{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:15:20Z","timestamp":1776262520481,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["02(0273)\/16\/EMR-II"],"award-info":[{"award-number":["02(0273)\/16\/EMR-II"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008789","name":"Department of Science and Technology, Government of West Bengal","doi-asserted-by":"publisher","award":["DST\/FT\/LS29\/2012"],"award-info":[{"award-number":["DST\/FT\/LS29\/2012"]}],"id":[{"id":"10.13039\/501100008789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.biochi.2019.05.001","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:34:34Z","timestamp":1557268474000},"page":"21-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"special_numbering":"C","title":["Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs)"],"prefix":"10.1016","volume":"163","author":[{"given":"Eshan","family":"Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumen","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subodh Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ribhav","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sampak","family":"Samanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpita","family":"Tawani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5913-4308","authenticated-orcid":false,"given":"Amit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2019.05.001_bib1","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1093\/nar\/gkg766","article-title":"RNA structure of trinucleotide repeats associated with human neurological diseases","volume":"31","author":"Sobczak","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biochi.2019.05.001_bib2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/hmg\/9.6.909","article-title":"Fourteen and counting: unraveling trinucleotide repeat diseases","volume":"9","author":"Cummings","year":"2000","journal-title":"Hum. Mol. Genet."},{"issue":"Suppl","key":"10.1016\/j.biochi.2019.05.001_bib3","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1038\/nm1066","article-title":"Protein aggregation and neurodegenerative disease","volume":"10","author":"Ross","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.biochi.2019.05.001_bib4","doi-asserted-by":"crossref","first-page":"e752","DOI":"10.1038\/cddis.2013.276","article-title":"Mechanisms of RNA-induced toxicity in CAG repeat disorders","volume":"4","author":"Nalavade","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biochi.2019.05.001_bib5","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1093\/hmg\/9.14.2197","article-title":"CREB-binding protein sequestration by expanded polyglutamine","volume":"9","author":"McCampbell","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biochi.2019.05.001_bib6","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/hmg\/8.6.977","article-title":"PQBP-1, a novel polyglutamine tract-binding protein, inhibits transcription activation by Brn-2 and affects cell survival","volume":"8","author":"Waragai","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biochi.2019.05.001_bib7","doi-asserted-by":"crossref","first-page":"8938","DOI":"10.1093\/nar\/gkr608","article-title":"CAG repeats mimic CUG repeats in the misregulation of alternative splicing","volume":"39","author":"Mykowska","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biochi.2019.05.001_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuron.2017.03.023","article-title":"Mutant huntingtin disrupts the nuclear pore complex","volume":"94","author":"Grima","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.biochi.2019.05.001_bib9","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.1093\/hmg\/ddv023","article-title":"A\u00a0Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits","volume":"24","author":"Aharony","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biochi.2019.05.001_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13023-016-0405-3","article-title":"The P42 peptide and Peptide-based therapies for Huntington's disease","volume":"11","author":"Marelli","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.biochi.2019.05.001_bib11","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/cmdc.201000156","article-title":"Off-target effects related to the phosphorothioate modification of nucleic acids","volume":"5","author":"Winkler","year":"2010","journal-title":"ChemMedChem"},{"key":"10.1016\/j.biochi.2019.05.001_bib12","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1089\/ard.1994.4.67","article-title":"Problems in interpretation of data derived from in\u00a0vitro and in\u00a0vivo use of antisense oligodeoxynucleotides","volume":"4","author":"Stein","year":"1994","journal-title":"Antisense Res. Dev."},{"key":"10.1016\/j.biochi.2019.05.001_bib13","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0165-6147(99)01420-0","article-title":"Sensible use of antisense: how to use oligonucleotides as research tools","volume":"21","author":"Myers","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.biochi.2019.05.001_bib14","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.drudis.2013.07.024","article-title":"Rational design of chemical genetic probes of RNA function and lead therapeutics targeting repeating transcripts","volume":"18","author":"Disney","year":"2013","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.biochi.2019.05.001_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nchembio.2251","article-title":"Precise small-molecule recognition of a toxic CUG RNA repeat expansion","volume":"13","author":"Rzuczek","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biochi.2019.05.001_bib16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nchembio708","article-title":"Small-molecule ligand induces nucleotide flipping in (CAG)n trinucleotide repeats","volume":"1","author":"Nakatani","year":"2005","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biochi.2019.05.001_bib17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1021\/acschembio.7b00699","article-title":"Myricetin reduces toxic level of CAG repeats RNA in Huntington's disease (HD) and Spino Cerebellar ataxia (SCAs)","volume":"13","author":"Khan","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.biochi.2019.05.001_bib18","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1093\/hmg\/ddm064","article-title":"Modulation of nucleosome dynamics in Huntington's disease","volume":"16","author":"Stack","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biochi.2019.05.001_bib19","doi-asserted-by":"crossref","first-page":"10335","DOI":"10.1523\/JNEUROSCI.2599-04.2004","article-title":"Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease","volume":"24","author":"Ferrante","year":"2004","journal-title":"J.\u00a0Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.biochi.2019.05.001_bib20","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.2174\/138161206777698828","article-title":"Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation","volume":"12","author":"Herbst","year":"2006","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.biochi.2019.05.001_bib21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/ng864","article-title":"A\u00a0bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila","volume":"30","author":"Kazantsev","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biochi.2019.05.001_bib22","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12035-012-8316-3","article-title":"Mouse models of polyglutamine diseases in therapeutic approaches: review and data table. Part II","volume":"46","author":"Switonski","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.biochi.2019.05.001_bib23","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/hmg\/ddl210","article-title":"Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models","volume":"15","author":"Ehrnhoefer","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.biochi.2019.05.001_bib24","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.phrs.2015.11.023","article-title":"Implication of coumarins towards central nervous system disorders","volume":"103","author":"Skalicka-Wozniak","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.biochi.2019.05.001_bib25","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ejmech.2015.07.010","article-title":"Coumarins as anticancer agents: a review on synthetic strategies, mechanism of action and SAR studies","volume":"101","author":"Thakur","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/187152307783219989","article-title":"The anti-inflammatory effect of coumarin and its derivatives","volume":"6","author":"Hadjipavlou-Litina","year":"2007","journal-title":"Anti-Inflammatory Anti-Allergy Agents Med. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib27","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.2174\/092986711803414395","article-title":"Coumarins as antioxidants","volume":"18","author":"Kostova","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib28","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.2174\/138955709789878141","article-title":"Natural coumarins as a novel class of neuroprotective agents","volume":"9","author":"Epifano","year":"2009","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.apjtm.2016.01.014","article-title":"Anti-Alzheimer's disease potential of coumarins from Angelica decursiva and Artemisia capillaris and structure-activity analysis","volume":"9","author":"Ali","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.biochi.2019.05.001_bib30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.bmcl.2007.09.100","article-title":"Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds","volume":"18","author":"Piazzi","year":"2008","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.biochi.2019.05.001_bib31","doi-asserted-by":"crossref","first-page":"e0131788","DOI":"10.1371\/journal.pone.0131788","article-title":"Structural insights reveal the dynamics of the repeating r(CAG) transcript found in Huntington's disease (HD) and spinocerebellar ataxias (SCAs)","volume":"10","author":"Tawani","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2019.05.001_bib32","first-page":"2785","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"JCoCh"},{"key":"10.1016\/j.biochi.2019.05.001_bib33","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib34","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1038\/srep01972","article-title":"Mahogunin ring finger-1 (MGRN1) suppresses chaperone-associated misfolded protein aggregation and toxicity","volume":"3","author":"Chhangani","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2019.05.001_bib35","doi-asserted-by":"crossref","first-page":"12755","DOI":"10.1074\/jbc.M109.078790","article-title":"Structural diversity of triplet repeat RNAs","volume":"285","author":"Sobczak","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib36","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1021\/ja3108627","article-title":"A\u00a0dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations","volume":"135","author":"Yildirim","year":"2013","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biochi.2019.05.001_bib37","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1021\/acs.biochem.7b00252","article-title":"Structure and dynamics of RNA repeat expansions that cause Huntington's disease and myotonic dystrophy type 1","volume":"56","author":"Chen","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2019.05.001_bib38","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/cb200413a","article-title":"Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts","volume":"7","author":"Kumar","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.biochi.2019.05.001_bib39","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.freeradbiomed.2009.01.019","article-title":"An in\u00a0vitro screening cascade to identify neuroprotective antioxidants in ALS","volume":"46","author":"Barber","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2019.05.001_bib40","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/10715769209079522","article-title":"Peroxyl radical scavenging by a series of coumarins","volume":"17","author":"Paya","year":"1992","journal-title":"Free Radic. Res. Commun."},{"key":"10.1016\/j.biochi.2019.05.001_bib41","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1016\/j.bmc.2014.05.032","article-title":"Coumarin hybrids as novel therapeutic agents","volume":"22","author":"Sandhu","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0167-4781(90)90107-D","article-title":"Interactions of berberine with poly(A) and tRNA","volume":"1049","author":"Nandi","year":"1990","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2019.05.001_bib43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0009-2797(95)03616-T","article-title":"Interaction of methylene blue with transfer RNA--a spectroscopic study","volume":"97","author":"Antony","year":"1995","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.biochi.2019.05.001_bib44","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1021\/bm0612079","article-title":"A\u00a0biophysical investigation on the binding and controlled DNA release in a cetyltrimethylammonium Bromide\u2212Sodium octyl sulfate cat-anionic vesicle system","volume":"8","author":"Bonincontro","year":"2007","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.biochi.2019.05.001_bib45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/bip.1969.360080208","article-title":"Studies of the optical properties of the proflavine\u2013DNA complex","volume":"8","author":"Li","year":"1969","journal-title":"Biopolymers"},{"key":"10.1016\/j.biochi.2019.05.001_bib46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/bip.1970.360090106","article-title":"Circular dichroism of acridine orange bound to DNA","volume":"9","author":"Zama","year":"1970","journal-title":"Biopolymers"},{"key":"10.1016\/j.biochi.2019.05.001_bib47","series-title":"Polarized Fluorescence of Polycyclic Hydrocarbons in Aqueous DNA Solutions: Effect of Flow-Orientation","author":"Green","year":"1967"},{"key":"10.1016\/j.biochi.2019.05.001_bib48","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/bip.1966.360040403","article-title":"Interaction of polynuclear aromatic hydrocarbons, 4-nitroquinoline 1-oxides, and various dyes with DNA","volume":"4","author":"Nagata","year":"1966","journal-title":"Biopolymers"},{"key":"10.1016\/j.biochi.2019.05.001_bib49","first-page":"219","article-title":"Evaluation of drug-nucleic acid interactions by thermal melting curves","volume":"90","author":"Wilson","year":"1997","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.biochi.2019.05.001_bib50","series-title":"Sequence-specific DNA Binding Agents","first-page":"130","article-title":"Thermal denaturation of drug-DNA complexes: tools and tricks","author":"Shi X","year":"2006"},{"key":"10.1016\/j.biochi.2019.05.001_bib51","doi-asserted-by":"crossref","first-page":"e23186","DOI":"10.1371\/journal.pone.0023186","article-title":"Targeting RNA by small molecules: comparative structural and thermodynamic aspects of aristololactam-\u03b2-D-glucoside and daunomycin binding to tRNA(phe)","volume":"6","author":"Das","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2019.05.001_bib52","doi-asserted-by":"crossref","first-page":"6262","DOI":"10.1021\/ja003016y","article-title":"An enthalpic component in Cooperativity:\u2009 the relationship between enthalpy, entropy, and noncovalent structure in weak associations","volume":"123","author":"Calderone","year":"2001","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.biochi.2019.05.001_bib53","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.3390\/ijms10083457","article-title":"Analysis of cooperativity by isothermal titration calorimetry","volume":"10","author":"Brown","year":"2009","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2019.05.001_bib54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0076-6879(08)04205-5","article-title":"Isothermal titration calorimetry: general formalism using binding polynomials","volume":"455","author":"Freire","year":"2009","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biochi.2019.05.001_bib55","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/cmdc.201100353","article-title":"Halogen bonding at the active sites of human cathepsin L and MEK1 kinase: efficient interactions in different environments","volume":"6","author":"Hardegger","year":"2011","journal-title":"ChemMedChem"},{"key":"10.1016\/j.biochi.2019.05.001_bib56","doi-asserted-by":"crossref","first-page":"5607","DOI":"10.1021\/jm200644r","article-title":"Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors","volume":"54","author":"Xu","year":"2011","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.biochi.2019.05.001_bib57","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.3390\/molecules22091397","article-title":"Looking back, looking forward at halogen bonding in drug Discovery","volume":"22","author":"Mendez","year":"2017","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.biochi.2019.05.001_bib58","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0278-6915(99)00010-1","article-title":"Coumarin metabolism, toxicity and carcinogenicity: relevance for human risk assessment","volume":"37","author":"Lake","year":"1999","journal-title":"Food Chem. Toxicol. Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"key":"10.1016\/j.biochi.2019.05.001_bib59","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4155\/tde.12.144","article-title":"Nanomedicine for uterine leiomyoma therapy","volume":"4","author":"Ali","year":"2013","journal-title":"Ther. Deliv."},{"key":"10.1016\/j.biochi.2019.05.001_bib60","doi-asserted-by":"crossref","first-page":"441","DOI":"10.3727\/096368914X678454","article-title":"Polyglutamine (PolyQ) diseases: genetics to treatments","volume":"23","author":"Fan","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.biochi.2019.05.001_bib61","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00109-004-0632-2","article-title":"A\u00a0novel therapeutic strategy for polyglutamine diseases by stabilizing aggregation-prone proteins with small molecules","volume":"83","author":"Tanaka","year":"2005","journal-title":"J.\u00a0Mol. Med. (Berl.)"},{"key":"10.1016\/j.biochi.2019.05.001_bib62","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1073\/pnas.0408936102","article-title":"A\u00a0potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in\u00a0vivo","volume":"102","author":"Zhang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908419301403?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908419301403?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:10:51Z","timestamp":1759540251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908419301403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":62,"alternative-id":["S0300908419301403"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2019.05.001","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rationally designed small molecules targeting toxic CAG repeat RNA that causes Huntington's disease (HD) and spinocerebellar ataxia (SCAs)","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2019.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}