{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:40:16Z","timestamp":1780105216995,"version":"3.54.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["SB\/YS\/LS-234\/2013"],"award-info":[{"award-number":["SB\/YS\/LS-234\/2013"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.biochi.2020.04.024","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T02:33:59Z","timestamp":1589769239000},"page":"13-22","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection"],"prefix":"10.1016","volume":"175","author":[{"given":"Sheetal","family":"Saini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath Kumar","family":"Kottarath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Kumar","family":"Dinda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Dube","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amogh Anant","family":"Sahasrabuddhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandreshwar Prasad","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudan","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambak Kumar","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.biochi.2020.04.024_bib1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.pt.2006.09.004","article-title":"Leishmaniasis and poverty","author":"Alvar","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.biochi.2020.04.024_bib2","author":"WHO"},{"issue":"4","key":"10.1016\/j.biochi.2020.04.024_bib3","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/infdis\/154.4.639","article-title":"A\u00a0prospective study of visceral leishmaniasis in an endemic area of Brazil","volume":"154","author":"Badaro","year":"1986","journal-title":"J.\u00a0Infect. Dis."},{"issue":"3","key":"10.1016\/j.biochi.2020.04.024_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/clinids\/8.3.447","article-title":"Reciprocal relationships between undernutrition and the parasitic disease visceral leishmaniasis","volume":"8","author":"Harrison","year":"1986","journal-title":"Rev. Infect. Dis."},{"issue":"1339","key":"10.1016\/j.biochi.2020.04.024_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1098\/rspb.1993.0123","article-title":"Malnutrition, age and the risk of parasitic disease: visceral leishmaniasis revisited","volume":"254","author":"Dye","year":"1993","journal-title":"Proc. Biol. Sci."},{"issue":"8","key":"10.1016\/j.biochi.2020.04.024_bib6","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1128\/IAI.69.8.4709-4718.2001","article-title":"Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection","volume":"69","author":"Anstead","year":"2001","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.biochi.2020.04.024_bib7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.plefa.2009.04.011","article-title":"Malnutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages","volume":"81","author":"Anstead","year":"2009","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"issue":"3","key":"10.1016\/j.biochi.2020.04.024_bib8","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1042\/bj2690807","article-title":"Uptake and incorporation of saturated and unsaturated fatty acids into macrophage lipids and their effect upon macrophage adhesion and phagocytosis","volume":"269","author":"Calder","year":"1990","journal-title":"Biochem. J."},{"issue":"Pt 2","key":"10.1016\/j.biochi.2020.04.024_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1042\/bj3000509","article-title":"The incorporation of fatty acids by lymphocytes and the effect on fatty acid composition and membrane fluidity","volume":"300","author":"Calder","year":"1994","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.biochi.2020.04.024_bib10","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","article-title":"The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice","volume":"49","author":"Guillou","year":"2010","journal-title":"Prog. Lipid Res."},{"issue":"11","key":"10.1016\/j.biochi.2020.04.024_bib11","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.micinf.2014.08.015","article-title":"Essential role of leukotriene B4 on Leishmania (Viannia) braziliensis killing by human macrophages","volume":"16","author":"Morato","year":"2014","journal-title":"Microb. Infect."},{"issue":"5","key":"10.1016\/j.biochi.2020.04.024_bib12","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.4049\/jimmunol.1400399","article-title":"Prostaglandin E2 negatively regulates the production of inflammatory cytokines\/chemokines and IL-17 in visceral leishmaniasis","volume":"193","author":"Saha","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.biochi.2020.04.024_bib13","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1186\/s13071-014-0601-8","article-title":"Prostaglandin E2\/Leukotriene B4 balance induced by Lutzomyia longipalpis saliva favors Leishmania infantum infection","volume":"7","author":"Ara\u00fajo-Santos","year":"2014","journal-title":"Parasites Vectors"},{"issue":"1","key":"10.1016\/j.biochi.2020.04.024_bib14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1186\/s13071-016-1781-1","article-title":"Crosstalk between purinergic receptors and lipid mediators in leishmaniasis","volume":"9","author":"Chaves","year":"2016","journal-title":"Parasites Vectors"},{"issue":"3","key":"10.1016\/j.biochi.2020.04.024_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0005-2760(94)00251-S","article-title":"Influence of cell culture conditions on diet-induced changes in lymphocyte fatty acid composition","volume":"1255","author":"Yaqoob","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.biochi.2020.04.024_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11745-998-0193-y","article-title":"Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity","volume":"33","author":"Peterson","year":"1998","journal-title":"Lipids"},{"issue":"1","key":"10.1016\/j.biochi.2020.04.024_bib17","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1046\/j.1440-1711.2000.00867.x","article-title":"Dietary fats affect macrophage-mediated cytotoxicity towards tumour cells","volume":"78","author":"Wallace","year":"2000","journal-title":"Immunol. Cell Biol."},{"issue":"3","key":"10.1016\/j.biochi.2020.04.024_bib18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1189\/jlb.69.3.449","article-title":"Dietary fatty acids influence the production of Th1- but not Th2-type cytokines","volume":"69","author":"Wallace","year":"2001","journal-title":"J.\u00a0Leukoc. Biol."},{"issue":"12","key":"10.1016\/j.biochi.2020.04.024_bib19","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1093\/jn\/133.12.4230","article-title":"The effect of eicosapentaenoic acid on rat lymphocyte proliferation depends upon its position in dietary triacylglycerols","volume":"133","author":"Kew","year":"2003","journal-title":"Nutr. J."},{"issue":"6","key":"10.1016\/j.biochi.2020.04.024_bib20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/sj.ejcn.1602132","article-title":"The effects of conjugated linoleic acid supplementation on immune function in healthy volunteers","volume":"59","author":"Nugent","year":"2005","journal-title":"Eur. J. Clin. Nutr."},{"issue":"4","key":"10.1016\/j.biochi.2020.04.024_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/00034983.1989.11812358","article-title":"A\u00a0rapid staining technique for Leishmania parasites in splenic aspirate smears","volume":"83","author":"Chunge","year":"1989","journal-title":"Ann. Trop. Med. Parasitol."},{"issue":"2","key":"10.1016\/j.biochi.2020.04.024_bib22","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.molbiopara.2016.06.005","article-title":"Pi inhibits intracellular accumulation of methylglyoxal in promastigote form of L.\u00a0donovani","volume":"207","author":"Tiwari","year":"2016","journal-title":"Mol. Biochem. Parasitol."},{"issue":"12","key":"10.1016\/j.biochi.2020.04.024_bib23","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/iai.57.12.3770-3777.1989","article-title":"Amastigote stage-specific monoclonal antibodies against Leishmania major","volume":"57","author":"Jaffe","year":"1989","journal-title":"Infect. Immun."},{"issue":"4","key":"10.1016\/j.biochi.2020.04.024_bib24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00436-005-1339-1","article-title":"Refractoriness to the treatment of sodium stibogluconate in Indian kala-azar field isolates persist in in\u00a0vitro and in\u00a0vivo experimental models","volume":"96","author":"Dube","year":"2005","journal-title":"Prasitol. Res."},{"issue":"1","key":"10.1016\/j.biochi.2020.04.024_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1515\/ap-2018-0009","article-title":"Characterization of phosphate transporter(s) and understanding their role in Leishmania donovani parasite","volume":"63","author":"Sindhu","year":"2018","journal-title":"Acta Parasitol."},{"key":"10.1016\/j.biochi.2020.04.024_bib26","article-title":"Parasitic load determination by differential expressions of 5-lipoxygenase and PGE2 synthases in Visceral Leishmaniasis","volume":"147","author":"Saini","year":"2020","journal-title":"Prostag. Other Lipid Mediat."},{"key":"10.1016\/j.biochi.2020.04.024_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2478\/s11686-019-00127-8","article-title":"Comparison between immuno-clinicopathological features of experimental and human visceral leishmaniasis by Leishmania donovani","volume":"65","author":"Saini","year":"2020","journal-title":"Acta Parasitol."},{"issue":"5","key":"10.1016\/j.biochi.2020.04.024_bib28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/clinchem\/39.5.825","article-title":"Fast HPLC Determination of serum free fatty acids in the picomole range","volume":"39","author":"Puttmann","year":"1993","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.biochi.2020.04.024_bib29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00436-018-6115-0","article-title":"Leishmania donovani reduces the levels of retinoic acid synthesizing enzymes in infected macrophages and favouring its own survival","volume":"118","author":"Verma","year":"2019","journal-title":"Parasitol. Res."},{"issue":"8","key":"10.1016\/j.biochi.2020.04.024_bib30","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1093\/ajcn\/34.8.1534","article-title":"Essential fatty acid deficiency in malnourished children","volume":"34","author":"Holman","year":"1981","journal-title":"Am. J. Clin. Nutr."},{"issue":"4\u20135","key":"10.1016\/j.biochi.2020.04.024_bib31","first-page":"595","article-title":"Polyunsaturated and essential fatty acids in malnourished children","volume":"12","author":"Leichsenring","year":"1992","journal-title":"Nutr. Res."},{"key":"10.1016\/j.biochi.2020.04.024_bib32","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0021-9258(20)78929-5","article-title":"On the nature and role of the fatty acids essential in nutrition","volume":"86","author":"George","year":"1930","journal-title":"J.\u00a0Biol. Chem."},{"issue":"3","key":"10.1016\/j.biochi.2020.04.024_bib33","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1365-2133.1976.tb07012.x","article-title":"Changes in transepidermal water loss and the composition of epidermal lecithin after applications of pure fatty acid triglycerides to skin of essential fatty acid-deficient rats","volume":"95","author":"Hartop","year":"1976","journal-title":"Br. J. Dermatol."},{"issue":"3","key":"10.1016\/j.biochi.2020.04.024_bib34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1054\/mehy.1998.1191","article-title":"The pathology of essential fatty acid deficiency: is it cell adhesion mediated?","volume":"55","author":"Jianga","year":"2000","journal-title":"Med. Hypotheses"},{"issue":"12","key":"10.1016\/j.biochi.2020.04.024_bib35","doi-asserted-by":"crossref","first-page":"6706","DOI":"10.4049\/jimmunol.171.12.6706","article-title":"Leishmania-Induced inhibition of macrophage antigen presentation analyzed at the single-cell level","volume":"171","author":"Courtney","year":"2003","journal-title":"J.\u00a0Immunol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908420300948?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908420300948?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:13:12Z","timestamp":1759540392000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908420300948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":35,"alternative-id":["S0300908420300948"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2020.04.024","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2020.04.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}