{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:52:57Z","timestamp":1790189577081,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013305","name":"Musculoskeletal Transplant Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM12550 3"],"award-info":[{"award-number":["P20GM12550 3"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007756","name":"University of Arkansas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008231","name":"Arkansas Biosciences Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008231","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018636","name":"College of Engineering, University of Arkansas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.biochi.2026.05.008","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:37:09Z","timestamp":1780443429000},"page":"167-180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations"],"prefix":"10.1016","volume":"247","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6653-4779","authenticated-orcid":false,"given":"David P.","family":"Heinrichs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7007-7155","authenticated-orcid":false,"given":"Thomas","family":"Needy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9090-4267","authenticated-orcid":false,"given":"Vitali","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine D.","family":"Comer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Zotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Berryhill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-3585","authenticated-orcid":false,"given":"Ana Regina","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-7982","authenticated-orcid":false,"given":"Hanna","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2783-7137","authenticated-orcid":false,"given":"Kevin A.","family":"Murach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Lowry","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8804-8284","authenticated-orcid":false,"given":"Rebekah M.","family":"Samsonraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.biochi.2026.05.008_bib1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"12","key":"10.1016\/j.biochi.2026.05.008_bib2","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/sctm.17-0129","article-title":"Concise review: multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine","volume":"6","author":"Samsonraj","year":"2017","journal-title":"Stem Cells Transl. Med."},{"issue":"5","key":"10.1016\/j.biochi.2026.05.008_bib3","doi-asserted-by":"crossref","first-page":"552","DOI":"10.4252\/wjsc.v6.i5.552","article-title":"Secretion of immunoregulatory cytokines by mesenchymal stem cells","volume":"6","author":"Kyurkchiev","year":"2014","journal-title":"WJSC"},{"issue":"6","key":"10.1016\/j.biochi.2026.05.008_bib4","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1002\/stem.1982","article-title":"Establishing criteria for human mesenchymal stem cell potency","volume":"33","author":"Samsonraj","year":"2015","journal-title":"Stem Cell."},{"issue":"3","key":"10.1016\/j.biochi.2026.05.008_bib5","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.biochi.2026.05.008_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2007.07.003","article-title":"Cellular senescence in cancer and aging","volume":"130","author":"Collado","year":"2007","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.biochi.2026.05.008_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11914-019-00504-2","article-title":"Targeting cell senescence for the treatment of age-related bone loss","volume":"17","author":"Pignolo","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"issue":"7","key":"10.1016\/j.biochi.2026.05.008_bib8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2026.05.008_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bonr.2023.101674","article-title":"An unbiased proteomics approach to identify the senescence-associated secretory phenotype of human bone marrow-derived mesenchymal stem cells","volume":"18","author":"Samsonraj","year":"2023","journal-title":"Bone Reports"},{"issue":"2","key":"10.1016\/j.biochi.2026.05.008_bib10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.biochi.2026.05.008_bib11","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"issue":"5","key":"10.1016\/j.biochi.2026.05.008_bib12","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland","year":"2020","journal-title":"J. Intern. Med."},{"issue":"4","key":"10.1016\/j.biochi.2026.05.008_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s40610-020-00140-1","article-title":"Senolytics: targeting senescent cells for age-associated diseases","volume":"6","author":"Al-Naggar","year":"2020","journal-title":"Curr Mol Bio Rep"},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib14","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/s41467-021-25453-2","article-title":"Long-term treatment with senolytic drugs dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice","volume":"12","author":"Novais","year":"2021","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.biochi.2026.05.008_bib15","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1002\/cncr.31232","article-title":"Dasatinib dose management for the treatment of chronic myeloid leukemia","volume":"124","author":"Talpaz","year":"2018","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.biochi.2026.05.008_bib16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.18632\/oncotarget.27462","article-title":"Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib","volume":"11","author":"Montenegro","year":"2020","journal-title":"Oncotarget"},{"key":"10.1016\/j.biochi.2026.05.008_bib17","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.biochi.2026.05.008_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2019.09.053","article-title":"First evidence that senolytics are effective at decreasing senescent cells in humans","volume":"56","author":"Ellison-Hughes","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.biochi.2026.05.008_bib19","article-title":"Assessing the effects of dasatinib on mesenchymal stem\/stromal cells","author":"Heinrichs","year":"2024","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.biochi.2026.05.008_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2006.02.009","article-title":"Molecular targets of dietary agents for prevention and therapy of cancer","author":"Aggarwal","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.biochi.2026.05.008_bib21","doi-asserted-by":"crossref","DOI":"10.1007\/s12195-025-00849-y","article-title":"Examining the effects of Quercetin on phenotypic characteristics of human mesenchymal stem cells","author":"Needy","year":"2025","journal-title":"Cell. Mol. Bioeng."},{"issue":"4","key":"10.1016\/j.biochi.2026.05.008_bib22","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The Achilles' heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.biochi.2026.05.008_bib23","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.biochi.2026.05.008_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13767","article-title":"Senolytic drugs, dasatinib and quercetin, attenuate adipose tissue inflammation, and ameliorate metabolic function in old age","volume":"22","author":"Islam","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib25","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13036-023-00361-9","article-title":"Clinical utility of mesenchymal stem\/stromal cells in regenerative medicine and cellular therapy","volume":"17","author":"Maldonado","year":"2023","journal-title":"J. Biol. Eng."},{"issue":"6","key":"10.1016\/j.biochi.2026.05.008_bib26","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1634\/stemcells.2007-0480","article-title":"Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells","volume":"26","author":"Rider","year":"2008","journal-title":"Stem Cell."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-62544-8","article-title":"Advantages of pooling of human bone marrow-derived mesenchymal stromal cells from different donors versus single-donor MSCs","volume":"14","author":"Kannan","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.biochi.2026.05.008_bib28","first-page":"215","article-title":"\u201cFlow Cytometric Analysis of Extracellular Vesicles,\u201d in exosomes and microvesicles","volume":"vol. 1545","author":"Morales-Kastresana","year":"2017"},{"issue":"11","key":"10.1016\/j.biochi.2026.05.008_bib29","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1089\/ten.tec.2017.0205","article-title":"A Versatile protocol for studying calvarial bone defect healing in a mouse model","volume":"23","author":"Samsonraj","year":"2017","journal-title":"Tissue Eng. C Methods"},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41392-024-01735-1","article-title":"Extracellular vesicles as tools and targets in therapy for diseases","volume":"9","author":"Kumar","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"12","key":"10.1016\/j.biochi.2026.05.008_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028555","article-title":"The tyrosine kinase inhibitor Dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cells","volume":"6","author":"Borriello","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.biochi.2026.05.008_bib32","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/leu.2010.84","article-title":"Second-generation TKI dasatinib inhibits proliferation of mesenchymal stem cells and osteoblast differentiation in vitro","volume":"24","author":"J\u00f6nsson","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.biochi.2026.05.008_bib33","doi-asserted-by":"crossref","DOI":"10.1051\/e3sconf\/202127103015","article-title":"Improvement of the ability of bone repair by reducing the aging degree of mesenchymal stem cell population by senolytic drugs","volume":"271","author":"Liu","year":"2021","journal-title":"E3S Web Conf."},{"issue":"4","key":"10.1016\/j.biochi.2026.05.008_bib34","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbrc.2008.06.077","article-title":"The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways","volume":"373","author":"Ahn","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.biochi.2026.05.008_bib35","first-page":"2062","article-title":"Quercetin stimulates osteogenic differentiation of bone marrow stromal cells through miRNA-206\/connexin 43 pathway","volume":"12","author":"Zhang","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-02544-0","article-title":"Senolytic effects of quercetin in an in vitro model of pre-adipocytes and adipocytes induced senescence","volume":"11","author":"Zoico","year":"2021","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.biochi.2026.05.008_bib37","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20240623","article-title":"Effect of the polyphenol flavonoids fisetin and quercetin on the adipogenic differentiation of human mesenchymal stromal cells","volume":"44","author":"Lorthongpanich","year":"2024","journal-title":"Biosci. Rep."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib38","doi-asserted-by":"crossref","first-page":"4827","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2026.05.008_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144855","article-title":"Alkaline phosphatase: structure, expression and its function in bone mineralization","volume":"754","author":"Vimalraj","year":"2020","journal-title":"Gene"},{"issue":"10","key":"10.1016\/j.biochi.2026.05.008_bib40","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1177\/00220345221100794","article-title":"The bone sialoprotein RGD domain modulates and maintains periodontal development","volume":"101","author":"Nagasaki","year":"2022","journal-title":"J. Dent. Res."},{"issue":"46","key":"10.1016\/j.biochi.2026.05.008_bib41","doi-asserted-by":"crossref","first-page":"30057","DOI":"10.1074\/jbc.273.46.30057","article-title":"The role of C\/EBP genes in adipocyte differentiation","volume":"273","author":"Darlington","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.biochi.2026.05.008_bib42","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.7150\/ijms.87089","article-title":"Dasatinib regulates the proliferation and osteogenic differentiation of PDLSCs through Erk and EID3 signals","volume":"20","author":"Jia","year":"2023","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.biochi.2026.05.008_bib43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jnutbio.2016.03.005","article-title":"Effects of quercetin, a natural phenolic compound, in the differentiation of human mesenchymal stem cells (MSC) into adipocytes and osteoblasts","volume":"32","author":"Casado-D\u00edaz","year":"2016","journal-title":"J. Nutr. Biochem."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/19768354.2025.2477050","article-title":"Combination of dasatinib and quercetin promotes osteogenic differentiation and stemness maintenance of hPDLSCs via YAP\/TAZ","volume":"29","author":"Qiu","year":"2025","journal-title":"Anim. Cell Syst."},{"key":"10.1016\/j.biochi.2026.05.008_bib45","first-page":"13","article-title":"Repurpose dasatinib and quercetin: targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration","volume":"25","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib46","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41536-021-00145-z","article-title":"Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice","volume":"6","author":"Zhou","year":"2021","journal-title":"npj Regen. Med."},{"key":"10.1016\/j.biochi.2026.05.008_bib47","article-title":"Mesenchymal stem cell secretome for regenerative medicine: where do we stand?","author":"Trigo","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.biochi.2026.05.008_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.04.013","article-title":"Extracellular vesicles for tissue repair and regeneration: evidence, challenges and opportunities","volume":"175","author":"Nagelkerke","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib49","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1038\/s41467-021-24384-2","article-title":"Specificities of exosome versus small ectosome secretion revealed by live intracellular tracking of CD63 and CD9","volume":"12","author":"Mathieu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2026.05.008_bib50","unstructured":"D. Ivanusic and J. Denner, \u201cThe large extracellular loop is important for recruiting CD63 to exosomes,\u201d Open Access."},{"issue":"12","key":"10.1016\/j.biochi.2026.05.008_bib51","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3390\/brainsci13121647","article-title":"Exosomal miRNAs as biomarkers of ischemic stroke","volume":"13","author":"Ciaccio","year":"2023","journal-title":"Brain Sci."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.14283\/jpad.2021.62","article-title":"Senolytic therapy to modulate the progression of alzheimer's disease (SToMP-AD): a pilot clinical trial","volume":"9","author":"Gonzales","year":"2022","journal-title":"The Journal of Prevention of Alzheimer\u2019s Disease"},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib53","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1038\/ncomms4446","article-title":"Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance","volume":"5","author":"Tsang","year":"2014","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.biochi.2026.05.008_bib54","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.4014\/jmb.1707.07040","article-title":"Lactoferrin protects human mesenchymal stem cells from oxidative stress-induced senescence and apoptosis","volume":"27","author":"Park","year":"2017","journal-title":"J. Microbiol. Biotechnol."},{"issue":"8","key":"10.1016\/j.biochi.2026.05.008_bib55","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1161\/ATVBAHA.117.309451","article-title":"Plasminogen activator Inhibitor-1 is a marker and a mediator of senescence","volume":"37","author":"Vaughan","year":"2017","journal-title":"ATVB"},{"issue":"10","key":"10.1016\/j.biochi.2026.05.008_bib56","doi-asserted-by":"crossref","first-page":"a016295","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harbor Perspect. Biol."},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib57","doi-asserted-by":"crossref","first-page":"7199","DOI":"10.1038\/s41467-021-27563-3","article-title":"Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta","volume":"12","author":"Chen","year":"2021","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.biochi.2026.05.008_bib58","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1210\/jc.2007-2836","article-title":"Identification of LTBP2 on chromosome 14q as a novel candidate gene for bone mineral density variation and fracture risk Association","volume":"93","author":"Cheung","year":"2008","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"12","key":"10.1016\/j.biochi.2026.05.008_bib59","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.3390\/cells11121966","article-title":"The senescence markers p16INK4A, p14ARF\/p19ARF, and p21 in organ development and homeostasis","volume":"11","author":"Wagner","year":"2022","journal-title":"Cells"},{"issue":"7372","key":"10.1016\/j.biochi.2026.05.008_bib60","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib61","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.cmet.2021.11.002","article-title":"Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity","volume":"34","author":"Wang","year":"2022","journal-title":"Cell Metab."},{"key":"10.1016\/j.biochi.2026.05.008_bib62","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.biochi.2025.04.002","article-title":"Phenotypic changes associated with continuous long term in vitro expansion of bone marrow-derived mesenchymal stem cells","volume":"234","author":"Maldonado","year":"2025","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/j.biochi.2026.05.008_bib63","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13045-021-01037-x","article-title":"Challenges and advances in clinical applications of mesenchymal stromal cells","volume":"14","author":"Zhou","year":"2021","journal-title":"J. Hematol. Oncol."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426001173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426001173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T03:43:47Z","timestamp":1785901427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908426001173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":63,"alternative-id":["S0300908426001173"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2026.05.008","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2026.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}