{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:20:18Z","timestamp":1790828418426,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Oceans and Fisheries, Republic of Korea","award":["20150220"],"award-info":[{"award-number":["20150220"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.biochi.2016.11.012","type":"journal-article","created":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T23:45:15Z","timestamp":1480635915000},"page":"7-19","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":84,"special_numbering":"C","title":["Magnetic hyperthermia and pH-responsive effective drug delivery to the sub-cellular level of human breast cancer cells by modified CoFe2O4 nanoparticles"],"prefix":"10.1016","volume":"133","author":[{"given":"Yunok","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhappan Santha","family":"Moorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panchanathan","family":"Manivasagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniyan","family":"Bharathiraja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junghwan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2016.11.012_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-7-144","article-title":"Magnetic nanoparticles: preparation, physical properties, and applications in biomedicine","volume":"7","author":"Akbarzadeh","year":"2012","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biochi.2016.11.012_bib2","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1016\/j.biomaterials.2010.01.057","article-title":"Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy","volume":"31","author":"Dilnawaz","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biochi.2016.11.012_bib3","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.phrs.2010.01.014","article-title":"Magnetic nanoparticles and targeted drug delivering","volume":"62","author":"Chomoucka","year":"2010","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biochi.2016.11.012_bib4","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nbt.3330","article-title":"Principles of nanoparticle design for overcoming biological barriers to drug delivery","volume":"33","author":"Blanco","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.biochi.2016.11.012_bib5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S1748-0132(07)70084-1","article-title":"Magnetic nanoparticles for drug delivery","volume":"2","author":"Arruebo","year":"2007","journal-title":"Nano Today"},{"key":"10.1016\/j.biochi.2016.11.012_bib6","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.addr.2011.03.008","article-title":"Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery","volume":"63","author":"Kumar","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.biochi.2016.11.012_bib7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.7150\/jca.8693","article-title":"Perspectives of breast cancer thermotherapies","volume":"5","author":"Alphandery","year":"2014","journal-title":"J.\u00a0Cancer"},{"key":"10.1016\/j.biochi.2016.11.012_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1191\/1740774506cn130oa","article-title":"Evaluating markers for the early detection of cancer: overview of study designs and methods","volume":"3","author":"Baker","year":"2006","journal-title":"Clin. Trials"},{"key":"10.1016\/j.biochi.2016.11.012_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5001\/omj.2016.19","article-title":"Hyperthermia: how can it be used?","volume":"31","author":"Behrouzkia","year":"2016","journal-title":"Oman Med. J."},{"key":"10.1016\/j.biochi.2016.11.012_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/OTT.S42815","article-title":"Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice","volume":"6","author":"Araya","year":"2013","journal-title":"Oncol. Targets. Ther."},{"key":"10.1016\/j.biochi.2016.11.012_bib11","first-page":"789","article-title":"Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells","volume":"7","author":"Wang","year":"2012","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biochi.2016.11.012_bib12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.biochi.2016.11.012_bib13","doi-asserted-by":"crossref","first-page":"13047","DOI":"10.1002\/anie.201306557","article-title":"Magnetically triggered dual functional nanoparticles for resistance-free apoptotic hyperthermia","volume":"52","author":"Yoo","year":"2013","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.biochi.2016.11.012_bib14","first-page":"2863","article-title":"Nanoparticles for hyperthermic therapy: synthesis strategies and applications in glioblastoma","volume":"9","author":"Verma","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biochi.2016.11.012_bib15","first-page":"209","article-title":"Effect of in\u00a0vitro magnetic fluid hyperthermia using citrate coated cobalt ferriter nanoparticles on tumor cell death","volume":"25","author":"Kahil","year":"2015","journal-title":"Rom. J. Biophys."},{"key":"10.1016\/j.biochi.2016.11.012_bib16","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1351\/pac200678051003","article-title":"One-pot synthesis of monodisperse iron oxide nanoparticles for potential biomedical applications","volume":"78","author":"Xie","year":"2006","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.biochi.2016.11.012_bib17","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.3390\/ma3074051","article-title":"Synthesis and characterization of multifunctional chitosan- MnFe2O4 nanoparticles for magnetic hyperthermia and drug delivery","volume":"3","author":"Kim","year":"2010","journal-title":"Materials"},{"key":"10.1016\/j.biochi.2016.11.012_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-015-0576-1","article-title":"Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery","volume":"17","author":"Kossatz","year":"2015","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.biochi.2016.11.012_bib19","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1021\/acs.biomac.5b01311","article-title":"Doxorubicin-loaded carborane-conjugated polymeric nanoparticles as delivery system for combination cancer therapy","volume":"16","author":"Xiong","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biochi.2016.11.012_bib20","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1021\/cm0628000","article-title":"Silane ligand exchange to make hydrophobic superparamagnetic nanoparticles water-dispersible","volume":"19","author":"De Palma","year":"2007","journal-title":"Chem. Mater."},{"key":"10.1016\/j.biochi.2016.11.012_bib21","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1021\/ja067457e","article-title":"Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia","volume":"129","author":"Jean-Paul Fortin","year":"2007","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biochi.2016.11.012_bib22","doi-asserted-by":"crossref","first-page":"5279","DOI":"10.1007\/s00216-013-6927-9","article-title":"Optimization of harvesting, extraction, and analytical protocols for UPLC-ESI-MS-based metabolomic analysis of adherent mammalian cancer cells","volume":"405","author":"Bi","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.biochi.2016.11.012_bib23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.msec.2010.01.006","article-title":"Doxorubicin loaded PVA coated iron oxide nanoparticles for targeted drug delivery","volume":"30","author":"Kayal","year":"2010","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.biochi.2016.11.012_bib24","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1109\/TMAG.2013.2239621","article-title":"Size-dependent relaxation properties of monodisperse magnetite nanoparticles measured over seven decades of frequency by AC susceptometry","volume":"49","author":"Ferguson","year":"2013","journal-title":"IEEE Trans. Magn."},{"key":"10.1016\/j.biochi.2016.11.012_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1049\/ip-nbt:20055018","article-title":"Use of magnetic nanoparticle heating in the treatment of breast cancer","author":"Hilger","year":"2005","journal-title":"IEEE Proc. Nanobiotechnol. IET"},{"key":"10.1016\/j.biochi.2016.11.012_bib26","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/smll.200801647","article-title":"Functionalized nanoparticles with long-term stability in biological media","volume":"5","author":"Fang","year":"2009","journal-title":"Small"},{"key":"10.1016\/j.biochi.2016.11.012_bib27","doi-asserted-by":"crossref","first-page":"14265","DOI":"10.1073\/pnas.0805135105","article-title":"Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts","volume":"105","author":"Lundqvist","year":"2008","journal-title":"Proc. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biochi.2016.11.012_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1556-276X-8-381","article-title":"Characterization of magnetic nanoparticle by dynamic light scattering","volume":"8","author":"Lim","year":"2013","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.biochi.2016.11.012_bib29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jconrel.2011.07.041","article-title":"Nuclear drug delivery for cancer chemotherapy","volume":"155","author":"Sui","year":"2011","journal-title":"J.\u00a0Control Release"},{"key":"10.1016\/j.biochi.2016.11.012_bib30","doi-asserted-by":"crossref","first-page":"C195","DOI":"10.1152\/ajpcell.00217.2011","article-title":"Doxorubicin acts via mitochondrial ROS to stimulate catabolism in C2C12 myotubes","volume":"302","author":"Gilliam","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biochi.2016.11.012_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep04469","article-title":"Heat stress induces apoptosis through transcription-independent p53-mediated mitochondrial pathways in human umbilical vein endothelial cell","volume":"4","author":"Gu","year":"2014","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2016.11.012_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/645460","article-title":"Drug-induced oxidative stress and toxicity","volume":"2012","author":"Deavall","year":"2012","journal-title":"J.\u00a0Toxicol."},{"key":"10.1016\/j.biochi.2016.11.012_bib33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.biomaterials.2009.09.053","article-title":"The effect of DMSA-functionalized magnetic nanoparticles on transendothelial migration of monocytes in the murine lung via a beta2 integrin-dependent pathway","volume":"31","author":"Valois","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.biochi.2016.11.012_bib34","first-page":"291","article-title":"Evaluation of thermal properties of ferrite nanoparticles for magnetic hyperthermia treatment","volume":"5","author":"Elbeshir","year":"2014","journal-title":"Int. J. Recent. Sci. Res."},{"key":"10.1016\/j.biochi.2016.11.012_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/nano5010063","article-title":"Magnetic properties of magnetic nanoparticles for efficient hyperthermia","volume":"5","author":"Obaidat","year":"2015","journal-title":"Nanomaterials"},{"key":"10.1016\/j.biochi.2016.11.012_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1088\/1742-6596\/200\/7\/072101","article-title":"Magnetic properties and energy absorption of CoFe2O4 nanoparticles for magnetic hyperthermia","volume":"200","author":"Torres","year":"2010","journal-title":"J.\u00a0Phys. Conf. Ser."},{"key":"10.1016\/j.biochi.2016.11.012_bib37","first-page":"1","article-title":"Engineered nanoparticles interacting with cells: size matters","volume":"12","author":"Shang","year":"2014","journal-title":"J.\u00a0Nanobiotechnol."},{"key":"10.1016\/j.biochi.2016.11.012_bib38","doi-asserted-by":"crossref","first-page":"3477","DOI":"10.1016\/j.scitotenv.2010.03.033","article-title":"Effect of dissolved organic matter on the stability of magnetite nanoparticles under different pH and ionic strength conditions","volume":"408","author":"Hu","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.biochi.2016.11.012_bib39","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.biomaterials.2008.12.038","article-title":"Influence of anchoring ligands and particle size on the colloidal stability and in\u00a0vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice","volume":"30","author":"Zhang","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.biochi.2016.11.012_bib40","doi-asserted-by":"crossref","first-page":"5478","DOI":"10.1021\/nn2007496","article-title":"Effect of gold nanoparticle aggregation on cell uptake and toxicity","volume":"5","author":"Albanese","year":"2011","journal-title":"ACS nano"},{"key":"10.1016\/j.biochi.2016.11.012_bib41","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1007\/s11051-013-1874-0","article-title":"Effect of surface charge on the colloidal stability and in\u00a0vitro uptake of carboxymethyl dextran-coated iron oxide nanoparticles","volume":"15","author":"Ayala","year":"2013","journal-title":"J.\u00a0Nanopart. Res."},{"key":"10.1016\/j.biochi.2016.11.012_bib42","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.1039\/C4CS00487F","article-title":"Nanoparticle colloidal stability in cell culture media and impact on cellular interactions","volume":"44","author":"Moore","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.biochi.2016.11.012_bib43","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1039\/C5TB00600G","article-title":"Surface charge-reversible polyelectrolyte complex nanoparticles for hepatoma-targeting delivery of doxorubicin","volume":"3","author":"Zhao","year":"2015","journal-title":"J.\u00a0Mater. Chem. B"},{"key":"10.1016\/j.biochi.2016.11.012_bib44","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.nano.2010.11.004","article-title":"Comparing cellular uptake and cytotoxicity of targeted drug carriers in cancer cell lines with different drug resistance mechanisms","volume":"7","author":"Lei","year":"2011","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biochi.2016.11.012_bib45","first-page":"1","article-title":"Photoacoustic \u201cnanobombs\u201d fight against undesirable vesicular compartmentalization of anticancer drugs","volume":"5","author":"Chen","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2016.11.012_bib46","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1039\/c2bm00156j","article-title":"Enhanced intracellular drug delivery of pH-sensitive doxorubicin\/poly (ethylene glycol)-block-poly (4-vinylbenzylphosphonate) nanoparticles in multi-drug resistant human epidermoid KB carcinoma cells","volume":"1","author":"Kamimura","year":"2013","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.biochi.2016.11.012_bib47","first-page":"152","article-title":"Intracellular trafficking of nuclear localization signal conjugated nanoparticles for cancer therapy","volume":"39","author":"Misra","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biochi.2016.11.012_bib48","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.2217\/nnm.13.146","article-title":"Thermal potentiation of chemotherapy by magnetic nanoparticles","volume":"8","author":"Rinaldi","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biochi.2016.11.012_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep30729","article-title":"Core-shell silver\/polymeric nanoparticles-based combinatorial therapy against breast cancer in-vitro","volume":"6","author":"Elbaz","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2016.11.012_bib50","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1039\/C6TB01743F","article-title":"Tumor therapy: targeted drug delivery systems","volume":"4","author":"Dai","year":"2016","journal-title":"J.\u00a0Mater. Chem. B"},{"key":"10.1016\/j.biochi.2016.11.012_bib51","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/74994","article-title":"Mitochondrial control of cell death","volume":"6","author":"Kroemer","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.biochi.2016.11.012_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.aquatox.2015.07.003","article-title":"An in\u00a0vivo evaluation of acute toxicity of cobalt ferrite (CoFe2O4) nanoparticles in larval-embryo Zebrafish (Danio rerio)","volume":"166","author":"Ahmad","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.biochi.2016.11.012_bib53","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/157341311795542435","article-title":"Biocompatibility studies of functionalized CoFe2O4 magnetic nanoparticles","volume":"7","author":"Kumar Prabhakar","year":"2011","journal-title":"Curr. Nanosci."},{"key":"10.1016\/j.biochi.2016.11.012_bib54","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.chemosphere.2015.08.008","article-title":"Toxicity of cobalt ferrite (CoFe2O4) nanobeads in Chlorella vulgaris: interaction, adaptation and oxidative stress","volume":"139","author":"Ahmad","year":"2015","journal-title":"Chemosphere"},{"key":"10.1016\/j.biochi.2016.11.012_bib55","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1006\/jcis.1997.5125","article-title":"Thiolation of maghemite nanoparticles by dimercaptosuccinic acid","volume":"194","author":"Fauconnier","year":"1997","journal-title":"J.\u00a0Colloid Interf. Sci."},{"key":"10.1016\/j.biochi.2016.11.012_bib56","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1039\/C5DT03923A","article-title":"Analysis of the influence of synthetic parameters on the structure and physico-chemical properties of non-spherical iron oxide nanocrystals and their biological stability and compatibility","volume":"45","author":"Pardo","year":"2016","journal-title":"Dalton Trans."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908416303157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908416303157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T03:30:39Z","timestamp":1536204639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908416303157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":56,"alternative-id":["S0300908416303157"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2016.11.012","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic hyperthermia and pH-responsive effective drug delivery to the sub-cellular level of human breast cancer cells by modified CoFe2O4 nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2016.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}