{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T00:14:45Z","timestamp":1759623285522,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["152\/2021\/JRG"],"award-info":[{"award-number":["152\/2021\/JRG"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.biochi.2023.06.006","type":"journal-article","created":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T05:18:29Z","timestamp":1687670309000},"page":"114-122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"PB","title":["Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats"],"prefix":"10.1016","volume":"214","author":[{"given":"Pragati","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Irshad","family":"Reza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anees A.","family":"Syed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athar","family":"Husain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7703-9307","authenticated-orcid":false,"given":"Jiaur R.","family":"Gayen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2023.06.006_bib1","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1152\/physiolgenomics.00131.2013","article-title":"Pancreastatin is an endogenous peptide that regulates glucose homeostasis","volume":"45","author":"Valicherla","year":"2013","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.biochi.2023.06.006_bib2","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1210\/jc.2005-0408","article-title":"Pancreastatin: multiple actions on human intermediary metabolism in\u00a0vivo, variation in disease, and naturally occurring functional genetic polymorphism","volume":"90","author":"O'Connor","year":"2005","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biochi.2023.06.006_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05133","article-title":"Combination of Pancreastatin inhibitor PSTi8 with metformin inhibits Fetuin-A in type 2 diabetic mice","volume":"6","author":"Singh","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.biochi.2023.06.006_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.biopha.2017.04.056","article-title":"Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition","volume":"91","author":"Jian","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biochi.2023.06.006_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05826","article-title":"PSTi8 with metformin ameliorates perimenopause induced steatohepatitis associated ER stress by regulating SIRT-1\/SREBP-1c axis","volume":"6","author":"Singh","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.biochi.2023.06.006_bib6","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.cmet.2015.09.023","article-title":"Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism","volume":"22","author":"Meex","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.biochi.2023.06.006_bib7","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.2337\/diab.40.11.1397","article-title":"Development of muscle insulin resistance after liver insulin resistance in high-fat\u2013fed rats","volume":"40","author":"Kraegen","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.biochi.2023.06.006_bib8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1007\/s00125-008-1252-0","article-title":"Failure of dietary quercetin to alter the temporal progression of insulin resistance among tissues of C57BL\/6J mice during the development of diet-induced obesity","volume":"52","author":"Stewart","year":"2009","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2023.06.006_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000499843","article-title":"Fetuin-B links nonalcoholic fatty liver disease to chronic kidney disease in obese Chinese adults: a cross-sectional study","volume":"74","author":"Lin","year":"2019","journal-title":"Ann. Nutr. Metab."},{"key":"10.1016\/j.biochi.2023.06.006_bib10","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/MEG.0000000000001354","article-title":"Serum fetuin-B level is an independent marker for nonalcoholic fatty liver disease in patients with type 2 diabetes","volume":"31","author":"El-Ashmawy","year":"2019","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biochi.2023.06.006_bib11","first-page":"2009","article-title":"Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides","author":"Muntjewerff","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.biochi.2023.06.006_bib12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s12325-017-0556-1","article-title":"NAFLD as a sexual dimorphic disease: role of gender and reproductive status in the development and progression of nonalcoholic fatty liver disease and inherent cardiovascular risk","volume":"34","author":"Ballestri","year":"2017","journal-title":"Adv. Ther."},{"key":"10.1016\/j.biochi.2023.06.006_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170147","article-title":"Pancreastatin inhibitor, PSTi8 ameliorates metabolic health by modulating AKT\/GSK-3\u03b2 and PKC\u03bb\/\u03b6\/SREBP1c pathways in high fat diet induced insulin resistance in peri-\/post-menopausal rats","volume":"120","author":"Valicherla","year":"2019","journal-title":"Peptides"},{"key":"10.1016\/j.biochi.2023.06.006_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118118","article-title":"Naringin ameliorates type 2 diabetes mellitus-induced steatohepatitis by inhibiting RAGE\/NF-\u03baB mediated mitochondrial apoptosis","volume":"257","author":"Syed","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2023.06.006_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144630","article-title":"Histochemical detection of collagen fibers by sirius red\/fast green is more sensitive than van gieson or sirius red alone in normal and inflamed rat colon","volume":"10","author":"Segnani","year":"2015","journal-title":"PLoS One"},{"year":"2013","series-title":"16s Metagenomic Sequencing Library Preparation","author":"Amplicon","key":"10.1016\/j.biochi.2023.06.006_bib16"},{"key":"10.1016\/j.biochi.2023.06.006_bib17","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1210\/jc.2003-030242","article-title":"The emergence of the metabolic syndrome with menopause","volume":"88","author":"Carr","year":"2003","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.biochi.2023.06.006_bib18","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s00535-003-1178-8","article-title":"Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background","volume":"38","author":"Kojima","year":"2003","journal-title":"J.\u00a0Gastroenterol."},{"key":"10.1016\/j.biochi.2023.06.006_bib19","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/sj.ijo.0801240","article-title":"Effects of the estrogen antagonist EM-652. HCl on energy balance and lipid metabolism in ovariectomized rats","volume":"24","author":"Picard","year":"2000","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.biochi.2023.06.006_bib20","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1210\/en.2008-1405","article-title":"Reduced energy expenditure and increased inflammation are early events in the development of ovariectomy-induced obesity","volume":"150","author":"Rogers","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2023.06.006_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1743-7075-2-5","article-title":"Fructose, insulin resistance, and metabolic dyslipidemia","volume":"2","author":"Basciano","year":"2005","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.biochi.2023.06.006_bib22","doi-asserted-by":"crossref","first-page":"1257S","DOI":"10.3945\/jn.108.098186","article-title":"Dietary fructose and glucose differentially affect lipid and glucose homeostasis","volume":"139","author":"Schaefer","year":"2009","journal-title":"J.\u00a0Nutr."},{"key":"10.1016\/j.biochi.2023.06.006_bib23","doi-asserted-by":"crossref","DOI":"10.7150\/thno.47037","article-title":"Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD\/NASH development","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.biochi.2023.06.006_bib24","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12020-016-1112-5","article-title":"Serum fetuin B level increased in subjects of nonalcoholic fatty liver disease: a case-control study","volume":"56","author":"Zhu","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.biochi.2023.06.006_bib25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.3748\/wjg.14.22","article-title":"Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease","volume":"14","author":"Kallwitz","year":"2008","journal-title":"World J. Gastroenterol. WJG."},{"key":"10.1016\/j.biochi.2023.06.006_bib26","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jhep.2015.02.019","article-title":"PPAR\u03b1 gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis","volume":"63","author":"Francque","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.biochi.2023.06.006_bib27","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1038\/oby.2008.435","article-title":"Developmental changes of gut microflora and enzyme activity in rat pups exposed to fat-rich diet","volume":"16","author":"Moze\u0161","year":"2008","journal-title":"Obesity"},{"key":"10.1016\/j.biochi.2023.06.006_bib28","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1007\/s00125-007-0791-0","article-title":"Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia","volume":"50","author":"Cani","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2023.06.006_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201900927","article-title":"Mastiha (Pistacia lentiscus) improves gut microbiota diversity, hepatic steatosis, and disease activity in a biopsy-confirmed mouse model of advanced non-alcoholic steatohepatitis and fibrosis","volume":"63","author":"Kannt","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.biochi.2023.06.006_bib30","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1093\/ndt\/gfx029","article-title":"Microbiome perturbation by oral vancomycin reduces plasma concentration of two gut-derived uremic solutes, indoxyl sulfate and p-cresyl sulfate, in end-stage renal disease","volume":"32","author":"Nazzal","year":"2017","journal-title":"Nephrol. Dial. Transplant."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090842300144X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090842300144X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:27:51Z","timestamp":1759541271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030090842300144X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":30,"alternative-id":["S030090842300144X"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2023.06.006","relation":{},"ISSN":["0300-9084"],"issn-type":[{"type":"print","value":"0300-9084"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pancreastatin deteriorates hepatic lipid metabolism via elevating fetuin B in ovariectomized rats","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2023.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights reserved.","name":"copyright","label":"Copyright"}]}}