{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T20:23:14Z","timestamp":1787430194947,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,8,18]],"date-time":"2027-08-18T00:00:00Z","timestamp":1818547200000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000090","name":"US Office of Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["WX81XWH-18-1-0565"],"award-info":[{"award-number":["WX81XWH-18-1-0565"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.biochi.2026.07.013","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:39:24Z","timestamp":1785253164000},"page":"121-130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Acute local and systemic effects of intra-articular administration of liposomal Ido-1 following anterior cruciate ligament rupture"],"prefix":"10.1016","volume":"248","author":[{"given":"Mackenzie","family":"Fleischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Hartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Bush","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Arveschoug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Vasileff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2415-6053","authenticated-orcid":false,"given":"Erin A.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Hankenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8257-5673","authenticated-orcid":false,"given":"Kevin C.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.biochi.2026.07.013_bib1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11926-014-0448-1","article-title":"Mechanisms of post-traumatic osteoarthritis after ACL injury","volume":"16","author":"Dare","year":"2014","journal-title":"Curr. Rheumatol. Rep."},{"issue":"1","key":"10.1016\/j.biochi.2026.07.013_bib2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13075-020-02156-5","article-title":"Post-traumatic osteoarthritis following ACL injury","volume":"22","author":"Wang","year":"2020","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.biochi.2026.07.013_bib3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jor.23341","article-title":"Review of current understanding of post-traumatic osteoarthritis resulting from sports injuries","volume":"35","author":"Carbone","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"10","key":"10.1016\/j.biochi.2026.07.013_bib4","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.arth.2016.03.026","article-title":"The rising incidence of degenerative and posttraumatic osteoarthritis of the knee in the United States military","volume":"31","author":"Showery","year":"2016","journal-title":"J. Arthroplast."},{"issue":"10","key":"10.1016\/j.biochi.2026.07.013_bib5","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1002\/art.20589","article-title":"High prevalence of knee osteoarthritis, pain and functional limitations in female soccer players twelve years after anterior cruciate ligament injury","volume":"50","author":"Lohmander","year":"2004","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.biochi.2026.07.013_bib6","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jor.23290","article-title":"Total knee arthroplasty for posttraumatic osteoarthritis in military personnel under age 50","volume":"35","author":"Murtha","year":"2017","journal-title":"J. Orthop. Res."},{"issue":"6","key":"10.1016\/j.biochi.2026.07.013_bib7","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J. Orthop. Res."},{"issue":"8","key":"10.1016\/j.biochi.2026.07.013_bib8","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrrheum.2013.72","article-title":"Post-traumatic osteoarthritis: from mouse models to clinical trials","volume":"9","author":"Little","year":"2013","journal-title":"Nat. Rev. Rheumatol."},{"issue":"8","key":"10.1016\/j.biochi.2026.07.013_bib9","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00011-015-0840-y","article-title":"Alterations in Hoffa's fat pad induced by an inflammatory response following idealized anterior cruciate ligament surgery","volume":"64","author":"Solbak","year":"2015","journal-title":"Inflamm. Res."},{"issue":"12","key":"10.1016\/j.biochi.2026.07.013_bib10","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.joca.2013.08.019","article-title":"Changes of early post-traumatic osteoarthritis in an ovine model of simulated ACL reconstruction are associated with transient acute post-injury synovial inflammation and tissue catabolism","volume":"21","author":"Heard","year":"2013","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.biochi.2026.07.013_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jor.22743","article-title":"Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis","volume":"33","author":"Mickiewicz","year":"2015","journal-title":"J. Orthop. Res."},{"issue":"1","key":"10.1016\/j.biochi.2026.07.013_bib12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12891-017-1576-3","article-title":"Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed","volume":"18","author":"Heard","year":"2017","journal-title":"BMC Muscoskelet. Disord."},{"issue":"2","key":"10.1016\/j.biochi.2026.07.013_bib13","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1177\/19476035221141417","article-title":"Improved understanding of the inflammatory response response in synovial fluid and serum after traumatic knee injury, excluding fractures of the knee: a systematic review","volume":"14","author":"Nieboer","year":"2023","journal-title":"Cartilage"},{"issue":"5","key":"10.1016\/j.biochi.2026.07.013_bib14","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00167-022-07045-9","article-title":"Concentration of synovial fluid biomarkers on the day of anterior cruciate ligament (ACL)-Reconstruction predict size and depth of cartilage lesions on 5-year follow-up","volume":"31","author":"Markus","year":"2023","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"issue":"22","key":"10.1016\/j.biochi.2026.07.013_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.193054","article-title":"Rheumatoid arthritis synovial fibroblasts modulate T cell activation","volume":"10","author":"Romoff","year":"2025","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.biochi.2026.07.013_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s13075-025-03596-7","article-title":"Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance","volume":"27","author":"Wu","year":"2025","journal-title":"Arthritis Res. Ther."},{"issue":"12","key":"10.1016\/j.biochi.2026.07.013_bib17","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1007\/s00726-023-03353-7","article-title":"Altered kynurenine pathway metabolism and association with disease activity in patients with systemic lupus","volume":"55","author":"Onmaz","year":"2023","journal-title":"Amino Acids"},{"key":"10.1016\/j.biochi.2026.07.013_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152497","article-title":"Tryptophan metabolic dysregulation drives immune activation and cartilage degradation in osteoarthritis: functional validation integrated with transcriptomic and single-cell RNA sequencing","volume":"782","author":"Hou","year":"2025","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"10.1016\/j.biochi.2026.07.013_bib19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/evj.13440","article-title":"Metabolism and global protein glycosylation are differentially expressed in healthy and osteoarthritic equine carpal synovial fluid","volume":"54","author":"Noordwijk","year":"2022","journal-title":"Equine Vet. J."},{"issue":"7","key":"10.1016\/j.biochi.2026.07.013_bib20","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/jor.23854","article-title":"Metabolomic serum profiling after ACL injury in rats: a pilot study implicating inflammation and immune dysregulation in post-traumatic osteoarthritis","volume":"36","author":"Maerz","year":"2018","journal-title":"J. Orthop. Res."},{"issue":"6349","key":"10.1016\/j.biochi.2026.07.013_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf9794","article-title":"Kynurenines: tryptophan's metabolites in exercise, inflammation, and mental health","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.biochi.2026.07.013_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/03000605221080877","article-title":"Th17\/Treg balance and indoleamine 2,3 dioxygenase activity in periodontitis-associated atherosclerotic patients","volume":"50","author":"Yang","year":"2022","journal-title":"J. Int. Med. Res."},{"issue":"4","key":"10.1016\/j.biochi.2026.07.013_bib23","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.4110\/in.2021.21.e26","article-title":"Indoleamine 2,3-dioxygenase in hematopoietic stem cell-derived cells suppresses rhinovirus-induced neutrophilic airway inflammation by regulating Th1- and Th17-type responses","volume":"21","author":"Hossain","year":"2021","journal-title":"Immune Netw."},{"key":"10.1016\/j.biochi.2026.07.013_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109758","article-title":"Dendritic cell-expressed IDO alleviates atherosclerosis by expanding CD4+ CD25+ Foxp3+ tregs through IDO-Kyn-AHR axis","volume":"116","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.biochi.2026.07.013_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.600428","article-title":"Immunosuppressive amino-acid catabolizing enzymes in multiple sclerosis","volume":"11","author":"Correale","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biochi.2026.07.013_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13223-020-00457-7","article-title":"Th17\/Treg imbalance is associated with reduced indoleamine 2,3 dioxygenase activity in childhood allergic asthma","volume":"16","author":"Hu","year":"2020","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.biochi.2026.07.013_bib27","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3389\/fimmu.2017.00880","article-title":"The IDO-AhR axis controls Th17\/Treg immunity in a pulmonary model of fungal infection","volume":"8","author":"de Araujo","year":"2017","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.biochi.2026.07.013_bib28","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1007\/s10439-015-1292-9","article-title":"Biomechanical characterization of a model of noninvasive traumatic anterior cruciate ligament injury in the rat","volume":"43","author":"Maerz","year":"2015","journal-title":"Ann. Biomed. Eng."},{"issue":"11","key":"10.1016\/j.biochi.2026.07.013_bib29","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1016\/j.joca.2016.06.013","article-title":"Articular cartilage degeneration following anterior cruciate ligament injury: a comparison of surgical transection and noninvasive rupture as preclinical models of post-traumatic osteoarthritis","volume":"24","author":"Maerz","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.biochi.2026.07.013_bib30","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/jor.24903","article-title":"Traumatic joint injury induces acute catabolic bone turnover concurrent with articular cartilage damage in a rat model of post-traumatic osteoarthritis","volume":"39","author":"Maerz","year":"2021","journal-title":"J. Orthop. Res."},{"issue":"2","key":"10.1016\/j.biochi.2026.07.013_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/03008207.2022.2136571","article-title":"Early patellofemoral cartilage and bone pathology in a rat model of noninvasive anterior cruciate ligament rupture","volume":"64","author":"Fleischer","year":"2023","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.biochi.2026.07.013_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2020.115417","article-title":"Automated microCT-based bone and articular cartilage analysis using iterative shape averaging and atlas-based registration","volume":"137","author":"Newton","year":"2020","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.biochi.2026.07.013_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.joca.2015.09.006","article-title":"Surface roughness and thickness analysis of contrast-enhanced articular cartilage using mesh parameterization","volume":"24","author":"Maerz","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.biochi.2026.07.013_bib34","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/art.43186","article-title":"Multiparametric profiling of circulating immune cells identifies an expansion of CD25(high) switched memory B cells in osteoarthritis","volume":"77","author":"Sahu","year":"2025","journal-title":"Arthritis Rehamatol"},{"issue":"3","key":"10.1016\/j.biochi.2026.07.013_bib35","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3899\/jrheum.170775","article-title":"Function and T cell receptor repertoire analyses of peripheral blood and infrapatellar fat pad T cells in knee osteoarthritis","volume":"46","author":"Sae-Jung","year":"2019","journal-title":"J. Rheumatol."},{"issue":"6","key":"10.1016\/j.biochi.2026.07.013_bib36","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10616-025-00856-x","article-title":"CHRDL2 inhibits the progression of osteoarthritis by regulating the balance of Th17\/Treg","volume":"77","author":"Li","year":"2025","journal-title":"Cytotechnology"},{"issue":"6","key":"10.1016\/j.biochi.2026.07.013_bib37","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/adhm.201500797","article-title":"Particles for local delivery of proteins using intra-articular route","volume":"5","author":"Khodabandehlou","year":"2016","journal-title":"Adv. Healthcare Mater."},{"issue":"17","key":"10.1016\/j.biochi.2026.07.013_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202410060","article-title":"Liposome-based interventions in knee osteoarthritis","volume":"21","author":"Mitsou","year":"2025","journal-title":"Small"},{"issue":"1\u20132","key":"10.1016\/j.biochi.2026.07.013_bib39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ijpharm.2016.11.002","article-title":"Encapsulation of NSAIDs for inflammation management: overview, progress, challenges and prospects","volume":"515","author":"Badri","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.biochi.2026.07.013_bib40","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.joca.2025.04.006","article-title":"Intra-articular MM-II for the treatment of knee osteoarthritis pain: efficacy and safety results from a 26-week, phase 2b, placebo-controlled, double-blind, randomized dose-ranging trial","volume":"33","author":"Schnitzer","year":"2025","journal-title":"Osteoarthr. Cartil."},{"issue":"7","key":"10.1016\/j.biochi.2026.07.013_bib41","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.joca.2025.02.774","article-title":"Empty large liposomes reduce cartilage degeneration in osteoarthritic rats by forming a lubricative coating","volume":"33","author":"Wechscler","year":"2025","journal-title":"Osteoarthr. Cartil."},{"issue":"7","key":"10.1016\/j.biochi.2026.07.013_bib42","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s12276-023-01028-7","article-title":"Immune regulation through tryptophan metabolism","volume":"55","author":"Seo","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biochi.2026.07.013_bib43","doi-asserted-by":"crossref","DOI":"10.1177\/11786469231182510","article-title":"Contribution of circulating host and microbial tryptophan metabolites toward Ah receptor activation","volume":"16","author":"Morgan","year":"2023","journal-title":"Int. J. Tryptophan Res."},{"key":"10.1016\/j.biochi.2026.07.013_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115771","article-title":"The effects of environmental aryl hydrocarbon receptor ligands on signaling and cell metabolism in cancer","volume":"216","author":"Piwarski","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"3","key":"10.1016\/j.biochi.2026.07.013_bib45","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00109-023-02289-5","article-title":"Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: role of tryptophan metabolites generated by gut host-microbiota","volume":"101","author":"Salminen","year":"2023","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.biochi.2026.07.013_bib46","article-title":"Significance of the peripheral blood Treg\/Th17 ratio as a prognostic immune biomarker in newly diagnosed multiple myeloma and its correlation with 1q21 gain\/amplification","volume":"16","author":"Wen","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.biochi.2026.07.013_bib47","unstructured":"Falivene J, Ghiglione Y, Laufer N, Socias ME, Holgado MP, Ruiz MJ, Maeto C, Figueroa MI, Giavedoni LD, Cahn P, Salomon H, Sued O, Turk G, Gherardi MM. Th17 and Th17\/Treg Ratio at Early HIV Infection Associated with Protective HIV-specific CD8(+) T-cell Responses and Disease Progression."},{"key":"10.1016\/j.biochi.2026.07.013_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103622","article-title":"The dynamics of Th17\/Treg ratio in SLE patients during pregnancy","volume":"151","author":"Braga","year":"2022","journal-title":"J. Reprod. Immunol."},{"issue":"1","key":"10.1016\/j.biochi.2026.07.013_bib49","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13075-023-03153-0","article-title":"Intra-articular delivery of an indoleamine 2,3-dioxygenase galectin-3 fusion protein for osteoarthritis treatment in Male lewis rats","volume":"25","author":"Partain","year":"2023","journal-title":"Arthritis Res. Ther."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426001732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300908426001732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T19:38:26Z","timestamp":1787427506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300908426001732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":49,"alternative-id":["S0300908426001732"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2026.07.013","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute local and systemic effects of intra-articular administration of liposomal Ido-1 following anterior cruciate ligament rupture","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2026.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}