{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T04:59:18Z","timestamp":1779944358865,"version":"3.53.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.biochi.2024.03.013","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T16:38:25Z","timestamp":1711643905000},"page":"35-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover"],"prefix":"10.1016","volume":"226","author":[{"given":"Johannes","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mitschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahima","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vogele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-9105","authenticated-orcid":false,"given":"Thomas","family":"Reinheckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"He\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2024.03.013_bib1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.neurobiolaging.2013.11.019","article-title":"Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapy","volume":"35","author":"Tan","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.biochi.2024.03.013_bib2","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1111\/febs.13980","article-title":"Inherited diseases caused by mutations in cathepsin protease genes","volume":"284","author":"Ketterer","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.biochi.2024.03.013_bib3","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/EBC20170055","article-title":"Dysregulation of autophagy as a common mechanism in lysosomal storage diseases","volume":"61","author":"Seranova","year":"2017","journal-title":"Essays Biochem."},{"key":"10.1016\/j.biochi.2024.03.013_bib4","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.bbadis.2015.05.011","article-title":"Genetics of the neuronal ceroid lipofuscinoses (Batten disease)","volume":"1852","author":"Mole","year":"2015","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"key":"10.1016\/j.biochi.2024.03.013_bib5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1212\/WNL.0b013e31825f0547","article-title":"New nomenclature and classification scheme for the neuronal ceroid lipofuscinoses","volume":"79","author":"Williams","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.biochi.2024.03.013_bib6","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/brain\/awl107","article-title":"Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis","volume":"129","author":"Siintola","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.biochi.2024.03.013_bib7","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1086\/504159","article-title":"Cathepsin D deficiency is associated with a human neurodegenerative disorder","volume":"78","author":"Steinfeld","year":"2006","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.biochi.2024.03.013_bib8","doi-asserted-by":"crossref","first-page":"4910","DOI":"10.1073\/pnas.82.15.4910","article-title":"Cloning and sequence analysis of cDNA for human cathepsin D","volume":"82","author":"Faust","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2024.03.013_bib9","doi-asserted-by":"crossref","first-page":"6898","DOI":"10.1523\/JNEUROSCI.20-18-06898.2000","article-title":"Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons","volume":"20","author":"Koike","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.biochi.2024.03.013_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcn.2007.05.002","article-title":"Involvement of lysosomal storage-induced p38 MAP kinase activation in the overproduction of nitric oxide by microglia in cathepsin D-deficient mice","volume":"35","author":"Yamasaki","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.biochi.2024.03.013_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.biochi.2015.07.020","article-title":"Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10","volume":"122","author":"Ketscher","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2024.03.013_bib12","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1002\/j.1460-2075.1995.tb00029.x","article-title":"Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells","volume":"14","author":"Saftig","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.biochi.2024.03.013_bib13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1080\/15548627.2019.1637200","article-title":"Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis","volume":"16","author":"Marques","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.biochi.2024.03.013_bib14","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1056\/NEJMoa1712649","article-title":"Study of intraventricular cerliponase alfa for CLN2 disease","volume":"378","author":"Schulz","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.biochi.2024.03.013_bib15","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1111\/j.1471-4159.2011.07255.x","article-title":"Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line","volume":"119","author":"Scholz","year":"2011","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.biochi.2024.03.013_bib16","doi-asserted-by":"crossref","first-page":"5133","DOI":"10.1038\/s41467-020-18935-2","article-title":"Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling","volume":"11","author":"Ketterer","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2024.03.013_bib17","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3390\/cells12162031","article-title":"Dipeptidyl-aminopeptidases 8 and 9 regulate autophagy and tamoxifen response in breast cancer cells","volume":"12","author":"Bettecken","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.biochi.2024.03.013_bib18","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1038\/s41467-022-30094-0","article-title":"Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity","volume":"13","author":"Fr\u00f6hlich","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2024.03.013_bib19","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1021\/acs.jproteome.8b00505","article-title":"S-trap, an ultrafast sample-preparation approach for shotgun proteomics","volume":"17","author":"Hailemariam","year":"2018","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.biochi.2024.03.013_bib20","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nmeth.4256","article-title":"MSFragger: ultrafast and comprehensive peptide identification in shotgun proteomics","volume":"14","author":"Kong","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biochi.2024.03.013_bib21","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/s41592-020-0912-y","article-title":"Philosopher: a versatile toolkit for shotgun proteomics data analysis","volume":"17","author":"Da","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.biochi.2024.03.013_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100077","article-title":"IonQuant enables accurate and sensitive label-free quantification with FDR-controlled match-between-runs","volume":"20","author":"Yu","year":"2021","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.biochi.2024.03.013_bib23","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.21105\/joss.01686","article-title":"Welcome to the tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J.\u00a0Open Source Softw."},{"key":"10.1016\/j.biochi.2024.03.013_bib24","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biochi.2024.03.013_bib25","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1073\/pnas.93.4.1518","article-title":"Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene","volume":"93","author":"Hoshimaru","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.biochi.2024.03.013_bib26","first-page":"357","article-title":"A\u00a0pathology atlas of the human cancer transcriptome","volume":"1979","author":"Uhlen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.biochi.2024.03.013_bib27","doi-asserted-by":"crossref","first-page":"19414","DOI":"10.18632\/oncotarget.6838","article-title":"The cytoskeletal arrangements necessary to neurogenesis","volume":"7","author":"Compagnucci","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2024.03.013_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.dnarep.2019.02.005","article-title":"USP7: structure, substrate specificity, and inhibition","volume":"76","author":"Pozhidaeva","year":"2019","journal-title":"DNA Repair"},{"key":"10.1016\/j.biochi.2024.03.013_bib29","article-title":"PSMA2 knockdown impacts expression of proteins involved in immune and cellular stress responses in human lung cells","volume":"1869","author":"Rashid","year":"2022","journal-title":"Biochem. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.biochi.2024.03.013_bib30","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1212\/NXG.0000000000000285","article-title":"TPP2 mutation associated with sterile brain inflammation mimicking MS","volume":"4","author":"Reinthaler","year":"2018","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.biochi.2024.03.013_bib31","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/cdd.2009.214","article-title":"Lysosomal membrane permeabilization and cathepsin release is a Bax\/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes","volume":"17","author":"Oberle","year":"2010","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.biochi.2024.03.013_bib32","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1038\/s41467-018-07741-6","article-title":"Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis","volume":"9","author":"Mart\u00ednez-F\u00e1bregas","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2024.03.013_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.nbd.2012.10.004","article-title":"Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain","volume":"50","author":"Koch","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.biochi.2024.03.013_bib34","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2024.03.013_bib35","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1080\/15548627.2021.1907167","article-title":"The role of mitophagy in the regulation of mitochondrial energetic status in neurons","volume":"17","author":"Han","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.biochi.2024.03.013_bib36","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1002\/1873-3468.13584","article-title":"Mitochondrial dysfunction increases fatty acid \u03b2-oxidation and translates into impaired neuroblast maturation","volume":"593","author":"Audano","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.biochi.2024.03.013_bib37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.freeradbiomed.2016.06.027","article-title":"Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes","volume":"100","author":"Baxter","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.biochi.2024.03.013_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.redox.2015.11.010","article-title":"Interplay between oxidant species and energy metabolism","volume":"8","author":"Quijano","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.biochi.2024.03.013_bib39","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1074\/mcp.M115.050179","article-title":"Lowering endogenous cathepsin D abundance results in reactive oxygen species accumulation and cell senescence","volume":"16","author":"Su","year":"2017","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.biochi.2024.03.013_bib40","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3390\/cells11050851","article-title":"Ubiquitination-proteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress","volume":"11","author":"Li","year":"2022","journal-title":"Cells"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424000713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424000713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T15:50:46Z","timestamp":1730908246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908424000713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":40,"alternative-id":["S0300908424000713"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2024.03.013","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2024.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}