{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T12:02:57Z","timestamp":1785153777119,"version":"3.55.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence nationale de la recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.biochi.2026.07.007","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:21:29Z","timestamp":1784301689000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["ER quality control: how cells detoxify their own membrane from lipid stress"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8820-597X","authenticated-orcid":false,"given":"Helin","family":"Elhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdou Rachid","family":"Thiam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2026.07.007_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrm3699","article-title":"The biophysics and cell biology of lipid droplets","volume":"14","author":"Thiam","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a041246","article-title":"Glycerolipid synthesis and lipid droplet formation in the endoplasmic reticulum","volume":"15","author":"Farese","year":"2023","journal-title":"Cold Spring Harbor Perspect. Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.tcb.2020.11.006","article-title":"Lipid droplet nucleation","volume":"31","author":"Thiam","year":"2021","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib4","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.0630588100","article-title":"Triglyceride accumulation protects against fatty acid-induced lipotoxicity","volume":"100","author":"Listenberger","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2026.07.007_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s40842-024-00187-4","article-title":"From adiposity to steatosis: Metabolic dysfunction-associated steatotic liver disease, a hepatic expression of metabolic syndrome \u2013 current insights and future directions","volume":"10","author":"Basil","year":"2024","journal-title":"Clin Diabetes Endocrinol"},{"key":"10.1016\/j.biochi.2026.07.007_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1534\/genetics.111.130286","article-title":"Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae","volume":"190","author":"Henry","year":"2012","journal-title":"Genetics"},{"key":"10.1016\/j.biochi.2026.07.007_bib7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1172\/JCI30400","article-title":"Inhibition of protein kinase C\u03b5 prevents hepatic insulin resistance in nonalcoholic fatty liver disease","volume":"117","author":"Samuel","year":"2007","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biochi.2026.07.007_bib8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62886","article-title":"Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets","volume":"10","author":"Zoni","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.biochi.2026.07.007_bib9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s42004-019-0175-7","article-title":"Local accumulation of diacylglycerol alters membrane properties nonlinearly due to its transbilayer activity","volume":"2","author":"Campomanes","year":"2019","journal-title":"Commun. Chem."},{"key":"10.1016\/j.biochi.2026.07.007_bib10","first-page":"4628","volume":"110","author":"Volmer","year":"2013"},{"key":"10.1016\/j.biochi.2026.07.007_bib11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.molcel.2017.06.012","article-title":"Activation of the unfolded protein response by lipid bilayer stress","volume":"67","author":"Halbleib","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib12","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0968-0004(00)01625-X","article-title":"Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization","volume":"25","author":"Cornell","year":"2000","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.biochi.2026.07.007_bib13","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.cub.2020.04.066","article-title":"Membrane curvature catalyzes lipid droplet assembly","volume":"30","author":"Santinho","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib14","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41594-021-00718-y","article-title":"Seipin forms a flexible cage at lipid droplet formation sites","volume":"29","author":"Arlt","year":"2022","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-26162-6","article-title":"Mechanism of lipid droplet formation by the yeast Sei1\/Ldb16 Seipin complex","volume":"12","author":"Klug","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2026.07.007_bib16","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2017205118","article-title":"Seipin accumulates and traps diacylglycerols and triglycerides in its ring-like structure","volume":"118","author":"Zoni","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2026.07.007_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2019.10.006","article-title":"LDAF1 and seipin form a lipid droplet assembly complex","author":"Chung","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib18","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202006111","article-title":"FIT2 is an acyl-coenzyme A diphosphatase crucial for endoplasmic reticulum homeostasis","volume":"219","author":"Becuwe","year":"2020","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41580-018-0085-z","article-title":"Dynamics and functions of lipid droplets","volume":"20","author":"Olzmann","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib20","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.devcel.2019.05.003","article-title":"Membrane asymmetry imposes directionality on lipid droplet emergence from the ER","volume":"50","author":"Chorlay","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.devcel.2019.05.016","article-title":"Seipin facilitates triglyceride flow to lipid droplet and counteracts droplet ripening via endoplasmic reticulum contact","volume":"50","author":"Salo","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib22","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1126\/science.1100747","article-title":"Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase","volume":"306","author":"Zimmermann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.biochi.2026.07.007_bib23","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2006.03.005","article-title":"Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome","volume":"3","author":"Lass","year":"2006","journal-title":"Cell Metab."},{"key":"10.1016\/j.biochi.2026.07.007_bib24","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.biochi.2026.07.007_bib25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cmet.2017.07.012","article-title":"Triglyceride synthesis by DGAT1 protects adipocytes from lipid-induced ER stress during lipolysis","volume":"26","author":"Chitraju","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.biochi.2026.07.007_bib26","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.devcel.2013.01.013","article-title":"Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets","volume":"24","author":"Wilfling","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41594-025-01689-0","article-title":"ATG2A-mediated DAG transfer recruits DGAT2 for lipid droplet growth","author":"Elhan","year":"2025","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib28","article-title":"ORP5 localizes to ER\u2013lipid droplet contacts and regulates the level of PI(4)P on lipid droplets","volume":"219","author":"Du","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib29","article-title":"ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER\u2013mitochondria contact sites","volume":"221","author":"Guyard","year":"2022","journal-title":"JCB (J. Cell Biol.)"},{"key":"10.1016\/j.biochi.2026.07.007_bib30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-biochem-083024-122821","article-title":"Lipid dynamics at membrane contact sites","volume":"94","author":"Reinisch","year":"2025","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.biochi.2026.07.007_bib31","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1091\/mbc.e11-09-0785","article-title":"Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets","volume":"23","author":"Velikkakath","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib32","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1083\/jcb.201811139","article-title":"ATG2 transports lipids to promote autophagosome biogenesis","volume":"218","author":"Valverde","year":"2019","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib33","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41594-019-0203-4","article-title":"Atg2 mediates direct lipid transfer between membranes for autophagosome formation","volume":"26","author":"Osawa","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib34","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2517469122","article-title":"ATG2 is a triglyceride transfer protein","volume":"122","author":"Korfhage","year":"2025","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.biochi.2026.07.007_bib35","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1083\/jcb.201807019","article-title":"VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites","volume":"217","author":"Kumar","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib36","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201845889","article-title":"TMEM41B is a novel regulator of autophagy and lipid mobilization","volume":"19","author":"Moretti","year":"2018","journal-title":"EMBO Rep."},{"key":"10.1016\/j.biochi.2026.07.007_bib37","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.cmet.2021.05.006","article-title":"TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis","volume":"33","author":"Huang","year":"2021","journal-title":"Cell Metab."},{"key":"10.1016\/j.biochi.2026.07.007_bib38","doi-asserted-by":"crossref","first-page":"6750","DOI":"10.1038\/s41467-021-26999-x","article-title":"The autophagy protein ATG9A enables lipid mobilization from lipid droplets","volume":"12","author":"Mailler","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.biochi.2026.07.007_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.molcel.2019.01.036","article-title":"Probing the global cellular responses to lipotoxicity caused by saturated fatty acids","volume":"74","author":"Piccolis","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib40","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"Magr\u00e9","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.biochi.2026.07.007_bib41","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.ajhg.2008.09.002","article-title":"Mutations in LPIN1 cause recurrent acute myoglobinuria in childhood","volume":"83","author":"Zeharia","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.biochi.2026.07.007_bib42","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.nutr.012809.104729","article-title":"Lipins: multifunctional lipid metabolism proteins","volume":"30","author":"Csaki","year":"2010","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.biochi.2026.07.007_bib43","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s42255-019-0066-3","article-title":"Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes","volume":"1","author":"Yang","year":"2019","journal-title":"Nat. Metab."},{"key":"10.1016\/j.biochi.2026.07.007_bib44","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.1073\/pnas.1113359108","article-title":"Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease","volume":"108","author":"Kumashiro","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.biochi.2026.07.007_bib45","doi-asserted-by":"crossref","DOI":"10.1111\/liv.16186","article-title":"Targeting PNPLA3 to treat MASH and MASH related fibrosis and cirrhosis","volume":"45","author":"Lind\u00e9n","year":"2025","journal-title":"Liver Int."},{"key":"10.1016\/j.biochi.2026.07.007_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib47","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.biochi.2026.07.007_bib48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"Acsl4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2017","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.biochi.2026.07.007_bib49","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cell.2019.04.001","article-title":"Neuron-astrocyte metabolic coupling protects against activity-induced fatty acid toxicity","volume":"177","author":"Ioannou","year":"2019","journal-title":"Cell"}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426001677?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426001677?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:24:44Z","timestamp":1785151484000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908426001677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":49,"alternative-id":["S0300908426001677"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2026.07.007","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ER quality control: how cells detoxify their own membrane from lipid stress","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2026.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}