{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T13:48:48Z","timestamp":1789220928301,"version":"build-2803163510"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21572207"],"award-info":[{"award-number":["21572207"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program of International S & T Cooperation","award":["2015DFG32530"],"award-info":[{"award-number":["2015DFG32530"]}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation of China","doi-asserted-by":"publisher","award":["LY16160003"],"award-info":[{"award-number":["LY16160003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1016\/j.biochi.2017.07.016","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T14:30:55Z","timestamp":1501597855000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":248,"special_numbering":"C","title":["TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections"],"prefix":"10.1016","volume":"142","author":[{"given":"Li Wen","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui Juan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan Ling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimasa","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2017.07.016_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1017\/S1361491607002031","article-title":"The black death and the origins of the \u2018great divergence\u2019 across Europe, 1300\u20131600","volume":"11","author":"Pamuk","year":"2007","journal-title":"Eur. Rev. Econ. Hist."},{"key":"10.1016\/j.biochi.2017.07.016_bib2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1126\/science.327.5973.1563","article-title":"What's old is new: 1918 virus matches 2009 H1N1 strain","volume":"327","author":"Cohen","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.biochi.2017.07.016_bib3","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3201\/eid1704.101865","article-title":"Should remaining stockpiles of smallpox virus (variola) be destroyed?","volume":"17","author":"Weinstein","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib4","first-page":"441","article-title":"Yersinia pestis and plague-an update","volume":"37","author":"Stock","year":"2014","journal-title":"Med. Monatsschr. Pharm."},{"key":"10.1016\/j.biochi.2017.07.016_bib5","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/S0140-6736(03)13168-6","article-title":"Advisors of Expert SARS group of Hospital Authority, Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS)","volume":"361","author":"Seto","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.biochi.2017.07.016_bib6","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1056\/NEJMe0909666","article-title":"Preparing for 2009 H1N1 influenza","volume":"361","author":"Wenzel","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2017.07.016_bib7","doi-asserted-by":"crossref","first-page":"7790","DOI":"10.1128\/JVI.01244-13","article-title":"Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group","volume":"87","author":"de Groot","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib8","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1056\/NEJMoa1304459","article-title":"Human infection with a novel avian-origin influenza A (H7N9) virus","volume":"368","author":"Gao","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2017.07.016_bib9","article-title":"Human infection with avian influenza A(H7N9) virus-China","author":"WHO","year":"2017","journal-title":"Dis. Outbreak News"},{"key":"10.1016\/j.biochi.2017.07.016_bib10","article-title":"Human infection with avian influenza A(H7N9) virus-China","author":"WHO","year":"2017","journal-title":"Dis. Outbreak News"},{"key":"10.1016\/j.biochi.2017.07.016_bib11","article-title":"Middle East respiratory syndrome coronavirus (MERS-CoV)-Saudi Arabia","author":"WHO","year":"2017","journal-title":"Dis. Outbreak News"},{"key":"10.1016\/j.biochi.2017.07.016_bib12","article-title":"Middle East respiratory syndrome coronavirus (MERS-CoV)-Saudi Arabia","author":"WHO","year":"2017","journal-title":"Dis. Outbreak News"},{"key":"10.1016\/j.biochi.2017.07.016_bib13","unstructured":"WHO, Middle East respiratory syndrome coronavirus (MERS-CoV)-Republic of Korea. http:\/\/www.who.int\/csr\/don\/07-july-2015-mers-korea\/en\/."},{"key":"10.1016\/j.biochi.2017.07.016_bib14","unstructured":"WHO, Middle East respiratory syndrome coronavirus (MERS-CoV)-Saudi Arabia. http:\/\/www.who.int\/csr\/don\/18-august-2015-mers-saudi-arabia\/en\/."},{"key":"10.1016\/j.biochi.2017.07.016_bib15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/rmv.657","article-title":"Novel insights into proteolytic cleavage of influenza virus hemagglutinin","volume":"20","author":"Bertram","year":"2010","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib16","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1056\/NEJMc0910060","article-title":"Emergence of oseltamivir-resistant pandemic H1N1 virus during prophylaxis","volume":"361","author":"Baz","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2017.07.016_bib17","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1586\/14787210.2014.870885","article-title":"Emergence of a novel drug resistant H7N9 influenza virus: evidence based clinical potential of a natural IFN-\u03b1 for infection control and treatment","volume":"12","author":"Liu","year":"2014","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"10.1016\/j.biochi.2017.07.016_bib18","doi-asserted-by":"crossref","first-page":"17987","DOI":"10.1021\/ja508461m","article-title":"Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel","volume":"136","author":"Wu","year":"2014","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biochi.2017.07.016_bib19","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1128\/JVI.03677-13","article-title":"The host protease TMPRSS2 plays a major role in in\u00a0vivo replication of emerging H7N9 and seasonal influenza viruses","volume":"88","author":"Sakai","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib20","doi-asserted-by":"crossref","first-page":"4744","DOI":"10.1128\/JVI.03799-13","article-title":"TMPRSS2 is a host factor that is essential for pneumotropism and pathogenicity of H7N9 influenza A virus in mice","volume":"88","author":"Tarnow","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib21","doi-asserted-by":"crossref","first-page":"12658","DOI":"10.1128\/JVI.01542-10","article-title":"Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2","volume":"84","author":"Matsuyama","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib22","doi-asserted-by":"crossref","first-page":"12552","DOI":"10.1128\/JVI.01890-13","article-title":"Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2","volume":"87","author":"Shirato","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib23","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/2049-632X.12053","article-title":"Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium","volume":"69","author":"B\u00f6ttcher","year":"2013","journal-title":"Pathog. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib24","doi-asserted-by":"crossref","first-page":"e792","DOI":"10.1016\/j.ijid.2013.07.002","article-title":"Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)\u2013possible lessons from a systematic review of SARS-CoV therapy","volume":"17","author":"Momattin","year":"2013","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nrd.2015.37","article-title":"Coronaviruses-drug discovery and therapeutic options","volume":"15","author":"Zumla","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biochi.2017.07.016_bib26","first-page":"1","article-title":"Potential cellular targets for anti-influenza drug development, Cell Immunol","volume":"1","author":"Imai","year":"2016","journal-title":"Immunother"},{"key":"10.1016\/j.biochi.2017.07.016_bib27","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2327-5073.1000238","article-title":"Serine proteases and their inhibitors in human airway epithelial cells: effects on influenza virus replication and airway inflammation","volume":"5","author":"Yamaya","year":"2016","journal-title":"Clin. Microbiol."},{"key":"10.1016\/j.biochi.2017.07.016_bib28","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1093\/infdis\/jiv246","article-title":"Identification of TMPRSS2 as a susceptibility gene for severe 2009 pandemic A (H1N1) influenza and A (H7N9) influenza","volume":"212","author":"Cheng","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib29","first-page":"1163","article-title":"TMPRSS2 (transmembrane protease, serine 2)","volume":"14","author":"Park","year":"2010","journal-title":"Atlas. Genet. Cytogenet. Oncol. Haematol."},{"key":"10.1016\/j.biochi.2017.07.016_bib30","first-page":"4180","article-title":"Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2","volume":"59","author":"Lin","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2009.12.022","article-title":"Androgen receptor and androgen-dependent gene expression in lung","volume":"317","author":"Mikkonen","year":"2010","journal-title":"Mol. Cell Enocrinol."},{"key":"10.1016\/j.biochi.2017.07.016_bib32","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1158\/2159-8290.CD-13-1010","article-title":"The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis","volume":"4","author":"Lucas","year":"2014","journal-title":"Cancer Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib33","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1097\/j.pain.0000000000000130","article-title":"TMPRSS2, a novel membrane-anchored mediator in cancer pain","volume":"156","author":"Lam","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.biochi.2017.07.016_bib34","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1128\/MCB.26.3.965-975.2006","article-title":"Phenotypic analysis of mice lacking the Tmprss2-encoded protease","volume":"26","author":"Kim","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2017.07.016_bib35","first-page":"309","article-title":"The structural biology of type I viral membrane fusion, Nature reviews","volume":"4","author":"Colman","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2017.07.016_bib36","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nsmb.1456","article-title":"Viral membrane fusion","volume":"15","author":"Harrison","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.biochi.2017.07.016_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4149\/av_2016_02_121","article-title":"The role of fusion activity of influenza A viruses in their biological properties","volume":"60","author":"Jakubcov\u00e1","year":"2016","journal-title":"Acta. Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib38","series-title":"Cleavage Activation of the Influenza Virus Hemagglutinin and its Role in Pathogenesis, Avian Influenza","first-page":"156","author":"Garten","year":"2008"},{"key":"10.1016\/j.biochi.2017.07.016_bib39","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.3390\/v4071144","article-title":"Influenza virus-mediated membrane fusion: determinants of hemagglutinin fusogenic activity and experimental approaches for assessing virus fusion","volume":"4","author":"Hamilton","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.biochi.2017.07.016_bib40","series-title":"The Hemagglutinin: a Determinant of Pathogenicity, Influenza Pathogenesis and Control","first-page":"3","author":"B\u00f6ttcher-Friebertsh\u00e4user","year":"2014"},{"key":"10.1016\/j.biochi.2017.07.016_bib41","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.bbamem.2013.10.004","article-title":"Receptor binding and pH stability-how influenza A virus hemagglutinin affects host-specific virus infection","volume":"1838","author":"Mair","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2017.07.016_bib42","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2174\/092986609788681715","article-title":"Composition and functions of the influenza fusion peptide","volume":"16","author":"Cross","year":"2009","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.biochi.2017.07.016_bib43","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.virusres.2014.11.021","article-title":"Host cell proteases: critical determinants of coronavirus tropism and pathogenesis","volume":"202","author":"Millet","year":"2015","journal-title":"Virus Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib44","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3390\/v4061011","article-title":"Mechanisms of coronavirus cell entry mediated by the viral spike protein","volume":"4","author":"Belouzard","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.biochi.2017.07.016_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.virusres.2014.10.005","article-title":"A\u00a0structural view of coronavirus\u2013receptor interactions","volume":"194","author":"Reguera","year":"2014","journal-title":"Virus Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib46","doi-asserted-by":"crossref","first-page":"12087","DOI":"10.1128\/JVI.01427-14","article-title":"DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry","volume":"88","author":"Zmora","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib47","doi-asserted-by":"crossref","first-page":"5605","DOI":"10.1128\/JVI.00140-10","article-title":"Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors","volume":"84","author":"B\u00f6ttcher-Friebertsh\u00e4user","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib48","doi-asserted-by":"crossref","first-page":"3200","DOI":"10.1128\/JVI.02205-08","article-title":"Proteolytic activation of the 1918 influenza virus hemagglutinin","volume":"83","author":"Chaipan","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib49","doi-asserted-by":"crossref","first-page":"11876","DOI":"10.1073\/pnas.0505577102","article-title":"Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry","volume":"102","author":"Simmons","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2017.07.016_bib50","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.antiviral.2013.09.028","article-title":"Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research","volume":"100","author":"Simmons","year":"2013","journal-title":"Antivir. Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib51","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbrc.2007.05.092","article-title":"Cleavage of spike protein of SARS coronavirus by protease factor Xa is associated with viral infectivity","volume":"359","author":"Du","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2017.07.016_bib52","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.antiviral.2015.01.011","article-title":"Protease inhibitors targeting coronavirus and filovirus entry","volume":"116","author":"Zhou","year":"2015","journal-title":"Antivir. Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib53","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1128\/JVI.00094-12","article-title":"Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry","volume":"86","author":"Kawase","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib54","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1128\/JVI.02062-10","article-title":"A\u00a0transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry","volume":"85","author":"Shulla","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib55","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.02232-10","article-title":"Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response","volume":"85","author":"Glowacka","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib56","doi-asserted-by":"crossref","first-page":"e1001258","DOI":"10.1371\/journal.ppat.1001258","article-title":"Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus","volume":"7","author":"Huang","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.biochi.2017.07.016_bib57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/diseases4030026","article-title":"Human coronaviruses: a review of virus\u2013host interactions","volume":"4","author":"Lim","year":"2016","journal-title":"Diseases"},{"key":"10.1016\/j.biochi.2017.07.016_bib58","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1128\/JVI.02202-13","article-title":"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein","volume":"88","author":"Heurich","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib59","doi-asserted-by":"crossref","first-page":"e76469","DOI":"10.1371\/journal.pone.0076469","article-title":"Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation","volume":"8","author":"Qian","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2017.07.016_bib60","doi-asserted-by":"crossref","first-page":"15214","DOI":"10.1073\/pnas.1407087111","article-title":"Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein","volume":"111","author":"Millet","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2017.07.016_bib61","doi-asserted-by":"crossref","first-page":"5502","DOI":"10.1128\/JVI.00128-13","article-title":"The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies","volume":"87","author":"Gierer","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib62","doi-asserted-by":"crossref","first-page":"4953","DOI":"10.1128\/JVI.00161-14","article-title":"Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection","volume":"88","author":"Barlan","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib63","doi-asserted-by":"crossref","first-page":"e35876","DOI":"10.1371\/journal.pone.0035876","article-title":"Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts","volume":"7","author":"Bertram","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2017.07.016_bib64","doi-asserted-by":"crossref","first-page":"e94267","DOI":"10.1371\/journal.pone.0094267","article-title":"Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea","volume":"9","author":"Faller","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2017.07.016_bib65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0166-3542(94)90038-8","article-title":"Aprotinin aerosol treatment of influenza and paramyxovirus bronchopneumonia of mice","volume":"23","author":"Ovcharenko","year":"1994","journal-title":"Antivir. Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib66","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.antiviral.2011.07.014","article-title":"Aprotinin and similar protease inhibitors as drugs against influenza","volume":"92","author":"Zhirnov","year":"2011","journal-title":"Antivir. Res."},{"key":"10.1016\/j.biochi.2017.07.016_bib67","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.pupt.2015.07.001","article-title":"The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells","volume":"33","author":"Yamaya","year":"2015","journal-title":"Pulm. Pharmacol. Ther."},{"key":"10.1016\/j.biochi.2017.07.016_bib68","doi-asserted-by":"crossref","first-page":"204","DOI":"10.2741\/okuno","article-title":"Retinoids in liver fibrosis and cancer","volume":"7","author":"Okuno","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.biochi.2017.07.016_bib69","first-page":"533","article-title":"Antiproteases in the treatment of chronic pancreatitis","volume":"8","author":"Motoo","year":"2007","journal-title":"JOP"},{"key":"10.1016\/j.biochi.2017.07.016_bib70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s10157-011-0506-1","article-title":"Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension","volume":"16","author":"Kitamura","year":"2012","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.biochi.2017.07.016_bib71","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1159\/000375308","article-title":"The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects","volume":"129","author":"Ueda","year":"2015","journal-title":"Nephron"},{"key":"10.1016\/j.biochi.2017.07.016_bib72","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/BF01718208","article-title":"Evaluation of anti-influenza effects of camostat in mice infected with non-adapted human influenza viruses","volume":"141","author":"Lee","year":"1996","journal-title":"Arch. Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib73","doi-asserted-by":"crossref","first-page":"02205","DOI":"10.1186\/1743-422X-8-27","article-title":"Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection","volume":"8","author":"Bahgat","year":"2011","journal-title":"Virol. J."},{"key":"10.1016\/j.biochi.2017.07.016_bib74","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1128\/AAC.01043-16","article-title":"Identification of nafamostat as a potent inhibitor of Middle East Respiratory Syndrome Coronavirus S protein-mediated membrane fusion using the split-protein-based cell-cell fusion assay","volume":"60","author":"Yamamoto","year":"2016","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.biochi.2017.07.016_bib75","doi-asserted-by":"crossref","first-page":"6324","DOI":"10.1016\/j.vaccine.2009.03.029","article-title":"MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition","volume":"27","author":"B\u00f6ttcher","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.biochi.2017.07.016_bib76","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.virol.2011.02.020","article-title":"Different host cell proteases activate the SARS-coronavirus spike-protein for cell\u2013cell and virus\u2013cell fusion","volume":"413","author":"Simmons","year":"2011","journal-title":"Virology"},{"key":"10.1016\/j.biochi.2017.07.016_bib77","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1042\/BJ20130101","article-title":"Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation","volume":"452","author":"Meyer","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.biochi.2017.07.016_bib78","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2015.01.040","article-title":"A\u00a0serpin shapes the extracellular environment to prevent influenza A virus maturation","volume":"160","author":"Dittmann","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2017.07.016_bib79","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.bbrc.2014.06.109","article-title":"Inhibition of influenza virus infection and hemagglutinin cleavage by the protease inhibitor HAI-2","volume":"450","author":"Hamilton","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2017.07.016_bib80","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/anae.12907","article-title":"The current place of aprotinin in the management of bleeding","volume":"70","author":"Royston","year":"2015","journal-title":"Anaesthesia"},{"key":"10.1016\/j.biochi.2017.07.016_bib81","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1128\/JVI.01294-10","article-title":"Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2","volume":"85","author":"B\u00f6ttcher","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib82","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/cid\/ciu053","article-title":"Comparison of patients hospitalized with influenza A subtypes H7N9, H5N1, and 2009 pandemic H1N1","volume":"58","author":"Wang","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib83","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMoa1305584","article-title":"Clinical findings in 111 cases of influenza A (H7N9) virus infection","volume":"368","author":"Gao","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2017.07.016_bib84","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1017\/S0950268814002866","article-title":"Prognosis and survival of 128 patients with severe avian influenza A (H7N9) infection in Zhejiang province, China","volume":"143","author":"Xiao","year":"2015","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.biochi.2017.07.016_bib85","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jcv.2013.09.004","article-title":"Age-specific and sex-specific morbidity and mortality from avian influenza A (H7N9)","volume":"58","author":"Dudley","year":"2013","journal-title":"J.\u00a0Clin. Virol."},{"key":"10.1016\/j.biochi.2017.07.016_bib86","doi-asserted-by":"crossref","first-page":"e19409","DOI":"10.1371\/journal.pone.0019409","article-title":"Sex-and age-related differences in morbidity rates of 2009 pandemic influenza A H1N1 virus of swine origin in Japan","volume":"6","author":"Eshima","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2017.07.016_bib87","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1056\/NEJMoa0906612","article-title":"National influenza a pandemic (H1N1) 2009 clinical investigation group of China, clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China","volume":"361","author":"Cao","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2017.07.016_bib88","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1086\/651083","article-title":"Effects of early oseltamivir therapy on viral shedding in 2009 pandemic influenza A (H1N1) virus infection","volume":"50","author":"Ling","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib89","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1755-7682-3-26","article-title":"Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in an university hospital of Morocco","volume":"3","author":"Louriz","year":"2010","journal-title":"Int. Arch. Med."},{"key":"10.1016\/j.biochi.2017.07.016_bib90","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/aje\/kwh056","article-title":"Do men have a higher case fatality rate of severe acute respiratory syndrome than women do?","volume":"159","author":"Karlberg","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.biochi.2017.07.016_bib91","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-3156.2008.02147.x","article-title":"Case fatality of SARS in mainland China and associated risk factors","volume":"14","author":"Jia","year":"2009","journal-title":"Trop. Med. Int. Heal. Th"},{"key":"10.1016\/j.biochi.2017.07.016_bib92","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2334-10-50","article-title":"A\u00a0comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan","volume":"10","author":"Lau","year":"2010","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib93","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S1473-3099(13)70204-4","article-title":"Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study","volume":"13","author":"Assiri","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.biochi.2017.07.016_bib94","first-page":"68","article-title":"Sex matters\u2013a preliminary analysis of Middle East respiratory syndrome in the Republic of Korea, 2015","volume":"6","author":"Jansen","year":"2015","journal-title":"West. Pac. Surveill. Response J."},{"key":"10.1016\/j.biochi.2017.07.016_bib95","first-page":"480","article-title":"Update: severe respiratory illness associated with Middle East respiratory syndrome coronavirus (MERS-CoV)-worldwide, 2012-2013","volume":"62","author":"Gasta\u00f1aduy","year":"2013","journal-title":"Morb. Mortal. Wkly. Rep. (MMWR)"},{"key":"10.1016\/j.biochi.2017.07.016_bib96","doi-asserted-by":"crossref","first-page":"16598","DOI":"10.1073\/pnas.1310744110","article-title":"Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques","volume":"110","author":"de Wit","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2017.07.016_bib97","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1038\/onc.2013.274","article-title":"Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver","volume":"33","author":"Chang","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.biochi.2017.07.016_bib98","doi-asserted-by":"crossref","first-page":"10418","DOI":"10.1073\/pnas.0704217104","article-title":"Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide","volume":"104","author":"Nickols","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2017.07.016_bib99","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.tibs.2014.02.007","article-title":"Enhancer RNAs and regulated transcriptional programs","volume":"39","author":"Lam","year":"2014","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biochi.2017.07.016_bib100","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cell.2014.12.023","article-title":"Ligand-dependent enhancer activation regulated by topoisomerase-I activity","volume":"160","author":"Puc","year":"2015","journal-title":"Cell"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908417301876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908417301876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:08:01Z","timestamp":1759540081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908417301876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":100,"alternative-id":["S0300908417301876"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2017.07.016","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2017.07.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}