{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:38:00Z","timestamp":1775475480404,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Government of India Department of Biotechnology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.biochi.2024.08.008","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T01:36:34Z","timestamp":1723253794000},"page":"15-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Unveiling the mechanism of hesperidin-induced LdTopI-mediated cell death pathway in protozoan parasite Leishmania donovani"],"prefix":"10.1016","volume":"228","author":[{"given":"Swati","family":"Lamba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Mazire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.biochi.2024.08.008_bib1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1007\/s00436-021-07139-2","article-title":"Leishmaniasis: where are we and are we heading?","volume":"120","author":"Sasidharan","year":"2021","journal-title":"Parasitol. Res."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib2","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0035-9203(94)90432-4","article-title":"Hepatotoxicity of sodium stibogluconate therapy for American cutaneous leishmaniasis","volume":"88","author":"Hepburn","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"issue":"3","key":"10.1016\/j.biochi.2024.08.008_bib3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1258\/td.2008.080369","article-title":"Severe adverse reactions to meglumine antimoniate in the treatment of visceral leishmaniasis: a report of 13 cases in the southwestern region of Brazil","volume":"39","author":"Oliveira","year":"2009","journal-title":"Trop. Doct."},{"issue":"2","key":"10.1016\/j.biochi.2024.08.008_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.actatropica.2011.02.007","article-title":"Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World","volume":"118","author":"Oliveira","year":"2011","journal-title":"Acta Trop."},{"issue":"6","key":"10.1016\/j.biochi.2024.08.008_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001688","article-title":"Monitoring toxicity associated with parenteral sodium stibogluconate in the day-case management of returned travellers with New World cutaneous leishmaniasis [corrected]","volume":"6","author":"Wise","year":"2012","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"8","key":"10.1016\/j.biochi.2024.08.008_bib6","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1074","article-title":"Chemistry and pharmacology of the Citrus bioflavonoid hesperidin","volume":"15","author":"Garg","year":"2001","journal-title":"Phytother Res."},{"key":"10.1016\/j.biochi.2024.08.008_bib7","series-title":"Trease and Evans' Pharmacognosy. Oxford, UK","author":"Evans","year":"1996"},{"key":"10.1016\/j.biochi.2024.08.008_bib8","series-title":"Studies in Natural Products Chemistry","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/B978-0-444-64056-7.00006-4","article-title":"Applications of hesperidin as an anticancer pro-drug: phytotherapy or an alternative chemotherapy","author":"Stanisic","year":"2018"},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib9","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.foodchem.2010.07.100","article-title":"Antifungal activity of natural and enzymatically-modified flavonoids isolated from citrus species","volume":"124","author":"Salas","year":"2011","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.18466\/cbayarfbe.370370","article-title":"Characterization and in\u00a0vitro evolution of antibacterial efficacy of novel hesperidin microemulsion","volume":"13","author":"Karay\u0131ld\u0131r\u0131m","year":"2017","journal-title":"Celal Bayar U niv Fen Bilim Derg"},{"issue":"5","key":"10.1016\/j.biochi.2024.08.008_bib11","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1248\/bpb.27.679","article-title":"Citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice","volume":"27","author":"Kawaguchi","year":"2004","journal-title":"Biol. Pharm. Bull."},{"issue":"3","key":"10.1016\/j.biochi.2024.08.008_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.2164\/jandrol.04181","article-title":"Biological activity assessment of a novel contraceptive antimicrobial agent","volume":"26","author":"Garg","year":"2005","journal-title":"J.\u00a0Androl."},{"issue":"12","key":"10.1016\/j.biochi.2024.08.008_bib13","doi-asserted-by":"crossref","first-page":"8112","DOI":"10.1021\/acsomega.0c05858","article-title":"Hesperidin targets Leishmania donovani sterol C-24 reductase to fight against leishmaniasis","volume":"6","author":"Tabrez","year":"2021","journal-title":"ACS Omega"},{"issue":"2","key":"10.1016\/j.biochi.2024.08.008_bib14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1042\/BJ20071286","article-title":"An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme","volume":"409","author":"Roy","year":"2008","journal-title":"Biochem. J."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib15","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/j.1365-2958.2006.05428.x","article-title":"Topoisomerases of kinetoplastid parasites: why so fascinating","volume":"62","author":"Das","year":"2006","journal-title":"Mol. Microbiol."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib16","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/nar\/gkj502","article-title":"Differential induction of Leishmania donovani bi-subunit topoisomerase I\u2013DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I","volume":"34","author":"Das","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.biochi.2024.08.008_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102287","article-title":"The HIV - 1 protease inhibitor Amprenavir targets Leishmania donovani topoisomerase I and induces oxidative stress-mediated programmed cell death","volume":"82","author":"Roy","year":"2021","journal-title":"Parasitol. Int."},{"issue":"6","key":"10.1016\/j.biochi.2024.08.008_bib18","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1128\/AAC.01648-08","article-title":"Topoisomerase I gene mutations at F270 in the large subunit and N184 in the small subunit contribute to the resistance mechanism of the unicellular parasite Leishmania donovani towards 3,3'-diindolylmethane","volume":"53","author":"Roy","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib19","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1128\/AAC.49.4.1441-1446.2005","article-title":"Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani","volume":"49","author":"Marquis","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"issue":"5","key":"10.1016\/j.biochi.2024.08.008_bib20","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1124\/mol.108.050161","article-title":"Mitochondria dependent ROS-mediated programmed cell death (PCD) induced by 3,3\u2032 -diindolylmethane (DIM) through inhibition of FoF1-ATP synthase in unicellular protozoan parasite Leishmania donovani","volume":"74","author":"Roy","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.biochi.2024.08.008_bib21","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exppara.2017.02.010","article-title":"Copper salisylaldoxime (CuSAL) imparts protective efficacy against visceral leishmaniasis by targeting Leishmania donovani topoisomerase IB","volume":"175","author":"Singh","year":"2017","journal-title":"Exp. Parasitol."},{"issue":"1\u20132","key":"10.1016\/j.biochi.2024.08.008_bib22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/BF03402104","article-title":"Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy","volume":"9","author":"Chowdhury","year":"2003","journal-title":"Mol. Med."},{"issue":"8","key":"10.1016\/j.biochi.2024.08.008_bib23","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/hmg\/ddh103","article-title":"The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants","volume":"13","author":"Mattiazzi","year":"2004","journal-title":"Hum. Mol. Genet."},{"issue":"2","key":"10.1016\/j.biochi.2024.08.008_bib24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF00048058","article-title":"A\u00a0biochemical hallmark of apoptosis: internucleosomal degradation of the genome","volume":"11","author":"Compton","year":"1992","journal-title":"Cancer Metastasis Rev."},{"issue":"10","key":"10.1016\/j.biochi.2024.08.008_bib25","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc1977","article-title":"Topoisomerase I inhibitors: camptothecins and beyond","volume":"6","author":"Pommier","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"7","key":"10.1016\/j.biochi.2024.08.008_bib26","first-page":"1509","article-title":"Differences in inhibition of chromosome separation and G2 arrest by DNA topoisomerase II inhibitors merbarone and VM-26","volume":"55","author":"Chen","year":"1995","journal-title":"Cancer Res."},{"issue":"2","key":"10.1016\/j.biochi.2024.08.008_bib27","first-page":"296","article-title":"Selection of human leukemic CEM cells for resistance to the DNA topoisomerase II catalytic inhibitor ICRF-187 results in increased levels of topoisomerase II alpha and altered G (2)\/M checkpoint and apoptotic responses","volume":"57","author":"Morgan","year":"2000","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib28","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/em.10072","article-title":"Catalytic inhibitors of topoisomerase II are DNA damaging agents: induction of chromosomal damage by merbarone and ICRF-187","volume":"39","author":"Wang","year":"2002","journal-title":"Environ. Mol. Mutagen."},{"issue":"3","key":"10.1016\/j.biochi.2024.08.008_bib29","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1021\/acs.jmedchem.7b01297","article-title":"Neutral porphyrin derivative exerts anticancer activity by targeting cellular topoisomerase I (Top 1) and promotes apoptotic cell death without stabilizing top1-DNA cleavage complexes","volume":"61","author":"Das","year":"2018","journal-title":"J.\u00a0Med. Chem."},{"issue":"4","key":"10.1016\/j.biochi.2024.08.008_bib30","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1128\/AAC.02193-13","article-title":"Disuccinyl betulin triggers metacaspase-dependent endonuclease G-mediated cell death in unicellular protozoan parasite Leishmania donovani","volume":"58","author":"Chowdhury","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"24","key":"10.1016\/j.biochi.2024.08.008_bib31","doi-asserted-by":"crossref","first-page":"11848","DOI":"10.1158\/0008-5472.CAN-07-1615","article-title":"Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death","volume":"67","author":"Ganguly","year":"2007","journal-title":"Cancer Res."},{"issue":"30","key":"10.1016\/j.biochi.2024.08.008_bib32","doi-asserted-by":"crossref","first-page":"22463","DOI":"10.1016\/S0021-9258(18)41552-9","article-title":"beta-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecin","volume":"268","author":"Li","year":"1993","journal-title":"J.\u00a0Biol. Chem."},{"issue":"3","key":"10.1016\/j.biochi.2024.08.008_bib33","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.4049\/jimmunol.166.3.1912","article-title":"The hamster as a model of human visceral leishmaniasis: progressive disease and impaired generation of nitric oxide in the face of a prominent Th1-like cytokine response","volume":"166","author":"Melby","year":"2001","journal-title":"J.\u00a0Immunol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424001937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424001937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T15:43:19Z","timestamp":1735314199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908424001937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":33,"alternative-id":["S0300908424001937"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2024.08.008","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the mechanism of hesperidin-induced LdTopI-mediated cell death pathway in protozoan parasite Leishmania donovani","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2024.08.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}