{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:45:27Z","timestamp":1786985127436,"version":"build-2736575974"},"reference-count":90,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.biochi.2021.06.001","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T05:07:32Z","timestamp":1622869652000},"page":"144-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Relaxin in hepatic fibrosis: What is known and where to head?"],"prefix":"10.1016","volume":"187","author":[{"given":"Devaraj","family":"Ezhilarasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2021.06.001_bib1","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","author":"Kisseleva","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biochi.2021.06.001_bib2","first-page":"e1499","article-title":"Liver fibrosis: pathophysiology and clinical implications","volume":"13","author":"Berumen","year":"2021","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"10.1016\/j.biochi.2021.06.001_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5152\/tjg.2018.17330","article-title":"Liver fibrosis","volume":"29","author":"Ayd\u0131n","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"key":"10.1016\/j.biochi.2021.06.001_bib4","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1177\/1535370220949148","article-title":"Endothelin-1 in portal hypertension: the intricate role of hepatic stellate cells","volume":"245","author":"Ezhilarasan","year":"2020","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.biochi.2021.06.001_bib5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.hbpd.2020.03.011","article-title":"Critical role of estrogen in the progression of chronic liver diseases","volume":"19","author":"Ezhilarasan","year":"2020","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.biochi.2021.06.001_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cells9040875","article-title":"Liver fibrosis: mechanistic concepts and therapeutic perspectives","volume":"9","author":"Roehlen","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biochi.2021.06.001_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jhep.2020.03.011","article-title":"Hepatic fibrosis: a convergent response to liver injury that is reversible","volume":"73","author":"Wang","year":"2020","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.biochi.2021.06.001_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev-pathol-052016-100322","article-title":"The role of cancer-associated fibroblasts and fibrosis in liver cancer","volume":"12","author":"Affo","year":"2017","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.biochi.2021.06.001_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.14218\/JCTH.2020.00026","article-title":"Hepatic antifibrotic pharmacotherapy: are we approaching success?","volume":"8","author":"Chang","year":"2020","journal-title":"J\u00a0Clin Transl Hepatol"},{"key":"10.1016\/j.biochi.2021.06.001_bib10","series-title":"Nanoparticles and Their Biomedical Applications","first-page":"45","article-title":"Nanomedicine for hepatic fibrosis","author":"Devaraj","year":"2020"},{"key":"10.1016\/j.biochi.2021.06.001_bib11","doi-asserted-by":"crossref","first-page":"173507","DOI":"10.1016\/j.ejphar.2020.173507","article-title":"MicroRNA interplay between hepatic stellate cell quiescence and activation","volume":"885","author":"Ezhilarasan","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"20","key":"10.1016\/j.biochi.2021.06.001_bib13","first-page":"30595","article-title":"The power of plasticity-metabolic regulation of hepatic stellate cells","volume":"S1550\u20134131","author":"Trivedi","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.biochi.2021.06.001_bib14","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1089\/jir.2020.0059","article-title":"Key players of hepatic fibrosis","volume":"40","author":"Dawood","year":"2020","journal-title":"J.\u00a0Interferon Cytokine Res."},{"key":"10.1016\/j.biochi.2021.06.001_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-3-030-44518-8_6","article-title":"Stellate cells in the tumor microenvironment","volume":"1263","author":"Roife","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biochi.2021.06.001_bib16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.hbpd.2018.04.003","article-title":"Hepatic fibrosis: it is time to go with hepatic stellate cell-specific therapeutic targets","volume":"17","author":"Ezhilarasan","year":"2018","journal-title":"Hepatobiliary Pancreat. Dis. Int."},{"key":"10.1016\/j.biochi.2021.06.001_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000456581","article-title":"Liver fibrosis: understanding the dynamics of bidirectional wound repair to inform the design of markers and therapies","volume":"35","author":"Iredale","year":"2017","journal-title":"Dig. Dis."},{"key":"10.1016\/j.biochi.2021.06.001_bib18","doi-asserted-by":"crossref","first-page":"604894","DOI":"10.3389\/fmed.2021.604894","article-title":"Novel immune subsets and related cytokines: emerging players in the progression of liver fibrosis","volume":"8","author":"Wan","year":"2021","journal-title":"Front. Med."},{"key":"10.1016\/j.biochi.2021.06.001_bib19","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000803","article-title":"Functional interaction between macrophages and hepatocytes dictate the outcome of liver fibrosis","volume":"4","author":"Xie","year":"2021","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.biochi.2021.06.001_bib20","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fphar.2014.00167","article-title":"The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies","volume":"5","author":"Xu","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.7150\/ijbs.25589","article-title":"Kupffer-derived matrix metalloproteinase-9 contributes to liver fibrosis resolution","volume":"14","author":"Feng","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib22","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3892\/mmr.2021.12003","article-title":"Interaction of non-parenchymal hepatocytes in the process of hepatic fibrosis (Review)","volume":"23","author":"Cheng","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biochi.2021.06.001_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1172\/JCI88881","article-title":"Liver inflammation and fibrosis","volume":"127","author":"Koyama","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.biochi.2021.06.001_bib24","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.bbadis.2012.09.008","article-title":"Natural killer and natural killer T cells in liver fibrosis","volume":"1832","author":"Gao","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.biochi.2021.06.001_bib25","doi-asserted-by":"crossref","first-page":"e220","DOI":"10.1111\/sms.12149","article-title":"The effect of relaxin on the musculoskeletal system","volume":"24","author":"Dehghan","year":"2014","journal-title":"Scand. J. Med. Sci. Sports"},{"key":"10.1016\/j.biochi.2021.06.001_bib26","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1152\/physrev.00001.2012","article-title":"Relaxin family peptides and their receptors","volume":"93","author":"Bathgate","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biochi.2021.06.001_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mce.2019.01.008","article-title":"Single chain peptide agonists of relaxin receptors","volume":"487","author":"Praveen","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biochi.2021.06.001_bib28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1196\/annals.1282.061","article-title":"Photonic monitoring in real time of vascular endothelial growth factor receptor 2 gene expression under relaxin-induced conditions in a novel murine wound model","volume":"1041","author":"Ryan","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib29","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.2008.03826.x","article-title":"Mechanisms of relaxin receptor (LGR7\/RXFP1) expression and function","volume":"1160","author":"Kern","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib30","doi-asserted-by":"crossref","unstructured":"Beiert T, Tiyerili V, Knappe V, Effelsberg V, Linhart M, St\u00f6ckigt F, Klein S, Schierwagen R, Trebicka J, Nickenig G, Schrickel JW & Andri\u00e9 RP. Relaxin reduces susceptibility to post-infarct atrial fibrillation in mice due to anti-fibrotic and anti-inflammatory properties. Biochem. Biophys. Res. Commun. 490, 643-649.","DOI":"10.1016\/j.bbrc.2017.06.091"},{"key":"10.1016\/j.biochi.2021.06.001_bib31","doi-asserted-by":"crossref","first-page":"R267","DOI":"10.1152\/ajpregu.00156.2011","article-title":"Maternal vasodilation in pregnancy: the emerging role of relaxin","volume":"301","author":"Conrad","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.biochi.2021.06.001_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1210\/er.2003-0013","article-title":"Relaxin's physiological roles and other diverse actions","volume":"25","author":"Sherwood","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biochi.2021.06.001_bib33","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.placenta.2009.04.009","article-title":"Relaxin stimulates interleukin-6 and interleukin-8 secretion from the extraplacental chorionic cytotrophoblast","volume":"30","author":"Bryant-Greenwood","year":"2009","journal-title":"Placenta"},{"key":"10.1016\/j.biochi.2021.06.001_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/1933719107310821","article-title":"Relaxin and the human fetal membranes","volume":"14","author":"Bryant-Greenwood","year":"2007","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1524-475X.2000.00361.x","article-title":"Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites","volume":"8","author":"Unemori","year":"2000","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.biochi.2021.06.001_bib36","doi-asserted-by":"crossref","first-page":"12183","DOI":"10.1073\/pnas.1900355116","article-title":"Intraarticular injection of relaxin-2 alleviates shoulder arthrofibrosis","volume":"116","author":"Blessing","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2021.06.001_bib37","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1749-6632.2008.03804.x","article-title":"Relaxin as a protective substance in the preserving solution for liver transplantation: spectrophotometric in\u00a0vivo imaging of local oxygen supply in an isolated perfused rat liver model","volume":"1160","author":"Boehnert","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib38","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.transproceed.2008.03.038","article-title":"Relaxin as a protective substance in preservation solutions for organ transplantation, as shown in an isolated perfused rat liver model","volume":"40","author":"Boehnert","year":"2008","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.biochi.2021.06.001_bib39","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1196\/annals.1282.065","article-title":"Relaxin as an additional protective substance in preserving and reperfusion solution for liver transplantation, shown in a model of isolated perfused rat liver","volume":"1041","author":"Boehnert","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib40","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.mce.2018.12.008","article-title":"Relaxin in liver transplantation: a personal perspective","volume":"482","author":"Kageyama","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biochi.2021.06.001_bib41","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/ajt.14706","article-title":"Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation","volume":"18","author":"Kageyama","year":"2018","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.biochi.2021.06.001_bib42","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/hep.29787","article-title":"Recombinant relaxin protects liver transplants from ischemia damage by hepatocyte glucocorticoid receptor: from bench-to-bedside","volume":"68","author":"Kageyama","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2021.06.001_bib43","doi-asserted-by":"crossref","first-page":"631","DOI":"10.3390\/ijms21020631","article-title":"Relaxin positively influences ischemia-reperfusion injury in solid organ transplantation: a comprehensive review","volume":"21","author":"Jakubauskiene","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib44","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.mce.2019.01.009","article-title":"Relaxin gene therapy: a promising new treatment option for various diseases with aberrant fibrosis or irregular angiogenesis","volume":"487","author":"Hong","year":"2019","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biochi.2021.06.001_bib45","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/j.1749-6632.2008.03783.x","article-title":"Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis","volume":"1160","author":"Bennett","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib46","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/1523-1747.ep12365206","article-title":"Human relaxin decreases collagen accumulation in\u00a0vivo in two rodent models of fibrosis","volume":"101","author":"Unemori","year":"1993","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.biochi.2021.06.001_bib47","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.intimp.2013.07.020","article-title":"Relaxin attenuates silica-induced pulmonary fibrosis by regulating collagen type I and MMP-2","volume":"17","author":"Li","year":"2013","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.biochi.2021.06.001_bib48","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.7150\/thno.38640","article-title":"Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1","volume":"10","author":"Wilhelmi","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.biochi.2021.06.001_bib49","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1113\/EP087189","article-title":"Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy","volume":"103","author":"Giam","year":"2018","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.biochi.2021.06.001_bib50","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/s41565-020-00836-6","article-title":"Hepatic macrophages act as a central hub for relaxin-mediated alleviation of liver fibrosis","volume":"16","author":"Hu","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biochi.2021.06.001_bib51","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/1523-1747.ep12616665","article-title":"Relaxin alone and in conjunction with interferon-gamma decreases collagen synthesis by cultured human scleroderma fibroblasts","volume":"99","author":"Unemori","year":"1992","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.biochi.2021.06.001_bib52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mce.2019.01.015","article-title":"Relaxin and extracellular matrix remodeling: mechanisms and signaling pathways","volume":"487","author":"Ng","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biochi.2021.06.001_bib53","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1196\/annals.1282.025","article-title":"The relaxin gene-knockout mouse: a model of progressive fibrosis","volume":"1041","author":"Samuel","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib54","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1095\/biolreprod63.3.697","article-title":"Collagen studies in late pregnant relaxin null mice","volume":"63","author":"Zhao","year":"2000","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.biochi.2021.06.001_bib55","doi-asserted-by":"crossref","first-page":"10681","DOI":"10.1016\/S0021-9258(18)87000-4","article-title":"Relaxin modulates synthesis and secretion of procollagenase and collagen by human dermal fibroblasts","volume":"265","author":"Unemori","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2021.06.001_bib56","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1172\/JCI119099","article-title":"Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in\u00a0vitro and inhibits lung fibrosis in a murine model in\u00a0vivo","volume":"98","author":"Unemori","year":"1996","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.biochi.2021.06.001_bib57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1196\/annals.1282.027","article-title":"Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue","volume":"1041","author":"Bennett","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib58","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.bcp.2006.12.007","article-title":"Relaxin receptors in hepatic stellate cells and cirrhotic liver","volume":"73","author":"Bennett","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib59","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/jgm.2872","article-title":"A\u00a0single adenovirus-mediated relaxin delivery attenuates established liver fibrosis in rats","volume":"18","author":"Kim","year":"2016","journal-title":"J.\u00a0Gene Med."},{"key":"10.1016\/j.biochi.2021.06.001_bib60","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/978-0-387-74672-2_7","article-title":"The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease","volume":"612","author":"Samuel","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biochi.2021.06.001_bib61","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0006-2952(03)00403-9","article-title":"Inhibition of markers of hepatic stellate cell activation by the hormone relaxin","volume":"66","author":"Bennett","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib62","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/gut.49.4.577","article-title":"Relaxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in\u00a0vivo","volume":"49","author":"Williams","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.biochi.2021.06.001_bib63","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/liv.12247","article-title":"Relaxin decreases the severity of established hepatic fibrosis in mice","volume":"34","author":"Bennett","year":"2014","journal-title":"Liver Int."},{"key":"10.1016\/j.biochi.2021.06.001_bib64","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.3389\/fimmu.2019.02852","article-title":"Therapeutic targeting of hepatic macrophages for the treatment of liver diseases","volume":"10","author":"van der Heide","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biochi.2021.06.001_bib65","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/s41565-020-00832-w","article-title":"A\u00a0relaxin-based nanotherapy for liver fibrosis","volume":"16","author":"Fallowfield","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.biochi.2021.06.001_bib66","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3390\/ijms20071723","article-title":"The role of fibrosis and liver-associated fibroblasts in the pathogenesis of hepatocellular carcinoma","volume":"20","author":"Baglieri","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2021.06.001_bib67","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1038\/s41467-019-10893-8","article-title":"Relaxin gene delivery mitigates liver metastasis and synergizes with check point therapy","volume":"10","author":"Hu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2021.06.001_bib68","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.nano.2018.12.008","article-title":"Engineered Relaxin as theranostic nanomedicine to diagnose and ameliorate liver cirrhosis","volume":"17","author":"Nag\u00f3rniewicz","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.biochi.2021.06.001_bib69","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.1038\/s41598-017-02916-5","article-title":"ML290 is a biased allosteric agonist at the relaxin receptor RXFP1","volume":"7","author":"Kocan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2021.06.001_bib70","doi-asserted-by":"crossref","first-page":"12435","DOI":"10.1096\/fj.201901046R","article-title":"Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis","volume":"33","author":"Kaftanovskaya","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.biochi.2021.06.001_bib71","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejmech.2018.06.008","article-title":"Optimization of the first small-molecule relaxin\/insulin-like family peptide receptor (RXFP1) agonists: activation results in an antifibrotic gene expression profile","volume":"156","author":"Wilson","year":"2018","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.biochi.2021.06.001_bib72","first-page":"1959","article-title":"Tratamiento hormonal de la cirrosis hep\u00e1tica Hormonal treatment of liver cirrhosis","volume":"58","author":"Vazquez","year":"1971","journal-title":"Prensa Med. Argent."},{"key":"10.1016\/j.biochi.2021.06.001_bib73","first-page":"546","article-title":"Alcohol and liver fibrosis--pathobiochemistry and treatment","volume":"33","author":"Schuppan","year":"1995","journal-title":"Z.\u00a0Gastroenterol."},{"key":"10.1016\/j.biochi.2021.06.001_bib74","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.1210\/endo.142.9.8387","article-title":"Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig","volume":"142","author":"Lenhart","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2021.06.001_bib75","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/bph.13529","article-title":"Anti-fibrotic actions of relaxin","volume":"174","author":"Samuel","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib76","doi-asserted-by":"crossref","first-page":"173832","DOI":"10.1016\/j.ejphar.2020.173832","article-title":"Advantages and challenges in nanomedicines for chronic liver diseases: a hepatologist's perspectives","volume":"893","author":"Ezhilarasan","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib77","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41374-019-0240-y","article-title":"Human relaxin-2 attenuates hepatic steatosis and fibrosis in mice with non-alcoholic fatty liver disease","volume":"99","author":"Lee","year":"2019","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biochi.2021.06.001_bib78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-2001-14935","article-title":"Relaxin causes changes of the liver. In\u00a0vivo studies in rats","volume":"33","author":"Bani","year":"2001","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.biochi.2021.06.001_bib79","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/bph.13695","article-title":"Serelaxin in clinical development: past, present and future","volume":"174","author":"Unemori","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib80","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1111\/bcp.13714","article-title":"Population pharmacokinetics of serelaxin in patients with acute or chronic heart failure, hepatic or renal impairment, or portal hypertension and in healthy subjects","volume":"84","author":"Soubret","year":"2018","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.biochi.2021.06.001_bib81","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.3748\/wjg.v23.i22.3999","article-title":"Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis","volume":"23","author":"Bennett","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.biochi.2021.06.001_bib82","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1002\/hep.26627","article-title":"Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in\u00a0vivo","volume":"59","author":"Fallowfield","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2021.06.001_bib83","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13063-020-4203-9","article-title":"A\u00a0phase 2 randomised controlled trial of serelaxin to lower portal pressure in cirrhosis (STOPP)","volume":"21","author":"Gifford","year":"2020","journal-title":"Trials"},{"key":"10.1016\/j.biochi.2021.06.001_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002248","article-title":"Serelaxin as a potential treatment for renal dysfunction in cirrhosis: preclinical evaluation and results of a randomized phase 2 trial","volume":"14","author":"Snowdon","year":"2017","journal-title":"PLoS Med."},{"key":"10.1016\/j.biochi.2021.06.001_bib85","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/cells8111419","article-title":"TGF-\u03b2 in hepatic stellate cell activation and liver fibrogenesis-updated 2019","volume":"8","author":"Dewidar","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biochi.2021.06.001_bib86","doi-asserted-by":"crossref","DOI":"10.1002\/path.5680","article-title":"TGF-\u03b2 as a driver of fibrosis: physiological roles and therapeutic opportunities","author":"Budi","year":"2021","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.biochi.2021.06.001_bib87","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3892\/etm.2020.9498","article-title":"Naringin attenuates renal interstitial fibrosis by regulating the TGF-\u03b2\/Smad signaling pathway and inflammation","volume":"21","author":"Wang","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.biochi.2021.06.001_bib88","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1369\/0022155415627681","article-title":"TGF-\u03b2\/SMAD pathway and its regulation in hepatic fibrosis","volume":"64","author":"Xu","year":"2016","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.biochi.2021.06.001_bib89","doi-asserted-by":"crossref","first-page":"731852","DOI":"10.1155\/2015\/731852","article-title":"Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in\u00a0vitro serum stability","volume":"2015","author":"Nair","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.biochi.2021.06.001_bib90","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/art.24380","article-title":"Relaxin Investigators and the Scleroderma Clinical Trials Consortium. Recombinant human relaxin in the treatment of systemic sclerosis with diffuse cutaneous involvement: a randomized, double-blind, placebo-controlled trial","volume":"60","author":"Khanna","year":"2009","journal-title":"Arthritis Rheum."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908421001474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908421001474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:20:17Z","timestamp":1759540817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908421001474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":90,"alternative-id":["S0300908421001474"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2021.06.001","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Relaxin in hepatic fibrosis: What is known and where to head?","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2021.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}