6","author":"Xie","year":"2004","journal-title":"Neoplasia"},{"key":"10.1016\/j.biochi.2015.03.015_bib42","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.canlet.2013.01.013","article-title":"TACC3 promotes epithelial-mesenchymal transition (EMT) through the activation of PI3K\/Akt and ERK signaling pathways","volume":"332","author":"Ha","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biochi.2015.03.015_bib43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/dna.2009.0884","article-title":"Transforming growth factor-beta1 up-regulation of human alpha(1)(I) collagen is mediated by Sp1 and smad2 transacting factors","volume":"28","author":"Sysa","year":"2009","journal-title":"DNA Cell. Biol."}],"updated-by":[{"DOI":"10.1016\/j.biochi.2022.11.016","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,1,7]],"date-time":"2023-01-07T00:00:00Z","timestamp":1673049600000},"record-id":"41912"},{"DOI":"10.1016\/j.biochi.2022.11.016","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000}},{"DOI":"10.1016\/j.biochi.2015.03.015","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000}}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090841500084X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090841500084X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:07:40Z","timestamp":1759540060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030090841500084X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":43,"alternative-id":["S030090841500084X"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2015.03.015","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RETRACTED: Effects of geniposide on hepatocytes undergoing epithelial\u2013mesenchymal transition in hepatic fibrosis by targeting TGF\u03b2\/Smad and ERK-MAPK signaling pathways","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2015.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}