{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:15:18Z","timestamp":1791227718970,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AT006896"],"award-info":[{"award-number":["R01AT006896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010629","name":"Fulbright Scholarship","doi-asserted-by":"publisher","award":["E056609"],"award-info":[{"award-number":["E056609"]}],"id":[{"id":"10.13039\/100010629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16POST30690001"],"award-info":[{"award-number":["16POST30690001"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.biochi.2019.08.013","type":"journal-article","created":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T11:28:13Z","timestamp":1566905293000},"page":"250-257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism"],"prefix":"10.1016","volume":"165","author":[{"given":"Abdul-Musawwir","family":"Alli-Oluwafuyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula B.","family":"Luis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumie","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1244-8764","authenticated-orcid":false,"given":"Juan A.","family":"Gim\u00e9nez-Bastida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Han","family":"Presley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Duvernay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezekiel O.","family":"Iwalewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4215-967X","authenticated-orcid":false,"given":"Claus","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2019.08.013_bib1","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.2174\/1568026615666150619142519","article-title":"Curcumin: a natural product for diabetes and its complications","volume":"15","author":"Nabavi","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.fct.2015.05.022","article-title":"The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: a recent update","volume":"83","author":"Ghosh","year":"2015","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.biochi.2019.08.013_bib3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ejphar.2015.02.045","article-title":"Experimental evidence for curcumin and its analogs for management of diabetes mellitus and its associated complications","volume":"756","author":"Rivera-Mancia","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biochi.2019.08.013_bib4","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.2337\/dc12-0116","article-title":"Curcumin extract for prevention of type 2 diabetes","volume":"35","author":"Chuengsamarn","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biochi.2019.08.013_bib5","doi-asserted-by":"crossref","DOI":"10.5812\/ijem.18081","article-title":"Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin","volume":"12","author":"Ghorbani","year":"2014","journal-title":"Int. J. Endocrinol. Metab."},{"key":"10.1016\/j.biochi.2019.08.013_bib6","doi-asserted-by":"crossref","first-page":"8289","DOI":"10.3390\/molecules19068289","article-title":"A\u00a0PPARgamma, NF-kappaB and AMPK-dependent mechanism may be involved in the beneficial effects of curcumin in the diabetic db\/db mice liver","volume":"19","author":"Jimenez-Flores","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.biochi.2019.08.013_bib7","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbrc.2013.04.092","article-title":"Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+\/calmodulin-dependent kinase II activation","volume":"435","author":"Takikawa","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2019.08.013_bib8","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/mnfr.201400871","article-title":"Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1 secretion","volume":"59","author":"Tsuda","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biochi.2019.08.013_bib9","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.cmet.2013.04.008","article-title":"Pharmacology, physiology, and mechanisms of incretin hormone action","volume":"17","author":"Campbell","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.biochi.2019.08.013_bib10","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1001\/jama.298.2.194","article-title":"Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis","volume":"298","author":"Amori","year":"2007","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.biochi.2019.08.013_bib11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrendo.2009.48","article-title":"Incretin-based therapies for type 2 diabetes mellitus","volume":"5","author":"Lovshin","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"issue":"Supplement","key":"10.1016\/j.biochi.2019.08.013_bib12","doi-asserted-by":"crossref","first-page":"S70","DOI":"10.2337\/db06-S020","article-title":"Glucagon-like Peptide 1 secretion by the L-cell. The view from within","volume":"55","author":"Lim","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2019.08.013_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600471","article-title":"Curcumin improves glucose tolerance via stimulation of glucagon-like peptide-1 secretion","volume":"61","author":"Kato","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biochi.2019.08.013_bib14","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1021\/acs.jafc.5b00244","article-title":"Degradation of curcumin: from mechanism to biological implications","volume":"63","author":"Schneider","year":"2015","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bcp.2017.03.002","article-title":"Oxidative metabolism of curcumin-glucuronide by peroxidases and isolated human leukocytes","volume":"132","author":"Luis","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2019.08.013_bib16","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1074\/jbc.M114.618785","article-title":"Unraveling curcumin degradation. Autoxidation proceeds through spiroepoxide and vinylether intermediates en route to the main bicyclopentadione","volume":"290","author":"Gordon","year":"2015","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib17","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/acs.chemrestox.7b00326","article-title":"Thiol reactivity of curcumin and its oxidation products","volume":"31","author":"Luis","year":"2018","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biochi.2019.08.013_bib18","doi-asserted-by":"crossref","first-page":"21243","DOI":"10.1074\/jbc.RA117.000123","article-title":"The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites","volume":"292","author":"Edwards","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib19","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1096\/fasebj.13.10.1137","article-title":"Is NF-kappaB the sensor of oxidative stress?","volume":"13","author":"Li","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.biochi.2019.08.013_bib20","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1073\/pnas.97.9.4844","article-title":"15-Deoxy-delta12,14-prostaglandin J2 inhibits multiple steps in the NF-kappaB signaling pathway","volume":"97","author":"Straus","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biochi.2019.08.013_bib21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1021\/bi3014455","article-title":"Oxidative metabolites of curcumin poison human type II topoisomerases","volume":"52","author":"Ketron","year":"2013","journal-title":"Biochemistry"},{"key":"10.1016\/j.biochi.2019.08.013_bib22","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/jlcr.3102","article-title":"Facile synthesis of deuterated and [(14) C]labeled analogs of vanillin and curcumin for use as mechanistic and analytical tools","volume":"56","author":"Gordon","year":"2013","journal-title":"J.\u00a0Label. Comp. Radiopharm."},{"key":"10.1016\/j.biochi.2019.08.013_bib23","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/acs.chemrestox.5b00009","article-title":"Oxidative transformation of demethoxy- and bisdemethoxycurcumin: products, mechanism of formation, and poisoning of human topoisomerase IIalpha","volume":"28","author":"Gordon","year":"2015","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biochi.2019.08.013_bib24","series-title":"The Impact of Food Bioactives on Health","first-page":"211","article-title":"STC-1 cells","author":"McCarthy","year":"2015"},{"key":"10.1016\/j.biochi.2019.08.013_bib25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.bmc.2013.11.006","article-title":"Curcumin glucuronides: assessing the proliferative activity against human cell lines","volume":"22","author":"Pal","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib26","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.foodchem.2013.11.021","article-title":"Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells","volume":"151","author":"Shoji","year":"2014","journal-title":"Food Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib27","doi-asserted-by":"crossref","first-page":"9189","DOI":"10.1021\/acs.jafc.6b04343","article-title":"Effects of stable degradation products of curcumin on cancer cell proliferation and inflammation","volume":"64","author":"Sanidad","year":"2016","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib28","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jnatprod.8b00873","article-title":"Beta-glucuronidase catalyzes deconjugation and activation of curcumin-glucuronide in bone","author":"Kunihiro","year":"2019","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.biochi.2019.08.013_bib29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1677\/joe.1.06557","article-title":"Meat hydrolysate and essential amino acid-induced glucagon-like peptide-1 secretion, in the human NCI-H716 enteroendocrine cell line, is regulated by extracellular signal-regulated kinase1\/2 and p38 mitogen-activated protein kinases","volume":"191","author":"Reimer","year":"2006","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.biochi.2019.08.013_bib30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1210\/en.2008-0726","article-title":"Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell","volume":"150","author":"Lim","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2019.08.013_bib31","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1074\/jbc.M110.178806","article-title":"Autoxidative and cyclooxygenase-2 catalyzed transformation of the dietary chemopreventive agent curcumin","volume":"286","author":"Griesser","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib32","first-page":"1058","article-title":"Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in\u00a0vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production","volume":"61","author":"Ireson","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.biochi.2019.08.013_bib33","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1073\/pnas.1016217108","article-title":"Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism","volume":"108","author":"Hassaninasab","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biochi.2019.08.013_bib34","doi-asserted-by":"crossref","first-page":"14145","DOI":"10.1074\/jbc.M500901200","article-title":"Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma","volume":"280","author":"Shiraki","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib35","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1016\/S0731-7085(96)02024-9","article-title":"Stability of curcumin in buffer solutions and characterization of its degradation products","volume":"15","author":"Wang","year":"1997","journal-title":"J.\u00a0Pharm. Biomed. Anal."},{"key":"10.1016\/j.biochi.2019.08.013_bib36","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.2337\/dbi18-0008","article-title":"The ascending GLP-1 road from clinical safety to reduction of cardiovascular complications","volume":"67","author":"Drucker","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2019.08.013_bib37","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1039\/C8OB00639C","article-title":"Stability and anti-inflammatory activity of the reduction-resistant curcumin analog, 2,6-dimethyl-curcumin","volume":"16","author":"Joseph","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0378-5173(91)90278-V","article-title":"Interaction of curcumin with glutathione","volume":"76","author":"Mathews","year":"1991","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biochi.2019.08.013_bib39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.cbpa.2010.11.012","article-title":"Chemical 'omics' approaches for understanding protein cysteine oxidation in biology","volume":"15","author":"Leonard","year":"2011","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.biochi.2019.08.013_bib40","doi-asserted-by":"crossref","first-page":"26480","DOI":"10.1074\/jbc.R113.467738","article-title":"The redox biochemistry of protein sulfenylation and sulfinylation","volume":"288","author":"Lo Conte","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib41","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.freeradbiomed.2014.11.013","article-title":"The basics of thiols and cysteines in redox biology and chemistry","volume":"80","author":"Poole","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2019.08.013_bib42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0163-7827(03)00014-6","article-title":"4-Hydroxy-2-nonenal: a product and mediator of oxidative stress","volume":"42","author":"Uchida","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.biochi.2019.08.013_bib43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/tx700177j","article-title":"15-Deoxy-Delta(12,14)-prostaglandin J2: an electrophilic trigger of cellular responses","volume":"21","author":"Uchida","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.biochi.2019.08.013_bib44","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A\u00a0dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2019.08.013_bib45","doi-asserted-by":"crossref","first-page":"44573","DOI":"10.1074\/jbc.M404175200","article-title":"Redox regulation of the calcium\/calmodulin-dependent protein kinases","volume":"279","author":"Howe","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2019.08.013_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2007.02.087","article-title":"Oxidation of calmodulin alters activation and regulation of CaMKII","volume":"356","author":"Robison","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2019.08.013_bib47","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.freeradbiomed.2017.08.018","article-title":"Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals","volume":"112","author":"Keyes","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2019.08.013_bib48","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1073\/pnas.0710402105","article-title":"Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cells","volume":"105","author":"Sonoda","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.biochi.2019.08.013_bib49","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3164\/jcbn.15-50","article-title":"(-)-Epigallocatechin-3-gallate induces secretion of anorexigenic gut hormones","volume":"57","author":"Song","year":"2015","journal-title":"J.\u00a0Clin. Biochem. Nutr."},{"key":"10.1016\/j.biochi.2019.08.013_bib50","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.molmed.2012.04.011","article-title":"Vanillin and ferulic acid: not the major degradation products of curcumin","volume":"18","author":"Gordon","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biochi.2019.08.013_bib51","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1021\/jf204517k","article-title":"Curcumin bioavailability from enriched bread: the effect of microencapsulated ingredients","volume":"60","author":"Vitaglione","year":"2012","journal-title":"J.\u00a0Agric. Food Chem."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908419302457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908419302457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:13:54Z","timestamp":1759540434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908419302457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":51,"alternative-id":["S0300908419302457"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2019.08.013","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Curcumin induces secretion of glucagon-like peptide-1 through an oxidation-dependent mechanism","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2019.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}