{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:34:05Z","timestamp":1790508845329,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["RS-2023-00301914"],"award-info":[{"award-number":["RS-2023-00301914"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.biochi.2025.05.007","type":"journal-article","created":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T06:27:30Z","timestamp":1748068050000},"page":"29-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nitric oxide initiates oxidative independent apoptosis-like death in Candida albicans by lupeol"],"prefix":"10.1016","volume":"235","author":[{"given":"Ji Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-433X","authenticated-orcid":false,"given":"Dong Gun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6229","key":"10.1016\/j.biochi.2025.05.007_bib1","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1126\/science.aaa6097","article-title":"How to bolster the antifungal pipeline","volume":"347","author":"Denning","year":"2015","journal-title":"Science"},{"issue":"Suppl 1","key":"10.1016\/j.biochi.2025.05.007_bib2","first-page":"S81","article-title":"Oral candidiasis: an overview","volume":"18","author":"Singh","year":"2014","journal-title":"J. Oral Maxillofac. Pathol."},{"issue":"2","key":"10.1016\/j.biochi.2025.05.007_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4161\/viru.22913","article-title":"Candida albicans pathogenicity mechanisms","volume":"4","author":"Mayer","year":"2013","journal-title":"Virulence"},{"issue":"4","key":"10.1016\/j.biochi.2025.05.007_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftw018","article-title":"Pathogenesis of Candida albicans biofilm","volume":"74","author":"Tsui","year":"2016","journal-title":"Pathogens and Disease"},{"issue":"7586","key":"10.1016\/j.biochi.2025.05.007_bib5","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.biochi.2025.05.007_bib6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2217\/fmb-2017-0172","article-title":"Emerging mechanisms of antimicrobial resistance in bacteria and fungi: advances in the era of genomics","volume":"13","author":"Sekyere","year":"2018","journal-title":"Future Microbiol."},{"key":"10.1016\/j.biochi.2025.05.007_bib7","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.mimet.2016.02.005","article-title":"Searching new antifungals: the use of in vitro and in vivo methods for evaluation of natural compounds","volume":"123","author":"Scorzoni","year":"2016","journal-title":"Journal of microbiological methods"},{"issue":"2","key":"10.1016\/j.biochi.2025.05.007_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.job.2021.03.004","article-title":"The in vivo anti-Candida albicans activity of flavonoids","volume":"63","author":"Nguyen","year":"2021","journal-title":"J. Oral Biosci."},{"key":"10.1016\/j.biochi.2025.05.007_bib9","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.foodres.2015.06.021","article-title":"Therapeutic potential of flavonoids and their mechanism of action against microbial and viral infections\u2014a review","volume":"77","author":"Ahmad","year":"2015","journal-title":"Food Res. Int."},{"issue":"8","key":"10.1016\/j.biochi.2025.05.007_bib10","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/antibiotics9080480","article-title":"Plant-based phytochemicals as possible alternative to antibiotics in combating bacterial drug resistance","volume":"9","author":"AlSheikh","year":"2020","journal-title":"Antibiotics"},{"issue":"2","key":"10.1016\/j.biochi.2025.05.007_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2009.04.033","article-title":"Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene","volume":"285","author":"Saleem","year":"2009","journal-title":"Cancer letters"},{"key":"10.1016\/j.biochi.2025.05.007_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105373","article-title":"Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy","volume":"164","author":"Liu","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.biochi.2025.05.007_bib13","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.1038\/s41598-021-87725-7","article-title":"Lupeol acetate as a potent antifungal compound against opportunistic human and phytopathogenic mold Macrophomina phaseolina","volume":"11","author":"Javed","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2025.05.007_bib14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1134\/S0026261716040093","article-title":"Terpenoids with antifungal activity trigger mitochondrial dysfunction in Saccharomyces cerevisiae","volume":"85","author":"Haque","year":"2016","journal-title":"Microbiology"},{"issue":"2","key":"10.1016\/j.biochi.2025.05.007_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.bbrc.2011.01.026","article-title":"The antimicrobial peptide, psacotheasin induces reactive oxygen species and triggers apoptosis in Candida albicans","volume":"405","author":"Hwang","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"4","key":"10.1016\/j.biochi.2025.05.007_bib16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1042\/BCJ20200925","article-title":"Lupeol-induced nitric oxide elicits apoptosis-like death within Escherichia coli in a DNA fragmentation-independent manner","volume":"478","author":"Kim","year":"2021","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.biochi.2025.05.007_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.tim.2008.03.003","article-title":"Apoptosis pathways in fungal growth, development and ageing","volume":"16","author":"Hamann","year":"2008","journal-title":"Trends Microbiol."},{"issue":"5","key":"10.1016\/j.biochi.2025.05.007_bib18","first-page":"833","article-title":"Fungal apoptosis: function, genes and gene function","volume":"33","author":"Sharon","year":"2009","journal-title":"FEMS (Fed. Eur. Microbiol. Soc.) Microbiol. Rev."},{"issue":"7","key":"10.1016\/j.biochi.2025.05.007_bib19","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.bbamcr.2008.03.010","article-title":"Mitochondria-dependent apoptosis in yeast","volume":"1783","author":"Pereira","year":"2008","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"1","key":"10.1016\/j.biochi.2025.05.007_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1242\/jcs.00848","article-title":"The S. cerevisiae HtrA-like protein Nma111p is a nuclear serine protease that mediates yeast apoptosis","volume":"117","author":"Fahrenkrog","year":"2004","journal-title":"J. Cell Sci."},{"issue":"10","key":"10.1016\/j.biochi.2025.05.007_bib21","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/sj.cdd.4401288","article-title":"Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions","volume":"10","author":"Egger","year":"2003","journal-title":"Cell Death Differ."},{"issue":"18","key":"10.1016\/j.biochi.2025.05.007_bib22","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1046\/j.1432-1327.2000.01589.x","article-title":"Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response","volume":"267","author":"Gray","year":"2000","journal-title":"Eur. J. Biochem."},{"issue":"4","key":"10.1016\/j.biochi.2025.05.007_bib23","first-page":"1567","article-title":"Biological activities of flavonoids: an overview","volume":"10","author":"Karak","year":"2019","journal-title":"Int. J. Pharma Sci. Res."},{"issue":"8","key":"10.1016\/j.biochi.2025.05.007_bib24","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1002\/jsfa.9628","article-title":"Regulation of the levels of health promoting compounds: lupeol, mangiferin and phenolic acids in the pulp and peel of mango fruit: a review","volume":"99","author":"Vithana","year":"2019","journal-title":"J. Sci. Food Agric."},{"issue":"7\u20138","key":"10.1016\/j.biochi.2025.05.007_bib25","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.lfs.2010.11.020","article-title":"Beneficial health effects of lupeol triterpene: a review of preclinical studies","volume":"88","author":"Siddique","year":"2011","journal-title":"Life Sci."},{"issue":"3","key":"10.1016\/j.biochi.2025.05.007_bib26","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1111\/ijfs.13341","article-title":"Phytochemical composition, cellular antioxidant capacity and antiproliferative activity in mango (Mangifera indica L.) pulp and peel","volume":"52","author":"Abbasi","year":"2017","journal-title":"Int. J. Food Sci. Technol."},{"issue":"14","key":"10.1016\/j.biochi.2025.05.007_bib27","doi-asserted-by":"crossref","first-page":"4328","DOI":"10.3390\/molecules26144328","article-title":"Redox imbalance and mitochondrial release of apoptogenic factors at the forefront of the antitumor action of mango peel extract","volume":"26","author":"Lo Galbo","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.biochi.2025.05.007_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154012","article-title":"Molecular pharmacology and therapeutic advances of the pentacyclic triterpene lupeol","volume":"99","author":"Sohag","year":"2022","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.biochi.2025.05.007_bib29","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1111\/j.1742-4658.2006.05250.x","article-title":"Nitric oxide and cell proliferation","volume":"273","author":"Villalobo","year":"2006","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.biochi.2025.05.007_bib30","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1083\/jcb.200104078","article-title":"Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p","volume":"154","author":"Polizotto","year":"2001","journal-title":"J. Cell Biol."},{"issue":"1\u20132","key":"10.1016\/j.biochi.2025.05.007_bib31","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.mrfmmm.2003.08.019","article-title":"Apoptosis-like yeast cell death in response to DNA damage and replication defects","volume":"532","author":"Burhans","year":"2003","journal-title":"Mutat. Res. Fund Mol. Mech. Mutagen"},{"issue":"1","key":"10.1016\/j.biochi.2025.05.007_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/emi.2016.87","article-title":"Endogenous nitric oxide accumulation is involved in the antifungal activity of Shikonin against Candida albicans","volume":"5","author":"Liao","year":"2016","journal-title":"Emerg. Microb. Infect."},{"issue":"8","key":"10.1016\/j.biochi.2025.05.007_bib33","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrd2222","article-title":"Peroxynitrite: biochemistry, pathophysiology and development of therapeutics","volume":"6","author":"Szab\u00f3","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"10","key":"10.1016\/j.biochi.2025.05.007_bib34","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.1007\/s00284-020-02132-x","article-title":"An insight on the role of nitric oxide in yeast apoptosis of curcumin-treated Candida albicans","volume":"77","author":"Kwun","year":"2020","journal-title":"Curr. Microbiol."},{"issue":"2\u20133","key":"10.1016\/j.biochi.2025.05.007_bib35","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0005-2728(99)00029-8","article-title":"Nitric oxide and cell death","volume":"1411","author":"Murphy","year":"1999","journal-title":"Biochim. Biophys. Acta Bioenerg."},{"issue":"17","key":"10.1016\/j.biochi.2025.05.007_bib36","first-page":"6388","article-title":"Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide","volume":"61","author":"Jaiswal","year":"2001","journal-title":"Cancer Res."},{"issue":"14","key":"10.1016\/j.biochi.2025.05.007_bib37","doi-asserted-by":"crossref","first-page":"6097","DOI":"10.1158\/0008-5472.CAN-04-4254","article-title":"Nitric oxide\u2013induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53","volume":"65","author":"McLaughlin","year":"2005","journal-title":"Cancer Res."},{"issue":"5247","key":"10.1016\/j.biochi.2025.05.007_bib38","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1126\/science.271.5247.357","article-title":"Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways","volume":"271","author":"Sanchez","year":"1996","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.biochi.2025.05.007_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/sj.neo.7900101","article-title":"Cell cycle and apoptosis","volume":"2","author":"Pucci","year":"2000","journal-title":"Neoplasia"},{"issue":"1","key":"10.1016\/j.biochi.2025.05.007_bib40","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbrc.2007.03.091","article-title":"Cell cycle-dependent mitochondrial biogenesis and dynamics in mammalian cells","volume":"357","author":"Lee","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"22","key":"10.1016\/j.biochi.2025.05.007_bib41","first-page":"4171","article-title":"A new mitochondrial pool of cyclin E, regulated by Drp1, is linked to cell-density-dependent cell proliferation","volume":"128","author":"Parker","year":"2015","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.biochi.2025.05.007_bib42","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1038\/s41418-020-0527-y","article-title":"Drp1 modulates mitochondrial stress responses to mitotic arrest","volume":"27","author":"Pe\u00f1a-Blanco","year":"2020","journal-title":"Cell Death Differ."},{"issue":"9","key":"10.1016\/j.biochi.2025.05.007_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.90","article-title":"Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models","volume":"2","author":"Seervi","year":"2011","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.biochi.2025.05.007_bib44","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-065X.2003.00048.x","article-title":"Caspase-activation pathways in apoptosis and immunity","volume":"193","author":"Creagh","year":"2003","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.biochi.2025.05.007_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.622534","article-title":"Reactive oxygen species in pathogen clearance: the killing mechanisms, the adaption response, and the side effects","volume":"11","author":"Li","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.biochi.2025.05.007_bib46","first-page":"666","article-title":"Synthesis, antibacterial, and antifungal evaluation of norfloxacin derivatives","volume":"5","author":"Khan","year":"2012","journal-title":"J. Pharm. Res."},{"issue":"11","key":"10.1016\/j.biochi.2025.05.007_bib47","doi-asserted-by":"crossref","first-page":"5173","DOI":"10.1128\/iai.62.11.5173-5176.1994","article-title":"Arginine-derived nitric oxide reduces fecal oocyst shedding in nude mice infected with Cryptosporidium parvum","volume":"62","author":"Leitch","year":"1994","journal-title":"Infect. Immun."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908425000975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908425000975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T14:20:15Z","timestamp":1751984415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908425000975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":47,"alternative-id":["S0300908425000975"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2025.05.007","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric oxide initiates oxidative independent apoptosis-like death in Candida albicans by lupeol","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2025.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}