{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:34:19Z","timestamp":1793201659237,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100022330","name":"CSIR - Central Food Technological Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochimie"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.biochi.2026.08.001","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:19:51Z","timestamp":1786029591000},"page":"59-68","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Obestatin and its fragment analog Nt8U influence levels of satiety peptides in diet-induced obese mice"],"prefix":"10.1016","volume":"250","author":[{"given":"Shilpa Talkad Shivashankara","family":"Murthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma Venkateswaran","family":"Manjappara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.biochi.2026.08.001_bib1","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1001\/jama.2023.19897","article-title":"Obesity management in adults","volume":"330","author":"Elmaleh-Sachs","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/j.biochi.2026.08.001_bib2","unstructured":"Obesity and Overweight, (n.d.). https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight (accessed October 28, 2024)."},{"key":"10.1016\/j.biochi.2026.08.001_bib3","first-page":"1","volume":"2","author":"Christaki","year":"2025"},{"key":"10.1016\/j.biochi.2026.08.001_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00442","article-title":"No guts, no loss: toward the ideal treatment for obesity in the twenty-first century","volume":"9","author":"Hope","year":"2018","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biochi.2026.08.001_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/MED.0000000000000859","article-title":"Gut hormones and appetite regulation","volume":"31","author":"Hong","year":"2024","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.biochi.2026.08.001_bib6","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake","volume":"310","author":"Zhang","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.biochi.2026.08.001_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.peptides.2008.09.022","article-title":"Is GPR39 the natural receptor of obestatin?","volume":"30","author":"Dong","year":"2009","journal-title":"Peptides (N.Y.)."},{"key":"10.1016\/j.biochi.2026.08.001_bib8","author":"Cowan"},{"key":"10.1016\/j.biochi.2026.08.001_bib9","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.bbrc.2007.12.036","article-title":"Fragments of obestatin as modulators of feed intake, circulating lipids, and stored fat","volume":"366","author":"Nagaraj","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.biochi.2026.08.001_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.regpep.2009.08.008","article-title":"Fragment analogs as better mimics of obestatin","volume":"158","author":"Nagaraj","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biochi.2026.08.001_bib11","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2020.34.s1.05063","article-title":"Effect of Obestatin and its fragment analog Nt8U on the epididymal and brain tissue of DIO-C57BL\/6 mice","volume":"34","author":"Shilpa","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.biochi.2026.08.001_bib12","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-19-0399","article-title":"Mechanisms controlling hormone secretion in human gut and its relevance to metabolism","volume":"244","author":"Martin","year":"2020","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.biochi.2026.08.001_bib13","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2174\/138920311795906673","article-title":"Interaction between Gastric and upper small intestinal hormones in the regulation of hunger and satiety: Ghrelin and cholecystokinin take the central stage","volume":"12","author":"Stengel","year":"2011","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.biochi.2026.08.001_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.biochi.2016.03.009","article-title":"Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters","volume":"125","author":"Nagaraj","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.biochi.2026.08.001_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1080\/13813455.2019.1687523","article-title":"DoseCal: a virtual calculator for dosage conversion between human and different animal species","volume":"128","author":"Janhavi","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.biochi.2026.08.001_bib16","author":"Mallikarjuna"},{"key":"10.1016\/j.biochi.2026.08.001_bib17","author":"Islam"},{"key":"10.1016\/j.biochi.2026.08.001_bib18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s12276-021-00677-w","article-title":"Role of the gut\u2013brain axis in energy and glucose metabolism","volume":"54","author":"Wachsmuth","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.biochi.2026.08.001_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12576-024-00904-9","article-title":"Satiety: a gut-brain-relationship","volume":"74","author":"Barakat","year":"2024","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.biochi.2026.08.001_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/jobe\/9919810","article-title":"Harnessing GLP-1 receptor agonists for obesity treatment: prospects and obstacles on the horizon","volume":"2025","author":"Abdelrahman","year":"2025","journal-title":"J. Obes."},{"key":"10.1016\/j.biochi.2026.08.001_bib21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10989-019-09846-y","article-title":"Impromptu effects of Nt8U with soyasaponins on obesity-related lipid parameters in high fat fed C57BL\/6 mice","volume":"26","author":"Singh","year":"2020","journal-title":"Int. J. Pept. Res. Ther."},{"key":"10.1016\/j.biochi.2026.08.001_bib22","article-title":"Obestatin inhibits feeding but does not modulate GH and corticosterone secretion in the rat","volume":"29","author":"Bresciani","year":"2006","journal-title":"J. Endocrinol. Investig."},{"key":"10.1016\/j.biochi.2026.08.001_bib23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.peptides.2007.02.003","article-title":"Direct and indirect effects of obestatin peptides on food intake and the regulation of glucose homeostasis and insulin secretion in mice","volume":"28","author":"Green","year":"2007","journal-title":"Peptides (N.Y.)."},{"key":"10.1016\/j.biochi.2026.08.001_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.regpep.2009.04.014","article-title":"Central administration of obestatin fails to show inhibitory effects on food and water intake in mice","volume":"156","author":"Van Dijck","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biochi.2026.08.001_bib25","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.peptides.2008.01.020","article-title":"Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents","volume":"29","author":"Kobelt","year":"2008","journal-title":"Peptides (N.Y.)."},{"key":"10.1016\/j.biochi.2026.08.001_bib26","first-page":"2185","article-title":"Anti-obesity effect in high-fat-diet-induced obese C57BL\/6 mice: study of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris","volume":"17","author":"Lee","year":"2019","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.biochi.2026.08.001_bib27","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1592\/phco.20.4.270.34882","article-title":"Orlistat, a new lipase inhibitor for the management of obesity","volume":"20","author":"Heck","year":"2000","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.biochi.2026.08.001_bib28","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0014-2999(02)01422-X","article-title":"Orlistat: its current status as an anti-obesity drug","volume":"440","author":"Ballinger","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.biochi.2026.08.001_bib29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s12020-017-1309-2","article-title":"Long-term obestatin treatment of mice type 2 diabetes increases insulin sensitivity and improves liver function","volume":"56","author":"Ko\u0142odziejski","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.biochi.2026.08.001_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.749050","article-title":"The Leptin system and diet: a mini review of the current evidence","volume":"12","author":"Mendoza-Herrera","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biochi.2026.08.001_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1237796","article-title":"Adiponectin and resistin modulate the progression of Alzheimer's disease in a metabolic syndrome model","volume":"14","author":"Cisternas","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biochi.2026.08.001_bib32","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1172\/JCI10842","article-title":"Obesity and insulin resistance","volume":"106","author":"Kahn","year":"2000","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.biochi.2026.08.001_bib33","article-title":"Association of Leptin with obesity and insulin resistance","volume":"12","author":"Kumar","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.biochi.2026.08.001_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/ijms23084082","article-title":"Pep19 has a positive effect on insulin sensitivity and ameliorates both hepatic and adipose tissue phenotype of diet-induced Obese mice","volume":"23","author":"Silv\u00e9rio","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.biochi.2026.08.001_bib35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1210\/er.2005-0005","article-title":"Adiponectin and adiponectin receptors","volume":"26","author":"Kadowaki","year":"2005","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.biochi.2026.08.001_bib36","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.beem.2013.02.005","article-title":"Adipose tissue dysfunction contributes to obesity related metabolic diseases","volume":"27","author":"Bl\u00fcher","year":"2013","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.biochi.2026.08.001_bib37","doi-asserted-by":"crossref","DOI":"10.7860\/NJLM\/2023\/58015.2703","article-title":"Correlation of serum adiponectin level with insulin resistance in healthy Obese individuals: a case-control study","author":"Tabassum","year":"2023","journal-title":"Natl. J. Lab. Med."},{"key":"10.1016\/j.biochi.2026.08.001_bib38","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3892\/mmr.2024.13219","article-title":"Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation-mediating treatment options","volume":"29","author":"Varra","year":"2024","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.biochi.2026.08.001_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s13679-020-00396-9","article-title":"The implication of gut hormones in the regulation of energy homeostasis and their role in the pathophysiology of obesity","volume":"9","author":"Koliaki","year":"2020","journal-title":"Curr. Obes. Rep."},{"key":"10.1016\/j.biochi.2026.08.001_bib40","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.regpep.2009.06.009","article-title":"CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem","volume":"157","author":"Noetzel","year":"2009","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biochi.2026.08.001_bib41","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1210\/en.2007-0678","article-title":"Urocortins and cholecystokinin-8 act synergistically to increase satiation in lean but not obese mice: involvement of corticotropin-releasing factor receptor-2 pathway","volume":"148","author":"Gourcerol","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2026.08.001_bib42","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1007\/s00125-023-05956-x","article-title":"Incretin hormones and type 2 diabetes","volume":"66","author":"Nauck","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.biochi.2026.08.001_bib43","doi-asserted-by":"crossref","DOI":"10.1210\/jendso\/bvaf173","article-title":"In vivo inhibition of dipeptidyl peptidase 4 and Neprilysin activity enables measurement of GLP-1 secretion in Male rats","volume":"9","author":"Galsgaard","year":"2025","journal-title":"J. Endocr. Soc."},{"key":"10.1016\/j.biochi.2026.08.001_bib44","doi-asserted-by":"crossref","DOI":"10.2174\/18749445-v16-e230320-2022-61","article-title":"Evaluation the effect of chronic obestatin therapy on the serum glucose, insulin and lipid levels in type 2 diabetic rats","volume":"16","author":"Al-Halbouni","year":"2023","journal-title":"Open Publ. Health J."},{"key":"10.1016\/j.biochi.2026.08.001_bib45","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/s42255-024-01113-9","article-title":"GLP-1 physiology in obesity and development of incretin-based drugs for chronic weight management","volume":"6","author":"Holst","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.biochi.2026.08.001_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.674704","article-title":"Benefits of sustained upregulated unimolecular GLP-1 and CCK receptor signalling in obesity-diabetes","volume":"12","author":"Tanday","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.biochi.2026.08.001_bib47","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1530\/JOE-12-0368","article-title":"Unraveling oxyntomodulin, GLP1's enigmatic brother","volume":"215","author":"Pocai","year":"2012","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.biochi.2026.08.001_bib48","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1152\/physrev.00057.2024","article-title":"Proglucagon-derived peptides: human physiology and therapeutic potential","volume":"106","author":"Gasbjerg","year":"2026","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.biochi.2026.08.001_bib49","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1056\/NEJMoa030204","article-title":"Inhibition of food intake in obese subjects by peptide YY 3\u201336","volume":"349","author":"Batterham","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.biochi.2026.08.001_bib50","doi-asserted-by":"crossref","first-page":"5782","DOI":"10.1210\/en.2012-1595","article-title":"A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin","volume":"153","author":"Egerod","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.biochi.2026.08.001_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0308942","article-title":"Single-cell transcriptomic atlas of enteroendocrine cells along the murine gastrointestinal tract","volume":"19","author":"Smith","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.biochi.2026.08.001_bib52","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.lfs.2018.05.036","article-title":"Expression analysis of a cholecystokinin system in human and rat white adipose tissue","volume":"206","author":"Plaza","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.biochi.2026.08.001_bib53","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.peptides.2015.06.006","article-title":"High fat diet impairs the function of glucagon-like peptide-1 producing L-cells","volume":"77","author":"Richards","year":"2016","journal-title":"Peptides (N.Y.)"},{"key":"10.1016\/j.biochi.2026.08.001_bib54","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molmet.2019.09.010","article-title":"Glucagon-like peptide 1 (GLP-1)","volume":"30","author":"M\u00fcller","year":"2019","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.biochi.2026.08.001_bib55","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.peptides.2017.09.018","article-title":"Oxyntomodulin: actions and role in diabetes","volume":"100","author":"Holst","year":"2018","journal-title":"Peptides (N.Y.)."},{"key":"10.1016\/j.biochi.2026.08.001_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1113\/jphysiol.2008.164269","article-title":"The role of peptide YY in appetite regulation and obesity","volume":"587","author":"Karra","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.biochi.2026.08.001_bib57","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.regpep.2004.06.007","article-title":"What do we know about the secretion and degradation of incretin hormones?","volume":"128","author":"Deacon","year":"2005","journal-title":"Regul. Pept."},{"key":"10.1016\/j.biochi.2026.08.001_bib58","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker","year":"2006","journal-title":"Cell Metab."}],"container-title":["Biochimie"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090842600177X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S030090842600177X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T15:09:31Z","timestamp":1793200171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S030090842600177X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":58,"alternative-id":["S030090842600177X"],"URL":"https:\/\/doi.org\/10.1016\/j.biochi.2026.08.001","relation":{},"ISSN":["0300-9084"],"issn-type":[{"value":"0300-9084","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Obestatin and its fragment analog Nt8U influence levels of satiety peptides in diet-induced obese mice","name":"articletitle","label":"Article Title"},{"value":"Biochimie","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.biochi.2026.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. and Soci\u00e9t\u00e9 Fran\u00e7aise de Biochimie et Biologie Mol\u00e9culaire (SFBBM). All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}