{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:47:34Z","timestamp":1792813654456,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Foundation","doi-asserted-by":"publisher","award":["NNF16OC0020670"],"award-info":[{"award-number":["NNF16OC0020670"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"publisher","award":["LF-OC-19-000033"],"award-info":[{"award-number":["LF-OC-19-000033"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012331","name":"LEO Foundation","doi-asserted-by":"publisher","award":["LF-OC-23-001220"],"award-info":[{"award-number":["LF-OC-23-001220"]}],"id":[{"id":"10.13039\/501100012331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023331","name":"LEO Pharma A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001734","name":"K\u00f8benhavns Universitet","doi-asserted-by":"publisher","award":["LF15007"],"award-info":[{"award-number":["LF15007"]}],"id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.biochi.2024.03.011","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T03:58:40Z","timestamp":1710820720000},"page":"99-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Matrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model"],"prefix":"10.1016","volume":"226","author":[{"given":"Heidi Kyung","family":"Noddeland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahap","family":"Canbay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonas","family":"Savickas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Bastholm","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Petersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Malmsten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"auf dem Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8609-4460","authenticated-orcid":false,"given":"Andrea","family":"Heinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2024.03.011_bib1","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jid.2021.06.019","article-title":"Mouse models of psoriasis: a comprehensive Review","volume":"142","author":"Gangwar","year":"2022","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.biochi.2024.03.011_bib2","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.biochi.2024.03.011_bib3","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3390\/pharmaceutics12090789","article-title":"Advanced characterization of imiquimod-induced psoriasis-like mouse model","volume":"12","author":"Jabeen","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biochi.2024.03.011_bib4","article-title":"Using imiquimod-induced psoriasis-like skin as a model to measure the skin penetration of anti-psoriatic drugs","volume":"10","author":"Lin","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2024.03.011_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejpb.2016.09.021","article-title":"Innovative drug vehicle for local treatment of inflammatory skin diseases: ex\u00a0vivo and in\u00a0vivo screening of five topical formulations containing poly(lactic acid) (PLA) nanoparticles","volume":"116","author":"Boisgard","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.biochi.2024.03.011_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118623","article-title":"Development, characterization and evaluation of topical methotrexate-entrapped deformable liposome on imiquimod-induced psoriasis in a mouse model","volume":"569","author":"Bahramizadeh","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.biochi.2024.03.011_bib7","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1080\/03639045.2019.1576722","article-title":"Dithranol-loaded nanostructured lipid carrier-based gel ameliorate psoriasis in imiquimod-induced mice psoriatic plaque model","volume":"45","author":"Sathe","year":"2019","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.biochi.2024.03.011_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281005","article-title":"Imiquimod induces skin inflammation in humanized BRGSF mice with limited human immune cell activity","volume":"18","author":"Christensen","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2024.03.011_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12090789","article-title":"Advanced characterization of imiquimod-induced psoriasis-like mouse model","volume":"12","author":"Jabeen","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.biochi.2024.03.011_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2133.2007.08265.x","article-title":"Imiquimod: mode of action","volume":"157","author":"Schon","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.biochi.2024.03.011_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/prca.201300081","article-title":"Proteases and proteomics: cutting to the core of human skin pathologies","volume":"8","author":"de Veer","year":"2014","journal-title":"Proteonomics Clin. Appl."},{"key":"10.1016\/j.biochi.2024.03.011_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20163847","article-title":"Matrix metalloproteases as influencers of the cells' social media","volume":"20","author":"Young","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.03.011_bib13","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1189\/jlb.0607338","article-title":"Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation","volume":"82","author":"Van Lint","year":"2007","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.biochi.2024.03.011_bib14","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.molmed.2013.11.005","article-title":"Proteases: common culprits in human skin disorders","volume":"20","author":"de Veer","year":"2014","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.biochi.2024.03.011_bib15","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.3390\/ijms21249739","article-title":"The roles of matrix metalloproteinases and their inhibitors in human diseases","volume":"21","author":"Cabral-Pacheco","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.03.011_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.matbio.2015.03.005","article-title":"The role of TIMPs in regulation of extracellular matrix proteolysis","volume":"44\u201346","author":"Arpino","year":"2015","journal-title":"Matrix Biol."},{"key":"10.1016\/j.biochi.2024.03.011_bib17","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1134\/S102279541109016X","article-title":"Genes expression of metalloproteinases (MMP-1, MMP-2, MMP-9, and MMP-12) associated with psoriasis","volume":"47","author":"Starodubtseva","year":"2011","journal-title":"Russ. J. Genet."},{"key":"10.1016\/j.biochi.2024.03.011_bib18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/039463200601900405","article-title":"VEGF is likely a key factor in the link between inflammation and angiogenesis in psoriasis: results of an immunohistochemical study","volume":"19","author":"Simonetti","year":"2006","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.biochi.2024.03.011_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155195","article-title":"Matrix metalloproteinase-7 could be a predictor for acute inflammation in psoriatic patients","volume":"134","author":"Abbes","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.biochi.2024.03.011_bib20","doi-asserted-by":"crossref","first-page":"28566","DOI":"10.3390\/ijms161226120","article-title":"Parallel reaction monitoring: a targeted experiment performed using high resolution and high mass accuracy mass spectrometry","volume":"16","author":"Rauniyar","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.03.011_bib21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cbpa.2020.09.009","article-title":"New strategies to identify protease substrates","volume":"60","author":"Canbay","year":"2021","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.biochi.2024.03.011_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2014.01.068","article-title":"Matrix metalloproteinases and their role in psoriasis","volume":"540","author":"Mezentsev","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.biochi.2024.03.011_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/0023677217724823","article-title":"PREPARE: guidelines for planning animal research and testing","volume":"52","author":"Smith","year":"2018","journal-title":"Lab. Anim."},{"key":"10.1016\/j.biochi.2024.03.011_bib24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/nmeth.1584","article-title":"mProphet: automated data processing and statistical validation for large-scale SRM experiments","volume":"8","author":"Reiter","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biochi.2024.03.011_bib25","first-page":"9","article-title":"Structure and function of human matrix metalloproteinases","author":"Laronha","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.biochi.2024.03.011_bib26","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1038\/s41598-019-39903-x","article-title":"Methodological refinement of Aldara-induced psoriasiform dermatitis model in mice","volume":"9","author":"Horv\u00e1th","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2024.03.011_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.703868","article-title":"Extracellular matrix enzymes and immune cell Biology","volume":"8","author":"McMahon","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.biochi.2024.03.011_bib28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fcell.2019.00068","article-title":"Unraveling the ECM-immune cell crosstalk in skin diseases","volume":"7","author":"Bhattacharjee","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.biochi.2024.03.011_bib29","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nrd4390","article-title":"Is there new hope for therapeutic matrix metalloproteinase inhibition?","volume":"13","author":"Vandenbroucke","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.biochi.2024.03.011_bib30","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nri1418","article-title":"Matrix metalloproteinases as modulators of inflammation and innate immunity","volume":"4","author":"Parks","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.biochi.2024.03.011_bib31","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1046\/j.1523-1747.2000.00138.x","article-title":"Basement membrane alterations in psoriasis are accompanied by epidermal overexpression of MMP-2 and its inhibitor TIMP-2","volume":"115","author":"Fleischmajer","year":"2000","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.biochi.2024.03.011_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12860-021-00395-1","article-title":"Extracellular matrix alterations in the skin of patients affected by psoriasis","volume":"22","author":"Wagner","year":"2021","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2024.03.011_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9913798","article-title":"Assessment of selected matrix metalloproteinases (MMPs) and correlation with cytokines in psoriatic patients","volume":"2021","author":"Michalak-Stoma","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.biochi.2024.03.011_bib34","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jid.2020.09.006","article-title":"MMP-9 mediates cross-talk between neutrophils and endothelial cells in psoriasis","volume":"141","author":"Alves-Filho","year":"2021","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.biochi.2024.03.011_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/jsre.1998.5495","article-title":"MMP-8 is the predominant collagenase in healing wounds and nonhealing ulcers","volume":"81","author":"Nwomeh","year":"1999","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.biochi.2024.03.011_bib36","doi-asserted-by":"crossref","first-page":"5503","DOI":"10.1158\/1078-0432.CCR-07-4041","article-title":"Matrilysin (MMP-7) is a novel broadly expressed tumor antigen recognized by antigen-specific T cells","volume":"14","author":"Yokoyama","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.biochi.2024.03.011_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92599-w","article-title":"Combination of retinoids and narrow-band ultraviolet B inhibits matrix metalloproteinase 13 expression in HaCaT keratinocytes and a mouse model of psoriasis","volume":"11","author":"Xi","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2024.03.011_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.actbio.2022.12.015","article-title":"Design and characterization of matrix metalloproteinase-responsive hydrogels for the treatment of inflammatory skin diseases","volume":"157","author":"Noddeland","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.biochi.2024.03.011_bib39","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1021\/acs.biomac.3c00265","article-title":"Protease-responsive hydrogel microparticles for intradermal drug delivery","volume":"24","author":"Noddeland","year":"2023","journal-title":"Biomacromolecules"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424000695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424000695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T10:50:40Z","timestamp":1730890240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908424000695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":39,"alternative-id":["S0300908424000695"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2024.03.011","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Matrix metalloproteinase landscape in the imiquimod-induced skin inflammation mouse model","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2024.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}