{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:28:40Z","timestamp":1790800120365,"version":"4.1.0"},"reference-count":282,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,2]],"date-time":"2022-06-02T00:00:00Z","timestamp":1654128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.biochi.2022.05.019","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T21:29:24Z","timestamp":1654118964000},"page":"153-171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Pigment epithelium-derived factor and its role in microvascular-related diseases"],"prefix":"10.1016","volume":"200","author":[{"given":"Yuzhuo","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiucheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xichun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caili","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-737X","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2022.05.019_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1113\/expphysiol.2008.043349","article-title":"Human endothelial function and microvascular ageing","volume":"94","author":"Gates","year":"2009","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib2","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1172\/JCI46322","article-title":"Angiopoietin-1 is essential in mouse vasculature during development and in response to injury","volume":"121","author":"Jeansson","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.biochi.2022.05.019_bib3","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.2337\/db15-1594","article-title":"Essential role of transglutaminase 2 in vascular endothelial growth factor-induced vascular leakage in the retina of diabetic mice","volume":"65","author":"Lee","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2022.05.019_bib4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1177\/003693306300801102","article-title":"I.\u00a0Anatomical features in normal and diseased hearts demonstrated by stereoarteriography","volume":"8","author":"Fulton","year":"1963","journal-title":"Scot. Med. J."},{"key":"10.1016\/j.biochi.2022.05.019_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.cld.2013.12.001","article-title":"Pathophysiology of portal hypertension","volume":"18","author":"Iwakiri","year":"2014","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.biochi.2022.05.019_bib6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1165\/rcmb.2013-0229OC","article-title":"Pigment epithelium-derived factor mediates impaired lung vascular development in neonatal hyperoxia","volume":"52","author":"Chetty","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biochi.2022.05.019_bib7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1097\/01.WCB.0000090682.07515.5A","article-title":"Microvascular Basal lamina damage after embolic stroke in the rat: relationship to cerebral blood flow","volume":"23","author":"Hamann","year":"2003","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.biochi.2022.05.019_bib8","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib9","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1113\/jphysiol.2004.079640","article-title":"The microcirculation: a motor for the systemic inflammatory response and large vessel disease induced by hypercholesterolaemia?","volume":"562","author":"Stokes","year":"2005","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0014-4835(91)90248-D","article-title":"A\u00a0pigment epithelium-derived factor with potent neuronal differentiative activity","volume":"53","author":"Tombran-Tink","year":"1991","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib11","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1080\/10715762.2019.1697809","article-title":"The role of pigment epithelium-derived factor in protecting against cellular stress","volume":"53","author":"Brook","year":"2019","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib12","doi-asserted-by":"crossref","first-page":"25992","DOI":"10.1074\/jbc.270.43.25992","article-title":"Pigment epithelium-derived factor behaves like a noninhibitory serpin. Neurotrophic activity does not require the serpin reactive loop","volume":"270","author":"Becerra","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.exer.2005.10.016","article-title":"Focus on molecules: pigment epithelium-derived factor (PEDF)","volume":"82","author":"Becerra","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib14","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1002\/pro.5560051220","article-title":"Recombinant human pigment epithelium-derived factor (PEDF): characterization of PEDF overexpressed and secreted by eukaryotic cells","volume":"5","author":"Stratikos","year":"1996","journal-title":"Protein Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib15","doi-asserted-by":"crossref","first-page":"38022","DOI":"10.1074\/jbc.M600353200","article-title":"Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor","volume":"281","author":"Notari","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1042\/CS20140631","article-title":"Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis","volume":"129","author":"He","year":"2015","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.biochi.2022.05.019_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1089\/hum.2021.068","article-title":"Strategies to attenuate myocardial infarction and no-reflow through preservation of vascular integrity by pigment epithelium-derived factor","volume":"33","author":"Zhang","year":"2022","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib18","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1111\/j.1742-4658.2010.07641.x","article-title":"Pigment epithelium-derived factor binds to cell-surface F(1)-ATP synthase","volume":"277","author":"Notari","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.biochi.2022.05.019_bib19","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/MCB.01211-10","article-title":"Identification of a novel inhibitor of the canonical Wnt pathway","volume":"31","author":"Park","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2022.05.019_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05401","article-title":"Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF","volume":"3","author":"Cheng","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.biochi.2022.05.019_bib21","doi-asserted-by":"crossref","first-page":"45400","DOI":"10.1074\/jbc.M208339200","article-title":"Mapping the type I collagen-binding site on pigment epithelium-derived factor. Implications for its antiangiogenic activity","volume":"277","author":"Meyer","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib22","doi-asserted-by":"crossref","first-page":"33310","DOI":"10.1074\/jbc.M801287200","article-title":"Pigment epithelium-derived factor binds to hyaluronan. Mapping of a hyaluronan binding site","volume":"283","author":"Becerra","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1159\/000492990","article-title":"Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and P38-mediated migration arrest","volume":"49","author":"Konson","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biochi.2022.05.019_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9090854","article-title":"Epigallocatechin-3-Gallate and PEDF 335 peptide, 67LR activators, attenuate vasogenic edema, and astroglial degeneration following status epilepticus","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.biochi.2022.05.019_bib25","doi-asserted-by":"crossref","first-page":"e2969","DOI":"10.1038\/cddis.2017.359","article-title":"Pigment epithelium-derived factor promotes tumor metastasis through an interaction with laminin receptor in hepatocellular carcinomas","volume":"8","author":"Hou","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biochi.2022.05.019_bib26","article-title":"PEDF mediates pathological neovascularization by regulating macrophage recruitment and polarization in the mouse model of oxygen-induced retinopathy","volume":"7","author":"Gao","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib27","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1159\/000485537","article-title":"M\u00fcller cell-derived PEDF mediates neuroprotection via STAT3 activation","volume":"44","author":"Eichler","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.biochi.2022.05.019_bib28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/978-1-4614-3209-8_102","article-title":"Pigment epithelium-derived factor protects cone photoreceptor-derived 661W cells from light damage through Akt activation","volume":"801","author":"Rapp","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.biochi.2022.05.019_bib29","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.cyto.2011.04.010","article-title":"PEDF inhibits IL8 production in prostate cancer cells through PEDF receptor\/phospholipase A2 and regulation of NF\u03baB and PPAR\u03b3","volume":"55","author":"Hirsch","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.biochi.2022.05.019_bib30","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jcmgh.2015.06.006","article-title":"Pigment epithelium-derived factor (PEDF) inhibits wnt\/\u03b2-catenin signaling in the liver","volume":"1","author":"Protiva","year":"2015","journal-title":"Cell Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biochi.2022.05.019_bib31","doi-asserted-by":"crossref","first-page":"e2838","DOI":"10.1038\/cddis.2017.114","article-title":"Deficiency of pigment epithelium-derived factor in nasopharyngeal carcinoma cells triggers the epithelial-mesenchymal transition and metastasis","volume":"8","author":"Zhang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biochi.2022.05.019_bib32","first-page":"219","article-title":"Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity","volume":"41","author":"Deshpande","year":"2012","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biochi.2022.05.019_bib33","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.bbrc.2005.07.140","article-title":"Involvement of the collagen I-binding motif in the anti-angiogenic activity of pigment epithelium-derived factor","volume":"335","author":"Hosomichi","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2022.05.019_bib34","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.exer.2008.06.003","article-title":"PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration","volume":"87","author":"Huang","year":"2008","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib35","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2337\/diabetes.54.1.243","article-title":"Decreased expression of pigment epithelium-derived factor is involved in the pathogenesis of diabetic nephropathy","volume":"54","author":"Wang","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2022.05.019_bib36","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1517\/14728220903241641","article-title":"Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease","volume":"13","author":"Rychli","year":"2009","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.biochi.2022.05.019_bib37","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/gutjnl-2014-307138","article-title":"Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats","volume":"64","author":"Mejias","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.biochi.2022.05.019_bib38","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1136\/jcp.56.4.277","article-title":"Loss of pigment epithelium derived factor expression in glioma progression","volume":"56","author":"Guan","year":"2003","journal-title":"J.\u00a0Clin. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib39","doi-asserted-by":"crossref","first-page":"L620","DOI":"10.1152\/ajplung.00188.2013","article-title":"PEDF expression regulates the proangiogenic and proinflammatory phenotype of the lung endothelium","volume":"306","author":"Shin","year":"2014","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib40","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbrc.2004.10.041","article-title":"Regulation of factors controlling angiogenesis in liver development: a role for PEDF in the formation and maintenance of normal vasculature","volume":"325","author":"Sawant","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2022.05.019_bib41","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1464-5491.2007.02281.x","article-title":"Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes","volume":"24","author":"Jenkins","year":"2007","journal-title":"Diabet. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib42","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.2174\/13816128113199990473","article-title":"Pigment epithelium-derived factor (PEDF) and cardiometabolic disorders","volume":"20","author":"Yamagishi","year":"2014","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.biochi.2022.05.019_bib43","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijcard.2016.09.123","article-title":"Circulating level of pigment epithelium-derived factor is associated with vascular function and structure: a cross-sectional study","volume":"225","author":"Kajikawa","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib44","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.sjopt.2018.05.002","article-title":"Role of oxidative stress, inflammation, hypoxia and angiogenesis in the development of diabetic retinopathy","volume":"32","author":"Al-Kharashi","year":"2018","journal-title":"Saudi J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1182\/blood-2013-09-512749","article-title":"Oxidative stress in angiogenesis and vascular disease","volume":"123","author":"Kim","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.biochi.2022.05.019_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15296","article-title":"Plastic roles of pericytes in the blood-retinal barrier","volume":"8","author":"Park","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2022.05.019_bib47","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"Brownlee","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2022.05.019_bib48","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1073\/pnas.96.19.10836","article-title":"Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition","volume":"96","author":"Miyamoto","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2022.05.019_bib49","doi-asserted-by":"crossref","first-page":"4401","DOI":"10.1113\/jphysiol.2008.156695","article-title":"Retinal ganglion cells in diabetes","volume":"586","author":"Kern","year":"2008","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2337\/diabetes.47.3.445","article-title":"M\u00fcller cell changes in human diabetic retinopathy","volume":"47","author":"Mizutani","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2022.05.019_bib51","doi-asserted-by":"crossref","first-page":"E2655","DOI":"10.1073\/pnas.1522014113","article-title":"Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus","volume":"113","author":"Sohn","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2022.05.019_bib52","first-page":"154","article-title":"Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissues","volume":"7","author":"Karakousis","year":"2001","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biochi.2022.05.019_bib53","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/bjo.2006.110890","article-title":"Positive association of pigment epithelium-derived factor with total antioxidant capacity in the vitreous fluid of patients with proliferative diabetic retinopathy","volume":"91","author":"Yokoi","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib54","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1055\/s-2003-41362","article-title":"Proliferative diabetic retinopathy is associated with a low level of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor. a pilot study","volume":"35","author":"Boehm","year":"2003","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib55","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jdiacomp.2012.05.005","article-title":"Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy","volume":"26","author":"Mohan","year":"2012","journal-title":"J.\u00a0Diabet. Complicat."},{"key":"10.1016\/j.biochi.2022.05.019_bib56","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jdiacomp.2014.01.008","article-title":"Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients","volume":"28","author":"Jenkins","year":"2014","journal-title":"J.\u00a0Diabet. Complicat."},{"key":"10.1016\/j.biochi.2022.05.019_bib57","first-page":"992","article-title":"Relationship between pigment epithelium-derived factor (PEDF) and renal function in patients with diabetic retinopathy","volume":"14","author":"Matsuyama","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biochi.2022.05.019_bib58","first-page":"227","article-title":"Inhibition by advanced glycation end products (AGEs) of pigment epithelium-derived factor (PEDF) gene expression in microvascular endothelial cells","volume":"31","author":"Yamagishi","year":"2005","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.mvr.2004.11.001","article-title":"Pigment epithelium-derived factor inhibits oxidative stress-induced apoptosis and dysfunction of cultured retinal pericytes","volume":"69","author":"Amano","year":"2005","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib60","first-page":"505","article-title":"Pigment epithelium-derived factor inhibits advanced glycation end-products-induced cytotoxicity in retinal pericytes","volume":"37","author":"Sheikpranbabu","year":"2011","journal-title":"Diabetes Metab."},{"key":"10.1016\/j.biochi.2022.05.019_bib61","first-page":"81","article-title":"Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy","volume":"139","author":"Schr\u00f6der","year":"1991","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib62","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1677\/JME-08-0011","article-title":"Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein","volume":"41","author":"Zhang","year":"2008","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.biochi.2022.05.019_bib63","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mvr.2005.04.001","article-title":"Pigment epithelium-derived factor (PEDF) promotes growth of pericytes through autocrine production of platelet-derived growth factor-B","volume":"69","author":"Yamagishi","year":"2005","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib64","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.mvr.2006.04.002","article-title":"Pigment epithelium-derived factor (PEDF) prevents diabetes- or advanced glycation end products (AGE)-elicited retinal leukostasis","volume":"72","author":"Yamagishi","year":"2006","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib65","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.ajpath.2010.10.014","article-title":"Overexpression of pigment epithelium-derived factor inhibits retinal inflammation and neovascularization","volume":"178","author":"Park","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib66","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00125-002-1013-4","article-title":"Pigment epithelium-derived factor prevents advanced glycation end products-induced monocyte chemoattractant protein-1 production in microvascular endothelial cells by suppressing intracellular reactive oxygen species generation","volume":"46","author":"Inagaki","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2022.05.019_bib67","doi-asserted-by":"crossref","first-page":"20213","DOI":"10.1074\/jbc.M602110200","article-title":"Pigment epithelium-derived factor inhibits advanced glycation end product-induced retinal vascular hyperpermeability by blocking reactive oxygen species-mediated vascular endothelial growth factor expression","volume":"281","author":"Yamagishi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib68","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/dmrr.1007","article-title":"Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy","volume":"25","author":"Yoshida","year":"2009","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.biochi.2022.05.019_bib69","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1167\/iovs.09-3511","article-title":"Inhibition of JAK2\/STAT3-mediated VEGF upregulation under high glucose conditions by PEDF through a mitochondrial ROS pathway in\u00a0vitro","volume":"51","author":"Zheng","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib70","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0896-1549(01)00010-4","article-title":"Vascular endothelial growth factor gene regulation and action in diabetic retinopathy","volume":"15","author":"Lu","year":"2002","journal-title":"Ophthalmol. Clin. North Am."},{"key":"10.1016\/j.biochi.2022.05.019_bib71","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000099244","article-title":"Pigment-epithelium-derived factor suppresses expression of receptor for advanced glycation end products in the eye of diabetic rats","volume":"39","author":"Yamagishi","year":"2007","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib72","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1073\/pnas.031252398","article-title":"Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor","volume":"98","author":"Stellmach","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2022.05.019_bib73","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1471-4914(02)02362-6","article-title":"anti-angiogenic guardian of ocular function","volume":"8","author":"Bouck","year":"2002","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib74","first-page":"821","article-title":"Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF-induced migration and growth","volume":"43","author":"Duh","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib75","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mvr.2010.02.012","article-title":"Antiangiogenic effects and transcriptional regulation of pigment epithelium-derived factor in diabetic retinopathy","volume":"80","author":"Wang","year":"2010","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib76","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1074\/jbc.M507401200","article-title":"Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1","volume":"281","author":"Cai","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/jme.1.02008","article-title":"Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy","volume":"37","author":"Zhang","year":"2006","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.biochi.2022.05.019_bib78","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2174\/156652410791065291","article-title":"Anti-vasopermeability effects of PEDF in retinal-renal disorders","volume":"10","author":"Ueda","year":"2010","journal-title":"Curr. Mol. Med."},{"issue":"Suppl 1","key":"10.1016\/j.biochi.2022.05.019_bib79","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.2337\/diacare.27.2007.S84","article-title":"Retinopathy in diabetes","volume":"27","author":"Fong","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/j.biochi.2022.05.019_bib80","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.ajo.2011.05.022","article-title":"Correlation between ficolin-3 and vascular endothelial growth factor-to-pigment epithelium-derived factor ratio in the vitreous of eyes with proliferative diabetic retinopathy","volume":"152","author":"Zheng","year":"2011","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib81","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1167\/iovs.08-2878","article-title":"Antipermeability function of PEDF involves blockade of the MAP kinase\/GSK\/beta-catenin signaling pathway and uPAR expression","volume":"51","author":"Yang","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021164","article-title":"PEDF regulates vascular permeability by a \u03b3-secretase-mediated pathway","volume":"6","author":"Cai","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2022.05.019_bib83","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1152\/physrev.00021.2004","article-title":"The retinal pigment epithelium in visual function","volume":"85","author":"Strauss","year":"2005","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biochi.2022.05.019_bib84","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0736-5748(98)00014-8","article-title":"PEDF (pigment epithelium-derived factor) promotes increase and maturation of pigment granules in pigment epithelial cells in neonatal albino rat retinal cultures","volume":"16","author":"Malchiodi-Albedi","year":"1998","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.biochi.2022.05.019_bib85","article-title":"Expression of pigment epithelium-derived factor and thrombospondin-1 regulate proliferation and migration of retinal pigment epithelial cells","volume":"3","author":"Farnoodian","year":"2015","journal-title":"Phys. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib86","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.abb.2014.07.021","article-title":"High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathy","volume":"560","author":"DI Kim","year":"2014","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.biochi.2022.05.019_bib87","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jcp.22756","article-title":"Hyperglycemia induces apoptosis via CB1 activation through the decrease of FAAH 1 in retinal pigment epithelial cells","volume":"227","author":"Lim","year":"2012","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib88","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.exer.2009.07.017","article-title":"Effects of high glucose concentration on the barrier function and the expression of tight junction proteins in human retinal pigment epithelial cells","volume":"89","author":"Villarroel","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib89","doi-asserted-by":"crossref","first-page":"C418","DOI":"10.1152\/ajpcell.00001.2016","article-title":"High glucose promotes the migration of retinal pigment epithelial cells through increased oxidative stress and PEDF expression","volume":"311","author":"Farnoodian","year":"2016","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib90","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exer.2013.12.018","article-title":"Barrier properties of cultured retinal pigment epithelium","volume":"126","author":"Rizzolo","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib91","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1111\/ceo.13579","article-title":"Effects of VEGF inhibitors on human retinal pigment epithelium under high glucose and hypoxia","volume":"47","author":"Bahrami","year":"2019","journal-title":"Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib92","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1080\/02713680601052320","article-title":"ARPE-19 cell growth and cell functions in euglycemic culture media","volume":"31","author":"Heimsath","year":"2006","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib93","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1007\/s00125-008-0991-2","article-title":"Human retinal pigment epithelium proteome changes in early diabetes","volume":"51","author":"Decanini","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2022.05.019_bib94","first-page":"761","article-title":"GLUT1 activity contributes to the impairment of PEDF secretion by the RPE","volume":"22","author":"Calado","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biochi.2022.05.019_bib95","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1167\/iovs.12-10959","article-title":"Retinal angiogenesis in the Ins2(Akita) mouse model of diabetic retinopathy","volume":"54","author":"Han","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib96","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.08.001","article-title":"The progress in understanding and treatment of diabetic retinopathy","volume":"51","author":"Stitt","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib97","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.conb.2013.08.006","article-title":"Retinal ganglion cell maps in the brain: implications for visual processing","volume":"24","author":"Dhande","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib98","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.preteyeres.2003.12.001","article-title":"Retinal ischemia: mechanisms of damage and potential therapeutic strategies","volume":"23","author":"Osborne","year":"2004","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib99","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/jnr.22732","article-title":"Hypoxia-induced upregulation of pigment epithelium-derived factor by retinal glial (M\u00fcller) cells","volume":"90","author":"Yang","year":"2012","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22010369","article-title":"Pigment epithelium-derived factor (PEDF) receptors are involved in survival of retinal neurons","volume":"22","author":"B\u00fcrger","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib101","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1167\/iovs.03-0052","article-title":"Retinal neuroprotection against ischemic injury mediated by intraocular gene transfer of pigment epithelium-derived factor","volume":"44","author":"Takita","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib102","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1076\/ceyr.22.4.245.5506","article-title":"Pigment epithelium derived factor as a neuroprotective agent against ischemic retinal injury","volume":"22","author":"Ogata","year":"2001","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib103","first-page":"1046","article-title":"Pigment epithelium-derived factor protects retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction","volume":"10","author":"Tian","year":"2017","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib104","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2202-8-11","article-title":"Pigment epithelium-derived factor protects retinal ganglion cells","volume":"8","author":"Pang","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.biochi.2022.05.019_bib105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.exer.2014.08.004","article-title":"Enhanced survival of retinal ganglion cells is mediated by M\u00fcller glial cell-derived PEDF","volume":"127","author":"Unterlauft","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib106","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1042\/CS20170066","article-title":"Negative regulators of angiogenesis: important targets for treatment of exudative AMD","volume":"131","author":"Farnoodian","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.biochi.2022.05.019_bib107","doi-asserted-by":"crossref","first-page":"2624","DOI":"10.1167\/iovs.13-11803","article-title":"Pigment epithelium-derived factor is retinal ganglion cell neuroprotective and axogenic after optic nerve crush injury","volume":"54","author":"Vigneswara","year":"2013","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib108","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.mcn.2015.08.001","article-title":"Eye drop delivery of pigment epithelium-derived factor-34 promotes retinal ganglion cell neuroprotection and axon regeneration","volume":"68","author":"Vigneswara","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.biochi.2022.05.019_bib109","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.2119\/molmed.2012.00008","article-title":"Pigment epithelium-derived factor (PEDF) peptide eye drops reduce inflammation, cell death and vascular leakage in diabetic retinopathy in Ins2(Akita) mice","volume":"18","author":"Liu","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib110","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib111","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1007\/s11064-012-0747-8","article-title":"Pigment epithelium-derived factor released by M\u00fcller glial cells exerts neuroprotective effects on retinal ganglion cells","volume":"37","author":"Unterlauft","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib112","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yexcr.2004.05.020","article-title":"PEDF derived from glial M\u00fcller cells: a possible regulator of retinal angiogenesis","volume":"299","author":"Eichler","year":"2004","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib113","doi-asserted-by":"crossref","first-page":"5161","DOI":"10.1167\/iovs.08-2201","article-title":"Regulation of pigment epithelium-derived factor production and release by retinal glial (M\u00fcller) cells under hypoxia","volume":"49","author":"Lange","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib114","doi-asserted-by":"crossref","first-page":"15715","DOI":"10.1523\/JNEUROSCI.2841-12.2012","article-title":"Conditional M\u00fcllercell ablation causes independent neuronal and vascular pathologies in a novel transgenic model","volume":"32","author":"Shen","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.biochi.2022.05.019_bib115","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00417-010-1362-5","article-title":"Pigment epithelium derived factor as an anti-inflammatory factor against decrease of glutamine synthetase expression in retinal M\u00fcller cells under high glucose conditions","volume":"248","author":"Shen","year":"2010","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib116","first-page":"941","article-title":"Pigment epithelium-derived factor protects the morphological structure of retinal M\u00fcller cells in diabetic rats","volume":"7","author":"Zhang","year":"2014","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib117","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/014107680309600605","article-title":"Laser management of diabetic retinopathy","volume":"96","author":"Dowler","year":"2003","journal-title":"J.\u00a0R. Soc. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib118","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.2147\/OPTH.S199758","article-title":"Two-year analysis of changes in the optic nerve and retina following anti-VEGF treatments in diabetic macular edema patients","volume":"13","author":"Filek","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib119","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/518426","article-title":"A\u00a0PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells","author":"Longeras","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1089\/hgtb.2015.169","article-title":"pEPito-driven PEDF expression ameliorates diabetic retinopathy hallmarks","volume":"27","author":"Calado","year":"2016","journal-title":"Hum. Gene Ther. Methods"},{"key":"10.1016\/j.biochi.2022.05.019_bib121","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.omtn.2020.08.036","article-title":"Dual-acting antiangiogenic gene therapy reduces inflammation and regresses neovascularization in diabetic mouse retina","volume":"22","author":"Araujo","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biochi.2022.05.019_bib122","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20186201","article-title":"Hypoxia-induced hyperpermeability of rat glomerular endothelial cells involves HIF-2\u03b1 mediated changes in the expression of occludin and ZO-1","volume":"51","author":"Luo","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib123","doi-asserted-by":"crossref","first-page":"952","DOI":"10.2174\/138945007781386884","article-title":"Molecular mechanisms of diabetic nephropathy and its therapeutic intervention","volume":"8","author":"Yamagishi","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.biochi.2022.05.019_bib124","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1093\/ndt\/gfn659","article-title":"Administration of pigment epithelium-derived factor (PEDF) reduces proteinuria by suppressing decreased nephrin and increased VEGF expression in the glomeruli of adriamycin-injected rats","volume":"24","author":"Fujimura","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.biochi.2022.05.019_bib125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1053\/jpsu.2003.50104","article-title":"Wilms' tumor growth is suppressed by antiangiogenic pigment epithelium-derived factor in a xenograft model","volume":"38","author":"Abramson","year":"2003","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.biochi.2022.05.019_bib126","doi-asserted-by":"crossref","first-page":"F891","DOI":"10.1152\/ajprenal.00149.2013","article-title":"Protective role of small pigment epithelium-derived factor (PEDF) peptide in diabetic renal injury","volume":"305","author":"Awad","year":"2013","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib127","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1055\/s-0042-108448","article-title":"Protective role of PEDF-derived synthetic peptide against experimental diabetic nephropathy","volume":"48","author":"Ishibashi","year":"2016","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib128","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mvr.2012.10.007","article-title":"PEDF inhibits AGE-induced podocyte apoptosis via PPAR-gamma activation","volume":"85","author":"Ishibashi","year":"2013","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib129","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133777","article-title":"Delayed treatment with a small pigment epithelium derived factor (PEDF) peptide prevents the progression of diabetic renal injury","volume":"10","author":"Awad","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2022.05.019_bib130","first-page":"643","article-title":"PEDF relieves kidney injury in type 2 diabetic nephropathy mice by reducing macrophage infiltration","volume":"72","author":"Li","year":"2021","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.biochi.2022.05.019_bib131","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mvr.2010.03.015","article-title":"Pigment epithelium-derived factor inhibits advanced glycation end product-elicited mesangial cell damage by blocking NF-kappaB activation","volume":"80","author":"Ide","year":"2010","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib132","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.kint.2016.09.036","article-title":"Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway","volume":"91","author":"He","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.biochi.2022.05.019_bib133","doi-asserted-by":"crossref","first-page":"7855","DOI":"10.3892\/mmr.2017.7563","article-title":"Pigment epithelium-derived factor protects human glomerular mesangial cells from diabetes via NOXO1-iNOS suppression","volume":"16","author":"Gao","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib134","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cmet.2009.06.001","article-title":"Pigment epithelium-derived factor contributes to insulin resistance in obesity","volume":"10","author":"Crowe","year":"2009","journal-title":"Cell Metabol."},{"issue":"Suppl 1","key":"10.1016\/j.biochi.2022.05.019_bib135","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1007\/s00592-012-0397-y","article-title":"Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients","volume":"49","author":"Gattu","year":"2012","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.biochi.2022.05.019_bib136","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jdiacomp.2014.01.008","article-title":"Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients","volume":"28","author":"Jenkins","year":"2014","journal-title":"J.\u00a0Diabet. Complicat."},{"key":"10.1016\/j.biochi.2022.05.019_bib137","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.2337\/db14-1111","article-title":"High levels of pigment epithelium-derived factor in diabetes impair wound healing through suppression of Wnt signaling","volume":"64","author":"Qi","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2022.05.019_bib138","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0039-6257(03)00030-4","article-title":"Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies","volume":"48","author":"Ambati","year":"2003","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib139","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1016\/j.febslet.2013.05.020","article-title":"The cell stress machinery and retinal degeneration","volume":"587","author":"Athanasiou","year":"2013","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biochi.2022.05.019_bib140","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.redox.2017.05.015","article-title":"Altered bioenergetics and enhanced resistance to oxidative stress in human retinal pigment epithelial cells from donors with age-related macular degeneration","volume":"13","author":"Ferrington","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.biochi.2022.05.019_bib141","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2005.05.007","article-title":"Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration","volume":"82","author":"Bhutto","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib142","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8941057","article-title":"Pigment epithelium-derived factor as a possible treatment agent for choroidal neovascularization","author":"Xi","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.biochi.2022.05.019_bib143","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0002-9394(02)01549-0","article-title":"Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration","volume":"134","author":"Holekamp","year":"2002","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib144","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ajo.2003.08.058","article-title":"Decrease of pigment epithelium-derived factor in aqueous humor with increasing age","volume":"137","author":"Ogata","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib145","first-page":"115","article-title":"PEDF and VEGF plasma level alterations in patients with dry form of age-related degeneration--a possible link to the development of the disease","volume":"114","author":"Machalinska","year":"2012","journal-title":"Klin. Oczna."},{"key":"10.1016\/j.biochi.2022.05.019_bib146","doi-asserted-by":"crossref","first-page":"C456","DOI":"10.1152\/ajpcell.00259.2017","article-title":"PEDF expression affects the oxidative and inflammatory state of choroidal endothelial cells","volume":"314","author":"Farnoodian","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib147","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.omtn.2019.01.012","article-title":"Suppression of choroidal neovascularization by AAV-based dual-acting antiangiogenic gene therapy","volume":"16","author":"AL","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.biochi.2022.05.019_bib148","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1167\/iovs.09-4455","article-title":"Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization","volume":"51","author":"Amaral","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib149","first-page":"1112","article-title":"Inhibition of choroidal neovascularization by lentivirus-mediated PEDF gene transfer in rats","volume":"9","author":"Yu","year":"2016","journal-title":"Int. J. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1089\/hum.2009.102","article-title":"Inhibition of choroidal neovascularization via brief subretinal exposure to a newly developed lentiviral vector pseudotyped with Sendai viral envelope proteins","volume":"21","author":"Murakami","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib151","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1097\/00029330-200709010-00013","article-title":"Role of pigment epithelium-derived factor on proliferation and migration of choroidal capillary endothelium induced by vascular endothelial growth factor in\u00a0vitro","volume":"120","author":"Wang","year":"2007","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.biochi.2022.05.019_bib152","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/j.bbrc.2006.07.188","article-title":"PEDF induces apoptosis in human endothelial cells by activating p38 MAP kinase dependent cleavage of multiple caspases","volume":"348","author":"Chen","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2022.05.019_bib153","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cardiores.2007.06.032","article-title":"PEDF induces p53-mediated apoptosis through PPAR gamma signaling in human umbilical vein endothelial cells","volume":"76","author":"Ho","year":"2007","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib154","doi-asserted-by":"crossref","first-page":"13517","DOI":"10.1074\/jbc.M110.117374","article-title":"Natural angiogenesis inhibitor signals through Erk5 activation of peroxisome proliferator-activated receptor gamma (PPARgamma)","volume":"285","author":"Biyashev","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib155","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s00417-011-1699-4","article-title":"Monocyte\/macrophages promote vasculogenesis in choroidal neovascularization in mice by stimulating SDF-1 expression in RPE cells","volume":"249","author":"Shi","year":"2011","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib156","first-page":"10","article-title":"PEDF-mediated mitophagy triggers the visual cycle by enhancing mitochondrial functions in a H(2)O(2)-injured rat model","author":"Kim","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.biochi.2022.05.019_bib157","first-page":"59","article-title":"PEDF protects human retinal pigment epithelial cells against oxidative stress via upregulation of UCP2 expression","volume":"19","author":"Wang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib158","doi-asserted-by":"crossref","first-page":"6742","DOI":"10.1167\/iovs.14-14696","article-title":"PEDF improves mitochondrial function in RPE cells during oxidative stress","volume":"55","author":"He","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib159","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41374-020-0470-z","article-title":"Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells","volume":"101","author":"Kim","year":"2021","journal-title":"Lab. Invest."},{"key":"10.1016\/j.biochi.2022.05.019_bib160","doi-asserted-by":"crossref","DOI":"10.1042\/AN20130028","article-title":"Pigment epithelium-derived factor reduces apoptosis and pro-inflammatory cytokine gene expression in a murine model of focal retinal degeneration","volume":"5","author":"Wang","year":"2013","journal-title":"ASN Neuro."},{"key":"10.1016\/j.biochi.2022.05.019_bib161","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1167\/iovs.15-19039","article-title":"A\u00a0novel inhibitor of 5-lipoxygenase (5-LOX) prevents oxidative stress-induced cell death of retinal pigment epithelium (RPE) cells","volume":"57","author":"Subramanian","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib162","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.yexcr.2011.11.002","article-title":"Microphthalmia-associated transcription factor acts through PEDF to regulate RPE cell migration","volume":"318","author":"Ma","year":"2012","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib163","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.bbrc.2006.01.164","article-title":"Pigment epithelium-derived factor protects retinal pigment epithelium from oxidant-mediated barrier dysfunction","volume":"342","author":"Ho","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2022.05.019_bib164","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00417-013-2562-6","article-title":"Efficacy of treatment with ranibizumab in patients with wet age-related macular degeneration in routine clinical care: data from the COMPASS health services research","volume":"252","author":"Wolf","year":"2014","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/eye.2016.208","article-title":"Risk of geographic atrophy in age-related macular degeneration patients treated with intravitreal anti-VEGF agents","volume":"31","author":"Gemenetzi","year":"2017","journal-title":"Eye"},{"key":"10.1016\/j.biochi.2022.05.019_bib166","doi-asserted-by":"crossref","DOI":"10.1038\/srep25509","article-title":"A\u00a0novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy","volume":"6","author":"Sulaiman","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib167","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/hum.2006.17.167","article-title":"Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial","volume":"17","author":"Campochiaro","year":"2006","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib168","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biochi.2022.05.019_bib169","first-page":"93","article-title":"Low diagnostic yield of elective coronary angiography","volume":"363","author":"Cuculi","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib170","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jcmg.2018.11.036","article-title":"Coronary microvascular dysfunction: clinical considerations and noninvasive diagnosis","volume":"13","author":"Schindler","year":"2020","journal-title":"JACC Cardiovasc. Imaging"},{"key":"10.1016\/j.biochi.2022.05.019_bib171","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.jcin.2015.06.017","article-title":"Prevalence of coronary microvascular dysfunction among patients with chest pain and nonobstructive coronary artery disease","volume":"8","author":"Sara","year":"2015","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.biochi.2022.05.019_bib172","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1582-4934.2009.00731.x","article-title":"The anti-angiogenic factor PEDF is present in the human heart and is regulated by anoxia in cardiac myocytes and fibroblasts","volume":"14","author":"Rychli","year":"2010","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib173","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ajpath.2010.10.018","article-title":"Administration of pigment epithelium-derived factor inhibits left ventricular remodeling and improves cardiac function in rats with acute myocardial infarction","volume":"178","author":"Ueda","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib174","article-title":"Pigment epithelium-derived factor attenuates myocardial fibrosis via inhibiting Endothelial-to-Mesenchymal Transition in rats with acute myocardial infarction","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib175","doi-asserted-by":"crossref","first-page":"5618","DOI":"10.3390\/ijms16035618","article-title":"PEDF improves cardiac function in rats with acute myocardial infarction via inhibiting vascular permeability and cardiomyocyte apoptosis","volume":"16","author":"Zhang","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib176","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.ijcard.2012.12.049","article-title":"Myocardial 'no-reflow'--diagnosis, pathophysiology and treatment","volume":"167","author":"Wong","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib177","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.jcin.2013.02.009","volume":"6","author":"Niccoli","year":"2013","journal-title":"JACC Cardiovasc. Interv."},{"key":"10.1016\/j.biochi.2022.05.019_bib178","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ijcard.2014.09.203","article-title":"Intracoronary injection of adenosine before reperfusion in patients with ST-segment elevation myocardial infarction: a randomized controlled clinical trial","volume":"177","author":"Garcia-Dorado","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib179","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/01.RES.79.5.911","article-title":"Molecular mechanisms of coronary collateral vessel growth","volume":"79","author":"Schaper","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib180","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ahj.2015.10.016","article-title":"A\u00a0protective role of early collateral blood flow in patients with ST-segment elevation myocardial infarction","volume":"171","author":"Kim","year":"2016","journal-title":"Am. Heart J."},{"key":"10.1016\/j.biochi.2022.05.019_bib181","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1093\/eurheartj\/eht195","article-title":"The human coronary collateral circulation: development and clinical importance","volume":"34","author":"Seiler","year":"2013","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.biochi.2022.05.019_bib182","article-title":"Native coronary collateral microcirculation reserve in rat hearts","volume":"8","author":"Liu","year":"2019","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.biochi.2022.05.019_bib183","article-title":"Pigment epithelium-derived factor increases native collateral blood flow to improve cardiac function and induce ventricular remodeling after acute myocardial infarction","volume":"8","author":"Liu","year":"2019","journal-title":"J.\u00a0Am. Heart Assoc."},{"issue":"Pt 4","key":"10.1016\/j.biochi.2022.05.019_bib184","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1242\/jcs.109.4.713","article-title":"Mechanism of endothelial cell shape change and cytoskeletal remodeling in response to fluid shear stress","volume":"109","author":"Malek","year":"1996","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib185","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1161\/CIR.0000000000000336","volume":"133","author":"Levine","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.biochi.2022.05.019_bib186","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.jhep.2007.10.012","article-title":"Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL)","volume":"48","author":"Chung","year":"2008","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.biochi.2022.05.019_bib187","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/db10-0845","article-title":"Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase","volume":"60","author":"Borg","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2022.05.019_bib188","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1053\/j.gastro.2008.09.065","article-title":"Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator","volume":"136","author":"Chung","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.biochi.2022.05.019_bib189","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.2353\/ajpath.2010.091085","article-title":"Pigment epithelium-derived factor is an intrinsic antifibrosis factor targeting hepatic stellate cells","volume":"177","author":"Ho","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib190","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/hep.27696","article-title":"Macrophage-derived vascular endothelial growth factor and angiogenesis within the hepatic scar-new pathways unmasked in the resolution of fibrosis","volume":"61","author":"Fallowfield","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2022.05.019_bib191","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/hep.21785","article-title":"Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats","volume":"46","author":"Fernandez","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2022.05.019_bib192","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0076-6879(05)07047-3","article-title":"Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF\/MEK\/ERK pathway in tumor cells and tyrosine kinases VEGFR\/PDGFR in tumor vasculature","volume":"407","author":"Adnane","year":"2006","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.biochi.2022.05.019_bib193","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/hep.23144","article-title":"Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis","volume":"50","author":"Patsenker","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2022.05.019_bib194","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.22872","article-title":"Antiangiogenic therapy: not just for cancer anymore?","volume":"49","author":"Shah","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.biochi.2022.05.019_bib195","first-page":"11","article-title":"Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin","volume":"2","author":"Tombran-Tink","year":"1996","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biochi.2022.05.019_bib196","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1164\/rccm.200308-1151OC","article-title":"Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis","volume":"170","author":"Cosgrove","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib197","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1165\/rcmb.2010-0365TR","article-title":"Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors","volume":"45","author":"Farkas","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biochi.2022.05.019_bib198","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1378\/chest.11-1962","article-title":"Angiogenesis in pulmonary fibrosis: too much or not enough?","volume":"142","author":"Hanumegowda","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.biochi.2022.05.019_bib199","doi-asserted-by":"crossref","first-page":"325","DOI":"10.2165\/00151829-200605050-00004","article-title":"Idiopathic pulmonary fibrosis : new concepts in pathogenesis and implications for drug therapy","volume":"5","author":"Horowitz","year":"2006","journal-title":"Treat. Respir. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.tcm.2005.11.004","article-title":"Defective lung vascular development in endothelial nitric oxide synthase-deficient mice","volume":"16","author":"Han","year":"2006","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib201","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1172\/JCI36136","article-title":"VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis in rats","volume":"119","author":"Farkas","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.biochi.2022.05.019_bib202","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.resp.2014.10.018","article-title":"Pro- and antiangiogenic markers in patients with pulmonary complications of systemic scleroderma","volume":"209","author":"G\u0142odkowska-Mr\u00f3wka","year":"2015","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib203","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4168\/aair.2016.8.2.161","article-title":"Administration of pigment epithelium-derived factor inhibits airway inflammation and remodeling in chronic OVA-induced mice via VEGF suppression","volume":"8","author":"Zha","year":"2016","journal-title":"Allergy Asthma Immunol. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib204","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1165\/rcmb.2013-0229OC","article-title":"Pigment epithelium-derived factor mediates impaired lung vascular development in neonatal hyperoxia","volume":"52","author":"C","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.biochi.2022.05.019_bib205","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002661RR","article-title":"Deficiency in pigment epithelium-derived factor accelerates pulmonary growth and development in a compensatory lung growth model","volume":"35","author":"Ko","year":"2021","journal-title":"Faseb. J."},{"key":"10.1016\/j.biochi.2022.05.019_bib206","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1046\/j.1471-4159.2002.00813.x","article-title":"Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis","volume":"81","author":"Kuncl","year":"2002","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.biochi.2022.05.019_bib207","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.expneurol.2007.05.012","article-title":"Correlation between levels of pigment epithelium-derived factor and vascular endothelial growth factor in the striatum of patients with Parkinson's disease","volume":"206","author":"Yasuda","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.biochi.2022.05.019_bib208","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1111\/j.1471-4159.2008.05529.x","article-title":"Gene transfer of PEDF attenuates ischemic brain damage in the rat middle cerebral artery occlusion model","volume":"106","author":"Sanagi","year":"2008","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.biochi.2022.05.019_bib209","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neulet.2007.07.021","article-title":"Changes in pigment epithelium-derived factor expression following kainic acid induced cerebellar lesion in rat","volume":"424","author":"Sanagi","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.biochi.2022.05.019_bib210","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s10571-019-00770-9","article-title":"Pigment epithelium-derived factor improves paracellular blood-brain barrier integrity in the normal and ischemic mouse brain","volume":"40","author":"Riabinska","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.biochi.2022.05.019_bib211","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1096\/fasebj.7.13.8405808","article-title":"Astrocytes in infectious and immune-mediated diseases of the central nervous system","volume":"7","author":"Mucke","year":"1993","journal-title":"Faseb. J."},{"key":"10.1016\/j.biochi.2022.05.019_bib212","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/glia.20171","article-title":"Pigment epithelium-derived factor induces pro-inflammatory genes in neonatal astrocytes through activation of NF-kappa B and CREB","volume":"50","author":"Yabe","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.biochi.2022.05.019_bib213","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s11064-012-0831-0","article-title":"The intrinsic PEDF is regulated by PPAR\u03b3 in permanent focal cerebral ischemia of rat","volume":"37","author":"Zhu","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib214","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2008.08.005","article-title":"Blood-brain barrier tight junction permeability and ischemic stroke","volume":"32","author":"Sandoval","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.biochi.2022.05.019_bib215","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/jcbfm.2012.201","article-title":"Neurovascular protection by targeting early blood-brain barrier disruption with neurotrophic factors after ischemia-reperfusion in rats","volume":"33","author":"Pillai","year":"2013","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.biochi.2022.05.019_bib216","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2007.04.088","article-title":"Administration of pigment epithelium-derived factor (PEDF) inhibits cold injury-induced brain edema in mice","volume":"1167","author":"Jinnouchi","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib217","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122729","article-title":"Tumor microenvironment and metabolism","volume":"18","author":"Yang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib218","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s12263-008-0076-3","article-title":"The role of microenvironment in tumor angiogenesis","volume":"3","author":"Ribatti","year":"2008","journal-title":"Genes Nutr."},{"key":"10.1016\/j.biochi.2022.05.019_bib219","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","article-title":"Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis","volume":"86","author":"Hanahan","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2022.05.019_bib220","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10456-017-9562-9","article-title":"Tumor angiogenesis and vascular normalization: alternative therapeutic targets","volume":"20","author":"Viallard","year":"2017","journal-title":"Angiogenesis"},{"key":"10.1016\/j.biochi.2022.05.019_bib221","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1136\/gutjnl-2011-300821","article-title":"Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice","volume":"61","author":"Grippo","year":"2012","journal-title":"Gut"},{"key":"10.1016\/j.biochi.2022.05.019_bib222","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1038\/onc.2009.284","article-title":"Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma","volume":"28","author":"Orgaz","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.biochi.2022.05.019_bib223","doi-asserted-by":"crossref","first-page":"R146","DOI":"10.1186\/bcr3356","article-title":"Loss of pigment epithelium-derived factor: a novel mechanism for the development of endocrine resistance in breast cancer","volume":"14","author":"Jan","year":"2012","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib224","first-page":"159","article-title":"The molecular impact of pigment epithelium-derived factor, PEDF, on lung cancer cells and the clinical significance","volume":"35","author":"Chen","year":"2009","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.biochi.2022.05.019_bib225","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3109\/07357901003735675","article-title":"Pigment epithelium-derived factor expression in colorectal cancer patients","volume":"28","author":"Wagsater","year":"2010","journal-title":"Cancer Invest."},{"key":"10.1016\/j.biochi.2022.05.019_bib226","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/09513590802549841","article-title":"The reduction in pigment epithelium-derived factor is a sign of malignancy in ovarian cancer expressing low-level of vascular endothelial growth factor","volume":"25","author":"Tsuchiya","year":"2009","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.biochi.2022.05.019_bib227","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000288239","article-title":"Prognostic role of pigment epithelium-derived factor in clear cell renal cell carcinoma","volume":"84","author":"Jiang","year":"2010","journal-title":"Urol. Int."},{"key":"10.1016\/j.biochi.2022.05.019_bib228","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1080\/07357900802175617","article-title":"Unfavorable prognostic value of human PEDF decreased in high-grade prostatic intraepithelial neoplasia: a differential proteomics approach","volume":"27","author":"Qingyi","year":"2009","journal-title":"Cancer Invest."},{"key":"10.1016\/j.biochi.2022.05.019_bib229","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2353\/ajpath.2010.090242","article-title":"Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells","volume":"176","author":"Kawaguchi","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib230","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3389\/fonc.2019.01520","article-title":"Pigment epithelium-derived factor promotes the growth and migration of human esophageal squamous cell carcinoma","volume":"9","author":"Tang","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.biochi.2022.05.019_bib231","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1016\/j.lfs.2005.05.048","article-title":"Pigment epithelium-derived factor (PEDF)-induced apoptosis and inhibition of vascular endothelial growth factor (VEGF) expression in MG63 human osteosarcoma cells","volume":"77","author":"Takenaka","year":"2005","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib232","doi-asserted-by":"crossref","first-page":"8737","DOI":"10.1158\/1078-0432.CCR-05-1323","article-title":"Pigment epithelium-derived factor gene therapy inhibits human pancreatic cancer in mice","volume":"11","author":"Hase","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib233","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.bbrc.2013.01.057","article-title":"Pigment epithelium-derived factor (PEDF) inhibits survival and proliferation of VEGF-exposed multiple myeloma cells through its anti-oxidative properties","volume":"431","author":"Seki","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2022.05.019_bib234","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/sj.cgt.7700675","article-title":"Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor","volume":"11","author":"Guan","year":"2004","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib235","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1203\/01.pdr.0000232789.86632.91","article-title":"Gene transfer of pigment epithelium-derived factor suppresses tumor growth and angiogenesis in a hepatoblastoma xenograft model","volume":"60","author":"Browne","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib236","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1111\/j.1349-7006.2011.02013.x","article-title":"Combination of pigment epithelium-derived factor with radiotherapy enhances the antitumor effects on nasopharyngeal carcinoma by downregulating vascular endothelial growth factor expression and angiogenesis","volume":"102","author":"Xu","year":"2011","journal-title":"Cancer Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib237","doi-asserted-by":"crossref","first-page":"967","DOI":"10.4161\/cbt.9.12.11635","article-title":"Growth suppression of cervical carcinoma by pigment epithelium-derived factor via anti-angiogenesis","volume":"9","author":"Yang","year":"2010","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib238","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1111\/j.1349-7006.2009.01332.x","article-title":"PEDF inhibits growth of retinoblastoma by anti-angiogenic activity","volume":"100","author":"Yang","year":"2009","journal-title":"Cancer Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib239","first-page":"681","article-title":"Pigment epithelium-derived factor inhibits angiogenesis and growth of gastric carcinoma by down-regulation of VEGF","volume":"26","author":"Zhang","year":"2011","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib240","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1126\/science.7533326","article-title":"The Fas death factor","volume":"267","author":"Nagata","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.biochi.2022.05.019_bib241","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1167\/iovs.02-0478","article-title":"The role of Fas-FasL in the development and treatment of ischemic retinopathy","volume":"44","author":"Barreiro","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.biochi.2022.05.019_bib242","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1074\/jbc.M110.151548","article-title":"Pigment epithelium-derived factor and its phosphomimetic mutant induce JNK-dependent apoptosis and p38-mediated migration arrest","volume":"286","author":"Konson","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib243","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1084\/jem.20040474","article-title":"Nuclear factor of activated T cells balances angiogenesis activation and inhibition","volume":"199","author":"Zaichuk","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib244","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s10555-010-9236-1","article-title":"Cancer and metastasis: prevention and treatment by green tea","volume":"29","author":"Khan","year":"2010","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.biochi.2022.05.019_bib245","first-page":"10593","article-title":"Inhibitory effects of pigment epithelium-derived factor on epithelial-mesenchymal transition, migration and invasion of breast cancer","volume":"10","author":"Zhou","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.biochi.2022.05.019_bib246","doi-asserted-by":"crossref","first-page":"19192","DOI":"10.18632\/oncotarget.24953","article-title":"Impact of pigment epithelium-derived factor on colorectal cancer in\u00a0vitro and in\u00a0vivo","volume":"9","author":"Harries","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2022.05.019_bib247","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1158\/0008-5472.CAN-15-2468","article-title":"Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts","volume":"76","author":"Ng","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib248","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1111\/jphp.12289","article-title":"Pigment epithelium-derived factor upregulates collagen I and downregulates matrix metalloproteinase 2 in osteosarcoma cells, and colocalises to collagen I and heat shock protein 47 in fetal and adult bone","volume":"66","author":"Alcantara","year":"2014","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.biochi.2022.05.019_bib249","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1471-2407-12-129","article-title":"AAV-mediated human PEDF inhibits tumor growth and metastasis in murine colorectal peritoneal carcinomatosis model","volume":"12","author":"Wu","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.biochi.2022.05.019_bib250","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.canlet.2018.10.031","article-title":"Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1","volume":"442","author":"Huang","year":"2019","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biochi.2022.05.019_bib251","doi-asserted-by":"crossref","first-page":"5632","DOI":"10.1158\/0008-5472.CAN-04-0230","article-title":"Inhibition of xenografted human melanoma growth and prevention of metastasis development by dual antiangiogenic\/antitumor activities of pigment epithelium-derived factor","volume":"64","author":"Garcia","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib252","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2014.180","article-title":"Pigment epithelium-derived factor expression prolongs survival and enhances the cytotoxicity of low-dose chemotherapy in castration-refractory prostate cancer","volume":"5","author":"Nelius","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.biochi.2022.05.019_bib253","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1007\/s00432-010-0830-y","article-title":"Evaluation of protein pigment epithelium-derived factor (PEDF) and microvessel density (MVD) as prognostic indicators in breast cancer","volume":"136","author":"Zhou","year":"2010","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biochi.2022.05.019_bib254","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/1756-9966-28-75","article-title":"Anti-tumor effect of adenovirus-mediated gene transfer of pigment epithelium-derived factor on mouse B16-F10 melanoma","volume":"28","author":"Yang","year":"2009","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib255","first-page":"511","article-title":"Angiostatin decreases cell migration and vascular endothelium growth factor (VEGF) to pigment epithelium derived factor (PEDF) RNA ratio in\u00a0vitro and in a murine ocular melanoma model","volume":"12","author":"Yang","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.biochi.2022.05.019_bib256","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.canlet.2012.11.055","article-title":"Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis","volume":"330","author":"Jia","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.biochi.2022.05.019_bib257","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3892\/ol.2015.3880","article-title":"Expression of pigment epithelium-derived factor is associated with a good prognosis and is correlated with epithelial-mesenchymal transition-related genes in infiltrating ductal breast carcinoma","volume":"11","author":"Zhou","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.biochi.2022.05.019_bib258","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0022-5223(02)73616-7","article-title":"In\u00a0vivo gene transfer of pigment epithelium-derived factor inhibits tumor growth in syngeneic murine models of thoracic malignancies","volume":"126","author":"Mahtabifard","year":"2003","journal-title":"J.\u00a0Thorac. Cardiovasc. Surg."},{"key":"10.1016\/j.biochi.2022.05.019_bib259","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3892\/or.2012.1621","article-title":"AAV-mediated gene transfer of human pigment epithelium-derived factor inhibits Lewis lung carcinoma growth in mice","volume":"27","author":"He","year":"2012","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib260","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1089\/hum.2015.135","article-title":"Mesenchymal stem cells engineered to secrete pigment epithelium-derived factor inhibit tumor metastasis and the formation of malignant ascites in a murine colorectal peritoneal carcinomatosis model","volume":"27","author":"Yang","year":"2016","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib261","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/cgt.2014.79","article-title":"Pigment epithelium-derived factor enhances tumor response to radiation through vasculature normalization in allografted lung cancer in mice","volume":"22","author":"Xu","year":"2015","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib262","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00417-019-04394-z","article-title":"Type I pig collagen enhances the efficacy of PEDF 34-mer peptide in a mouse model of laser-induced choroidal neovascularization","volume":"257","author":"Kim","year":"2019","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.biochi.2022.05.019_bib263","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105323","article-title":"Exploration of novel anti-angiogenic PEDF-derived peptides with improved activities by inhibiting proliferation, suppressing migration, and inducing 67LR internalization","volume":"116","author":"Shi","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.biochi.2022.05.019_bib264","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/cbdd.12055","article-title":"The future of peptide-based drugs","volume":"81","author":"Craik","year":"2013","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.biochi.2022.05.019_bib265","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.1158\/0008-5472.CAN-10-0434","article-title":"Phosphomimetic mutants of pigment epithelium-derived factor with enhanced antiangiogenic activity as potent anticancer agents","volume":"70","author":"Konson","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib266","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.bcp.2014.09.012","article-title":"Proapoptotic PEDF functional peptides inhibit prostate tumor growth--a mechanistic study","volume":"92","author":"Gong","year":"2014","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2022.05.019_bib267","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.exer.2006.04.014","article-title":"A\u00a0PEDF N-terminal peptide protects the retina from ischemic injury when delivered in PLGA nanospheres","volume":"83","author":"Li","year":"2006","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib268","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1208\/s12248-009-9081-8","article-title":"Poly(ethylene glycol)-modified proteins: implications for poly(lactide-co-glycolide)-based microsphere delivery","volume":"11","author":"Pai","year":"2009","journal-title":"AAPS J."},{"key":"10.1016\/j.biochi.2022.05.019_bib269","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1124\/jpet.112.192575","article-title":"Polyethylene glycol-modified pigment epithelial-derived factor: new prospects for treatment of retinal neovascularization","volume":"342","author":"Bai","year":"2012","journal-title":"J.\u00a0Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.biochi.2022.05.019_bib270","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1479-5876-11-86","article-title":"Systemically administered liposome-encapsulated Ad-PEDF potentiates the anti-cancer effects in mouse lung metastasis melanoma","volume":"11","author":"Shi","year":"2013","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib271","article-title":"Multigenic lentiviral vectors for combined and tissue-specific expression of miRNA- and protein-based antiangiogenic factors","volume":"2","author":"AL","year":"2015","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.biochi.2022.05.019_bib272","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.omtm.2019.10.013","article-title":"Preclinical evaluation of a cell-based gene therapy using the sleeping beauty transposon system in choroidal neovascularization","volume":"15","author":"Hernandez","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"10.1016\/j.biochi.2022.05.019_bib273","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107798","article-title":"Novel anti-angiogenic PEDF-derived small peptides mitigate choroidal neovascularization","volume":"188","author":"Sheibani","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.biochi.2022.05.019_bib274","doi-asserted-by":"crossref","first-page":"755","DOI":"10.3892\/or.2017.5719","article-title":"P18 peptide, a functional fragment of pigment epithelial-derived factor, inhibits angiogenesis in hepatocellular carcinoma via modulating VEGF\/VEGFR2 signalling pathway","volume":"38","author":"Wang","year":"2017","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib275","first-page":"743","article-title":"Pigment epithelial-derived factor gene loaded novel COOH-PEG-PLGA-COOH nanoparticles promoted tumor suppression by systemic administration","volume":"11","author":"Yu","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.biochi.2022.05.019_bib276","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2012.08.043","article-title":"Pigment epithelium-derived factor gene loaded in cRGD-PEG-PEI suppresses colorectal cancer growth by targeting endothelial cells","volume":"438","author":"Li","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biochi.2022.05.019_bib277","article-title":"Promising nanocarriers for PEDF gene targeting delivery to cervical cancer cells mediated by the over-expressing FR\u03b1","volume":"6","author":"Yang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib278","first-page":"661","article-title":"The pigment epithelial-derived factor gene loaded in PLGA nanoparticles for therapy of colon carcinoma","volume":"24","author":"Cui","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib279","doi-asserted-by":"crossref","first-page":"419","DOI":"10.4161\/cbt.6.3.3757","article-title":"Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2","volume":"6","author":"Guan","year":"2007","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.biochi.2022.05.019_bib280","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3892\/ijmm.2012.1015","article-title":"Therapeutic potential of bone marrow-derived mesenchymal stem cells producing pigment epithelium-derived factor in lung carcinoma","volume":"30","author":"Chen","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.biochi.2022.05.019_bib281","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20110124","article-title":"Mesenchymal stem cells overexpressing PEDF decrease the angiogenesis of gliomas","volume":"33","author":"Wang","year":"2013","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.biochi.2022.05.019_bib282","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.omtn.2017.08.001","article-title":"Long-term PEDF release in rat Iris and retinal epithelial cells after sleeping beauty transposon-mediated gene delivery","volume":"9","author":"Garcia-Garcia","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908422001602?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908422001602?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:23:35Z","timestamp":1759541015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908422001602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":282,"alternative-id":["S0300908422001602"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2022.05.019","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pigment epithelium-derived factor and its role in microvascular-related diseases","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2022.05.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}