{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:34:39Z","timestamp":1790832879243,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100010942","name":"University of North Carolina at Charlotte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010942","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.biochi.2020.10.003","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T07:56:14Z","timestamp":1602143774000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Dbr1 functions in mRNA processing, intron turnover and human diseases"],"prefix":"10.1016","volume":"180","author":[{"given":"Arundhati","family":"Mohanta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0647-7411","authenticated-orcid":false,"given":"Kausik","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/0092-8674(91)90466-C","article-title":"Isolation and characterization of the gene encoding yeast debranching enzyme","volume":"65","author":"Chapman","year":"1991","journal-title":"Cell"},{"issue":"18","key":"10.1016\/j.biochi.2020.10.003_bib2","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1093\/nar\/28.18.3666","article-title":"Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants","volume":"28","author":"Kim","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.biochi.2020.10.003_bib3","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1261\/rna.058552.116","article-title":"Mechanistic insights into the manganese-dependent phosphodiesterase activity of yeast Dbr1 with bis-p-nitrophenylphosphate and branched RNA substrates","volume":"22","author":"Schwer","year":"2016","journal-title":"RNA"},{"issue":"9","key":"10.1016\/j.biochi.2020.10.003_bib4","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1017\/S1355838298980785","article-title":"Intronic snoRNA biosynthesis in Saccharomyces cerevisiae depends on the lariat-debranching enzyme: intron length effects and activity of a precursor snoRNA","volume":"4","author":"Ooi","year":"1998","journal-title":"RNA"},{"key":"10.1016\/j.biochi.2020.10.003_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13007-018-0351-2","article-title":"Functional intron-derived miRNAs and host-gene expression in plants","volume":"14","author":"Shapulatov","year":"2018","journal-title":"Plant Methods"},{"key":"10.1016\/j.biochi.2020.10.003_bib6","first-page":"594678","article-title":"MicroRNA-biogenesis and pre-mRNA splicing crosstalk","volume":"2009","author":"Shomron","year":"2009","journal-title":"J\u00a0biomed biotechnol"},{"issue":"7516","key":"10.1016\/j.biochi.2020.10.003_bib7","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nature13695","article-title":"Saturation editing of genomic regions by multiplex homology-directed repair","volume":"513","author":"Findlay","year":"2014","journal-title":"Nature"},{"issue":"6822","key":"10.1016\/j.biochi.2020.10.003_bib8","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib9","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3233\/ISB-00142","article-title":"Distributions of exons and introns in the human genome","volume":"4","author":"Sakharkar","year":"2004","journal-title":"Silico Biol."},{"issue":"4709","key":"10.1016\/j.biochi.2020.10.003_bib10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1126\/science.2990042","article-title":"An RNA processing activity that debranches RNA lariats","volume":"229","author":"Ruskin","year":"1985","journal-title":"Science"},{"issue":"51","key":"10.1016\/j.biochi.2020.10.003_bib11","doi-asserted-by":"crossref","first-page":"14727","DOI":"10.1073\/pnas.1612729114","article-title":"Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1","volume":"113","author":"Clark","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib12","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2013-14-3-r22","article-title":"Retrotransposition of gene transcripts leads to structural variation in mammalian genomes","volume":"14","author":"Ewing","year":"2013","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.biochi.2020.10.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.MDNA3-0053-2014","article-title":"The Ty1 LTR-retrotransposon of budding yeast, Saccharomyces cerevisiae","volume":"3","author":"Curcio","year":"2015","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.biochi.2020.10.003_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1742-4690-2-63","article-title":"DBR1 siRNA inhibition of HIV-1 replication","volume":"2","author":"Ye","year":"2005","journal-title":"Retrovirology"},{"issue":"5655","key":"10.1016\/j.biochi.2020.10.003_bib15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1087023","article-title":"RNA branching and debranching in the yeast retrovirus-like element Ty1","volume":"303","author":"Cheng","year":"2004","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib16","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1261\/rna.7124405","article-title":"An evaluation of detection methods for large lariat RNAs","volume":"11","author":"Coombes","year":"2005","journal-title":"RNA"},{"issue":"9","key":"10.1016\/j.biochi.2020.10.003_bib17","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1261\/rna.629607","article-title":"Ty1 reverse transcriptase does not read through the proposed 2\u2019,5\u2019-branched retrotransposition intermediate in\u00a0vitro","volume":"13","author":"Pratico","year":"2007","journal-title":"RNA"},{"issue":"21","key":"10.1016\/j.biochi.2020.10.003_bib18","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1093\/nar\/gkg824","article-title":"Inhibition of pre-mRNA splicing by synthetic branched nucleic acids","volume":"31","author":"Carriero","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"8","key":"10.1016\/j.biochi.2020.10.003_bib19","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1261\/rna.044602.114","article-title":"A\u00a0homolog of lariat-debranching enzyme modulates turnover of branched RNA","volume":"20","author":"Garrey","year":"2014","journal-title":"RNA"},{"issue":"19","key":"10.1016\/j.biochi.2020.10.003_bib20","doi-asserted-by":"crossref","first-page":"6349","DOI":"10.1093\/nar\/gki934","article-title":"Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase","volume":"33","author":"Khalid","year":"2005","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.biochi.2020.10.003_bib21","doi-asserted-by":"crossref","first-page":"10845","DOI":"10.1093\/nar\/gku725","article-title":"Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1","volume":"42","author":"Montemayor","year":"2014","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"10.1016\/j.biochi.2020.10.003_bib22","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/1873-3468.12677","article-title":"Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+)\/Mn(2+) heterobinucleation","volume":"591","author":"Ransey","year":"2017","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.biochi.2020.10.003_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1285","article-title":"Complete sequencing and characterization of 21,243 full-length human cDNAs","volume":"36","author":"Ota","year":"2004","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biochi.2020.10.003_bib24","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/srep01090","article-title":"hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity","volume":"3","author":"Kataoka","year":"2013","journal-title":"Sci. Rep."},{"issue":"34","key":"10.1016\/j.biochi.2020.10.003_bib25","doi-asserted-by":"crossref","first-page":"E7970","DOI":"10.1073\/pnas.1808816115","article-title":"Lariat intronic RNAs in the cytoplasm of vertebrate cells","volume":"115","author":"Talhouarne","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.biochi.2020.10.003_bib26","doi-asserted-by":"crossref","DOI":"10.1002\/wrna.1386","article-title":"Emerging roles and context of circular RNAs","volume":"8","author":"Panda","year":"2017","journal-title":"Wiley Interdiscip Rev RNA"},{"issue":"5","key":"10.1016\/j.biochi.2020.10.003_bib27","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1093\/molbev\/msj084","article-title":"Proceedings of the SMBE tri-national young investigators\u2019 workshop 2005. Investigating the intron recognition mechanism in eukaryotes","volume":"23","author":"Collins","year":"2006","journal-title":"Mol. Biol. Evol."},{"issue":"2","key":"10.1016\/j.biochi.2020.10.003_bib28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20150028","article-title":"Metallophosphoesterases: structural fidelity with functional promiscuity","volume":"467","author":"Matange","year":"2015","journal-title":"Biochem J"},{"issue":"44","key":"10.1016\/j.biochi.2020.10.003_bib29","doi-asserted-by":"crossref","first-page":"13615","DOI":"10.1073\/pnas.1518646112","article-title":"The human gene damage index as a gene-level approach to prioritizing exome variants","volume":"112","author":"Itan","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.biochi.2020.10.003_bib30","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.cell.2018.02.019","article-title":"Inborn errors of RNA lariat metabolism in humans with brainstem viral infection","volume":"172","author":"Zhang","year":"2018","journal-title":"Cell"},{"issue":"7741","key":"10.1016\/j.biochi.2020.10.003_bib31","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41586-018-0828-1","article-title":"Excised linear introns regulate growth in yeast","volume":"565","author":"Morgan","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1261\/rna.040980.113","article-title":"Endogenous U2.U5.U6 snRNA complexes in S. pombe are intron lariat spliceosomes","volume":"20","author":"Chen","year":"2014","journal-title":"RNA"},{"issue":"2","key":"10.1016\/j.biochi.2020.10.003_bib33","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.3390\/ijms16023705","article-title":"Identification of the specific interactors of the human lariat RNA debranching enzyme 1 protein","volume":"16","author":"Masaki","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.biochi.2020.10.003_bib34","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/gtc.12114","article-title":"Identification of a novel component C2ORF3 in the lariat-intron complex: lack of C2ORF3 interferes with pre-mRNA splicing via intron turnover pathway","volume":"19","author":"Yoshimoto","year":"2014","journal-title":"Gene Cell."},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib35","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41422-019-0143-x","article-title":"Structures of the human spliceosomes before and after release of the ligated exon","volume":"29","author":"Zhang","year":"2019","journal-title":"Cell Res."},{"issue":"10","key":"10.1016\/j.biochi.2020.10.003_bib36","doi-asserted-by":"crossref","first-page":"e2409","DOI":"10.1038\/cddis.2016.313","article-title":"XAB2 functions in mitotic cell cycle progression via transcriptional regulation of CENPE","volume":"7","author":"Hou","year":"2016","journal-title":"Cell Death Dis."},{"issue":"12","key":"10.1016\/j.biochi.2020.10.003_bib37","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/ng.2434","article-title":"Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models","volume":"44","author":"Armakola","year":"2012","journal-title":"Nat. Genet."},{"issue":"31","key":"10.1016\/j.biochi.2020.10.003_bib38","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1038\/sj.onc.1203048","article-title":"Human POMp75 is identified as the pro-oncoprotein TLS\/FUS: both POMp75 and POMp 100 DNA homologous pairing activities are associated to cell proliferation","volume":"18","author":"Bertrand","year":"1999","journal-title":"Oncogene"},{"issue":"48","key":"10.1016\/j.biochi.2020.10.003_bib39","doi-asserted-by":"crossref","first-page":"34337","DOI":"10.1074\/jbc.274.48.34337","article-title":"Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS\/FUS and is able to promote D-loop formation","volume":"274","author":"Baechtold","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib40","doi-asserted-by":"crossref","DOI":"10.1177\/1759091414544472","article-title":"Functions of FUS\/TLS from DNA repair to stress response: implications for ALS","volume":"6","author":"Sama","year":"2014","journal-title":"ASN Neuro"},{"issue":"16","key":"10.1016\/j.biochi.2020.10.003_bib41","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1101\/gad.267286.115","article-title":"ALS mutations in TLS\/FUS disrupt target gene expression","volume":"29","author":"Coady","year":"2015","journal-title":"Genes Dev."},{"issue":"Pt 15","key":"10.1016\/j.biochi.2020.10.003_bib42","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1242\/jcs.110.15.1741","article-title":"TLS (FUS) binds RNA in\u00a0vivo and engages in nucleo-cytoplasmic shuttling","volume":"110","author":"Zinszner","year":"1997","journal-title":"J.\u00a0Cell Sci."},{"issue":"6","key":"10.1016\/j.biochi.2020.10.003_bib43","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.cub.2005.01.058","article-title":"The RNA binding protein TLS is translocated to dendritic spines by mGluR 5 activation and regulates spine morphology","volume":"15","author":"Fujii","year":"2005","journal-title":"Curr. Biol."},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib44","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1128\/MCB.18.3.1181","article-title":"Processing of the precursors to small nucleolar RNAs and rRNAs requires common components","volume":"18","author":"Petfalski","year":"1998","journal-title":"Mol. Cell Biol."},{"issue":"7","key":"10.1016\/j.biochi.2020.10.003_bib45","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1002\/j.1460-2075.1993.tb05954.x","article-title":"A\u00a0novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA","volume":"12","author":"Fragapane","year":"1993","journal-title":"EMBO J."},{"issue":"25","key":"10.1016\/j.biochi.2020.10.003_bib46","doi-asserted-by":"crossref","first-page":"5824","DOI":"10.1093\/nar\/21.25.5824","article-title":"Two different snoRNAs are encoded in introns of amphibian and human L1 ribosomal protein genes","volume":"21","author":"Prislei","year":"1993","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.biochi.2020.10.003_bib47","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1101\/gad.11.7.941","article-title":"The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation","volume":"11","author":"Ganot","year":"1997","journal-title":"Genes Dev."},{"issue":"5569","key":"10.1016\/j.biochi.2020.10.003_bib48","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1126\/science.1069415","article-title":"Genomewide analysis of mRNA processing in yeast using splicing-specific microarrays","volume":"296","author":"Clark","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.biochi.2020.10.003_bib49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1745-6150-7-29","article-title":"Identifying the mechanisms of intron gain: progress and trends","volume":"7","author":"Yenerall","year":"2012","journal-title":"Biol. Direct"},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib50","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0092-8674(95)90092-6","article-title":"A\u00a0group II intron RNA is a catalytic component of a DNA endonuclease involved in intron mobility","volume":"83","author":"Zimmerly","year":"1995","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib51","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0092-8674(95)90027-6","article-title":"Group II intron mobility occurs by target DNA-primed reverse transcription","volume":"82","author":"Zimmerly","year":"1995","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.biochi.2020.10.003_bib52","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cell.2007.06.028","article-title":"The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila","volume":"130","author":"Okamura","year":"2007","journal-title":"Cell"},{"issue":"7149","key":"10.1016\/j.biochi.2020.10.003_bib53","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature05983","article-title":"Intronic microRNA precursors that bypass Drosha processing","volume":"448","author":"Ruby","year":"2007","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.biochi.2020.10.003_bib54","doi-asserted-by":"crossref","first-page":"e1006422","DOI":"10.1371\/journal.pgen.1006422","article-title":"Intron lariat RNA inhibits MicroRNA Biogenesis by Sequestering the dicing Complex in arabidopsis","volume":"12","author":"Li","year":"2016","journal-title":"PLoS Genet."},{"issue":"12","key":"10.1016\/j.biochi.2020.10.003_bib55","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1128\/JVI.00704-14","article-title":"Impairment of HIV-1 cDNA synthesis by DBR1 knockdown","volume":"88","author":"Galvis","year":"2014","journal-title":"J.\u00a0Virol."},{"issue":"38","key":"10.1016\/j.biochi.2020.10.003_bib56","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1038\/onc.2017.150","article-title":"Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development","volume":"36","author":"Han","year":"2017","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.biochi.2020.10.003_bib57","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1002\/j.1460-2075.1988.tb02960.x","article-title":"Trypanosome trans-splicing utilizes 2\u2019-5\u2019 branches and a corresponding debranching activity","volume":"7","author":"Sutton","year":"1988","journal-title":"EMBO J."},{"issue":"21","key":"10.1016\/j.biochi.2020.10.003_bib58","doi-asserted-by":"crossref","first-page":"11279","DOI":"10.1073\/pnas.94.21.11279","article-title":"Binding of RNA template to a complex of HIV-1 reverse transcriptase\/primer\/template","volume":"94","author":"Canard","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"23","key":"10.1016\/j.biochi.2020.10.003_bib59","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01377-17","article-title":"Conformational changes in the 5\u2019 end of the HIV-1 genome dependent on the debranching enzyme DBR1 during early stages of infection","volume":"91","author":"Galvis","year":"2017","journal-title":"J.\u00a0Virol."},{"issue":"6340","key":"10.1016\/j.biochi.2020.10.003_bib60","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3321","article-title":"A\u00a0subcellular map of the human proteome","volume":"356","author":"Thul","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.biochi.2020.10.003_bib61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/2152-7806.169561","article-title":"A\u00a0comprehensive review of amyotrophic lateral sclerosis","volume":"6","author":"Zarei","year":"2015","journal-title":"Surg. Neurol. Int."},{"issue":"6415","key":"10.1016\/j.biochi.2020.10.003_bib62","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib63","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10048-010-0239-4","article-title":"RNA processing pathways in amyotrophic lateral sclerosis","volume":"11","author":"van Blitterswijk","year":"2010","journal-title":"Neurogenetics"},{"issue":"9","key":"10.1016\/j.biochi.2020.10.003_bib64","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1084\/jem.2129insight4","article-title":"Inborn errors underlying herpes simplex encephalitis: from TLR3 to IRF3","volume":"212","author":"Zhang","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib65","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0092-8674(86)90616-1","article-title":"Identification of a novel Y branch structure as an intermediate in trypanosome mRNA processing: evidence for trans splicing","volume":"47","author":"Murphy","year":"1986","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib66","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0092-8674(86)90617-3","article-title":"Evidence for trans splicing in trypanosomes","volume":"47","author":"Sutton","year":"1986","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.biochi.2020.10.003_bib67","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.cell.2015.03.020","article-title":"Non-coding RNA Generated following lariat debranching mediates Targeting of AID to DNA","volume":"161","author":"Zheng","year":"2015","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.biochi.2020.10.003_bib68","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1101\/gr.166819.113","article-title":"LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq","volume":"24","author":"Bitton","year":"2014","journal-title":"Genome Res."},{"issue":"6","key":"10.1016\/j.biochi.2020.10.003_bib69","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4161\/rna.24604","article-title":"On the classification of long non-coding RNAs","volume":"10","author":"Ma","year":"2013","journal-title":"RNA Biol."},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib70","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nri.2016.2","article-title":"Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity","volume":"16","author":"Casellas","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"7655","key":"10.1016\/j.biochi.2020.10.003_bib71","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nature22366","article-title":"Architecture of the human interactome defines protein communities and disease networks","volume":"545","author":"Huttlin","year":"2017","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.biochi.2020.10.003_bib72","doi-asserted-by":"crossref","DOI":"10.3390\/genes9030134","article-title":"The unforeseen non-coding RNAs in head and neck cancer","volume":"9","author":"Irimie","year":"2018","journal-title":"Genes"},{"issue":"1","key":"10.1016\/j.biochi.2020.10.003_bib73","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/s41467-018-03523-2","article-title":"An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2020.10.003_bib74","doi-asserted-by":"crossref","first-page":"7354260","DOI":"10.1155\/2017\/7354260","article-title":"Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs","volume":"2017","author":"Lizarbe","year":"2017","journal-title":"BioMed Res. Int."},{"issue":"8","key":"10.1016\/j.biochi.2020.10.003_bib75","doi-asserted-by":"crossref","first-page":"e1005422","DOI":"10.1371\/journal.pgen.1005422","article-title":"Retrohoming of a mobile group II intron in human cells suggests how eukaryotes limit group II intron proliferation","volume":"11","author":"Truong","year":"2015","journal-title":"PLoS Genet."},{"issue":"7569","key":"10.1016\/j.biochi.2020.10.003_bib76","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nature14877","article-title":"Panorama of ancient metazoan macromolecular complexes","volume":"525","author":"Wan","year":"2015","journal-title":"Nature"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908420302613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908420302613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:17:53Z","timestamp":1759540673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908420302613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":76,"alternative-id":["S0300908420302613"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2020.10.003","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dbr1 functions in mRNA processing, intron turnover and human diseases","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2020.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}