{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:06:06Z","timestamp":1792649166180,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["N41\/DBS\/000435"],"award-info":[{"award-number":["N41\/DBS\/000435"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.biochi.2022.04.013","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T21:44:50Z","timestamp":1651009490000},"page":"130-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Heart and kidney H2S production is reduced in hypertensive and older rats"],"prefix":"10.1016","volume":"199","author":[{"given":"Dominika","family":"Szl\u0119zak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Hutsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Ufnal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Wr\u00f3bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2022.04.013_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.phrs.2017.11.003","article-title":"Hypertension and cardiovascular risk: general aspects","volume":"129","author":"Kjeldsen","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"21","key":"10.1016\/j.biochi.2022.04.013_bib2","doi-asserted-by":"crossref","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","article-title":"The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener","volume":"20","author":"Zhao","year":"2001","journal-title":"EMBO J."},{"issue":"3","key":"10.1016\/j.biochi.2022.04.013_bib3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pharmthera.2009.05.005","article-title":"Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases","volume":"123","author":"Li","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.biochi.2022.04.013_bib4","doi-asserted-by":"crossref","first-page":"4579140","DOI":"10.1155\/2018\/4579140","article-title":"An update on hydrogen sulfide and nitric oxide interactions in the cardiovascular system","volume":"2018","author":"Wu","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.biochi.2022.04.013_bib5","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1124\/jpet.108.149963","article-title":"Production and actions of hydrogen sulfide, a novel gaseous bioactive substance, in the kidneys","volume":"329","author":"Xia","year":"2009","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.biochi.2022.04.013_bib6","doi-asserted-by":"crossref","first-page":"564281","DOI":"10.3389\/fphar.2020.564281","article-title":"Roles of hydrogen sulfide donors in common kidney diseases","volume":"11","author":"Ngowi","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2183\/pjab.91.131","article-title":"Hydrogen sulfide and polysulfides as signaling molecules","volume":"91","author":"Kimura","year":"2015","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"issue":"10","key":"10.1016\/j.biochi.2022.04.013_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/antiox7100129","article-title":"Role of hydrogen sulfide in NRF2- and Sirtuin-dependent maintenance of cellular redox balance","volume":"7","author":"Corsello","year":"2018","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.bbrc.2003.11.081","article-title":"The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats","volume":"313","author":"Yan","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib12","doi-asserted-by":"crossref","first-page":"H2093","DOI":"10.1152\/ajpheart.00088.2007","article-title":"Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats","volume":"293","author":"Shi","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5901","key":"10.1016\/j.biochi.2022.04.013_bib13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.biochi.2022.04.013_bib14","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1291\/hypres.31.1619","article-title":"Regulatory effect of hydrogen sulfide on vascular collagen content in spontaneously hypertensive rats","volume":"31","author":"Zhao","year":"2008","journal-title":"Hypertens. Res."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib15","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1161\/ATVBAHA.108.179333","article-title":"Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice","volume":"29","author":"Wang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1161\/CIRCULATIONAHA.109.920991","article-title":"Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice","volume":"122","author":"Calvert","year":"2010","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.biochi.2022.04.013_bib17","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s11011-018-0301-8","article-title":"Ameliorative effects of hydrogen sulfide (NaHS) on chronic kidney disease-induced brain dysfunction in rats: implication on role of nitric oxide (NO) signaling","volume":"33","author":"Askari","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.biochi.2022.04.013_bib18","doi-asserted-by":"crossref","first-page":"6717212","DOI":"10.1155\/2018\/6717212","article-title":"Hydrogen sulfide attenuates LPS-induced acute kidney injury by inhibiting inflammation and oxidative stress","volume":"2018","author":"Chen","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biochi.2022.04.013_bib19","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jss.2018.10.033","article-title":"Effect of hydrogen sulfide on kidney injury in rat model of crush syndrome","volume":"235","author":"Tek\u015fen","year":"2019","journal-title":"J.\u00a0Surg. Res."},{"issue":"5","key":"10.1016\/j.biochi.2022.04.013_bib20","doi-asserted-by":"crossref","first-page":"H874","DOI":"10.1152\/ajpheart.00637.2016","article-title":"Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism","volume":"312","author":"Weber","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"5","key":"10.1016\/j.biochi.2022.04.013_bib21","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3390\/cells10051238","article-title":"Hypertension and aging affect liver sulfur metabolism in rats","volume":"10","author":"Szl\u0119zak","year":"2021","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.biochi.2022.04.013_bib22","doi-asserted-by":"crossref","first-page":"H1805","DOI":"10.1152\/ajpheart.00536.2018","article-title":"Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats","volume":"315","author":"Huc","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1042\/bj2060267","article-title":"Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat","volume":"206","author":"Stipanuk","year":"1982","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib24","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.bjp.0706367","article-title":"Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia","volume":"146","author":"Collin","year":"2005","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0021-9258(18)70476-6","article-title":"A\u00a0crystalline enzyme that cleaves homoserine and cystathionine. I. Isolation procedure and some physicochemical properties","volume":"230","author":"Matsuo","year":"1958","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.04.013_bib26","first-page":"113","article-title":"Cystathionine \u03b3-lyase (EC: 4.4.1.1) an enzymatic assay of \u03b1-ketobutyrate using lactate dehydrogenase","volume":"44","author":"Czubak","year":"2002","journal-title":"Acta Biol. Cracov. Ser. Zool."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib27","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0009-8981(74)90031-X","article-title":"3-Mercaptopyruvate sulfurtransferase (EC 2.8.1.2): a simple assay adapted to human blood cells","volume":"51","author":"Valentine","year":"1974","journal-title":"Clin. Chim. Acta"},{"issue":"6","key":"10.1016\/j.biochi.2022.04.013_bib28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/15376520490434683","article-title":"Sulfurtransferases and cyanide detoxification in mouse liver, kidney, and brain","volume":"14","author":"Wr\u00f3bel","year":"2004","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.biochi.2022.04.013_bib29","first-page":"334","article-title":"Rhodanese","volume":"vol. 2","author":"S\u00f6rbo","year":"1955"},{"key":"10.1016\/j.biochi.2022.04.013_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.niox.2014.09.159","article-title":"An application of RP-HPLC for determination of the activity of cystathionine \u03b2-synthase and \u03b3-cystathionase in tissue homogenates","volume":"46","author":"Bronowicka-Adamska","year":"2015","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.biochi.2022.04.013_bib31","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0076-6879(87)43009-7","article-title":"Sulfane sulfur","volume":"143","author":"Wood","year":"1987","journal-title":"Methods Enzymol."},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J.\u00a0Biol. Chem."},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-4347(01)00298-5","article-title":"A\u00a0new and versatile method for determination of thiolamines of biological importance","volume":"761","author":"Dominick","year":"2001","journal-title":"J.\u00a0Chromatogr. B Biomed. Sci. Appl."},{"issue":"21","key":"10.1016\/j.biochi.2022.04.013_bib34","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1016\/j.jchromb.2011.05.026","article-title":"RP-HPLC method for quantitative determination of cystathionine, cysteine and glutathione: an application for the study of the metabolism of cysteine in human brain","volume":"879","author":"Bronowicka-Adamska","year":"2011","journal-title":"J.\u00a0Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"issue":"11","key":"10.1016\/j.biochi.2022.04.013_bib35","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.3390\/biom10111565","article-title":"Kidney ischemia-reperfusion decreases hydrogen sulfide and increases oxidative stress in the heart","volume":"10","author":"Wijerathne","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/cvr\/cvu026","article-title":"Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition","volume":"102","author":"Bucci","year":"2014","journal-title":"Cardiovasc. Res."},{"issue":"10","key":"10.1016\/j.biochi.2022.04.013_bib37","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3390\/biom11101549","article-title":"Hydrogen sulphide treatment prevents renal ischemia-reperfusion injury by inhibiting the expression of ICAM-1 and NF-kB concentration in normotensive and hypertensive rats","volume":"11","author":"Hashmi","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.biochi.2022.04.013_bib38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.niox.2016.09.007","article-title":"Intracolonic hydrogen sulfide lowers blood pressure in rats","volume":"60","author":"Tomasova","year":"2016","journal-title":"Nitric Oxide"},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib39","article-title":"Changes in the vasoactive effects of nitric oxide, hydrogen sulfide and the structure of the rat thoracic aorta: the role of age and essential hypertension","volume":"69","author":"Berenyiova","year":"2018","journal-title":"J.\u00a0Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.biochi.2022.04.013_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154995","article-title":"Cystathione gamma lyase\/hydrogen sulphide pathway up regulation enhances the responsiveness of \u03b11A and \u03b11B-adrenoreceptors in the kidney of rats with left ventricular hypertrophy","volume":"11","author":"Ahmad","year":"2016","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib41","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.3748\/wjg.v20.i4.1079","article-title":"Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease","volume":"20","author":"Wang","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"5","key":"10.1016\/j.biochi.2022.04.013_bib42","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3760\/cma.j.issn.0366-6999.20132694","article-title":"Potential biomarkers predicting risk of pulmonary hypertension in congenital heart disease: the role of homocysteine and hydrogen sulfide","volume":"127","author":"Sun","year":"2014","journal-title":"Chin. Med. J."},{"issue":"12","key":"10.1016\/j.biochi.2022.04.013_bib43","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1093\/ndt\/gfp378","article-title":"Hydrogen sulphide-generating pathways in haemodialysis patients: a study on relevant metabolites and transcriptional regulation of genes encoding for key enzymes","volume":"24","author":"Perna","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biochi.2022.04.013_bib44","doi-asserted-by":"crossref","first-page":"113833","DOI":"10.1016\/j.bcp.2020.113833","article-title":"Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase","volume":"176","author":"Peleli","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2022.04.013_bib45","doi-asserted-by":"crossref","first-page":"7570489","DOI":"10.1155\/2016\/7570489","article-title":"Protective effects of hydrogen sulfide in the ageing kidney","volume":"2016","author":"Hou","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib46","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11357-018-0018-y","article-title":"Hydrogen sulfide ameliorates aging-associated changes in the kidney","volume":"40","author":"Lee","year":"2018","journal-title":"Geroscience"},{"issue":"1","key":"10.1016\/j.biochi.2022.04.013_bib47","doi-asserted-by":"crossref","first-page":"H71","DOI":"10.1152\/ajpheart.00574.2014","article-title":"MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery","volume":"310","author":"Kuo","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib48","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/micc.12083","article-title":"Contribution of hydrogen sulfide to the control of coronary blood flow","volume":"21","author":"Casalini","year":"2014","journal-title":"Microcirculation"},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib49","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/bph.14100","article-title":"Multiple role of 3-mercaptopyruvate sulfurtransferase: antioxidative function, H2 S and polysulfide production and possible SOx production","volume":"175","author":"Nagahara","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.biochi.2022.04.013_bib50","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1515\/hsz-2020-0249","article-title":"3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking","volume":"402","author":"Pedre","year":"2020","journal-title":"Biol. Chem."},{"key":"10.1016\/j.biochi.2022.04.013_bib51","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.12659\/MSM.893234","article-title":"Roles of sulfur metabolism and rhodanese in detoxification and anti-oxidative stress functions in the liver: responses to radiation exposure","volume":"21","author":"Nakajima","year":"2015","journal-title":"Med. Sci. Mon."},{"key":"10.1016\/j.biochi.2022.04.013_bib52","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.freeradbiomed.2013.07.003","article-title":"Oxidative stress and vascular inflammation in aging","volume":"65","author":"El Assar","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2022.04.013_bib53","doi-asserted-by":"crossref","first-page":"3565127","DOI":"10.1155\/2016\/3565127","article-title":"Cell senescence, and novel molecular mechanisms in aging and age-related diseases","volume":"2016","author":"Davalli","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"5","key":"10.1016\/j.biochi.2022.04.013_bib54","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1681\/ASN.2012030268","article-title":"Cystathionine \u03b3-lyase protects against renal ischemia\/reperfusion by modulating oxidative stress","volume":"24","author":"Bos","year":"2013","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.biochi.2022.04.013_bib55","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.freeradbiomed.2017.08.017","article-title":"Hydrogen sulfide-producing cystathionine \u03b3-lyase is critical in the progression of kidney fibrosis","volume":"112","author":"Han","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2022.04.013_bib56","doi-asserted-by":"crossref","first-page":"3562972","DOI":"10.1155\/2020\/3562972","article-title":"Anethole dithiolethione increases glutathione in kidney by inhibiting \u03b3-glutamyltranspeptidase: biochemical interpretation and pharmacological consequences","volume":"2020","author":"Giustarini","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"3","key":"10.1016\/j.biochi.2022.04.013_bib57","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.taap.2004.10.004","article-title":"Role of glutathione transport processes in kidney function","volume":"204","author":"Lash","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"6","key":"10.1016\/j.biochi.2022.04.013_bib58","first-page":"624","article-title":"The laboratory rat: relating its age with human's","volume":"4","author":"Sengupta","year":"2013","journal-title":"Int. J. Prev. Med."},{"issue":"2","key":"10.1016\/j.biochi.2022.04.013_bib59","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3181\/00379727-150-39048","article-title":"Effect of treatment on longevity in spontaneously hypertensive rats","volume":"150","author":"Freis","year":"1975","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.biochi.2022.04.013_bib60","first-page":"G1","article-title":"ILAR committee on care and use of spontaneously hypertensive (SHR) rats. Spontaneously hypertensive (SHR) rats: guidelines for breeding, care, and use","volume":"19","year":"1976","journal-title":"ILAR News (Inst. Lab. Anim. Resour.)"},{"issue":"4","key":"10.1016\/j.biochi.2022.04.013_bib61","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0024-3205(84)90630-1","article-title":"Food restriction increases life span of hypertensive animals","volume":"34","author":"Lloyd","year":"1984","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.biochi.2022.04.013_bib62","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1210\/en.2014-1362","article-title":"MiR-22\/Sp-1 links estrogens with the up-regulation of cystathionine \u03b3-lyase in myocardium, which contributes to estrogenic cardioprotection against oxidative stress","volume":"156","author":"Wang","year":"2015","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.biochi.2022.04.013_bib63","doi-asserted-by":"crossref","first-page":"H1569","DOI":"10.1152\/ajpheart.00396.2018","article-title":"Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan","volume":"315","author":"Stanhewicz","year":"2018","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908422001080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908422001080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:22:44Z","timestamp":1759540964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908422001080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":63,"alternative-id":["S0300908422001080"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2022.04.013","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heart and kidney H2S production is reduced in hypertensive and older rats","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2022.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}