{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:19:58Z","timestamp":1778509198029,"version":"3.51.4"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.biochi.2020.10.007","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T02:49:05Z","timestamp":1603334945000},"page":"217-227","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3\u2032-diindolylmethane and chemotherapy drugs"],"prefix":"10.1016","volume":"179","author":[{"given":"Sergey V.","family":"Nikulin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris Ya.","family":"Alekseev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya S.","family":"Sergeeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel A.","family":"Karalkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizaveta K.","family":"Nezhurina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina A.","family":"Kirsanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina K.","family":"Sviridova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suraja A.","family":"Akhmedova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadezhda N.","family":"Volchenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larisa V.","family":"Bolotina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey I.","family":"Osipyants","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry M.","family":"Hushpulian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxim A.","family":"Topchiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey F.","family":"Asachenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia P.","family":"Koval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry S.","family":"Shcherbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vsevolod I.","family":"Kiselev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry S.","family":"Mikhaylenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udo","family":"Schumacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1816-8699","authenticated-orcid":false,"given":"Andrey A.","family":"Poloznikov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2020.10.007_bib1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA","volume":"68","author":"Bray","year":"2018","journal-title":"Canc. J. Clin."},{"key":"10.1016\/j.biochi.2020.10.007_bib2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5306\/wjco.v5.i3.412","article-title":"Biological subtypes of breast cancer: prognostic and therapeutic implications","volume":"5","author":"Yersal","year":"2014","journal-title":"World J. Clin. Oncol."},{"key":"10.1016\/j.biochi.2020.10.007_bib3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cpet.2018.02.006","article-title":"Overview of breast cancer therapy","volume":"13","author":"Moo","year":"2018","journal-title":"Pet. Clin."},{"key":"10.1016\/j.biochi.2020.10.007_bib4","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1056\/NEJM199810013391407","article-title":"Treatment of breast cancer","volume":"339","author":"Hortobagyi","year":"1998","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2018.00227","article-title":"Recent advances in the treatment of breast cancer","volume":"8","author":"Tong","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biochi.2020.10.007_bib6","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/1097-0142(19800701)46:1<162::AID-CNCR2820460127>3.0.CO;2-B","article-title":"Causes of death in breast cancer a clinicopathologic study","volume":"46","author":"Hagemeister","year":"1980","journal-title":"Cancer"},{"key":"10.1016\/j.biochi.2020.10.007_bib7","doi-asserted-by":"crossref","first-page":"5574","DOI":"10.1002\/cam4.2474","article-title":"Are 90% of deaths from cancer caused by metastases?","volume":"8","author":"Dillek\u00e5s","year":"2019","journal-title":"Canc. Med"},{"key":"10.1016\/j.biochi.2020.10.007_bib8","first-page":"85","article-title":"Recurrent breast cancer: treatment strategies for maintaining and prolonging good quality of life","volume":"107","author":"Gerber","year":"2010","journal-title":"Dtsch. Arztebl. Int."},{"key":"10.1016\/j.biochi.2020.10.007_bib9","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1200\/JCO.2014.55.4139","article-title":"Past, present, and future challenges in breast cancer treatment","volume":"32","author":"Sledge","year":"2014","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.biochi.2020.10.007_bib10","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1592\/phco.29.8.954","article-title":"Overcoming drug resistance in patients with metastatic breast cancer","volume":"29","author":"Wong","year":"2009","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.biochi.2020.10.007_bib11","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ccell.2020.03.009","article-title":"Overcoming endocrine resistance in breast cancer","volume":"37","author":"Hanker","year":"2020","journal-title":"Canc. Cell"},{"key":"10.1016\/j.biochi.2020.10.007_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature22794","article-title":"Rare cell variability and drug-induced reprogramming as a mode of cancer drug resistance","volume":"546","author":"Shaffer","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2020.10.007_bib13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13148-019-0675-4","article-title":"Epigenetics in cancer therapy and nanomedicine","volume":"11","author":"Roberti","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.biochi.2020.10.007_bib14","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.drup.2011.08.001","article-title":"Epigenetics and chemoresistance in colorectal cancer: an opportunity for treatment tailoring and novel therapeutic strategies","volume":"14","author":"Crea","year":"2011","journal-title":"Drug Resist. Updates"},{"key":"10.1016\/j.biochi.2020.10.007_bib15","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019505","article-title":"Epigenetic determinants of cancer","volume":"8","author":"Baylin","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.biochi.2020.10.007_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1399-0004.2011.01809.x","article-title":"Epigenetic modifications in cancer","volume":"81","author":"Kanwal","year":"2012","journal-title":"Clin. Genet."},{"key":"10.1016\/j.biochi.2020.10.007_bib17","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.molcel.2016.09.027","article-title":"Impact of MicroRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression","volume":"64","author":"Denzler","year":"2016","journal-title":"Mol. Cell."},{"key":"10.1016\/j.biochi.2020.10.007_bib18","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13148-019-0776-0","article-title":"The timeline of epigenetic drug discovery: from reality to dreams","volume":"11","author":"Ganesan","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.biochi.2020.10.007_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13148-018-0587-8","article-title":"The role and mechanisms of action of microRNAs in cancer drug resistance","volume":"11","author":"Si","year":"2019","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.biochi.2020.10.007_bib20","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.omtn.2020.03.003","article-title":"The promising role of miR-21 as a cancer biomarker and its importance in RNA-based therapeutics","volume":"20","author":"Bautista-S\u00e1nchez","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biochi.2020.10.007_bib21","article-title":"MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and bcl-2 in lung squamous carcinoma, gejiu city, China","volume":"9","author":"Xu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.biochi.2020.10.007_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115919","article-title":"MiR-21 enhances melanoma invasiveness via inhibition of tissue inhibitor of metalloproteinases 3 expression: in\u00a0vivo effects of MiR-21 inhibitor","volume":"10","author":"Martin del Campo","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.biochi.2020.10.007_bib23","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cmet.2018.03.004","article-title":"RNA-targeted therapeutics","volume":"27","author":"Crooke","year":"2018","journal-title":"Cell Metabol."},{"key":"10.1016\/j.biochi.2020.10.007_bib24","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1002\/jcph.957","article-title":"RNA therapeutics in Oncology: advances, challenges, and future directions","volume":"57","author":"MacLeod","year":"2017","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.biochi.2020.10.007_bib25","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.chembiol.2019.04.011","article-title":"The natural product butylcycloheptyl prodiginine binds pre-miR-21, inhibits dicer-mediated processing of pre-miR-21, and blocks cellular proliferation","volume":"26","author":"Matarlo","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.biochi.2020.10.007_bib26","doi-asserted-by":"crossref","unstructured":"M. Junaid, R. Dash, N. Islam, J. Chowdhury, M.J. Alam, S.D. Nath, M.A.S. Shakil, A. Azam, S.M. Quader, S.M. Zahid Hosen, Molecular simulation studies of 3,3\u2019-diindolylmethane as a potent MicroRNA-21 antagonist., J. Pharm. BioAllied Sci. 9 (n.d.) 259\u2013265. doi:10.4103\/jpbs.JPBS_266_16.","DOI":"10.4103\/JPBS.JPBS_266_16"},{"key":"10.1016\/j.biochi.2020.10.007_bib27","unstructured":"H.L. Bradlow, Review. Indole-3-carbinol as a chemoprotective agent in breast and prostate cancer., In\u00a0Vivo. 22 (n.d.) 441-5. http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/18712169."},{"key":"10.1016\/j.biochi.2020.10.007_bib28","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.3892\/ol.2015.3008","article-title":"3,3\u2019-diindolylmethane potentiates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of gastric cancer cells","volume":"9","author":"Ye","year":"2015","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biochi.2020.10.007_bib29","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/0960327115597985","article-title":"Antiproliferative and anti-inflammatory properties of diindolylmethane and lupeol against N-butyl-N-(4-hydroxybutyl) nitrosamine induced bladder carcinogenesis in experimental rats","volume":"35","author":"Prabhu","year":"2016","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biochi.2020.10.007_bib30","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1158\/0008-5472.CAN-09-1924","article-title":"Chemopreventive agent 3,3\u2019-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases","volume":"70","author":"Li","year":"2010","journal-title":"Canc. Res"},{"key":"10.1016\/j.biochi.2020.10.007_bib31","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1158\/0008-5472.CAN-09-1924","article-title":"Chemopreventive agent 3,3\u2019-diindolylmethane selectively induces proteasomal degradation of class I histone deacetylases","volume":"70","author":"Li","year":"2010","journal-title":"Canc. Res"},{"key":"10.1016\/j.biochi.2020.10.007_bib32","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.12323","article-title":"3,3\u2032-Diindolylmethane ameliorates experimental hepatic fibrosis via inhibiting miR-21 expression","volume":"170","author":"Zhang","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biochi.2020.10.007_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s11010-011-0985-0","article-title":"3,3\u2032-Diindolylmethane inhibits breast cancer cell growth via miR-21-mediated Cdc25A degradation","volume":"358","author":"Jin","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.biochi.2020.10.007_bib34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbamcr.2014.10.017","article-title":"Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog","volume":"1853","author":"Wang","year":"2015","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.biochi.2020.10.007_bib35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2119\/2006-00007.Auborn","article-title":"Indole-3-Carbinol prevents PTEN loss in cervical cancer in\u00a0vivo","volume":"11","author":"Qi","year":"2005","journal-title":"Mol. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2018.07.002","article-title":"3,3\u2032-Diindolylmethane suppresses ovarian cancer cell viability and metastasis and enhances chemotherapy sensitivity via STAT3 and Akt signaling in\u00a0vitro and in\u00a0vivo","author":"Zou","year":"2018","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biochi.2020.10.007_bib37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/thy.2010.0245","article-title":"3,3\u2032-Diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease: a pilot study","volume":"21","author":"Rajoria","year":"2011","journal-title":"Thyroid"},{"key":"10.1016\/j.biochi.2020.10.007_bib38","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1053\/j.gastro.2011.07.050","article-title":"Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and barrett\u2019s epithelium","volume":"141","author":"Sato","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biochi.2020.10.007_bib39","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.cell.2015.03.053","article-title":"Prospective derivation of a living organoid biobank of colorectal cancer patients","volume":"161","author":"Van De Wetering","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2020.10.007_bib40","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cell.2017.11.010","article-title":"A\u00a0living biobank of breast cancer organoids captures disease heterogeneity","volume":"172","author":"Sachs","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2020.10.007_bib41","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/s41591-019-0422-6","article-title":"An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity","volume":"25","author":"Kopper","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41568-018-0007-6","article-title":"Organoids in cancer research","volume":"18","author":"Drost","year":"2018","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.biochi.2020.10.007_bib43","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s13045-018-0662-9","article-title":"Organoid technology and applications in cancer research","volume":"11","author":"Xu","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"issue":"80-","key":"10.1016\/j.biochi.2020.10.007_bib44","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.aao2774","article-title":"Patient-derived organoids model treatment response of metastatic gastrointestinal cancers","volume":"359","author":"Vlachogiannis","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.biochi.2020.10.007_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay2574","article-title":"Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients","volume":"11","author":"Ooft","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib46","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S0140-6736(71)90287-X","article-title":"A\u00a0rapid banding technique for human chromosomes","volume":"298","author":"Seabright","year":"1971","journal-title":"Lancet"},{"key":"10.1016\/j.biochi.2020.10.007_bib47","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1158\/1078-0432.CCR-16-3083","article-title":"Clinically relevant concentrations of anticancer drugs: a guide for nonclinical studies","volume":"23","author":"Liston","year":"2017","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.biochi.2020.10.007_bib48","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1200\/JCO.2011.37.2482","article-title":"Clinically used breast cancer markers such as estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 are unstable throughout tumor progression","volume":"30","author":"Lindstr\u00f6m","year":"2012","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.biochi.2020.10.007_bib49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/mi.10.3.3","article-title":"A\u00a0new class of estrogen receptor beta-selective activators","volume":"10","author":"Lo","year":"2010","journal-title":"Mol. Interv."},{"key":"10.1016\/j.biochi.2020.10.007_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF00047587","article-title":"Chromosomal abnormalities in human breast cancer","volume":"9","author":"Mars","year":"1990","journal-title":"Canc. METASTASIS Rev"},{"key":"10.1016\/j.biochi.2020.10.007_bib51","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5114\/pjp.2018.76703","article-title":"Fibroma of the breast: a rare tumour in the spectrum of the benign spindle cell tumours of the mammary stroma","volume":"69","author":"Gaetano","year":"2018","journal-title":"Pol. J. Pathol."},{"key":"10.1016\/j.biochi.2020.10.007_bib52","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.prp.2014.01.016","article-title":"Myofibroblastoma of the breast with smooth muscle differentiation showing deletion of 13q14 region: report of a case","volume":"210","author":"Tr\u00e9pant","year":"2014","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.biochi.2020.10.007_bib53","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.humpath.2012.01.015","article-title":"Mammary and vaginal myofibroblastomas are genetically related lesions: fluorescence in situ hybridization analysis shows deletion of 13q14 region","volume":"43","author":"Magro","year":"2012","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.biochi.2020.10.007_bib54","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/1098-2744(200011)29:3<151::AID-MC4>3.0.CO;2-6","article-title":"Loss of heterozygosity at 13q14 correlates withRB1 gene underexpression in human breast cancer","volume":"29","author":"Bieche","year":"2000","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.biochi.2020.10.007_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046814","article-title":"Molecular alterations associated with breast cancer mortality","volume":"7","author":"Voeghtly","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.biochi.2020.10.007_bib56","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.molonc.2010.06.003","article-title":"Cytogenomics of cancers: from chromosome to sequence","volume":"4","author":"Bernheim","year":"2010","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.biochi.2020.10.007_bib57","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s41586-019-1056-z","article-title":"Genomic characterization of metastatic breast cancers","volume":"569","author":"Bertucci","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2020.10.007_bib58","unstructured":"The innovative Russian biotech company GORDIZ, (n.d.). https:\/\/gordiz.ru\/en\/company\/."},{"key":"10.1016\/j.biochi.2020.10.007_bib59","unstructured":"Cellosaurus - a knowledge resource on cell lines, (n.d.). https:\/\/web.expasy.org\/cellosaurus\/."},{"key":"10.1016\/j.biochi.2020.10.007_bib60","first-page":"329","article-title":"CELL line individualization BY STR multiplex system IN the cell bank found CROSS-CONTAMINATION between ECV304 and EJ-1\/T24, tissue cult","volume":"18","author":"Tanabe","year":"1999","journal-title":"Responsive Community"},{"key":"10.1016\/j.biochi.2020.10.007_bib61","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1034\/j.1600-0854.2001.020202.x","article-title":"Prominin: a story of cholesterol, plasma membrane protrusions and human pathology","volume":"2","author":"Corbeil","year":"2001","journal-title":"Traffic"},{"key":"10.1016\/j.biochi.2020.10.007_bib62","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1242\/jcs.02439","article-title":"Release of extracellular membrane particles carrying the stem cell marker prominin-1 (CD133) from neural progenitors and other epithelial cells","volume":"118","author":"Marzesco","year":"2005","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.biochi.2020.10.007_bib63","doi-asserted-by":"crossref","first-page":"38029","DOI":"10.18632\/oncotarget.5703","article-title":"Polarized cell migration induces cancer type-specific CD133\/integrin\/Src\/Akt\/GSK3\u03b2\/\u03b2-catenin signaling required for maintenance of cancer stem cell properties","volume":"6","author":"Su","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2020.10.007_bib64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40169-018-0198-1","article-title":"The role of CD133 in cancer: a concise review","volume":"7","author":"Glumac","year":"2018","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib65","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1111\/j.1582-4934.2008.00455.x","article-title":"High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability","volume":"13","author":"Croker","year":"2009","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib66","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.4161\/cc.22543","article-title":"Mesenchymal traits are selected along with stem features in breast cancer cells grown as mammospheres","volume":"11","author":"Borgna","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.biochi.2020.10.007_bib67","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1158\/1541-7786.MCR-11-0156","article-title":"Understanding the dual nature of CD44 in breast cancer progression","volume":"9","author":"V Louderbough","year":"2011","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.biochi.2020.10.007_bib68","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-018-0605-5","article-title":"The biology and role of CD44 in cancer progression: therapeutic implications","volume":"11","author":"Chen","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.biochi.2020.10.007_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051239","article-title":"Tumorigenic and metastatic role of CD44-\/low\/CD24-\/low cells in luminal breast cancer","volume":"12","author":"Vikram","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.biochi.2020.10.007_bib70","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3390\/ijms18122574","article-title":"Drug resistance driven by cancer stem cells and their niche","volume":"18","author":"Prieto-Vila","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2020.10.007_bib71","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/1535370217731291","article-title":"MicroRNAs as biomarkers for clinical studies","volume":"243","author":"Pogribny","year":"2018","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib72","article-title":"miR-21-5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3","author":"Chen","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib73","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.toxlet.2014.11.001","article-title":"MicroRNA-21, up-regulated by arsenite, directs the epithelial\u2013mesenchymal transition and enhances the invasive potential of transformed human bronchial epithelial cells by targeting PDCD4","volume":"232","author":"Luo","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biochi.2020.10.007_bib74","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.toxlet.2014.05.005","article-title":"miR-21 regulates N-methyl-N-nitro-N\u2032-nitrosoguanidine-induced gastric tumorigenesis by targeting FASLG and BTG2","volume":"228","author":"Yang","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.biochi.2020.10.007_bib75","doi-asserted-by":"crossref","first-page":"36321","DOI":"10.18632\/oncotarget.9216","article-title":"Targeting miR-21-3p inhibits proliferation and invasion of ovarian cancer cells","volume":"7","author":"B\u00e1ez-Vega","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2020.10.007_bib76","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1093\/nar\/gkm641","article-title":"Tissue-dependent paired expression of miRNAs","volume":"35","author":"Ro","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biochi.2020.10.007_bib77","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/ijc.30902","article-title":"Different miR-21-3p isoforms and their different features in colorectal cancer","volume":"141","author":"Jiao","year":"2017","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.biochi.2020.10.007_bib78","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.canlet.2014.08.020","article-title":"miR-21-3p is a positive regulator of L1CAM in several human carcinomas","volume":"354","author":"Doberstein","year":"2014","journal-title":"Canc. Lett."},{"key":"10.1016\/j.biochi.2020.10.007_bib79","first-page":"402","article-title":"A\u00a0phase I dose-escalation study of oral BR-DIM (BioResponse 3,3\u2019- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer","volume":"2","author":"Heath","year":"2010","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.biochi.2020.10.007_bib80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1878-5085-4-25","article-title":"Comparative preclinical pharmacokinetics study of 3,3\u2032-diindolylmethane formulations: is personalized treatment and targeted chemoprevention in the horizon?","volume":"4","author":"Paltsev","year":"2013","journal-title":"EPMA J."},{"key":"10.1016\/j.biochi.2020.10.007_bib81","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1741-7015-10-9","article-title":"Diindolylmethane suppresses ovarian cancer growth and potentiates the effect of cisplatin in tumor mouse model by targeting signal transducer and activator of transcription 3 (STAT3)","volume":"10","author":"Kandala","year":"2012","journal-title":"BMC Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib82","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jss.2006.02.008","article-title":"3,3\u2032-Diindolylmethane and paclitaxel act synergistically to promote apoptosis in HER2\/neu human breast cancer cells","volume":"132","author":"McGuire","year":"2006","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.biochi.2020.10.007_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-74039-3_1","article-title":"Overview of resistance to systemic therapy in patients with breast cancer","volume":"608","author":"Gonzalez-Angulo","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biochi.2020.10.007_bib84","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3892\/etm.2014.1649","article-title":"3,3\u2032-Diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in\u00a0vitro and in\u00a0vivo by regulation of epithelial mesenchymal transition","volume":"7","author":"Wu","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biochi.2020.10.007_bib85","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000487629","article-title":"Explorative analysis of low-dose metronomic chemotherapy with cyclophosphamide and methotrexate in a cohort of metastatic breast cancer patients","volume":"13","author":"Krajnak","year":"2018","journal-title":"Breast Care"},{"key":"10.1016\/j.biochi.2020.10.007_bib86","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1186\/s12885-018-4792-9","article-title":"A\u00a0new promising way of maintenance therapy in advanced ovarian cancer: a comparative clinical study","volume":"18","author":"Kiselev","year":"2018","journal-title":"BMC Canc."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908420302650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908420302650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:19:31Z","timestamp":1759540771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908420302650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":86,"alternative-id":["S0300908420302650"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2020.10.007","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breast cancer organoid model allowed to reveal potentially beneficial combinations of 3,3\u2032-diindolylmethane and chemotherapy drugs","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2020.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}