{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:38:29Z","timestamp":1781735909077,"version":"3.54.5"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.biochi.2024.11.013","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:00:42Z","timestamp":1732089642000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Signaling pathways in skin cancers and the protective functions of melatonin"],"prefix":"10.1016","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6060-4605","authenticated-orcid":false,"given":"Azin","family":"Zolfagharypoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6264-9849","authenticated-orcid":false,"given":"Atra","family":"Ajdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3794-6206","authenticated-orcid":false,"given":"Farnoosh","family":"Seirafianpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-5070","authenticated-orcid":false,"given":"Yeganeh","family":"Pakbaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-5769","authenticated-orcid":false,"given":"Azam","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6619-2330","authenticated-orcid":false,"given":"Saeed","family":"Mehrzadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12935-021-01892-1","article-title":"An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress","volume":"21","author":"Mehrzadi","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/1573394717666210526140950","article-title":"Therapeutic application of melatonin in the treatment of melanoma: a review","volume":"17","author":"Fatemi","year":"2021","journal-title":"Curr. Cancer Ther. Rev."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2217\/epi-2020-0241","article-title":"Melatonin and regulation of miRNAs: novel targeted therapy for cancerous and noncancerous disease","volume":"13","author":"Pourhanifeh","year":"2021","journal-title":"Epigenomics"},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib4","first-page":"945","article-title":"Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1\u03b1\/ROS\/VEGF","volume":"43","author":"Cheng","year":"2019","journal-title":"Int. J. Mol. Med."},{"issue":"5","key":"10.1016\/j.biochi.2024.11.013_bib5","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1007\/s11033-021-06439-1","article-title":"Melatonin and neuroblastoma: a novel therapeutic approach","volume":"48","author":"Pourhanifeh","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.biochi.2024.11.013_bib6","first-page":"1","article-title":"Melatonin and urological cancers: a new therapeutic approach","volume":"20","author":"Pourhanifeh","year":"2020","journal-title":"Cancer Cell Int."},{"issue":"5","key":"10.1016\/j.biochi.2024.11.013_bib7","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1002\/jcp.27391","article-title":"Melatonin and cancer: from the promotion of genomic stability to use in cancer treatment","volume":"234","author":"Farhood","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.biochi.2024.11.013_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173471","article-title":"Melatonin and gastrointestinal cancers: current evidence based on underlying signaling pathways","volume":"886","author":"Pourhanifeh","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.biochi.2024.11.013_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/fcp.12780","article-title":"Therapeutic potentials of melatonin in the treatment of lymphoma: a review of current evidence","volume":"36","author":"Moradian","year":"2022","journal-title":"Fund. Clin. Pharmacol."},{"issue":"19","key":"10.1016\/j.biochi.2024.11.013_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/nu14193934","article-title":"Is melatonin the \"next vitamin D\"?: a review of emerging science, clinical uses, safety, and dietary supplements","volume":"14","author":"Minich","year":"2022","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib11","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1530\/ERC-15-0030","article-title":"Melatonin: an inhibitor of breast cancer","volume":"22","author":"Hill","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"issue":"1667","key":"10.1016\/j.biochi.2024.11.013_bib12","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2014.0121","article-title":"Artificial light at night: melatonin as a mediator between the environment and epigenome","volume":"370","author":"Haim","year":"2015","journal-title":"Phil. Trans. Roy. Soc. Lond. B Biol. Sci."},{"issue":"6","key":"10.1016\/j.biochi.2024.11.013_bib13","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1517\/13543784.2012.681045","article-title":"Melatonin uses in oncology: breast cancer prevention and reduction of the side effects of chemotherapy and radiation","volume":"21","author":"Sanchez-Barcelo","year":"2012","journal-title":"Expet Opin. Invest. Drugs"},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib14","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/jpi.12362","article-title":"Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin","volume":"61","author":"Hosseinzadeh","year":"2016","journal-title":"J.\u00a0Pineal Res."},{"issue":"19","key":"10.1016\/j.biochi.2024.11.013_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194948","article-title":"Protective effects of melatonin on the skin: future perspectives","volume":"20","author":"Rusanova","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.biochi.2024.11.013_bib16","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1007\/s00432-020-03292-w","article-title":"Melatonin: an endogenous miraculous indolamine, fights against cancer progression","volume":"146","author":"Samanta","year":"2020","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.biochi.2024.11.013_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107825","article-title":"SARS-CoV-2 and other coronaviruses negatively influence mitochondrial quality control: beneficial effects of melatonin","volume":"224","author":"Mehrzadi","year":"2021","journal-title":"Pharmacol. Therapeut."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/14728222.2020.1737015","article-title":"Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment","volume":"24","author":"Mehrzadi","year":"2020","journal-title":"Expert Opin. Ther. Targets"},{"issue":"9","key":"10.1016\/j.biochi.2024.11.013_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26092506","article-title":"Melatonin in cancer treatment: current knowledge and future opportunities","volume":"26","author":"Talib","year":"2021","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0891-5849(96)00046-9","article-title":"Evaluation of the antioxidant activity of melatonin in\u00a0vitro","volume":"21","author":"Marshall","year":"1996","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.biochi.2024.11.013_bib21","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2174\/1389450120666190319162147","article-title":"Molecular aspects of melatonin treatment in tinnitus: a review","volume":"20","author":"Hosseinzadeh","year":"2019","journal-title":"Curr. Drug Targets"},{"issue":"10","key":"10.1016\/j.biochi.2024.11.013_bib22","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1007\/s00198-023-06836-1","article-title":"Melatonin and bone-related diseases: an updated mechanistic overview of current evidence and future prospects","volume":"34","author":"Bagherifard","year":"2023","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.biochi.2024.11.013_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.biopha.2018.09.044","article-title":"Evaluating the protective effects of melatonin on di (2-ethylhexyl) phthalate-induced testicular injury in adult mice","volume":"108","author":"Bahrami","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.biochi.2024.11.013_bib24","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.biopha.2017.11.007","article-title":"The potential use of melatonin to treat protozoan parasitic infections: a review","volume":"97","author":"Daryani","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"27","key":"10.1016\/j.biochi.2024.11.013_bib25","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1021\/acs.jpcb.5b04920","article-title":"N-acetylserotonin and 6-hydroxymelatonin against oxidative stress: implications for the overall protection exerted by melatonin","volume":"119","author":"\u00c1lvarez-Diduk","year":"2015","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.biochi.2024.11.013_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.lfs.2018.03.032","article-title":"Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin","volume":"201","author":"Hosseinzadeh","year":"2018","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/fcp.12566","article-title":"Melatonin and morphine: potential beneficial effects of co-use","volume":"35","author":"Hemati","year":"2021","journal-title":"Fund. Clin. Pharmacol."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2174\/1871524922666220429121253","article-title":"The effects of vitamin D3 and melatonin combination on Pentylenetetrazole-induced seizures in mice","volume":"22","author":"Hosseinzadeh","year":"2022","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib29","doi-asserted-by":"crossref","first-page":"281","DOI":"10.2174\/1574885517666220531104009","article-title":"The anticonvulsant activity of thiamine, vitamin D3, and melatonin combination on pentylenetetrazole-induced seizures in mice","volume":"17","author":"Mehrzadi","year":"2022","journal-title":"Curr. Drug Ther."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib30","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2174\/1574885518666230811121026","article-title":"Evaluating the antidepressant-like properties of melatonin and vitamin D3 combination in mice subjected to restraint stress: investigating the involvement of oxidative stress","volume":"19","author":"Mehrzadi","year":"2024","journal-title":"Curr. Drug Ther."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib31","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/1871524923666221121111501","article-title":"Antidepressant-like properties of melatonin and atorvastatin combination following the restraint stress in mice: a study of oxidative stress factors","volume":"23","author":"Nikoui","year":"2023","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/1871524921666210623161212","article-title":"Anti-convulsive effect of thiamine and melatonin combination in mice: involvement of oxidative stress","volume":"21","author":"Dehdashtian","year":"2021","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.biochi.2024.11.013_bib33","article-title":"Mechanism of action and promising clinical application of melatonin from a dermatological perspective","volume":"6","author":"Zhang","year":"2023","journal-title":"J.\u00a0Transl. Autoimmun."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010305","article-title":"Associations between melatonin, neuroinflammation, and brain alterations in depression","volume":"23","author":"Won","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.biochi.2024.11.013_bib35","doi-asserted-by":"crossref","first-page":"711","DOI":"10.2174\/1389450123666220114151654","article-title":"Anti-degenerative effect of melatonin on intervertebral disc: protective contribution against inflammation, oxidative stress, apoptosis, and autophagy","volume":"23","author":"Hemati","year":"2022","journal-title":"Curr. Drug Targets"},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib36","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.3390\/ijms14048638","article-title":"Melatonin: buffering the immune system","volume":"14","author":"Carrillo-Vico","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"28","key":"10.1016\/j.biochi.2024.11.013_bib37","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2174\/1381612825666190829151314","article-title":"Melatonin as a modulator of degenerative and regenerative signaling pathways in injured retinal ganglion cells","volume":"25","author":"Juybari","year":"2019","journal-title":"Curr. Pharmaceut. Des."},{"issue":"10","key":"10.1016\/j.biochi.2024.11.013_bib38","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1080\/17474124.2023.2267439","article-title":"Protective and therapeutic potential of melatonin against intestinal diseases: updated review of current data based on molecular mechanisms","volume":"17","author":"Mehrzadi","year":"2023","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.biochi.2024.11.013_bib39","first-page":"1","article-title":"Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms","author":"Hosseinzadeh","year":"2024","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.biochi.2024.11.013_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120866","article-title":"Melatonin effect on platelets and coagulation: implications for a prophylactic indication in COVID-19","volume":"307","author":"Hosseinzadeh","year":"2022","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib41","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1111\/j.1600-079X.2011.00863.x","article-title":"Therapeutic effects of melatonin on heatstroke-induced multiple organ dysfunction syndrome in rats","volume":"50","author":"Lin","year":"2011","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.biochi.2024.11.013_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13098-020-00537-z","article-title":"Melatonin: new insights on its therapeutic properties in diabetic complications","volume":"12","author":"Pourhanifeh","year":"2020","journal-title":"Diabetol. Metab. Syndrome"},{"key":"10.1016\/j.biochi.2024.11.013_bib43","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mrgentox.2018.04.002","article-title":"Dose-dependent proliferative and cytotoxic effects of melatonin on human epidermoid carcinoma and normal skin fibroblast cells","volume":"829\u2013830","author":"Kocyigit","year":"2018","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2174\/157015910792246155","article-title":"Antiinflammatory activity of melatonin in central nervous system","volume":"8","author":"Esposito","year":"2010","journal-title":"Curr. Neuropharmacol."},{"issue":"6","key":"10.1016\/j.biochi.2024.11.013_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12061567","article-title":"Role and therapeutic potential of melatonin in the central nervous system and cancers","volume":"12","author":"Gurunathan","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1016\/j.biochi.2024.11.013_bib46","doi-asserted-by":"crossref","first-page":"e3336","DOI":"10.1002\/dmrr.3336","article-title":"Therapeutic application of nutraceuticals in diabetic nephropathy: current evidence and future implications","volume":"36","author":"Dehdashtian","year":"2020","journal-title":"Diabetes Metabol. Res. Rev."},{"key":"10.1016\/j.biochi.2024.11.013_bib47","article-title":"Melatonin in the treatment of fibromyalgia symptoms: a systematic review","volume":"38","author":"Hemati","year":"2020","journal-title":"Compl. Ther. Clin. Pract."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib48","doi-asserted-by":"crossref","first-page":"102","DOI":"10.32794\/mr112500144","article-title":"Melatonin: therapeutic potential for stroke and other neurodegenerative diseases","volume":"6","author":"Hosseinzadeh","year":"2023","journal-title":"Melatonin Res."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib49","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/jpi.12197","article-title":"Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex\u00a0vivo and cultured keratinocytes","volume":"58","author":"Kleszczy\u0144ski","year":"2015","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.biochi.2024.11.013_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122557","article-title":"Melatonin: current evidence on protective and therapeutic roles in gynecological diseases","author":"Hosseinzadeh","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2024.11.013_bib51","article-title":"Melatonin potentials against viral infections including COVID-19: current evidence and new findings","volume":"287","author":"Juybari","year":"2020","journal-title":"Virus Res."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib52","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10557-020-07052-3","article-title":"Clinical application of melatonin in the treatment of cardiovascular diseases: current evidence and new insights into the cardioprotective and cardiotherapeutic properties","volume":"36","author":"Pourhanifeh","year":"2022","journal-title":"Cardiovasc. Drugs Ther."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib53","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/carcin\/bgac008","article-title":"A\u00a0combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer","volume":"43","author":"Zhao","year":"2022","journal-title":"Carcinogenesis"},{"issue":"19","key":"10.1016\/j.biochi.2024.11.013_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197174","article-title":"Melatonin and autophagy in aging-related neurodegenerative diseases","volume":"21","author":"Luo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.11.013_bib55","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.lfs.2017.12.001","article-title":"Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress","volume":"193","author":"Dehdashtian","year":"2018","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib56","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s43440-023-00554-5","article-title":"Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis","volume":"76","author":"Hosseinzadeh","year":"2024","journal-title":"Pharmacol. Rep."},{"issue":"12","key":"10.1016\/j.biochi.2024.11.013_bib57","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/14728222.2018.1541318","article-title":"Oxidative\/nitrosative stress, autophagy and apoptosis as therapeutic targets of melatonin in idiopathic pulmonary fibrosis","volume":"22","author":"Hosseinzadeh","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"issue":"5","key":"10.1016\/j.biochi.2024.11.013_bib58","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/CIRCRESAHA.118.312829","article-title":"Pak2 as a novel therapeutic target for cardioprotective endoplasmic reticulum stress response","volume":"124","author":"Binder","year":"2019","journal-title":"Circ. Res."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib59","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s12192-019-00994-0","article-title":"Melatonin ameliorates endoplasmic reticulum stress in N2a neuroblastoma cell hypoxia-reoxygenation injury by activating the AMPK-Pak2 pathway","volume":"24","author":"Xing","year":"2019","journal-title":"Cell Stress & Chaperones"},{"issue":"24","key":"10.1016\/j.biochi.2024.11.013_bib60","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1038\/onc.2011.469","article-title":"Melatonin triggers p53Ser phosphorylation and prevents DNA damage accumulation","volume":"31","author":"Santoro","year":"2012","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib61","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10456-019-09689-7","article-title":"Role of melatonin in controlling angiogenesis under physiological and pathological conditions","volume":"23","author":"Ma","year":"2020","journal-title":"Angiogenesis"},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib62","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-079X.2007.00498.x","article-title":"Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells","volume":"44","author":"Dai","year":"2008","journal-title":"J.\u00a0Pineal Res."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib63","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.3892\/or.2017.5446","article-title":"Melatonin inhibits angiogenesis in SH-SY5Y human neuroblastoma cells by downregulation of VEGF","volume":"37","author":"Gonz\u00e1lez","year":"2017","journal-title":"Oncol. Rep."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib64","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/ceo.12802","article-title":"Hypoxia-induced vascular endothelial growth factor secretion by retinal pigment epithelial cells is inhibited by melatonin via decreased accumulation of hypoxia-inducible factors-1\u03b1 protein","volume":"45","author":"Lai","year":"2017","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"21","key":"10.1016\/j.biochi.2024.11.013_bib65","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040843","article-title":"Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis","volume":"18","author":"Reiter","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.biochi.2024.11.013_bib67","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1177\/09603271211002883","article-title":"Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer","volume":"40","author":"Karadas","year":"2021","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.biochi.2024.11.013_bib68","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.2147\/OTT.S298512","article-title":"Role and therapeutic potential of melatonin in various type of cancers","volume":"14","author":"Gurunathan","year":"2021","journal-title":"OncoTargets Ther."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18040763","article-title":"Melatonin reduces angiogenesis in serous papillary ovarian carcinoma of ethanol-preferring rats","volume":"18","author":"Zonta","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib70","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1600-079X.2012.01030.x","article-title":"Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model","volume":"54","author":"Kim","year":"2013","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.biochi.2024.11.013_bib71","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.taap.2017.09.022","article-title":"Melatonin as an angiogenesis inhibitor to combat cancer: mechanistic evidence","volume":"335","author":"Goradel","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib72","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12501","article-title":"Melatonin and its derivatives counteract the ultraviolet B radiation-induced damage in human and porcine skin ex\u00a0vivo","volume":"65","author":"Skobowiat","year":"2018","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.biochi.2024.11.013_bib73","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.mce.2015.11.016","article-title":"Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells","volume":"422","author":"Yun","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.biochi.2024.11.013_bib74","article-title":"Melatonin suppresses the expression of 45S preribosomal RNA and upstream binding factor and enhances the antitumor activity of puromycin in MDA-MB-231 breast cancer cells","volume":"2013","author":"Jung","year":"2013","journal-title":"Evid. base Compl. Alternative Med. : eCAM."},{"issue":"6","key":"10.1016\/j.biochi.2024.11.013_bib75","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/fcp.12813","article-title":"Melatonin has an inhibitory effect on MCF-7 and MDA-MB-231 human breast cancer cell lines by inducing autophagy and apoptosis","volume":"36","author":"\u00d6nder","year":"2022","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"6","key":"10.1016\/j.biochi.2024.11.013_bib76","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1080\/08820139.2019.1586918","article-title":"Exogenous melatonin up-regulates expression of CD62L by lymphocytes in aged mice under inflammatory and non-inflammatory conditions","volume":"48","author":"Perfilyeva","year":"2019","journal-title":"Immunol. Invest."},{"issue":"5","key":"10.1016\/j.biochi.2024.11.013_bib77","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/ar.21361","article-title":"Role of CD4+ CD25+ regulatory T cells in melatonin-mediated inhibition of murine gastric cancer cell growth in\u00a0vivo and in\u00a0vitro","volume":"294","author":"Liu","year":"2011","journal-title":"Anat. Rec. (Hoboken, NJ : 2007)"},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib78","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pharep.2017.07.017","article-title":"Melatonin suppresses eosinophils and Th17 cells in hamsters treated with a combination of human liver fluke infection and a chemical carcinogen","volume":"70","author":"Wongsena","year":"2018","journal-title":"Pharmacol. Rep. : PR."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib79","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124384","article-title":"Propionibacterium acnes augments antitumor, anti-angiogenesis and immunomodulatory effects of melatonin on breast cancer implanted in mice","volume":"10","author":"Talib","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib80","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1177\/0748730415577723","article-title":"Circadian clocks in the immune system","volume":"30","author":"Labrecque","year":"2015","journal-title":"J.\u00a0Biol. Rhythm."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib81","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/jcp.29036","article-title":"Immunoregulatory role of melatonin in cancer","volume":"235","author":"Moradkhani","year":"2020","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib82","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0959-9673.2006.00474.x","article-title":"The role of melatonin in immuno-enhancement: potential application in cancer","volume":"87","author":"Miller","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"issue":"Suppl","key":"10.1016\/j.biochi.2024.11.013_bib83","article-title":"Immune evasion in cancer: mechanistic basis and therapeutic strategies","volume":"35","author":"Vinay","year":"2015","journal-title":"Semin. Cancer Biol."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib84","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0923-1811(01)00133-5","article-title":"The effects of the melatonin on ultraviolet-B irradiated cultured dermal fibroblasts","volume":"27","author":"Ryoo","year":"2001","journal-title":"J.\u00a0Dermatol. Sci."},{"issue":"7","key":"10.1016\/j.biochi.2024.11.013_bib85","article-title":"Melatonin prevents UVB-induced skin photoaging by inhibiting oxidative damage and MMP expression through JNK\/AP-1 signaling pathway in human dermal fibroblasts","volume":"12","author":"Yuksel Egrilmez","year":"2022","journal-title":"Life (Basel)"},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib86","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1600-079X.2007.00542.x","article-title":"Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3\/casp-7) and PARP in UVR-exposed HaCaT keratinocytes","volume":"44","author":"Fischer","year":"2008","journal-title":"J.\u00a0Pineal Res."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib87","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/jpi.12146","article-title":"Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes","volume":"57","author":"Janjetovic","year":"2014","journal-title":"J.\u00a0Pineal Res."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib88","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/s41598-017-01305-2","article-title":"Melatonin and its metabolites protect human melanocytes against UVB-induced damage: involvement of NRF2-mediated pathways","volume":"7","author":"Janjetovic","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib89","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/jpi.12018","article-title":"Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex\u00a0vivo human skin","volume":"54","author":"Fischer","year":"2013","journal-title":"J.\u00a0Pineal Res."},{"issue":"11","key":"10.1016\/j.biochi.2024.11.013_bib90","doi-asserted-by":"crossref","first-page":"12075","DOI":"10.18632\/oncotarget.7679","article-title":"Melatonin protects skin keratinocyte from hydrogen peroxide-mediated cell death via the SIRT1 pathway","volume":"7","author":"Lee","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2024.11.013_bib91","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.biocel.2015.05.018","article-title":"Nuclear redox imbalance affects circadian oscillation in HaCaT keratinocytes","volume":"65","author":"Ranieri","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib92","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/jpi.12338","volume":"61","author":"Kleszczy\u0144ski","year":"2016","journal-title":"J.\u00a0Pineal Res."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib93","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0923-1811(01)00088-3","article-title":"Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts","volume":"26","author":"Kim","year":"2001","journal-title":"J.\u00a0Dermatol. Sci."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib94","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.0959-9673.2005.00412.x","article-title":"Ultrastructural evaluation of the radioprotective effects of melatonin against X-ray-induced skin damage in Albino rats","volume":"86","author":"Hussein","year":"2005","journal-title":"Int. J. Exp. Pathol."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib95","first-page":"72","article-title":"Biochemical and histopathological evaluation of the radioprotective effects of melatonin against gamma ray-induced skin damage","volume":"12","author":"Shabeeb","year":"2019","journal-title":"Curr. Rad."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib96","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010326","article-title":"Age associated decrease of MT-1 melatonin receptor in human dermal skin fibroblasts impairs protection against UV-induced DNA damage","volume":"21","author":"Dong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib97","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12728","article-title":"Mitochondrial function is controlled by melatonin and its metabolites in\u00a0vitro in human melanoma cells","volume":"70","author":"Bilska","year":"2021","journal-title":"J.\u00a0Pineal Res."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib98","first-page":"665","article-title":"Oncostatic effects of the indole melatonin and expression of its cytosolic and nuclear receptors in cultured human melanoma cell lines","volume":"29","author":"Fischer","year":"2006","journal-title":"Int. J. Oncol."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib99","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/excr.1993.1137","article-title":"Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells","volume":"206","author":"Slominski","year":"1993","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.biochi.2024.11.013_bib100","first-page":"11","article-title":"Medical implications of melatonin: receptor-mediated and receptor-independent actions","volume":"52","author":"Reiter","year":"2007","journal-title":"Adv. Med. Sci."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib101","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12557","article-title":"Pan-cancer genomic analyses reveal prognostic and immunogenic features of the tumor melatonergic microenvironment across 14 solid cancer types","volume":"66","author":"Lv","year":"2019","journal-title":"J.\u00a0Pineal Res."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21020548","article-title":"Melatonin-induced cytoskeleton reorganization leads to inhibition of melanoma cancer cell proliferation","volume":"21","author":"Alvarez-Artime","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib103","doi-asserted-by":"crossref","first-page":"194","DOI":"10.32794\/mr11250057","article-title":"Melatonin inhibits human melanoma cells proliferation and invasion via cell cycle arrest and cytoskeleton remodeling","volume":"3","author":"Moreno","year":"2020","journal-title":"Melatonin Res."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib104","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.3390\/ijms14023901","article-title":"A\u00a0comparison of B16 melanoma cells and 3T3 fibroblasts concerning cell viability and ROS production in the presence of melatonin, tested over a wide range of concentrations","volume":"14","author":"Bonmati-Carrion","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.11.013_bib105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2014.07.024","article-title":"Melatonin and its metabolites accumulate in the human epidermis in\u00a0vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in\u00a0vitro","volume":"404","author":"Kim","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib106","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/exd.12618","article-title":"The role of melanin pigment in melanoma","volume":"24","author":"Slominski","year":"2015","journal-title":"Exp. Dermatol."},{"issue":"14","key":"10.1016\/j.biochi.2024.11.013_bib107","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144970","article-title":"Melatonin induces melanogenesis in human SK-MEL-1 melanoma cells involving glycogen synthase kinase-3 and reactive oxygen species","volume":"21","author":"Perdomo","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.biochi.2024.11.013_bib108","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1056\/NEJMoa021481","article-title":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis","volume":"347","author":"Ong","year":"2002","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib109","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13046-019-1036-z","article-title":"Melatonin synergizes BRAF-targeting agent vemurafenib in melanoma treatment by inhibiting iNOS\/hTERT signaling and cancer-stem cell traits","volume":"38","author":"Hao","year":"2019","journal-title":"J.\u00a0Exp. Clin. Cancer Res. : CR"},{"key":"10.1016\/j.biochi.2024.11.013_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101197","article-title":"Ku80 promotes melanoma growth and regulates antitumor effect of melatonin by targeting HIF1-\u03b1 dependent PDK-1 signaling pathway","volume":"25","author":"Liu","year":"2019","journal-title":"Redox Biol."},{"issue":"8","key":"10.1016\/j.biochi.2024.11.013_bib111","doi-asserted-by":"crossref","first-page":"12142","DOI":"10.1002\/jcp.28129","article-title":"Potential use of melatonin in skin cancer treatment: a review of current biological evidence","volume":"234","author":"Pourhanifeh","year":"2019","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib112","first-page":"NP49","article-title":"Comparison of the protective effects of melatonin and silymarin against gentamicin-induced nephrotoxicity in rats","volume":"21","author":"Ghaznavi","year":"2016","journal-title":"J.\u00a0Evidence-based Compl. & Alternative Med."},{"key":"10.1016\/j.biochi.2024.11.013_bib113","series-title":"Comparing the Protective Effects of Melatonin and Silymarin against Gentamicin-Induced Nephrotoxicity in Rat","author":"Mehrzadi","year":"2015"},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib114","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1139\/cjpp-2015-0277","article-title":"Melatonin synergistically enhances protective effect of atorvastatin against gentamicin-induced nephrotoxicity in rat kidney","volume":"94","author":"Mehrzadi","year":"2016","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"3","key":"10.1016\/j.biochi.2024.11.013_bib115","first-page":"119","article-title":"Anticancer neuroimmunomodulation by pineal hormones other than melatonin: preliminary phase II study of the pineal indole 5-methoxytryptophol in association with low-dose IL-2 and melatonin","volume":"11","author":"Lissoni","year":"1997","journal-title":"J.\u00a0Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.biochi.2024.11.013_bib116","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.lfs.2019.05.009","article-title":"Modulation of apoptosis by melatonin for improving cancer treatment efficiency: an updated review","volume":"228","author":"Mortezaee","year":"2019","journal-title":"Life Sci."},{"issue":"12","key":"10.1016\/j.biochi.2024.11.013_bib117","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123974","article-title":"Melatonin sensitizes human colorectal cancer cells to \u03b3-ray ionizing radiation in\u00a0vitro and in\u00a0vivo","volume":"19","author":"Wang","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2024.11.013_bib118","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.redox.2018.02.025","article-title":"Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS","volume":"16","author":"Zou","year":"2018","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib119","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12551-017-0256-8","article-title":"The melatonin immunomodulatory actions in radiotherapy","volume":"9","author":"Najafi","year":"2017","journal-title":"Biophys. Rev."},{"issue":"4","key":"10.1016\/j.biochi.2024.11.013_bib120","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/1534735411425484","article-title":"Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials","volume":"11","author":"Seely","year":"2012","journal-title":"Integr. Cancer Ther."},{"key":"10.1016\/j.biochi.2024.11.013_bib121","first-page":"43","article-title":"PO-090: oncostatic effect of melatonin in head and neck cancer: role of mitochondrial function","volume":"122","author":"Escames","year":"2017","journal-title":"Radiother. Oncol."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib122","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1600-079X.2009.00727.x","article-title":"Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway","volume":"48","author":"Casado-Zapico","year":"2010","journal-title":"J.\u00a0Pineal Res."},{"key":"10.1016\/j.biochi.2024.11.013_bib123","doi-asserted-by":"crossref","first-page":"7895","DOI":"10.2147\/OTT.S174100","article-title":"Therapeutic strategies of melatonin in cancer patients: a systematic review and meta-analysis","volume":"11","author":"Wang","year":"2018","journal-title":"OncoTargets Ther."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib124","first-page":"2","article-title":"Five year-survival with high-dose melatonin and other antitumor pineal hormones in advanced cancer patients eligible for the only palliative therapy","volume":"2","author":"Lissoni","year":"2018","journal-title":"Russ. J. Oncol."},{"issue":"1","key":"10.1016\/j.biochi.2024.11.013_bib125","article-title":"Melatonin as a repurposed drug for melanoma treatment","volume":"11","author":"Pathipaka","year":"2023","journal-title":"Med. Sci. (Basel, Switzerland)"},{"key":"10.1016\/j.biochi.2024.11.013_bib126","first-page":"899","article-title":"Cancer stem cell theory: therapeutic implications for nanomedicine","volume":"8","author":"Wang","year":"2013","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.biochi.2024.11.013_bib127","doi-asserted-by":"crossref","first-page":"Av3","DOI":"10.1667\/RRAV01.1","article-title":"A\u00a0direct measurement of the radiation sensitivity of normal mouse bone marrow cells. 1961","volume":"178","author":"Till","year":"2012","journal-title":"Radiat. Res."},{"issue":"10","key":"10.1016\/j.biochi.2024.11.013_bib128","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109921","article-title":"High expression of hTERT and stemness genes in BORIS\/CTCFL positive cells isolated from embryonic cancer cells","volume":"9","author":"Alberti","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.biochi.2024.11.013_bib129","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1158\/0008-5472.CAN-16-1887","article-title":"WNT\/\u03b2-Catenin directs self-renewal symmetric cell division of hTERT(high) prostate cancer stem cells","volume":"77","author":"Zhang","year":"2017","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.biochi.2024.11.013_bib130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099943","article-title":"Melatonin enhances the anti-tumor effect of fisetin by inhibiting COX-2\/iNOS and NF-\u03baB\/p300 signaling pathways","volume":"9","author":"Yi","year":"2014","journal-title":"PLoS One"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424002682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908424002682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T15:55:02Z","timestamp":1741622102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908424002682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":130,"alternative-id":["S0300908424002682"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2024.11.013","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Signaling pathways in skin cancers and the protective functions of melatonin","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2024.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}