{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:07:31Z","timestamp":1777698451297,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.biochi.2021.08.011","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:04:01Z","timestamp":1631124241000},"page":"91-103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines"],"prefix":"10.1016","volume":"191","author":[{"given":"Walid","family":"Al-Zyoud","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-1529","authenticated-orcid":false,"given":"Hazem","family":"Haddad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2021.08.011_bib1","series-title":"Genetics: from Genes to Genomes","author":"Hartwell","year":"2011"},{"key":"10.1016\/j.biochi.2021.08.011_bib2","article-title":"New SARS-CoV-2 variants \u2014 clinical, public health, and vaccine implications","author":"Karim","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2021.08.011_bib3","series-title":"SARS-CoV-2 Variants of Concern","year":"2021"},{"key":"10.1016\/j.biochi.2021.08.011_bib4","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/s41564-020-0770-5","article-title":"A\u00a0dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology","volume":"5","author":"Rambaut","year":"2020","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.biochi.2021.08.011_bib5","series-title":"Tracking the International Spread of SARS-CoV-2 Lineages B.1.1.7 and B.1.351\/501Y-V2 - SARS-CoV-2 Coronavirus\/nCoV-2019 Genomic Epidemiology - Virological","year":"2021"},{"key":"10.1016\/j.biochi.2021.08.011_bib6","series-title":"Emergence and Rapid Spread of a New Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Lineage with Multiple Spike Mutations in South Africa","first-page":"2020","author":"Tegally","year":"2020"},{"key":"10.1016\/j.biochi.2021.08.011_bib7","series-title":"Global Report Investigating Novel Coronavirus Haplotypes","author":"lineages","year":"2021"},{"key":"10.1016\/j.biochi.2021.08.011_bib8","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.cell.2020.06.043","article-title":"Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus","volume":"182","author":"Korber","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2021.08.011_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/ijcp.13525","article-title":"SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate","volume":"74","author":"Becerra-Flores","year":"2020","journal-title":"Int. J. Clin. Pract."},{"key":"10.1016\/j.biochi.2021.08.011_bib10","doi-asserted-by":"crossref","first-page":"100896","DOI":"10.1016\/j.bbrep.2020.100896","article-title":"Mutational sensitivity of D614G in spike protein of SARS-CoV-2 in Jordan","volume":"25","author":"Al-Zyoud","year":"2021","journal-title":"Biochem. Biophys. Reports"},{"key":"10.1016\/j.biochi.2021.08.011_bib11","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/s41586-020-2895-3","article-title":"Spike mutation D614G alters SARS-CoV-2 fitness","volume":"592","author":"Plante","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2021.08.011_bib12","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1093\/bioinformatics\/bty407","article-title":"Nextstrain: real-time tracking of pathogen evolution","volume":"34","author":"Hadfield","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biochi.2021.08.011_bib13","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 web portal for protein modeling, prediction and analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.biochi.2021.08.011_bib14","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky300","article-title":"DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability","volume":"46","author":"Rodrigues","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biochi.2021.08.011_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A\u00a0new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2021.08.011_bib16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER suite: protein structure and function prediction","volume":"12","author":"Yang","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biochi.2021.08.011_bib17","doi-asserted-by":"crossref","DOI":"10.1186\/s12859-015-0548-6","article-title":"Maestro - multi agent stability prediction upon point mutations","volume":"16","author":"Laimer","year":"2015","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.biochi.2021.08.011_bib18","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/pro.3749","article-title":"DALI and the persistence of protein shape","volume":"29","author":"Holm","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.biochi.2021.08.011_bib19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1002\/prot.20264","article-title":"Scoring function for automated assessment of protein structure template quality","volume":"57","author":"Zhang","year":"2004","journal-title":"Proteins Struct. Funct. Genet."},{"key":"10.1016\/j.biochi.2021.08.011_bib20","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/bioinformatics\/btq066","article-title":"How significant is a protein structure similarity with TM-score\u00a0= 0.5?","volume":"26","author":"Xu","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.biochi.2021.08.011_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2020.04.007","article-title":"COVID-19: the first documented coronavirus pandemic in history","author":"Liu","year":"2020","journal-title":"Biomed. J."},{"key":"10.1016\/j.biochi.2021.08.011_bib22","article-title":"The N501Y spike substitution enhances SARS-CoV-2 transmission","author":"Liu","year":"2021","journal-title":"BioRxiv Prepr. Serv. Biol."},{"key":"10.1016\/j.biochi.2021.08.011_bib23","series-title":"Transmission, Infectivity, and Antibody Neutralization of an Emerging SARS-CoV-1 2 Variant in California Carrying a L452R Spike Protein Mutation 2","first-page":"2021","author":"Deng","year":"2021"},{"key":"10.1016\/j.biochi.2021.08.011_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/S2666-5247(21)00068-9","article-title":"SARS-CoV-2 spike E484K mutation reduces antibody neutralization","author":"Jangra","year":"2021","journal-title":"The Lancet Microbe"},{"key":"10.1016\/j.biochi.2021.08.011_bib25","series-title":"Estimated Transmissibility and Impact of SARS-CoV-2 Lineage B.1.1.7 in England","author":"Davies","year":"2021"},{"key":"10.1016\/j.biochi.2021.08.011_bib26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.chom.2021.02.003","article-title":"Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies","volume":"29","author":"Greaney","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.biochi.2021.08.011_bib27","first-page":"e124","article-title":"Will mutations in the spike protein of SARS-CoV-2 lead to the failure of COVID-19 vaccines?","volume":"36","author":"Jia","year":"2021","journal-title":"J.\u00a0Kor. Med. Sci."},{"key":"10.1016\/j.biochi.2021.08.011_bib28","doi-asserted-by":"crossref","first-page":"100889","DOI":"10.1016\/j.nmni.2021.100889","article-title":"Extensive genetic diversity with novel mutations in spike glycoprotein of SARS-CoV-2, Bangladesh in late 2020","volume":"41","author":"Afrin","year":"2021","journal-title":"New Microbes New Infect"},{"key":"10.1016\/j.biochi.2021.08.011_bib29","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/d41586-021-00728-2","article-title":"Five reasons why COVID herd immunity is probably impossible","volume":"591","author":"Aschwanden","year":"2021","journal-title":"Nature"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908421002030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908421002030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:20:16Z","timestamp":1759540816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908421002030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":29,"alternative-id":["S0300908421002030"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2021.08.011","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamics prediction of emerging notable spike protein mutations in SARS-CoV-2 implies a need for updated vaccines","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2021.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}